scholarly journals Native beta-adrenergic support for left ventricular dysfunction in experimental mitral regurgitation normalizes indexes of pump and contractile function.

Circulation ◽  
1994 ◽  
Vol 89 (2) ◽  
pp. 818-826 ◽  
Author(s):  
M Nagatsu ◽  
M R Zile ◽  
H Tsutsui ◽  
P G Schmid ◽  
G DeFreyte ◽  
...  
Keyword(s):  
Mitral Regurgitation ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Contractile Function ◽  
Left Ventricular ◽  
Beta Adrenergic

Left ventricular function in experimental volume overload hypertrophy

1989 ◽  
Vol 256 (4) ◽  
pp. H974-H981 ◽  
Author(s):  
B. A. Carabello ◽  
K. Nakano ◽  
W. Corin ◽  
R. Biederman ◽  
J. F. Spann
Keyword(s):  
Mitral Regurgitation ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Contractile Function ◽  
Weight Ratio ◽  
Volume Overload ◽  
Left Ventricular ◽  
Mean Velocity

Left ventricular function in volume overload hypertrophy is controversial. In humans, chronic severe volume overload eventually results in left ventricular dysfunction; paradoxically, experimental volume overload hypertrophy has nearly always been associated with normal left ventricular function. However, in most cases, experimental volume overload hypertrophy has either been mild or only present for a short duration. To help resolve the issue of contractile function in volume overload hypertrophy, we examined ventricular function in a recently described model of severe chronic experimental mitral regurgitation. Left ventricular function was measured before and 3 mo after the creation of severe mitral regurgitation (averaged regurgitant fraction 0.64 +/- 0.04). At 3 mo end-diastolic volume had increased from 78 +/- 5 to 114 +/- 7 ml (P less than 0.01). Significant left ventricular hypertrophy had occurred with an increase in the left ventricular weight-to-body weight ratio from 3.84 +/- 0.2 to 5.22 +/- 0.2 (P less than 0.01). All indicators of left ventricular function (ejection fraction, the end ejection stress-volume relationship, this relationship corrected for eccentric hypertrophy, and mean velocity of circumferential fiber shortening at a common stress) were reduced at 3 mo. Our study produced 64% volume overload which was maintained for 3 mo at which time there was a 36% increase in left ventricular mass. This amount of volume overload of this duration produced significant left ventricular dysfunction.

scholarly journals Forward Left Ventricular Ejection Fraction as a Predictor of Postoperative Left Ventricular Dysfunction in Patients with Degenerative Mitral Regurgitation

2021 ◽  
Vol 10 (14) ◽  
pp. 3013
Author(s):  
Juyoun Kim ◽  
Jae-Sik Nam ◽  
Youngdo Kim ◽  
Ji-Hyun Chin ◽  
In-Cheol Choi
Keyword(s):  
Left Ventricular Ejection Fraction ◽  
Mitral Regurgitation ◽  
Ejection Fraction ◽  
Left Ventricular Dysfunction ◽  
Predictive Value ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Normal Lvef

Background: Left ventricular dysfunction (LVD) can occur immediately after mitral valve repair (MVr) for degenerative mitral regurgitation (DMR) in some patients with normal preoperative left ventricular ejection fraction (LVEF). This study investigated whether forward LVEF, calculated as left ventricular outflow tract stroke volume divided by left ventricular end-diastolic volume, could predict LVD immediately after MVr in patients with DMR and normal LVEF. Methods: Echocardiographic and clinical data were retrospectively evaluated in 234 patients with DMR ≥ moderate and preoperative LVEF ≥ 60%. LVD and non-LVD were defined as LVEF < 50% and ≥50%, respectively, as measured by echocardiography after MVr and before discharge. Results: Of the 234 patients, 52 (22.2%) developed LVD at median three days (interquartile range: 3–4 days). Preoperative forward LVEF in the LVD and non-LVD groups were 24.0% (18.9–29.5%) and 33.2% (26.4–39.4%), respectively (p < 0.001). Receiver operating characteristic (ROC) analyses showed that forward LVEF was predictive of LVD, with an area under the ROC curve of 0.79 (95% confidence interval: 0.73–0.86), and an optimal cut-off was 31.8% (sensitivity: 88.5%, specificity: 58.2%, positive predictive value: 37.7%, and negative predictive value: 94.6%). Preoperative forward LVEF significantly correlated with preoperative mitral regurgitant volume (correlation coefficient [CC] = −0.86, p < 0.001) and regurgitant fraction (CC = −0.98, p < 0.001), but not with preoperative LVEF (CC = 0.112, p = 0.088). Conclusion: Preoperative forward LVEF could be useful in predicting postoperative LVD immediately after MVr in patients with DMR and normal LVEF, with an optimal cut-off of 31.8%.

Left ventricular dysfunction in patients with mitral regurgitation

1981 ◽  
Vol 47 ◽  
pp. 410
Author(s):  
Lewis C. Lipson ◽  
Kenneth M. Kent ◽  
Robert O. Bonow ◽  
Douglas R. Rosing ◽  
Charles L. McIntosh ◽  
...  
Keyword(s):  
Mitral Regurgitation ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Left Ventricular

Coaptation Mechanism of Dilated Mitral Valves

2010 ◽  
Author(s):  
Bo Gao ◽  
Zhaoming He
Keyword(s):  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Functional Mitral Regurgitation ◽  
Common Complication ◽  
Mitral Valves ◽  
Global Left Ventricular ◽  
Normal Mitral Valve

Functional mitral regurgitation, which occurs as a consequence of regional of global left ventricular or global left ventricular dysfunction despite structurally normal mitral valve (MV), is a common complication in patients with ischemic or non-ischemic cardiomyopathies [1].

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