scholarly journals Aldosterone, C-Reactive Protein, and Plasma B-Type Natriuretic Peptide Are Associated With the Development of Metabolic Syndrome and Longitudinal Changes in Metabolic Syndrome Components: Findings from the Jackson Heart Study

Diabetes Care ◽  
2013 ◽  
Vol 36 (10) ◽  
pp. 3084-3092 ◽  
Author(s):  
S. K. Musani ◽  
R. S. Vasan ◽  
A. Bidulescu ◽  
J. Liu ◽  
V. Xanthakis ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Natriuretic Peptide ◽  
Jackson Heart Study ◽  
C Reactive Protein ◽  
Longitudinal Changes ◽  
Reactive Protein ◽  
Heart Study ◽  
Metabolic Syndrome Components

Abstract P015: Plasma Brain Natriuretic Peptide Concentration Is Inversely Associated With Prevalent Metabolic Syndrome and Metabolic Syndrome Components: Findings From the Jackson Heart Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Harsha Nagarajarao ◽  
Solomon K Musani ◽  
Vasan S Ramachandran ◽  
Aurelian Bidulescu ◽  
Herman A Taylor ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
African Americans ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Assessment Model ◽  
Jackson Heart Study ◽  
Men And Women ◽  
Plasma Brain Natriuretic Peptide ◽  
Heart Study ◽  
Metabolic Syndrome Components

Introduction: There is emerging evidence that brain natriuretic peptide (BNP) may play a role in human metabolism. Suppressed concentrations in BNP in obese individuals may contribute to clinical phenotypes of metabolic syndrome. There is limited data on the relation of BNP to metabolic syndrome in African Americans. Methods: To assess the association between plasma brain natriuretic peptide (BNP) concentration and metabolic syndrome (MetS) and MetS risk factors in blacks, we analyzed cross-sectional data from 3,729 Jackson Heart Study participants free of heart failure (mean age, 54 years; 64% women). We performed sex-specific Tobit regression analysis on log transformed BNP to account for the left censored BNP distribution and adjusted for clinical and echocardiographic variables. Prevalence of MetS was 44% and 35% in women and men, respectively. We estimated percent changes for the underlying variables by back-transformation. Results: Plasma BNP concentration was inversely associated with metabolic syndrome components (fasting glucose and waist circumference in both men and women; and triglycerides in women). Sex-specific multivariable adjusted BNP concentrations were significantly lower in subjects with MetS than those without. In men, BNP concentration was 35% lower (P < 0.0001); and in women it was 31% lower (P < 0.0001). Men and women with insulin resistance represented by elevated homeostasis assessment model (HOMA-IR) index had significantly (P < 0.0001) lower BNP concentration compared to those with low HOMA-IR index. Discussion and Conclusion: We found in a community based cohort of African Americans a significant relation of low BNP concentration to MetS and individual components of MetS. This data supports a growing body of evidence that BNP plays a potential crucial role in total body metabolism.

scholarly journals Perceived Discrimination and Trajectories of C-Reactive Protein: The Jackson Heart Study

2020 ◽  
Vol 58 (2) ◽  
pp. 199-207 ◽  
Author(s):  
Kendra D. Sims ◽  
Mario Sims ◽  
LáShauntá M. Glover ◽  
Ellen Smit ◽  
Michelle C. Odden
Keyword(s):  
Perceived Discrimination ◽  
Jackson Heart Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Heart Study

scholarly journals High-Sensitivity C-Reactive Protein Is Associated With Incident Type 2 Diabetes Among African Americans: The Jackson Heart Study

Diabetes Care ◽  
2015 ◽  
Vol 38 (9) ◽  
pp. 1694-1700 ◽  
Author(s):  
Valery S. Effoe ◽  
Adolfo Correa ◽  
Haiying Chen ◽  
Mary E. Lacy ◽  
Alain G. Bertoni
Keyword(s):  
Type 2 Diabetes ◽  
African Americans ◽  
High Sensitivity ◽  
Jackson Heart Study ◽  
C Reactive Protein ◽  
Incident Type ◽  
Reactive Protein ◽  
Heart Study ◽  
Incident Type 2 Diabetes

THE EPIDEMIOLOGY, HERITABILITY, AND GENETIC LINKAGE OF C-REACTIVE PROTEIN IN THE JACKSON HEART STUDY.

