scholarly journals Betaine as a Determinant of Postmethionine Load Total Plasma Homocysteine Before and After B-Vitamin Supplementation

2004 ◽  
Vol 24 (2) ◽  
pp. 301-307 ◽  
Author(s):  
Pål I. Holm ◽  
Øyvind Bleie ◽  
Per M. Ueland ◽  
Ernst A. Lien ◽  
Helga Refsum ◽  
...  
Keyword(s):  
Plasma Homocysteine ◽  
Vitamin Supplementation ◽  
Total Plasma ◽  
Before And After ◽  
B Vitamin

Homocysteine, folic acid and vitamin B12 in relation to pre- and postnatal health aspects

2005 ◽  
Vol 43 (10) ◽  
Author(s):  
Rima Obeid ◽  
Wolfgang Herrmann
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Pregnancy Outcomes ◽  
Pregnancy Complications ◽  
Plasma Homocysteine ◽  
Vitamin B ◽  
Total Plasma ◽  
Vitamin Status ◽  
B Vitamin ◽  
Early Abortion

AbstractStudies linking hyperhomocysteinemia (HHCY) and B-vitamin deficiency to some health aspects in children have been accumulating. Low B-vitamin status inearly life, even as early as the time of conception, may endanger the potential for new life and may negatively influence the health of the offspring. Early abortion, pregnancy complications and poor pregnancy outcomes have been linked to elevated concentrations of total plasma homocysteine (tHcy) and low folate or vitamin B

scholarly journals Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease

2009 ◽  
Vol 15 (8) ◽  
pp. 955 ◽  
Author(s):  
Muhammed Hadithi ◽  
Chris JJ Mulder ◽  
Frank Stam ◽  
Joshan Azizi ◽  
J Bart A Crusius ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Plasma Homocysteine ◽  
Vitamin Supplementation ◽  
B Vitamin

scholarly journals B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial

2017 ◽  
Vol 114 (13) ◽  
pp. 3503-3508 ◽  
Author(s):  
Jia Zhong ◽  
Oskar Karlsson ◽  
Guan Wang ◽  
Jun Li ◽  
Yichen Guo ◽  
...  
Keyword(s):  
Fine Particles ◽  
Health Benefit ◽  
Vitamin Supplementation ◽  
Vitamin B ◽  
Individual Level ◽  
Oxidative Energy Metabolism ◽  
Before And After ◽  
Significant Public Health ◽  
Exposure Experiment ◽  
B Vitamin

Acute exposure to fine particle (PM2.5) induces DNA methylation changes implicated in inflammation and oxidative stress. We conducted a crossover trial to determine whether B-vitamin supplementation averts such changes. Ten healthy adults blindly received a 2-h, controlled-exposure experiment to sham under placebo, PM2.5 (250 μg/m3) under placebo, and PM2.5 (250 μg/m3) under B-vitamin supplementation (2.5 mg/d folic acid, 50 mg/d vitamin B6, and 1 mg/d vitamin B12), respectively. We profiled epigenome-wide methylation before and after each experiment using the Infinium HumanMethylation450 BeadChip in peripheral CD4+ T-helper cells. PM2.5 induced methylation changes in genes involved in mitochondrial oxidative energy metabolism. B-vitamin supplementation prevented these changes. Likewise, PM2.5 depleted 11.1% [95% confidence interval (CI), 0.4%, 21.7%; P = 0.04] of mitochondrial DNA content compared with sham, and B-vitamin supplementation attenuated the PM2.5 effect by 102% (Pinteraction = 0.01). Our study indicates that individual-level prevention may be used to complement regulations and control potential mechanistic pathways underlying the adverse PM2.5 effects, with possible significant public health benefit in areas with frequent PM2.5 peaks.

