One year B-vitamins increases serum and whole blood folate forms and lowers plasma homocysteine in older Germans

2015 ◽  
Vol 53 (3) ◽  
Author(s):  
Susanne H. Kirsch ◽  
Wolfgang Herrmann ◽  
Vera Kruse ◽  
Rudolf Eckert ◽  
Stefan Gräber ◽  
...  
Keyword(s):  
Vitamin D ◽  
Whole Blood ◽  
Baseline Level ◽  
Plasma Homocysteine ◽  
B Vitamins ◽  
Vitamin Supplementation ◽  
Baseline Serum ◽  
One Year ◽  
B Vitamin

AbstractWe aimed to study the effect of long-term supplementation of B-vitamins on folate forms in serum and whole blood (WB) in elderly German subjects.59 participants (mean age 67 years) were randomized to daily receive either vitamin DB-vitamins supplementation for 6 months led to higher concentrations of 5-methyltetrahydrofolate (5-methylTHF) in serum (mean 49.1 vs. 19.6 nmol/L) and WB (1332 vs. 616 nmol/L). Also non-methyl-folate concentrations in serum and WB were higher after 6 months with B-vitamins supplementation. Unmetabolized folic acid (UFA) increased after supplementation. tHcy concentration was lowered after 1 year of B-vitamin supplementation (mean 13.1 vs. 9.6 μmol/L). A stronger reduction of tHcy after 1 year was found in participants who had baseline level >12.5 μmol/L (mean 17.0 vs. 11.9 μmol/L) compared to those with baseline tHcy lower than this limit (mean 9.1 vs. 7.4 μmol/L). In contrast, the increases in serum and WB 5-methylTHF were comparable between the two groups.One year B-vitamins supplementation increased the levels of 5-methylTHF and non-methyl-folate in serum and WB, normalized tHcy, but caused an increase in the number of cases with detectable UFA in serum. Lowering of tHcy was predicted by baseline tHcy, but not by baseline serum or WB 5-methylTHF.

scholarly journals Nutrition and the psychoneuroimmunology of postpartum depression

2012 ◽  
Vol 25 (1) ◽  
pp. 180-192 ◽  
Author(s):  
E. R. Ellsworth-Bowers ◽  
E. J. Corwin
Keyword(s):  
Vitamin D ◽  
Postpartum Depression ◽  
B Vitamins ◽  
Trace Minerals ◽  
Future Research ◽  
Potential Contribution ◽  
Micronutrient Deficiencies ◽  
Vitamin Status ◽  
Micronutrient Status ◽  
B Vitamin

Postpartum depression (PPD) is a relatively common and often severe mood disorder that develops in women after childbirth. The aetiology of PPD is unclear, although there is emerging evidence to suggest a psychoneuroimmune connection. Additionally, deficiencies in n-3 PUFA, B vitamins, vitamin D and trace minerals have been implicated. This paper reviews evidence for a link between micronutrient status and PPD, analysing the potential contribution of each micronutrient to psychoneuroimmunological mechanisms of PPD. Articles related to PPD and women's levels of n-3 PUFA, B vitamins, vitamin D and the trace minerals Zn and Se were reviewed. Findings suggest that while n-3 PUFA levels have been shown to vary inversely with PPD and link with psychoneuroimmunology, there is mixed evidence regarding the ability of n-3 PUFA to prevent or treat PPD. B vitamin status is not clearly linked to PPD, even though it seems to vary inversely with depression in non-perinatal populations and may have an impact on immunity. Vitamin D and the trace minerals Zn and Se are linked to PPD and psychoneuroimmunology by intriguing, but small, studies. Overall, evidence suggests that certain micronutrient deficiencies contribute to the development of PPD, possibly through psychoneuroimmunological mechanisms. Developing a better understanding of these mechanisms is important for guiding future research, clinical practice and health education regarding PPD.

THE EFFECT OF 'CONCERN FOR OSTEOPOROSIS' AND SELF-PERCEIVED 'RISK OF OSTEOPOROSIS AND FRACTURE' ON ANTI-OSTEOPOROSIS BEHAVIOR OF POST MENOPAUSAL WOMEN- A CROSS-SECTIONAL STUDY.