2007 ◽  
Vol 55 (1) ◽  
pp. S258
Author(s):  
E. R. Fox ◽  
E. J. Benjamin ◽  
D. F. Sarpong ◽  
C. N. Rotimi ◽  
J. G. Wilson ◽  
...  
Keyword(s):  
Genetic Linkage ◽  
Jackson Heart Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Heart Study

Association Between Occupational Sitting With High Sensitivity C-Reactive Protein: The Jackson Heart Study

2021 ◽  
pp. 155982762110597
Author(s):  
Raymond Jones ◽  
Keith C. Norris ◽  
Stephanie M. McCoy ◽  
Roland J. Thorpe ◽  
Marino A. Bruce ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Behavioral Risk ◽  
Jackson Heart Study ◽  
Linear Regression Models ◽  
C Reactive Protein ◽  
Occupational Sitting ◽  
Reactive Protein ◽  
Heart Study ◽  
Specific Association ◽  
Female Specific

Modifiable, behavioral risk factors like occupational sitting may contribute to inflammation, an important cardiovascular risk factor. This study evaluated the association of self-reported occupational sitting with changes in c-reactive protein (CRP) and the role of sex. We examined occupational sitting and baseline CRP levels for 2889 African American participants in the Jackson Heart Study. Four multivariable linear regression models were estimated to determine the association of occupational sitting and CRP. Analyses were conducted in 2020. The mean age was 50.8 years and 61% were female. Participants who reported occupational sitting as “often/always” had CRP levels of 4.9±6.8 mg/L, “sometimes” had levels of 4.8±8.1 mg/L, and “never/seldom” had levels of 4.3±6.8 mg/L. In the unadjusted model, “often/always” engaging in occupational sitting was significantly associated with higher levels of CRP when compared to “never/seldom” ( P < .05). This differed by sex with female participants who reported “often/always” occupational sitting had CRP levels of 6.0±7.6 mg/L compared to only 5.1±6.9 mg/L for “never/seldom.” Neither the overall association nor the female-specific association remained statistically significant in the adjusted models. We found an association between occupational sitting and inflammation, measured by CRP. This association varied by sex but did not remain significant after fully adjusting for covariates.

Abstract P027: Perceived Discrimination and Trajectory of High-Sensitivity C-Reactive Protein: The Jackson Heart Study

Circulation ◽  
2019 ◽  
Vol 139 (Suppl_1) ◽  
Author(s):  
Kendra D Sims ◽  
Mario Sims ◽  
LáShauntá Glover ◽  
Ellen Smit ◽  
Michelle C Odden
Keyword(s):  
Perceived Discrimination ◽  
High Sensitivity ◽  
Jackson Heart Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Heart Study

scholarly journals The relation of C - reactive protein to chronic kidney disease in African Americans: the Jackson Heart Study

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Ervin R Fox ◽  
Emelia J Benjamin ◽  
Daniel F Sarpong ◽  
Harsha Nagarajarao ◽  
Jason K Taylor ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
African Americans ◽  
Kidney Disease ◽  
Jackson Heart Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Heart Study

scholarly journals Epidemiology, Heritability, and Genetic Linkage of C-Reactive Protein in African Americans (from the Jackson Heart Study)

2008 ◽  
Vol 102 (7) ◽  
pp. 835-841 ◽  
Author(s):  
Ervin R. Fox ◽  
Emelia J. Benjamin ◽  
Daniel F. Sarpong ◽  
Charles N. Rotimi ◽  
James G. Wilson ◽  
...  
Keyword(s):  
African Americans ◽  
Genetic Linkage ◽  
Jackson Heart Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Heart Study
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