Abstract P027: Perceived Discrimination and Trajectory of High-Sensitivity C-Reactive Protein: The Jackson Heart Study

Circulation ◽  
2019 ◽  
Vol 139 (Suppl_1) ◽  
Author(s):  
Kendra D Sims ◽  
Mario Sims ◽  
LáShauntá Glover ◽  
Ellen Smit ◽  
Michelle C Odden
Keyword(s):  
Perceived Discrimination ◽  
High Sensitivity ◽  
Jackson Heart Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Heart Study

scholarly journals Perceived Discrimination and Trajectories of C-Reactive Protein: The Jackson Heart Study

2020 ◽  
Vol 58 (2) ◽  
pp. 199-207 ◽  
Author(s):  
Kendra D. Sims ◽  
Mario Sims ◽  
LáShauntá M. Glover ◽  
Ellen Smit ◽  
Michelle C. Odden
Keyword(s):  
Perceived Discrimination ◽  
Jackson Heart Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Heart Study

scholarly journals High-Sensitivity C-Reactive Protein Is Associated With Incident Type 2 Diabetes Among African Americans: The Jackson Heart Study

Diabetes Care ◽  
2015 ◽  
Vol 38 (9) ◽  
pp. 1694-1700 ◽  
Author(s):  
Valery S. Effoe ◽  
Adolfo Correa ◽  
Haiying Chen ◽  
Mary E. Lacy ◽  
Alain G. Bertoni
Keyword(s):  
Type 2 Diabetes ◽  
African Americans ◽  
High Sensitivity ◽  
Jackson Heart Study ◽  
C Reactive Protein ◽  
Incident Type ◽  
Reactive Protein ◽  
Heart Study ◽  
Incident Type 2 Diabetes

Association Between Occupational Sitting With High Sensitivity C-Reactive Protein: The Jackson Heart Study

2021 ◽  
pp. 155982762110597
Author(s):  
Raymond Jones ◽  
Keith C. Norris ◽  
Stephanie M. McCoy ◽  
Roland J. Thorpe ◽  
Marino A. Bruce ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Behavioral Risk ◽  
Jackson Heart Study ◽  
Linear Regression Models ◽  
C Reactive Protein ◽  
Occupational Sitting ◽  
Reactive Protein ◽  
Heart Study ◽  
Specific Association ◽  
Female Specific

Modifiable, behavioral risk factors like occupational sitting may contribute to inflammation, an important cardiovascular risk factor. This study evaluated the association of self-reported occupational sitting with changes in c-reactive protein (CRP) and the role of sex. We examined occupational sitting and baseline CRP levels for 2889 African American participants in the Jackson Heart Study. Four multivariable linear regression models were estimated to determine the association of occupational sitting and CRP. Analyses were conducted in 2020. The mean age was 50.8 years and 61% were female. Participants who reported occupational sitting as “often/always” had CRP levels of 4.9±6.8 mg/L, “sometimes” had levels of 4.8±8.1 mg/L, and “never/seldom” had levels of 4.3±6.8 mg/L. In the unadjusted model, “often/always” engaging in occupational sitting was significantly associated with higher levels of CRP when compared to “never/seldom” ( P < .05). This differed by sex with female participants who reported “often/always” occupational sitting had CRP levels of 6.0±7.6 mg/L compared to only 5.1±6.9 mg/L for “never/seldom.” Neither the overall association nor the female-specific association remained statistically significant in the adjusted models. We found an association between occupational sitting and inflammation, measured by CRP. This association varied by sex but did not remain significant after fully adjusting for covariates.