2021 ◽  
pp. 28-31
Author(s):  
Deepali Srivastava ◽  
Sandeepa Srivastava ◽  
Ashish Kumar ◽  
Sanjiv Kumar
Keyword(s):  
Vitamin D ◽  
Risk Perception ◽  
Perceived Risk ◽  
Vitamin D Supplementation ◽  
Medical Advice ◽  
Vitamin Supplementation ◽  
Cross Sectional ◽  
Increased Risk ◽  
Bmd Testing ◽  
One Year

Introduction: Osteoporosis is more prevalent in women, especially following menopause. The total affected population would have been around 35 to 40 million. Morbidity due to disease includes decreased mobility, decreased quality of life, and increased risk of mortality following an osteoporotic fracture. The morbidity due to the disease may be decreased through diet, exercise, supplementation, and medication. The objective of this study is to determine the effect of 'concern for osteoporosis' and self-perceived 'risk of osteoporosis and fracture' on antiosteoporosis behaviour such as (1) calcium and vitamin D supplementation, (2) seeking medical advice, (3) undergoing bone mineral (BMD) testing, and (4) taking antiosteoporosis medication (AOM). Material And Method:The study was conducted on women attending outpatient clinic of the Obstretics and Gynaecology and Orthopaedics department. Patients were required to ll up the Global Longitudinal Osteoporosis in Women Questionnaire. Enrolled patients were contacted after one year by means of telephone calls, hospital visits and home visits and data was collected for self-reported use of supplements, self-reported seeking of medical advice regarding osteoporosis, self-reported BMD testing, and self-reported use of antiosteoporosis medications etc. Results:Total of 1562 women were enrolled for the study out of which data of only 1000 women was analyzed at end of one year. At the end of one year period 360 women reported use of Calcium and or Vitamin D. Table 4 depicts the association between the use of vitamin supplementation and concern and risk perception. Concern (P=0.61), risk perception to osteoporosis (P=0.13), and risk perception to fracture (P=0.29) were not signicantly associated with use of vitamin supplementation in the next 12 months (i.e., calcium and/or vitamin D). Concern (p= <0.001), risk perception to osteoporosis (p=<0.001), and risk perception to fracture (p=<0.001) were signicantly associated with women seeking medical care during the next one year. Concern (p=0.35) was not signicantly associated with undergoing BMD examination. Risk perception to osteoporosis (p=0.03) and risk perception to fracture (p=0.03) were signicantly associated with women undergoing BMD medical examination in one year. Concern about osteoporosis (p=0.64) was not signicantly associated with treatment with anti-osteoporotic medication. Risk perception to osteoporosis (p=0.06) and risk perception to fracture (p=0.002) were signicantly associated with women. Conclusion: Concern for osteoporosis is associated with likelihood of seeking medical advice. Perception of risk for Osteoporosis and fractures is positively associated with seeking medical advice, BMD examination and AOM treatment

Long-Term Vitamin D Supplementation Improves Bone Mineral Density (BMD) in Patients with Sickle Cell Disease.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3800-3800
Author(s):  
Adeboye H. Adewoye ◽  
Michael F. Holick ◽  
Lillian C. McMahon ◽  
Qanli Ma ◽  
Martin H. Steinberg
Keyword(s):  
Vitamin D ◽  
Sickle Cell Disease ◽  
Post Treatment ◽  
P Value ◽  
Z Score ◽  
Cell Disease ◽  
Oral Vitamin ◽  
25 Oh Vitamin D ◽  
One Year

Abstract Among the many complications of sickle cell disease (SCD) are osteopenia and osteoporosis. We and others have previously documented a high prevalence of low serum 25-OH vitamin D level with accompanying osteopenia and osteoporosis in patients with SCD; however the long-term effects of treatment on BMD have not been reported. We hypothesized that supplementation with oral vitamin D and calcium will result in an improvement in BMD and accordingly, treated 6 adult subjects with SCD for 12 months with oral supplementation with vitamin D and calcium and studied the effects of treatment on BMD. Subjects with serum 25-OH D levels <20 ng/ml were placed on 50,000 IU of oral vitamin D weekly for 8 weeks, followed by 50,000 IU every other week for 44 weeks; subjects also received 1000 mg of elemental calcium daily. We evaluated BMD at weeks 1 and 52. Subjects had a mean pre-treatment plasma 25-OH vitamin D of 9.1 ng/ml. BMD was abnormal in all subjects; 4 subjects had osteoporosis with a Z-score <-2.5, and 2 subjects had osteopenia with a Z-score −1.9 to −2.5 (in the lumbo-sacral vertebrae). All subjects had mildly elevated intact PTH levels which were within the reference range but declined further post-treatment. Following one year of treatment with vitamin D and calcium, we observed a mean post-treatment increase in BMD of 5.4% (p value <0.02) and a 176% increase in plasma 25-OH D level (from 9.1ng/ml to 28ng/ml; p value <0.009). All patients with SCD we have studied have hypovitaminosis D that in adults is associated with low BMD. In patients followed for one year who received supplementation with calcium and vitamin D, 25-OH D level increased in all and BMD improved in four of six subjects. These results suggest that this treatment regimen can be effective is restoring BMD. The reasons for apparent unresponsiveness in some patients must be further evaluated. Clinical trials to document the effectiveness of treatment for this ubiquitous problem should be instituted. Mean change in 25-OH vitamin D level Mean change in 25-OH vitamin D level Mean Change in BMD: Pre and Post Treatment Mean Change in BMD: Pre and Post Treatment

