Angiotensin II Type 2 Receptor mRNA Expression in the Developing Cardiopulmonary System of the Rat

Hypertension ◽  
1996 ◽  
Vol 28 (1) ◽  
pp. 91-97 ◽  
Author(s):  
Sadoutounissa Shanmugam ◽  
Pierre Corvol ◽  
Jean-Marie Gasc
2000 ◽  
Vol 69 (Supplement) ◽  
pp. S400
Author(s):  
Bryan N. Becker ◽  
Lynn M. Jacobson ◽  
Debra A. Hullett ◽  
Yolanda T. Becker ◽  
Terry D. Oberley ◽  
...  

Author(s):  
Anne Monique Nuyt ◽  
Zsolt Lenkei ◽  
Miklos Palkovits ◽  
Pierre Corvol ◽  
Catherine Llorens-Cort�s

Author(s):  
Wusa Makena ◽  
Abdullahi Ibrahim Iliya ◽  
Joseph Olajide Hambolu ◽  
James Abrak Timbuak ◽  
Uduak Emmanuel Umana ◽  
...  

Type 2 diabetes (T2D) occur as a result of insulin resistance and malfunction in insulin signaling. Controlling hyperglycemia and activation of insulin signaling are important in the management of T2D. The study aimed to evaluate the effect of Genistein and Momordica charantia L. fruit on oxidative stress, markers of inflammation, and their role on proglucagon and insulin receptor mRNA expression by RT-PCR in diabetic rats. Thirty-five albino rats were divided into seven groups (n=5). Group I (non-diabetic) and group II (diabetic control) were treated with distilled water, groups III and IV received 250mg/kg and 500mg/kg lyophilized MCF respectively. Groups V and VI received 10mg/kg and 20mg/kg Genistein respectively while group VII received 500mg/kg Metformin. The administration lasted for 28 days. MCF and Genistein significantly reduced IL-1β and TNFα levels that was elevated in serum of diabetic rats. Treatment with MCF and Genistein significant increased the expression of proglucagon mRNA in the small intestine and insulin receptor mRNA in the liver of diabetic rats. In conclusion, MCF and Genistein ameliorate type 2 diabetes complications by preventing the loss of insulin-positive cells, inhibiting IL-1β and TNFα and up-regulating proglucagon and insulin receptor mRNA expression. Novelty: • MCF and Genistein has an inhibitory effect on diabetic induced IL-1β and TNFα production. • MCF and Genistein up-regulates proglucagon and insulin receptor mRNA expression.


1996 ◽  
Vol 22 (4) ◽  
pp. 363-368 ◽  
Author(s):  
G. C. Dell ◽  
S. D. Morley ◽  
J. J. Mullins ◽  
B. C. Williams ◽  
S. W. Walker

1995 ◽  
Vol 47 (4) ◽  
pp. 1095-1100 ◽  
Author(s):  
Sadoutounissa Shanmugam ◽  
Zsolt G. Lenkei ◽  
Jean-Marie R. Gasc ◽  
Pierre L. Corvol ◽  
Catherine M. Llorens-Cortes

1995 ◽  
Vol 42 (1) ◽  
pp. 15-22 ◽  
Author(s):  
HIROMICHI SUZUKI ◽  
HIROTAKA SHIBATA ◽  
MAROHITO MURAKAMI ◽  
ATSUHISA SATO ◽  
MAREO NAITO ◽  
...  

2006 ◽  
Vol 7 (3) ◽  
pp. 549
Author(s):  
L. Guasti ◽  
F. Marino ◽  
M. Cosentino ◽  
M. Ferrari ◽  
M. Cimpanelli ◽  
...  

2004 ◽  
Vol 26 (6) ◽  
pp. 475-483 ◽  
Author(s):  
Zhiming Zhu ◽  
Shanjun Zhu ◽  
Jijun Zhu ◽  
Markus van der Giet ◽  
Martin Tepel

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