Abstract P221: Combined Low Vitamin D and K Status is Associated With Greater Left Ventricular Mass

Introduction: Low vitamin D and vitamin K status are both associated with cardiovascular disease risk. New evidence from experimental studies on bone health suggest an interaction between vitamin D and K, however, a joint association with vascular health outcomes is largely unknown. Hypothesis: We assessed the hypothesis that combined low vitamin D and low vitamin K status is prospectively associated with unfavorable measures of cardiac structure and function. Methods: In the Hoorn Study, a population-based cohort study of 598 participants, mean age 70.1±6.6 years, 51% female, had physical examinations in 2000-2001 (baseline for the current analyses), and of these 265 had a follow-up in 2007-2009. In baseline samples, vitamin D and K status were assessed by measuring 25-hydroxyvitamin D [25(OH)D] and dephosphorylated uncarboxylated matrix gla protein (dp-ucMGP). High dp-ucMGP is indicative of a low vitamin K status. We studied the combined association of 25(OH)D and dp-ucMGP with echocardiographic measures of left ventricular mass index, left ventricular ejection fraction and left atrium volume index after 8 years of follow-up using linear regression analyses. The group high 25(OH)D/low dp-ucMGP was the reference group. We adjusted our analyses for potential confounders including follow-up time and baseline echocardiographic measures. Results: Mean 25(OH)D was 57.8 nmol/L and median was dp-ucMGP was 567 pmol/L. The low 25(OH)D/high dp-ucMGP category was associated with a greater left ventricle mass index:4.8 g/m 2.7 (95% CI 0.6, 9.1) at follow-up compared to the reference group, in the fully adjusted model (Table 1). No associations were observed between 25(OH)D and dp-ucMGP categories with systolic and diastolic function after 8 years of follow-up. Conclusion: In conclusion, these results suggest that high levels of 25(OH)D and low levels of dp-ucMGP are associated with a greater left ventricle mass index. Vitamin D and K supplementation trials are the next step to assess a causal relationship with cardiac structure.

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High vitamin K status is prospectively associated with decreased left ventricular mass in women: the Hoorn Study

Nutrition Journal ◽

10.1186/s12937-021-00742-0 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Joline W. J. Beulens ◽

Elisa Dal Canto ◽

Coen D. A. Stehouwer ◽

Roger J. M. W. Rennenberg ◽

Petra J. M. Elders ◽

...

Keyword(s):

Heart Failure ◽

Left Ventricular Mass ◽

Vitamin K ◽

Left Ventricular ◽

Volume Index ◽

Left Ventricular Ejection ◽

Cardiac Structure ◽

High Vitamin ◽

Ventricular Mass

Abstract Background Vitamin K is associated with reduced cardiovascular disease risk such as heart failure, possibly by carboxylation of matrix-gla protein (MGP), a potent inhibitor of vascular calcification. The relationship of vitamin K intake or status with cardiac structure and function is largely unknown. Therefore this study aims to investigate the prospective association of vitamin K status and intake with echocardiographic measures. Methods This study included 427 participants from the Hoorn Study, a population-based cohort. Vitamin K status was assessed at baseline by plasma desphospho-uncarboxylated MGP (dp-ucMGP) with higher concentrations reflecting lower vitamin K status. Vitamin K intake was assessed at baseline with a validated food-frequency questionnaire. Echocardiography was performed at baseline and after a mean follow-up time of 7.6, SD=±0.7 years. We used linear regression for the association of vitamin K status and intake with left ventricular ejection fraction (LVEF), left atrial volume index (LAVI) and left ventricular mass index (LVMI), adjusted for potential confounders. Results The mean age was 66.8, SD=±6.1 years (51% were male). A high vitamin K status was prospectively associated with decreased LVMI (change from baseline to follow-up: -5.0, 95% CI: -10.5;0.4 g/m2.7) for the highest quartile compared to the lowest in women (P-interaction sex=0.07). No association was found in men. Vitamin K status was not associated with LVEF or LAVI. Vitamin K intake was not associated with any of the echocardiographic measures. Conclusions This study showed a high vitamin K status being associated with decreased LVMI only in women, while intakes of vitamin K were not associated with any cardiac structure or function measures. These results extend previous findings for a role of vitamin K status to decrease heart failure risk.

