scholarly journals Propionyl- l -Carnitine Improves Postischemic Blood Flow Recovery and Arteriogenetic Revascularization and Reduces Endothelial NADPH-Oxidase 4–Mediated Superoxide Production

2010 ◽  
Vol 30 (3) ◽  
pp. 426-435 ◽  
Author(s):  
Maria Antonietta Stasi ◽  
Maria Giovanna Scioli ◽  
Gaetano Arcuri ◽  
Giovan Giuseppe Mattera ◽  
Katia Lombardo ◽  
...  
Keyword(s):  
Blood Flow ◽  
Nadph Oxidase ◽  
Superoxide Production ◽  
Nadph Oxidase 4

scholarly journals Ultrasound Parameters of Umbilical Artery Blood Flow Are Associated with Amniotic Fluid and Umbilical Artery Concentrations of Erythropoietin and Oxidative Stress Injury

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Jiewen Tao ◽  
JingWang ◽  
Weiqi Jiang ◽  
Qi Meng ◽  
Mingjuan Xu
Keyword(s):  
Blood Flow ◽  
Nadph Oxidase ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Umbilical Artery ◽  
Stress Injury ◽  
Blood Flows ◽  
Nadph Oxidase 4 ◽  
Intrauterine Hypoxia ◽  
Ultrasound Parameters

Intrauterine hypoxia is the most frequent adverse intrauterine condition that occurs under a variety of circumstances including preeclampsia, placental insufficiency, high-altitude pregnancy, and any inflammatory condition during pregnancy resulting from gestational diabetes or even maternal obesity. However, early diagnosis of intrauterine hypoxia is still a challenge. In this study, we comparatively analyzed the systolic to diastolic ratio (S/D), resistant index (RI), and pulse index (PI) of the umbilical artery (UmA) and middle cerebral artery (MCA) blood flows obtained from 46 pregnant women with intrauterine hypoxia and 80 normal pregnant women at 28-31, 32-36, and 37-41 gestational weeks. Results found that the S/D, RI, and PI of UmA and MCA blood flows at 28-31, 32-36, and 37-41 gestational weeks were all increased in hypoxic fetuses than in normal fetuses ( P < 0.05 ). The malondialdehyde (MDA) level was elevated but superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities were reduced in the UmA blood of pregnant women with intrauterine hypoxia compared with normal pregnant women ( P < 0.05 ). It was found that the NADPH oxidase 2 (Nox2) and NADPH oxidase 4 (Nox4) activities were increased in the UmA blood of pregnant women with intrauterine hypoxia compared with normal pregnant women ( P < 0.05 ). Results of ELISA methods showed that the expression level of survivin was lower but the expression levels of caspase-3, caspase-6, and caspase-9 were higher in the placental tissues of pregnant women with intrauterine hypoxia than those in normal pregnant women ( P < 0.05 ). The concentrations of erythropoietin in the amniotic fluid and UmA blood were increased in pregnant women with intrauterine hypoxia compared with normal pregnant women ( P < 0.05 ). The Spearman correlation analysis showed that the S/D, RI, and PI of UmA blood flow at 37-41 gestational weeks were positively correlated with the levels of Nox2, Nox4, and MAD and the UmA concentration of erythropoietin but negatively correlated with the activities of SOD, GSH-Px, and CAT ( P < 0.05 ). In summary, the study indicates that ultrasound parameters of the UmA blood flow including S/D, RI, and PI could serve as predictors of intrauterine hypoxia.

scholarly journals Control of Hepatic Nuclear Superoxide Production by Glucose 6-Phosphate Dehydrogenase and NADPH Oxidase-4

2011 ◽  
Vol 286 (11) ◽  
pp. 8977-8987 ◽  
Author(s):  
Netanya Y. Spencer ◽  
Ziying Yan ◽  
Ryan L. Boudreau ◽  
Yulong Zhang ◽  
Meihui Luo ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Superoxide Production ◽  
Nadph Oxidase 4 ◽  
Glucose 6 Phosphate Dehydrogenase

Ammoniak induziert NADPH-Oxidase 4- vermittelt oxidativen Stress in kultivierten Rattenastrozyten

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
A Karababa ◽  
S Aygul ◽  
B Görg ◽  
D Häussinger
Keyword(s):  
Nadph Oxidase ◽  
Nadph Oxidase 4

scholarly journals Hypoxia promotes the metastasis of pancreatic cancer through regulating NOX4/KDM5A-mediated histone methylation modification changes in a HIF1A-independent manner

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Hongzhen Li ◽  
Chunyan Peng ◽  
Chenhui Zhu ◽  
Shuang Nie ◽  
Xuetian Qian ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Nadph Oxidase ◽  
Western Blot ◽  
Cancer Progression ◽  
Histone Methylation ◽  
Invasion And Metastasis ◽  
Independent Manner ◽  
Nadph Oxidase 4