One year B-vitamins increases serum and whole blood folate forms and lowers plasma homocysteine in older Germans

2015 ◽  
Vol 53 (3) ◽  
Author(s):  
Susanne H. Kirsch ◽  
Wolfgang Herrmann ◽  
Vera Kruse ◽  
Rudolf Eckert ◽  
Stefan Gräber ◽  
...  
Keyword(s):  
Vitamin D ◽  
Whole Blood ◽  
Baseline Level ◽  
Plasma Homocysteine ◽  
B Vitamins ◽  
Vitamin Supplementation ◽  
Baseline Serum ◽  
One Year ◽  
B Vitamin

AbstractWe aimed to study the effect of long-term supplementation of B-vitamins on folate forms in serum and whole blood (WB) in elderly German subjects.59 participants (mean age 67 years) were randomized to daily receive either vitamin DB-vitamins supplementation for 6 months led to higher concentrations of 5-methyltetrahydrofolate (5-methylTHF) in serum (mean 49.1 vs. 19.6 nmol/L) and WB (1332 vs. 616 nmol/L). Also non-methyl-folate concentrations in serum and WB were higher after 6 months with B-vitamins supplementation. Unmetabolized folic acid (UFA) increased after supplementation. tHcy concentration was lowered after 1 year of B-vitamin supplementation (mean 13.1 vs. 9.6 μmol/L). A stronger reduction of tHcy after 1 year was found in participants who had baseline level >12.5 μmol/L (mean 17.0 vs. 11.9 μmol/L) compared to those with baseline tHcy lower than this limit (mean 9.1 vs. 7.4 μmol/L). In contrast, the increases in serum and WB 5-methylTHF were comparable between the two groups.One year B-vitamins supplementation increased the levels of 5-methylTHF and non-methyl-folate in serum and WB, normalized tHcy, but caused an increase in the number of cases with detectable UFA in serum. Lowering of tHcy was predicted by baseline tHcy, but not by baseline serum or WB 5-methylTHF.

Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality

2012 ◽  
Vol 31 (4) ◽  
pp. 448-454 ◽  
Author(s):  
Tao Huang ◽  
Ying Chen ◽  
Bin Yang ◽  
Jing Yang ◽  
Mark L. Wahlqvist ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Plasma Homocysteine ◽  
Vitamin Supplementation ◽  
All Cause Mortality ◽  
B Vitamin

scholarly journals Effects of Folic Acid Before and After Vitamin B12 on Plasma Homocysteine Concentrations in Hemodialysis Patients with Known MTHFR Genotypes

2006 ◽  
Vol 52 (1) ◽  
pp. 145-148 ◽  
Author(s):  
Anna Pastore ◽  
Sandro De Angelis ◽  
Stefania Casciani ◽  
Rosalba Ruggia ◽  
Gianna Di Giovamberardino ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Plasma Homocysteine ◽  
University Hospital ◽  
Total Plasma ◽  
Dialysis Unit ◽  
Mthfr Genotype ◽  
Normal Vitamin ◽  
Before And After ◽  
First Time

Abstract Background: Treatment with folic acid and vitamin B12 appears to be effective in lowering total plasma homocysteine (tHcy) concentrations, but whether vitamin B12 alone lowers tHcy in patients with normal vitamin B12 status is unknown. The aims of the present study were to explore the effect of individual supplementation with folic acid or vitamin B12 on tHcy concentrations in hemodialysis (HD) patients and to compare changes in tHcy concentrations with MTHFR genotype. Methods: We recruited 200 HD patients (119 men) from the “Umberto I” Hospital (Frosinone, Italy) and the Dialysis Unit of University Hospital “Tor Vergata”. These patients were randomized blindly into 2 groups of 100 each. Unfortunately, during the study, 36 patients in the first group and 16 in the second group died. The first group was treated initially with vitamin B12 for 2 months and with folic acid for a following 2 months. The second group was treated initially with folic acid and then with vitamin B12. Samples were drawn before administration of either, after the first and second periods, and again 2 months after treatment. Results: The concentrations of tHcy decreased in both groups after the consecutive vitamin therapies, and the decrease was genotype-dependent. The decrease was greater for the T/T genotype (P <0.05) and was more significant when the treatment was started with folic acid (P <0.01). Conclusion: The alternating vitamin treatment demonstrated for the first time the importance of folate therapy and the secondary contribution of vitamin B12in lowering tHcy in HD patients.

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