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Relationship Between Adaptive Morphological and Electrophysiological Remodeling of the Left Ventricle in Young Athletes After an 8-Month Period of Sports Training

Pediatric Exercise Science ◽

10.1123/pes.2015-0106 ◽

2016 ◽

Vol 28 (1) ◽

pp. 71-76

Author(s):

Zbigniew Krenc

Keyword(s):

Left Ventricle ◽

Left Ventricular Mass ◽

Physical Training ◽

Early Period ◽

Left Ventricular ◽

Young Athletes ◽

Left Ventricle Mass ◽

Ventricular Mass ◽

Before And After

Purpose:The aim of this investigation was to assess the influence of an 8-month physical training period on left ventricular voltages identified by resting ECG in relation to changes in left ventricle mass in adolescent athletes.Methods:The study encompassed 28 adolescents aged 13 years (14 boys and 14 girls) from a sports secondary school. Clinical assessment was performed on all athletes before and after 8 months of physical training.Results:Sokolov-Lyon voltage index, Cornell voltage index, and maximum spatial QRS vector magnitude demonstrated statistically significant decline during the study period. The specific potential of the myocardium also significantly decreased during 8 months of training. The Sokolov-Lyon voltage criterion for left ventricular hypertrophy was fulfilled in 9 athletes (32.1%) at the beginning of the observation and only in 3 athletes (10.7%) at the end of the study. On the other hand, mean left ventricular mass and mean left ventricular mass index significantly increased after long-term training. No statistically significant correlations were identified between relative changes in left ventricular mass and QRS voltages.Conclusion:An early period of intensive physical training in young athletes is associated with a decrease in QRS amplitude and a relative voltage deficit over the left ventricle.

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Cardiovascular risk and unproportional high weight of left ventrical myocardium in climacteric women

Kazan medical journal ◽

10.17816/kmj1504 ◽

2014 ◽

Vol 95 (3) ◽

pp. 315-322

Author(s):

A R Sadykova ◽

A R Shamkina ◽

R I Gizyatoullova

Keyword(s):

Left Ventricle ◽

Arterial Hypertension ◽

Left Ventricular Mass ◽

Target Organ Damage ◽

Organ Damage ◽

Left Ventricular ◽

Left Ventricle Mass ◽

Ventricular Mass ◽

Left Ventricle Hypertrophy ◽

Ventricle Hypertrophy

Aim. To study the distribution of cardiovascular risk factors, target organ damage, associated clinical conditions and to stratify the 10-year risk of arterial hypertension complications in menopausal females depending on presence of inappropriately high left ventricular mass. Methods. 107 females from city of Kazan aged 42-59 years entered the study, including 11 women with normal blood pressure, 16 patients with high normal blood pressure, and 80 patients with hypertension according to All-Russia scientific Society of Cardiologists classification (2010) with disease duration of 0-34 years. Mean age of patients with hypertension was 51.4±4.0 years. Patients with secondary hypertension were excluded from the study. All patients underwent a questionnaire survey, physical examination, biochemical blood test, ECG, echocardiography, and cervical extracranial vessel ultrasonography. Actual left ventricle mass was calculated according to R.B. Devereux et al. (1977) and was adjusted to the body surface area. Proper left ventricle mass was defined by G. Simone et al. (1998). Disproportion coefficient was calculated as a ratio of actual left ventricle mass to proper left ventricle mass. Left ventricle hypertrophy was diagnosed using the Sokolow-Lyon index and left ventricle mass index ≥ 110 g/m2 (Echo-signs of left ventricle hypertrophy). Results. In menopausal women, inappropriately high left ventricular mass was associated with significantly (р 0.05, Fisher exact test) higher frequency of obesity, especially its abdominal type, as well as target organ damage, including Echo-signs of left ventricle hypertrophy, very high added 10-year risk of developing arterial hypertension complications. It was also associated with significantly (р 0.05, the U-criterion) higher mean values of waist circumference, waist to hip circumference ratio, body mass index, total number of damaged target organs and 10-year risk for developing arterial hypertension complications. Conclusion. Distinguishing the patients with inappropriately high left ventricular mass among menopausal women is important for planning the measures to prevent cardiovascular events.