Abstract Background Hypoxia is a characteristic of the tumor microenvironments within pancreatic cancer (PC), which has been linked to its malignancy. Recently, hypoxia has been reported to regulate the activity of important carcinogenic pathways by changing the status of histone modification. NOX4, a member of NADPH oxidase (NOX), has been found to be activated by hypoxia and promote cancer progression in several cancers. But whether it is involved in the epigenetic changes of tumor cells induced by hypoxia is still unclear, and its biological roles in PC also need to be explored. Methods A hypoxic-related gene signature and its associated pathways in PC were identified by analyzing the pancreatic cancer gene expression data from GEO and TCGA database. Candidate downstream gene (NOX4), responding to hypoxia, was validated by RT-PCR and western blot. Then, we evaluated the relationship between NOX4 expression and clinicopathologic parameters in 56 PC patients from our center. In vitro and in vivo assays were preformed to explore the phenotype of NOX4 in PC. Immunofluorescence, western blot and chromatin immunoprecipitation assays were further applied to search for a detailed mechanism. Results We quantified hypoxia and developed a hypoxia signature, which was associated with worse prognosis and elevated malignant potential in PC. Furthermore, we found that NADPH oxidase 4 (NOX4), which was induced by hypoxia and upregulated in PC in a HIF1A-independent manner, caused inactivation of lysine demethylase 5A (KDM5A), increased the methylation modification of histone H3 and regulated the transcription of EMT-associated gene_ snail family transcriptional repressor 1 (SNAIL1). This served to promote the invasion and metastasis of PC. NOX4 deficiency repressed hypoxia-induced EMT, reduced expression of H3K4ME3 and impaired the invasion and metastasis of PC cells; however, knockdown of KDM5A reversed the poor expression of H3KEME3 induced by NOX4 deficiency, thereby promoting EMT. Conclusions This study highlights the prognostic role of hypoxia-related genes in PC and strong correlation with EMT pathway. Our results also creatively discovered that NOX4 was an essential mediator for hypoxia-induced histone methylation modification and EMT in PC cells.

scholarly journals Chronic Ethanol Ingestion Increases Superoxide Production and NADPH Oxidase Expression in the Lung

2006 ◽  
Vol 34 (3) ◽  
pp. 314-319 ◽  
Author(s):  
John A. Polikandriotis ◽  
Heidi L. Rupnow ◽  
Shawn C. Elms ◽  
Roza E. Clempus ◽  
Duncan J. Campbell ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Chronic Ethanol ◽  
Superoxide Production ◽  
Ethanol Ingestion

scholarly journals Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4

2011 ◽  
Vol 108 (38) ◽  
pp. 16098-16103 ◽  
Author(s):  
Q.-A. Sun ◽  
D. T. Hess ◽  
L. Nogueira ◽  
S. Yong ◽  
D. E. Bowles ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Nadph Oxidase ◽  
Ryanodine Receptor ◽  
Redox Regulation ◽  
Release Channel ◽  
Nadph Oxidase 4

scholarly journals QSYQ Attenuates Oxidative Stress and Apoptosis Induced Heart Remodeling Rats through Different Subtypes of NADPH-Oxidase

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Yong Wang ◽  
Chun Li ◽  
Yuli Ouyang ◽  
Tianjiao Shi ◽  
Xiaomin Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Nadph Oxidase ◽  
Caspase 3 ◽  
Ventricular Remodeling ◽  
Cardiac Injury ◽  
Myocardial Tissue ◽  
Therapeutic Effects ◽  
Histological Changes ◽  
Nadph Oxidase 4

We aim to investigate the therapeutic effects of QSYQ, a drug of heart failure (HF) in clinical practice in China, on a rat heart failure (HF) model. 3 groups were divided: HF model group (LAD ligation), QSYQ group (LAD ligation and treated with QSYQ), and sham-operated group. After 4 weeks, rats were sacrificed for cardiac injury measurements. Rats with HF showed obvious histological changes including necrosis and inflammation foci, elevated ventricular remodeling markers levels(matrix metalloproteinases-2, MMP-2), deregulated ejection fraction (EF) value, increased formation of oxidative stress (Malondialdehyde, MDA), and up-regulated levels of apoptotic cells (caspase-3, p53 and tunnel) in myocardial tissue. Treatment of QSYQ improved cardiac remodeling through counter-acting those events. The improvement of QSYQ was accompanied with a restoration of NADPH oxidase 4 (NOX4) and NADPH oxidase 2 (NOX2) pathways in different patterns. Administration of QSYQ could attenuate LAD-induced HF, and AngII-NOX2-ROS-MMPs pathway seemed to be the critical potential targets for QSYQ to reduce the remodeling. Moreover, NOX4 was another key targets to inhibit the p53 and Caspase3, thus to reduce the hypertrophy and apoptosis, and eventually provide a synergetic cardiac protective effect.

scholarly journals Cytokines promote lipolysis in 3T3-L1 adipocytes through induction of NADPH oxidase 3 expression and superoxide production

2018 ◽  
Vol 59 (12) ◽  
pp. 2321-2328 ◽  
Author(s):  
Nahla Issa ◽  
Gabriel Lachance ◽  
Kerstin Bellmann ◽  
Mathieu Laplante ◽  
Krisztian Stadler ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Superoxide Production
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