TYPE 2 ANGIOTENSIN II RECEPTOR mRNA EXPRESSION IN HUMAN RENAL ALLOGRAFTS IS ASSOCIATED WITH CHRONIC REJECTION.

2000 ◽  
Vol 69 (Supplement) ◽  
pp. S400
Author(s):  
Bryan N. Becker ◽  
Lynn M. Jacobson ◽  
Debra A. Hullett ◽  
Yolanda T. Becker ◽  
Terry D. Oberley ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Mrna Expression ◽  
Chronic Rejection ◽  
Angiotensin Ii Receptor ◽  
Renal Allografts ◽  
Receptor Mrna

scholarly journals Angiotensin II Receptor mRNA Expression and Vasoconstriction in Human Coronary Arteries: Effects of Heart Failure and Age

2004 ◽  
Vol 95 (6) ◽  
pp. 266-272 ◽  
Author(s):  
Angelica Wackenfors ◽  
Emil Pantev ◽  
Malin Emilson ◽  
Lars Edvinsson ◽  
Malin Malmsjo
Keyword(s):  
Heart Failure ◽  
Angiotensin Ii ◽  
Mrna Expression ◽  
Coronary Arteries ◽  
Angiotensin Ii Receptor ◽  
Receptor Mrna

Ontogeny of angiotensin II type 2 receptor mRNA expression in fetal and neonatal rat brain

1999 ◽  
Vol 407 (2) ◽  
pp. 193-206 ◽  
Author(s):  
Anne Monique Nuyt ◽  
Zsolt Lenkei ◽  
Miklos Palkovits ◽  
Pierre Corvol ◽  
Catherine Llorens-Cort�s
Keyword(s):  
Angiotensin Ii ◽  
Mrna Expression ◽  
Rat Brain ◽  
Neonatal Rat ◽  
Receptor Mrna ◽  
Neonatal Rat Brain

Angiotensin II Type 2 Receptor mRNA Expression in the Developing Cardiopulmonary System of the Rat

Hypertension ◽  
1996 ◽  
Vol 28 (1) ◽  
pp. 91-97 ◽  
Author(s):  
Sadoutounissa Shanmugam ◽  
Pierre Corvol ◽  
Jean-Marie Gasc
Keyword(s):  
Angiotensin Ii ◽  
Mrna Expression ◽  
Receptor Mrna ◽  
Cardiopulmonary System

Type 2 angiotensin II receptor expression in human renal allografts: an association with chronic allograft nephropathy

2002 ◽  
Vol 57 (01) ◽  
pp. 19-26 ◽  
Author(s):  
B.N. Becker ◽  
L.M. Jacobson ◽  
D.A. Hullett ◽  
N.A. Radke ◽  
T.D. Oberley ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Chronic Allograft Nephropathy ◽  
Receptor Expression ◽  
Angiotensin Ii Receptor ◽  
Renal Allografts

Genistein and Momordica charantia L. prevents oxidative stress and upregulate proglucagon and insulin receptor mRNA in diabetic rats.

2021 ◽  
Author(s):  
Wusa Makena ◽  
Abdullahi Ibrahim Iliya ◽  
Joseph Olajide Hambolu ◽  
James Abrak Timbuak ◽  
Uduak Emmanuel Umana ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Insulin Receptor ◽  
Mrna Expression ◽  
Insulin Signaling ◽  
Diabetic Rats ◽  
Momordica Charantia ◽  
Receptor Mrna ◽  
Group I

Type 2 diabetes (T2D) occur as a result of insulin resistance and malfunction in insulin signaling. Controlling hyperglycemia and activation of insulin signaling are important in the management of T2D. The study aimed to evaluate the effect of Genistein and Momordica charantia L. fruit on oxidative stress, markers of inflammation, and their role on proglucagon and insulin receptor mRNA expression by RT-PCR in diabetic rats. Thirty-five albino rats were divided into seven groups (n=5). Group I (non-diabetic) and group II (diabetic control) were treated with distilled water, groups III and IV received 250mg/kg and 500mg/kg lyophilized MCF respectively. Groups V and VI received 10mg/kg and 20mg/kg Genistein respectively while group VII received 500mg/kg Metformin. The administration lasted for 28 days. MCF and Genistein significantly reduced IL-1β and TNFα levels that was elevated in serum of diabetic rats. Treatment with MCF and Genistein significant increased the expression of proglucagon mRNA in the small intestine and insulin receptor mRNA in the liver of diabetic rats. In conclusion, MCF and Genistein ameliorate type 2 diabetes complications by preventing the loss of insulin-positive cells, inhibiting IL-1β and TNFα and up-regulating proglucagon and insulin receptor mRNA expression. Novelty: • MCF and Genistein has an inhibitory effect on diabetic induced IL-1β and TNFα production. • MCF and Genistein up-regulates proglucagon and insulin receptor mRNA expression.

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