Treatment of early brain injury after subarachnoid hemorrhage in the rat model by inhibiting p53-induced ferroptosis

2021 ◽  
pp. 136134
Author(s):  
Hong Kuang ◽  
Tianhong Wang ◽  
Lei Liu ◽  
Chunhai Tang ◽  
Tao Li ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Rat Model ◽  
Early Brain Injury

Tetramethylpyrazine Protects Against Early Brain Injury and Inhibits the PERK/Akt Pathway in a Rat Model of Subarachnoid Hemorrhage

2018 ◽  
Vol 43 (8) ◽  
pp. 1650-1659 ◽  
Author(s):  
Zhengkai Shao ◽  
Pei Wu ◽  
Xuefeng Wang ◽  
Meishan Jin ◽  
Shuang Liu ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Rat Model ◽  
Early Brain Injury ◽  
Akt Pathway

PARP inhibition attenuates early brain injury through NF-κB/MMP-9 pathway in a rat model of subarachnoid hemorrhage

2016 ◽  
Vol 1644 ◽  
pp. 32-38 ◽  
Author(s):  
Ting Chen ◽  
Wei Wang ◽  
Jian-Ru Li ◽  
Hang-Zhe Xu ◽  
Yu-Cong Peng ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Rat Model ◽  
Early Brain Injury ◽  
Parp Inhibition

scholarly journals GPR18 Agonist Resolvin D2 Reduces the Early Brain Injury in A Rat Model of Subarachnoid Hemorrhage by Multi-Mechanisms of Protection

2021 ◽  
Author(s):  
Tongyu Zhang ◽  
Gang Zuo ◽  
Hongqi Zhang
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
White Matter ◽  
Western Blot ◽  
Rat Model ◽  
Time Course ◽  
Early Brain Injury ◽  
Brain Regions ◽  
White Matter Injury ◽  
Tnf Α

Abstract Background Early brain injury (EBI) is the early phase of secondary complications resulted in poor prognosis of subarachnoid hemorrhage (SAH). GPR18 is a G protein-coupled receptor which has been reported for neuroprotection in ischemia. In this study, we aimed to use resolvin D2 (RvD2) as an agonist to investigate the roles of GPR18 in different brain regions during EBI. Methods Location and time course of GPR18 after SAH were measured with immunofluorescence and western blot in endovascular perforation rat model. RvD2 was given one hour intranasally post-SAH, and SAH grades, neurobehavior and brain water content tests were performed after 24 hours. TUNEL and DHE staining were measured 24 hours post-SAH in cortex. Immunofluorescence, western blot and immunohistochemistry of proteins related to EBI in different brain regions were also performed. Results We found GPR18 mainly located in meninges, hypothalamus, cortex and white matter. And GPR18 expression increased in meninges and hypothalamus after EBI, however, it decreased in cortex and white matter. RvD2 could improve neurological scores and brain edema. Mast cell degranulation was attenuated, Chymase and Typtase expression decreased after RvD2 administration in meninges. RvD2 attenuated inflammation with increase of POMC, IL-10 and decrease of NPY, TNF-α in hypothalamus. In cortex, RvD2 alleviated oxidative stress and apoptosis, protected blood-brain barrier. RvD2 also ameliorated white matter injury by MBP elevation and APP depression. Conclusions Current results emphasized the importance of GPR18 in the whole brain during EBI. Upregulation of GPR18 with RvD2 may improve neurological functions with multi-mechanisms in different brain regions.

Pentoxifylline Alleviates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage

2016 ◽  
Vol 158 (9) ◽  
pp. 1721-1730 ◽  
Author(s):  
Ethem Goksu ◽  
Ozgur Dogan ◽  
Pınar Ulker ◽  
Gamze Tanrıover ◽  
Esma Konuk ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Rat Model ◽  
Early Brain Injury
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