scholarly journals Effect of Vasospasm on Heme Oxygenases in a Rat Model of Subarachnoid Hemorrhage

Stroke ◽  
1998 ◽  
Vol 29 (3) ◽  
pp. 683-689 ◽  
Author(s):  
Minoru Kuroki ◽  
Kenji Kanamaru ◽  
Hidenori Suzuki ◽  
Shiro Waga ◽  
Reiji Semba
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Rat Model ◽  
Heme Oxygenases

The calcimimetic R-568 attenuates subarachnoid hemorrhage-induced vasospasm through PI3K/Akt/eNOS signaling pathway in the rat model

2021 ◽  
Vol 1765 ◽  
pp. 147508
Author(s):  
İlker Güleç ◽  
Aslıhan Şengelen ◽  
Feyza Karagöz-Güzey ◽  
Evren Önay-Uçar ◽  
Burak Eren ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Signaling Pathway ◽  
Rat Model

Treatment of early brain injury after subarachnoid hemorrhage in the rat model by inhibiting p53-induced ferroptosis

2021 ◽  
pp. 136134
Author(s):  
Hong Kuang ◽  
Tianhong Wang ◽  
Lei Liu ◽  
Chunhai Tang ◽  
Tao Li ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Rat Model ◽  
Early Brain Injury

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

10.3791/62567 ◽  
2021 ◽  
Author(s):  
Jesper Peter Bömers ◽  
Sara Ellinor Johansson ◽  
Lars Edvinsson ◽  
Tiit Illimar Mathiesen ◽  
Kristian Agmund Haanes
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Rat Model ◽  
Single Injection ◽  
Autologous Blood ◽  
Experimental Subarachnoid Hemorrhage

Involvement of neutrophils in machineries underlying the rupture of intracranial aneurysms

2019 ◽  
Author(s):  
Mika Kushamae ◽  
Haruka Miyata ◽  
Manabu Shirai ◽  
Kampei Shimizu ◽  
Mieko Oka ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Rat Model ◽  
Immunohistochemical Study ◽  
Therapeutic Modality ◽  
Major Type ◽  
Collagenolytic Activity ◽  
Inflammatory Stimuli ◽  
A Site ◽  
Gene Expression Profile Data

Abstract Background: Subarachnoid hemorrhage due to rupture of an intracranial aneurysm (IA) has quite a poor prognosis once after the onset despite of the modern technical advancement. The development of a novel therapeutic modality to prevent rupture or a diagnostic method to stratify dangerous lesions from many stable ones is thus mandatory for social health. To this end, mechanisms underlying rupture of lesions should be clarified. Methods: We and others have developed the rat model in which induced IAs spontaneously rupture resulting in subarachnoid hemorrhage. To clarify molecular cascades regulating rupture, we obtained gene expression profile data from rupture-prone lesions and revealed the enrichment of neutrophil-related terms in rupture-prone lesions by Gene Ontology analysis. Next, to validate a role of neutrophils in rupture of lesions, G-CSF was administered to a rat model. Results: As a result, G-CSF treatment not only increased number of neutrophils infiltrating in lesions but also significantly facilitated rupture of the lesions without increase the incidence. To clarify mechanisms how neutrophils facilitate rupture of IAs, we used HL-60 cell line and found that inflammatory stimuli enhanced the collagenolytic activity of MMP9. Immunohistochemical study using IA lesions from a rat model identified neutrophils as a major type of cells producing MMP9 around a site of rupture and consistently the collagenolytic activity of MMP9 was detected in ruptured lesions. Conclusions: These results combined together suggest the crucial role of neutrophil to rupture of IAs and also propose the potential of this type of cells as a candidate of therapeutic or diagnostic targets.

Tetramethylpyrazine Protects Against Early Brain Injury and Inhibits the PERK/Akt Pathway in a Rat Model of Subarachnoid Hemorrhage

2018 ◽  
Vol 43 (8) ◽  
pp. 1650-1659 ◽  
Author(s):  
Zhengkai Shao ◽  
Pei Wu ◽  
Xuefeng Wang ◽  
Meishan Jin ◽  
Shuang Liu ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Rat Model ◽  
Early Brain Injury ◽  
Akt Pathway

PARP inhibition attenuates early brain injury through NF-κB/MMP-9 pathway in a rat model of subarachnoid hemorrhage

2016 ◽  
Vol 1644 ◽  
pp. 32-38 ◽  
Author(s):  
Ting Chen ◽  
Wei Wang ◽  
Jian-Ru Li ◽  
Hang-Zhe Xu ◽  
Yu-Cong Peng ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Rat Model ◽  
Early Brain Injury ◽  
Parp Inhibition

scholarly journals The Effect of Blood Glutamate Scavengers Oxaloacetate and Pyruvate on Neurological Outcome in a Rat Model of Subarachnoid Hemorrhage

2012 ◽  
Vol 9 (3) ◽  
pp. 649-657 ◽  
Author(s):  
Matthew Boyko ◽  
Israel Melamed ◽  
Benjamin Fredrick Gruenbaum ◽  
Shaun Evan Gruenbaum ◽  
Sharon Ohayon ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Rat Model ◽  
Neurological Outcome

scholarly journals Protective Effects of Urinary Trypsin Inhibitor on Vascular Permeability Following Subarachnoid Hemorrhage in a Rat Model

2013 ◽  
Vol 19 (9) ◽  
pp. 659-666 ◽  
Author(s):  
Ning Zhou ◽  
Ting Xu ◽  
Ying Bai ◽  
Sherchan Prativa ◽  
Jia-Zhou Xu ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Vascular Permeability ◽  
Trypsin Inhibitor ◽  
Rat Model ◽  
Protective Effects ◽  
Urinary Trypsin Inhibitor

scholarly journals Role of SCH79797 in Maintaining Vascular Integrity in Rat Model of Subarachnoid Hemorrhage

Stroke ◽  
2013 ◽  
Vol 44 (5) ◽  
pp. 1410-1417 ◽  
Author(s):  
Junhao Yan ◽  
Anatol Manaenko ◽  
Sheng Chen ◽  
Damon Klebe ◽  
Qingyi Ma ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Rat Model ◽  
Vascular Integrity
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