scholarly journals Characterization of Kcnk3 -Mutated Rat, a Novel Model of Pulmonary Hypertension

2019 ◽  
Vol 125 (7) ◽  
pp. 678-695 ◽  
Author(s):  
Mélanie Lambert ◽  
Véronique Capuano ◽  
Angèle Boet ◽  
Laurent Tesson ◽  
Thomas Bertero ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Novel Model

Characterization of a Pulmonary Hypertension Model Caused by Left Heart Disease in Mouse

2020 ◽  
Author(s):  
L. K. Pallos ◽  
J. M. Dietrich ◽  
A. Simon ◽  
E. Carls ◽  
M. Matthey ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Heart Disease ◽  
Left Heart ◽  
Left Heart Disease

Multidetector Computed Tomography for Detection and Characterization of Pulmonary Hypertension in Consideration of WHO Classification

2012 ◽  
Vol 36 (2) ◽  
pp. 175-180 ◽  
Author(s):  
Christian Dornia ◽  
Tobias J. Lange ◽  
Gundula Behrens ◽  
Jaroslava Stiefel ◽  
René Müller-Wille ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Pulmonary Hypertension ◽  
Multidetector Computed Tomography ◽  
Who Classification

Assessing Bypassed Hydrocarbons

2021 ◽  
Author(s):  
Stanley Oifoghe ◽  
Nora Alarcon ◽  
Lucrecia Grigoletto
Keyword(s):  
Continental Shelf ◽  
Reservoir Characterization ◽  
Gamma Ray ◽  
West African ◽  
The Novel ◽  
The West ◽  
Present Case Study ◽  
Novel Model

Abstract Hydrocarbons are bypassed in known fields. This is due to reservoir heterogeneities, complex lithology, and limitations of existing technology. This paper seeks to identify the scenarios of bypassed hydrocarbons, and to highlight how advances in reservoir characterization techniques have improved assessment of bypassed hydrocarbons. The present case study is an evaluation well drilled on the continental shelf, off the West African Coastline. The targeted thin-bedded reservoir sands are of Cenomanian age. Some technologies for assessing bypassed hydrocarbon include Gamma Ray Spectralog and Thin Bed Analysis. NMR is important for accurate reservoir characterization of thinly bedded reservoirs. The measured NMR porosity was 15pu, which is 42% of the actual porosity. Using the measured values gave a permeability of 5.3mD as against the actual permeability of 234mD. The novel model presented in this paper increased the porosity by 58% and the permeability by 4315%.

scholarly journals Right heart catheterization for pulmonary hypertension during the coronavirus disease 2019 pandemic

2020 ◽  
Vol 10 (3) ◽  
pp. 204589402094878 ◽  
Author(s):  
Kanza N. Qaiser ◽  
James E Lane ◽  
Adriano R. Tonelli
Keyword(s):  
Pulmonary Hypertension ◽  
Right Heart Catheterization ◽  
Heart Catheterization ◽  
Clinical Practices ◽  
Right Heart ◽  
Diagnostic Modality ◽  
Hypertension Therapy ◽  
Pulmonary Arterial ◽  
Pulmonary Arterial Hypertension Therapy

Right heart catheterization is an essential diagnostic modality in the evaluation of pulmonary hypertension. The coronavirus disease 2019 pandemic has resulted in deferral of elective procedures including right heart catheterization. The benefits of proceeding with right heart catheterization, such as further characterization of hemodynamic subtype and severity of pulmonary hypertension, initiation of targeted pulmonary arterial hypertension therapy, as well as further hemodynamic testing, need to be carefully balanced with the risk of potentially exposing both patients and health care personnel to coronavirus disease 2019 infection. This review article aims to provide best clinical practices for safely performing right heart catheterization in pulmonary hypertension patients during the coronavirus disease 2019 pandemic.

scholarly journals Development and characterization of a novel model of invasive pneumococcal pneumonia in invasively ventilated PIGS

2015 ◽  
Vol 3 (S1) ◽  
Author(s):  
G Li Bassi ◽  
R Amaro ◽  
C Chiurazzi ◽  
E Aguilera Xiol ◽  
C Travierso ◽  
...  
Keyword(s):  
Pneumococcal Pneumonia ◽  
Novel Model

Induction and Characterization of Pulmonary Hypertension in Mice using the Hypoxia/SU5416 Model

10.3791/59252 ◽  
2020 ◽  
Author(s):  
Olympia Bikou ◽  
Roger J. Hajjar ◽  
Lahouaria Hadri ◽  
Yassine Sassi
Keyword(s):  
Pulmonary Hypertension