scholarly journals Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease

2009 ◽  
Vol 15 (8) ◽  
pp. 955 ◽  
Author(s):  
Muhammed Hadithi ◽  
Chris JJ Mulder ◽  
Frank Stam ◽  
Joshan Azizi ◽  
J Bart A Crusius ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Plasma Homocysteine ◽  
Vitamin Supplementation ◽  
B Vitamin

scholarly journals Betaine as a Determinant of Postmethionine Load Total Plasma Homocysteine Before and After B-Vitamin Supplementation

2004 ◽  
Vol 24 (2) ◽  
pp. 301-307 ◽  
Author(s):  
Pål I. Holm ◽  
Øyvind Bleie ◽  
Per M. Ueland ◽  
Ernst A. Lien ◽  
Helga Refsum ◽  
...  
Keyword(s):  
Plasma Homocysteine ◽  
Vitamin Supplementation ◽  
Total Plasma ◽  
Before And After ◽  
B Vitamin

scholarly journals B-vitamins and prevention of dementia

2008 ◽  
Vol 67 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Robert Clarke
Keyword(s):  
Folic Acid ◽  
Cognitive Function ◽  
Meta Analysis ◽  
B Vitamins ◽  
Vitamin Supplementation ◽  
Vitamin B ◽  
Cross Sectional ◽  
Principal Investigators ◽  
Individual Participant ◽  
B Vitamin

Elevated plasma homocysteine (Hcy) concentrations have been implicated with risk of cognitive impairment and dementia, but it is unclear whether low vitamin B12 or folate status is responsible for cognitive decline. Most studies reporting associations between cognitive function and Hcy or B-vitamins have used a cross-sectional or case–control design and have been unable to exclude the possibility that such associations are a result of the disease rather than being causal. The Hcy hypothesis of dementia has attracted considerable interest, as Hcy can be easily lowered by folic acid and vitamin B12, raising the prospect that B-vitamin supplementation could lower the risk of dementia. While some trials assessing effects on cognitive function have used folic acid alone, vitamin B12 alone or a combination, few trials have included a sufficient number of participants to provide reliable evidence. An individual-patient-data meta-analysis of all randomised trials of the effects on cognitive function and vascular risk of lowering Hcy with B-vitamins will maximise the power to assess the epidemiologically-predicted differences in risk. Among the twelve large randomised Hcy-lowering trials for prevention of vascular disease, data should be available on about 30 000 participants with cognitive function. The principal investigators of such trials have agreed to combine individual-participant data from their trials after their separate publication.

scholarly journals Development and validation of an LC-MS/MS method for determination of B vitamins and some its derivatives in whole blood

2021 ◽  
Author(s):  
David Kahoun ◽  
Pavla Fojtíková ◽  
František Vácha ◽  
Eva Nováková ◽  
Václav Hypša
Keyword(s):  
Whole Blood ◽  
Trichloroacetic Acid ◽  
Zinc Sulphate ◽  
Pantothenic Acid ◽  
B Vitamins ◽  
Process Efficiency ◽  
Internal Standards ◽  
Tetrahydrofolic Acid ◽  
B Vitamin