Factors associated with baseline and serial changes in circulating NT-proBNP and high-sensitivity cardiac troponin T in a population-based cohort (Dallas Heart Study)

2021 ◽  
Author(s):  
Christopher W Puleo ◽  
Colby R Ayers ◽  
Sonia Garg ◽  
Ian J Neeland ◽  
Alana A Lewis ◽  
...  
Keyword(s):  
Body Composition ◽  
Cardiac Troponin ◽  
Troponin T ◽  
High Sensitivity ◽  
Left Ventricular ◽  
Cardiac Troponin T ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Heart Study ◽  
Dallas Heart Study

Aim: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) associate with structural heart disease and heart failure risk in individuals without known cardiovascular disease (CVD). However, few data are available regarding whether factors influencing levels of these two biomarkers are similar or distinct. We performed serial measurement of NT-proBNP and hs-cTnT in a contemporary multiethnic cohort with extensive phenotyping, with the goal of identifying their respective biological determinants in a population without known or suspected CVD. Methods: We evaluated 1877 participants of the Dallas Heart Study who had NT-proBNP and hs-cTnT measured and were free from clinical CVD at the each of its two examinations (2000–2002 and 2007–2009). Variables collected included demographic and risk factors, high-sensitivity C-reactive protein, body composition via dual-energy x-ray absorptiometry, coronary artery calcium by computed tomography, and cardiac dimensions and function by cardiac MRI. Linear regression was used to identify associations of these factors with each biomarker at baseline and with changes in biomarkers over follow-up. Results: NT-proBNP and hs-cTnT were poorly correlated at baseline (Spearman rho 0.083, p = 0.015), with only moderate correlation between change values (rho 0.18, p < 0.001). hs-cTnT positively associated and NT-proBNP inversely associated with male gender and black race. At baseline, both NT-proBNP and hs-cTnT associated with left ventricular end-diastolic volume and wall thickness, but only NT-proBNP associated with left atrial size. Changes in cardiac dimensions between phases were more strongly associated with changes in NT-proBNP than hs-cTnT. NT-proBNP was more strongly associated with high-sensitivity C-reactive protein and measures of body composition than hs-cTnT. Conclusion: Among individuals without CVD in the general population, NT-proBNP and hs-cTnT are nonredundant biomarkers that are differentially associated with demographic and cardiac factors. These findings indicate that hs-cTnT and NT-proBNP may reflect different pathophysiological pathways.

THE EPIDEMIOLOGY, HERITABILITY, AND GENETIC LINKAGE OF C-REACTIVE PROTEIN IN THE JACKSON HEART STUDY.

2007 ◽  
Vol 55 (1) ◽  
pp. S258
Author(s):  
E. R. Fox ◽  
E. J. Benjamin ◽  
D. F. Sarpong ◽  
C. N. Rotimi ◽  
J. G. Wilson ◽  
...  
Keyword(s):  
Genetic Linkage ◽  
Jackson Heart Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Heart Study

scholarly journals The relation of C - reactive protein to chronic kidney disease in African Americans: the Jackson Heart Study

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Ervin R Fox ◽  
Emelia J Benjamin ◽  
Daniel F Sarpong ◽  
Harsha Nagarajarao ◽  
Jason K Taylor ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
African Americans ◽  
Kidney Disease ◽  
Jackson Heart Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Heart Study

scholarly journals Elevated High Sensitivity C-Reactive Protein Is Associated with Type 2 Diabetes Mellitus: The Persian Gulf Healthy Heart Study

2008 ◽  
Vol 55 (4) ◽  
pp. 717-722 ◽  
Author(s):  
Iraj NABIPOUR ◽  
Katayoun VAHDAT ◽  
Seyed Mojtaba JAFARI ◽  
Saeideh BEIGI ◽  
Majid ASSADI ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Persian Gulf ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Heart Study ◽  
The Persian Gulf

scholarly journals Epidemiology, Heritability, and Genetic Linkage of C-Reactive Protein in African Americans (from the Jackson Heart Study)

2008 ◽  
Vol 102 (7) ◽  
pp. 835-841 ◽  
Author(s):  
Ervin R. Fox ◽  
Emelia J. Benjamin ◽  
Daniel F. Sarpong ◽  
Charles N. Rotimi ◽  
James G. Wilson ◽  
...  
Keyword(s):  
African Americans ◽  
Genetic Linkage ◽  
Jackson Heart Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Heart Study
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