A Randomized, Placebo-Controlled, Double-Blind, Parallel Study of Various Doses of Losartan Potassium Compared With Enalapril Maleate in Patients With Essential Hypertension

Hypertension ◽  
1995 ◽  
Vol 25 (6) ◽  
pp. 1345-1350 ◽  
Author(s):  
Alan H. Gradman ◽  
Karen E. Arcuri ◽  
Allan I. Goldberg ◽  
Leila S. Ikeda ◽  
Edward B. Nelson ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Losartan Potassium ◽  
Parallel Study ◽  
Double Blind ◽  
Enalapril Maleate

Imidapril hydrochloride in essential hypertension: a double-blind comparative study using enalapril maleate as a control

1995 ◽  
Vol 13 (supplement 3) ◽  
pp. S23-S30 ◽  
Author(s):  
Takao Saruta ◽  
Teruo Omae ◽  
Morio Kuramochi ◽  
Osamu limura ◽  
Kaoru Yoshinaga ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Comparative Study ◽  
Double Blind ◽  
Enalapril Maleate ◽  
Imidapril Hydrochloride

scholarly journals Midazolam-Flumazenil Topical Anaesthesia for Microlaryngoscopy with Jet Ventilation

1997 ◽  
Vol 25 (4) ◽  
pp. 358-364
Author(s):  
W. Rushatamukayanunt ◽  
T. Tritrakarn
Keyword(s):  
Treated Group ◽  
Muscle Relaxants ◽  
Total Intravenous Anaesthesia ◽  
Topical Anaesthesia ◽  
Parallel Study ◽  
Jet Ventilation ◽  
Double Blind ◽  
Intravenous Anaesthesia ◽  
Single Intravenous Injection ◽  
High Incidence

A comparison between midazolam and midazolam-flumazenil for total intravenous anaesthesia in combination with topical anaesthesia and muscle relaxants was performed in a double-blind, parallel study in 40 patients scheduled for microlaryngoscopy with or without bronchoscopic procedures using jet ventilation with oxygen. A single intravenous injection of midazolam 0.3 mg/kg, lignocaine spray and muscle relaxants provided adequate anaesthesia and good operative conditions throughout the procedures, which took 20 to 30 minutes. Patients who had placebo at the end of the procedures had a longer recovery and a high incidence of airway obstruction (20%). Administration of flumazenil provided prompt awakening in 19 of 20 patients (95%) within five minutes, resulting in rapid and favourable recovery without resedation or other side-effects, while only three of 20 (15%) patients in the placebo-treated group had improved consciousness within five minutes. The simplicity and reliability of the midazolam-flumazenil technique is attractive. We consider it worthy of further investigation for wider application in clinical practice.

scholarly journals Effects of supplementation with purified red clover (Trifolium pratense) isoflavones on plasma lipids and insulin resistance in healthy premenopausal women

2003 ◽  
Vol 89 (4) ◽  
pp. 467-474 ◽  
Author(s):  
Sarah J. Blakesmith ◽  
Philippa M. Lyons–Wall ◽  
Caroline George ◽  
George E. Joannou ◽  
Peter Petocz ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Trifolium Pratense ◽  
Plasma Lipids ◽  
Premenopausal Women ◽  
Red Clover ◽  
Fold Increase ◽  
Cholesterol Homeostasis ◽  
Plasma Lipoproteins ◽  
Parallel Study ◽  
Double Blind

Consumption of isoflavone-rich soyabean protein is reported to reduce total and LDL-cholesterol, but the specific components responsible are undetermined. In a previous crossover trial we showed that purified isoflavones, derived from red clover (Trifolium pratense), raised HDL3-cholesterol in premenopausal women; however, these findings were inconclusive due to period and carryover effects. In an attempt to overcome this problem, we utilised a parallel study designed to re-examine the effects of purified isoflavones on plasma lipoproteins and markers of insulin resistance in premenopausal women. Twenty-five healthy premenopausal women participated in a double-blind, randomised, parallel study. The treatment group (n12) consumed a placebo for the first menstrual cycle and an isoflavone supplement (86 mg/d, derived from red clover) for three cycles, while the placebo group (n13) consumed a placebo supplement for four menstrual cycles. Blood samples were collected weekly during cycles 1, 3 and 4. Supplementation with isoflavones resulted in a 15-fold increase in urinary isoflavone excretion (P<0·0001). There were no significant effects on total cholesterol, LDL- and HDL-cholesterol, HDL subfractions, triacylglycerol, lipoprotein(a), glucose or insulin concentrations. Our present results indicate that purified isoflavones derived from red clover have no effect on cholesterol homeostasis or insulin resistance in premenopausal women, a group which is at low risk of CHD.

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