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Impact of Transcendental Meditation on Left Ventricular Mass in African American Adolescents

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2012/923153 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 11

Author(s):

Vernon A. Barnes ◽

Gaston K. Kapuku ◽

Frank A. Treiber

Keyword(s):

African American ◽

Left Ventricular Mass ◽

Ventricular Remodeling ◽

Transcendental Meditation ◽

African American Adolescents ◽

Left Ventricular ◽

Ventricular Mass ◽

Cardiovascular Morbidity And Mortality ◽

Before And After

Background. An early sign of ventricular remodeling is increased left ventricular mass (LVM) which over time may lead to left ventricular hypertrophy, the strongest predictor of cardiovascular morbidity and mortality, other than advancing age.Methods. 62 (30 TM; 32 CTL) African American adolescents (age16.2±1.3years) with high normal systolic BP were randomly assigned to either 4-month Transcendental Meditation (TM) or health education control groups. The echocardiographic-derived measure of LVM index (LVMI = LVM/ht2.7) was measured before and after the 4-month TM study and at 4-month followup. 2D-guided M-mode echocardiography using a Hewlett Packard 5500 echosonograph was used to determine LVMI.Results. The TM group exhibited a greater decrease in LVMI at 4-month followup compared to the CTL group (−2.6 versus +0.3 gm/ht2.7,P<0.04). The TM group exhibited a lesser increase in BMI at 4-month follow-up compared to the CTL group (0.2±1.6versus1.1±1.4,P<0.03).Conclusion. These findings indicate that among a group of prehypertensive African American adolescents, 4 months of TM compared to heath education resulted in a significant decrease in LVMI, and these changes were maintained at 4-month follow-up.

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Arterial Stiffness Is Associated with Clinical Outcome and Cardiorenal Injury in Lateralized Primary Aldosteronism

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgaa566 ◽

2020 ◽

Vol 105 (11) ◽

Author(s):

Chieh-Kai Chan ◽

Wei-Shiung Yang ◽

Yen-Hung Lin ◽

Kuo-How Huang ◽

Ching-Chu Lu ◽

...

Keyword(s):

Arterial Stiffness ◽

Clinical Outcome ◽

Left Ventricular Mass ◽

Primary Aldosteronism ◽

Clinical Success ◽

Multivariate Logistic Regression Analysis ◽

Left Ventricular ◽

Secondary Outcome ◽

Ventricular Mass

Abstract Context The association between arterial stiffness and clinical outcome in lateralized primary aldosteronism (PA) patients after adrenalectomy has not been clearly identified. Objective We hypothesized that arterial stiffness estimated by brachial-ankle pulse wave velocity (baPWV) before adrenalectomy was associated with the clinical outcomes and cardiorenal injury in lateralized PA patients after adrenalectomy. Design and Patients We designed a retrospective observational cohort study. We collected lateralized PA patients who had undergone adrenalectomy between 2013 and 2016 from the Taiwan Primary Aldosteronism Investigation database. The primary outcome was achieving complete clinical success at 1 year after adrenalectomy. The secondary outcome was estimated glomerular filtration rate declining over 20% and improved left ventricular mass index. Results We enrolled 221 patients with lateralized PA (50.7% men; mean age, 51.9 years), of whom 101 patients (45.7%) achieved complete clinical success at the 1-year follow-up assessment after adrenalectomy. Lower baPWV before adrenalectomy (odds ratio = 0.998; 95% confidence interval, 0.996-0.999; P = 0.003) correlated with higher likelihood of complete clinical success by multivariate logistic regression analysis. Multifactorial adjusted generalized additive model demonstrated that preoperative baPWV<1600 cm/sec was significantly associated with complete cure of hypertension. In addition, higher preoperative baPWV was associated with renal function decline and less left ventricular mass regression after adrenalectomy in lateralized PA patients during the follow-up period. Conclusions Our study demonstrated that the preoperative severe arterial stiffness was associated with absent complete clinical success in lateralized PA patients after adrenalectomy, and this effect may contribute to cardiorenal injury, which at least partially explains kidney function deterioration and lessened regression of heart mass.

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