Abstract 005: Childhood Risk Factors and Cardiovascular Disease Outcomes in Adulthood. Preliminary Findings From the International Childhood Cardiovascular Cohort (i3C) Consortium

Circulation ◽  
2019 ◽  
Vol 139 (Suppl_1) ◽  
Author(s):  
Olli Raitakari ◽  
David R Jacobs ◽  
Jessica Woo ◽  
Elaine M Urbina ◽  
Lydia Bazzano ◽  
...  
2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Terence Dwyer ◽  
Olli T. Raitakari ◽  
David Jacobs ◽  
Jessica G. Woo ◽  
Elaine M. Urbina ◽  
...  

Abstract Background Atherosclerosis develops silently for decades before adult cardiovascular disease (aCVD) occurs. There is currently no evidence directly linking childhood risk factors to aCVD outcomes. Methods i3C is an international consortium of 7 cohorts involving 40,709 participants enrolled between 1970-95 in childhood (age 3-19) who underwent measurement for BMI, SBP, total cholesterol, and triglycerides, and smoking (the last mostly in adolescence). Participants were followed by direct contact and review of medical records or death registry ascertainment through adulthood in 2014-19. 20,560 participants were found and interviewed or had died in the approximately 40 years since enrollment; 738 had a CVD event, confirmed by medical record review (n = 449) or death certificate ICD code (n = 289). Results Estimated hazard ratios (HRs) for childhood risk factors and their confidence intervals are displayed in the table below. The CIs excluded 1.0 for all these variables in the univariable analysis and, although the HRs were reduced in multivariable analysis which included all of these risk factors, the CIs still excluded 1.0. Conclusion Exposure to CVD risk factors in youth predicts adult CVD with implications for primordial CVD prevention. Key messages Intervention to reduce CVD risk factors in childhood is likely to reduce risk of adult CVD


PEDIATRICS ◽  
1989 ◽  
Vol 84 (4) ◽  
pp. 633-641 ◽  
Author(s):  
R. M. Lauer ◽  
W. R. Clarke

In adult populations, elevated blood pressure is related to the development of occlusive atherosclerosis, stroke, and renal disease. The significance of blood pressure levels in childhood, unless extremely elevated, has not been related to disease outcomes. In this study, the risk of high blood pressure in young adult life is evaluated based on the observations of blood pressure and other factors made during the school-aged years. Subjects, 2445 in number, were first observed at ages 7 through 18 years and again between 20 and 30 years. During childhood, measurements of blood pressure, height, and weight were made in alternate years. At adult ages, the same measurements were again made and a health questionnaire was administered. According to the data, adult blood pressure is correlated with childhood blood pressure, body size, and change in ponderosity from childhood to adult life. Adult ponderosity is related to childhood ponderosity, and those who are most obese as adults show the greatest increase in weight for height from their childhood years. These observations suggest that strategies to prevent the acquisition of excess ponderosity during adolescence may be useful in preventing adult hypertension.


PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0166846 ◽  
Author(s):  
Pasmore Malambo ◽  
Andre P. Kengne ◽  
Anniza De Villiers ◽  
Estelle V. Lambert ◽  
Thandi Puoane

Author(s):  
Lindsay R. Pool ◽  
Liliana Aguayo ◽  
Michal Brzezinski ◽  
Amanda M. Perak ◽  
Matthew M. Davis ◽  
...  

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