AbstractObligate symbiotic bacteria associated with the insects feeding exclusively on vertebrate blood are supposed to complement B vitamins presumably lacking in their diet, vertebrate blood. Recent genomic analyses revealed considerable differences in biosynthetic capacities across different symbionts, indicating that levels of B vitamins vary across different vertebrate hosts. However, a rigorous determination of B vitamins content in blood of various vertebrates has not yet been approached. A reliable analytical method focused on B vitamin complex in blood and hemolymph can provide valuable informative background and understanding of general principles of insect symbiosis.In this work chromatographic separation of a mixture of eight B vitamins (B1 – thiamine, B2 – riboflavin, B3 – niacin, B5 – pantothenic acid, B6 – pyridoxine, B7 – biotin, B9 – folic acid and B12 – cyanocobalamine), four B vitamin derivatives (B3 – niacinamide, B6 – pyridoxal-5-phosphate, B6 – 4-pyridoxic acid and B9 – tetrahydrofolic acid) and 3 stable isotope labelled internal standards (B3 – niacin-13C6, B5 – pantothenic acid (di-β-alanine-13C6,15N2) and B7 – biotin-(ring-6,6-d2)) on C30 column was developed. Detection was carried out using dual-pressure linear ion trap mass spectrometer in FullScan MS/MS and SIM mode. Matching internal standards with analytes was done according to the results of linearity, accuracy and precision. Except for vitamin B9 (tetrahydrofolic acid) instrument quantitation limits of all analytes were ranging from 0.42 to 5.0 μg/L, correlation coefficients from 0.9997 to 1.0000 and QC coefficients from 0.53 to 3.2 %.Optimization of whole blood sample preparation step was focused especially on evaluation of two types of protein-precipitation agents: trichloroacetic acid and zinc sulphate in methanol. Samples of whole blood prepared in six independent replicates were spiked at 10 μg/L and 100 μg/L level. The best results were obtained for zinc sulphate in methanol, but only nine analytes (B1 – thiamine, B2 – riboflavin, B3 – niacin, B3 – niacinamide, B5 – pantothenic acid, B6 – pyridoxine, B6 – 4-pyridoxic acid, B7 – biotin and B12 – cyanocobalamine) were successfully validated. Accuracy of the procedure using this protein-precipitating agent was ranging from 89 to 120 %, precision from 0.5 to 13 % and process efficiency from 65 to 108 %.HighlightsLC-MS/MS method for quantitation of eight B vitamins and four B vitamin derivatives was developed.Deproteinization agents trichloroacetic acid and ZnSO4/methanol were tested for protein precipitation of whole blood.Accuracy, precision and process efficiency were evaluated.Successful method validation for seven B vitamins and two B vitamin derivatives in whole blood.

scholarly journals Mosaic Patterns of B-vitamin Synthesis and Utilization in a Natural Marine Microbial Community

2018 ◽  
Author(s):  
Laura Gómez-Consarnau ◽  
Rohan Sachdeva ◽  
Scott M. Gifford ◽  
Lynda S. Cutter ◽  
Jed A. Fuhrman ◽  
...  
Keyword(s):  
Microbial Community ◽  
Microbial Communities ◽  
De Novo ◽  
B Vitamins ◽  
Microbial Consortia ◽  
Vitamin B ◽  
Complex Interactions ◽  
Spatial Changes ◽  
One Year ◽  
B Vitamin

Aquatic environments contain diverse microbial communities whose complex interactions mediate the cycling of major and trace nutrients such as vitamins. B-vitamins are essential coenzymes that many organisms cannot synthesize. Thus their exchange among de-novo synthesizers and auxotrophs is expected to play an important role in the microbial consortia and explain some of the temporal and spatial changes observed in diversity. In this study, we analyzed metatranscriptomes of a natural coastal microbial community, diel sampled-quarterly over one year to try to identify the potential major B-vitamin synthesizers and consumers. Our transcriptomic data show that the best-represented taxa dominated the expression of synthesis genes for some B-vitamins but lacked transcripts for others. For instance, Rhodobacterales dominated the expression of vitamin-B12synthesis, but not of vitamin-B7, whose synthesis transcripts were mainly represented by Flavobacteria.In contrast, bacterial groups that constituted less than 4% of the community (e.g., Verrucomicrobia) accounted for most of the vitamin-B1synthesis transcripts. Furthermore, ambient vitamin-B1concentrations were higher in samples collected during the day, and were positively correlated with chlorophyll-aconcentration. Our analysis supports the hypothesis that the mosaic of metabolic interdependencies through B-vitamin synthesis and exchange are key processes that contribute to shaping microbial communities in nature.

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