Characterization of the Centroidal Geometry of Human Ribs

2013 ◽  
Vol 135 (11) ◽  
Author(s):  
Matthew W. Kindig ◽  
Richard W. Kent
Keyword(s):  
Cross Sections ◽  
Posterior Extremity ◽  
Radius Of Curvature ◽  
Cross Sectional ◽  
Surface Reconstructions ◽  
C1 Continuity ◽  
Best Fit ◽  
Novel Model ◽  
Geometric Primitives

While a number of studies have quantified overall ribcage morphology (breadth, depth, kyphosis/lordosis) and rib cross-sectional geometry in humans, few studies have characterized the centroidal geometry of individual ribs. In this study, a novel model is introduced to describe the centroidal path of a rib (i.e., the sequence of centroids connecting adjacent cross-sections) in terms of several physically-meaningful and intuitive geometric parameters. Surface reconstructions of rib levels 2–10 from 16 adult male cadavers (aged 31–75 years) were first extracted from CT scans, and the centroidal path was calculated in 3D for each rib using a custom numerical method. The projection of the centroidal path onto the plane of best fit (i.e., the “in-plane” centroidal path) was then modeled using two geometric primitives (a circle and a semiellipse) connected to give C1 continuity. Two additional parameters were used to describe the deviation of the centroidal path from this plane; further, the radius of curvature was calculated at various points along the rib length. This model was fit to each of the 144 extracted ribs, and average trends in rib size and shape with rib level were reported. In general, upper ribs (levels 2–5) had centroidal paths which were closer to circular, while lower ribs (levels 6–10) tended to be more elliptical; further the centroidal curvature at the posterior extremity was less pronounced for lower ribs. Lower ribs also tended to exhibit larger deviations from the best-fit plane. The rib dimensions and trends with subject stature were found to be consistent with findings previously reported in the literature. This model addresses a critical need in the biomechanics literature for the accurate characterization of rib geometry, and can be extended to a larger population as a simple and accurate way to represent the centroidal shape of human ribs.

PULMONARY HYPERTENSION IN PAEDIATRIC PATIENTS: DATA FROM THE COMPERA-KIDS REGISTRY

2015 ◽  
Vol 101 (1) ◽  
pp. e1.47-e1
Author(s):  
Matthias Gorenflo ◽  
David Pittrow ◽  
Dörte Huscher ◽  
Victoria Ziesenitz ◽  
Joseph Pattathu ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Treatment Options ◽  
Anticoagulation Therapy ◽  
Right Heart Catheterization ◽  
Functional Class ◽  
Right Atrial ◽  
Heart Catheterization ◽  
Study Cohort ◽  
Paediatric Patients

BackgroundPulmonary hypertension (PH/PAH) can have many possible causes in childhood. The aim of the COMPERA registry is the characterization of patients of all ages with PH/PAH and their treatment patterns.MethodsSince June 2013, paediatric patients can be included in the COMPERA registry (ClinTrials.gov: NCT01347216) which has originally been established for adult patients with pulmonary hypertension in 2007.ResultsUntil 2015, 78 patients <18 years (47 Pat <6 years) with pulmonary hypertension were enrolled, of whom 65.4% had PAH due to congenital heart disease (PAH-CHD), 25.6% had idiopathic PAH (iPAH), 3 had persistent PH of the newborn, 2 had PH associated with interstitial lung disease, and two had other PH. The patients were 6.1±6.0 years old, 52.6% girls; NYHA functional class I/II in 55.0%, and III in 42.3%. Mean disease duration after diagnosis was 37.7±55.8 months. Right heart catheterization data were available for 82.1% of the patients. Mean pulmonary artery pressure was 42.8±19.4 mmHg, right atrial pressure was 8.0±8.8 mmHg, cardiac index was 3.6±1.2 l/min/m2. Monotherapy was received by 65.4% of the patients whereas 33.4% of the patients had combination therapy. Phosphodiesterase-5 inhibitors (PDE5I) were administered to 76.9% of the patients, 35.9% of the patients received endothelin receptor antagonists and 3.8% received prostacyclins. About 24% of patients received anticoagulation therapy.ConclusionThe most common form of PH in this study cohort is PAH-CHD, followed by iPAH. Treatment options for children primarily comprise PDE5I. Only a small number of paediatric patients receive anticoagulation therapy.

scholarly journals Experimental intravascular hemolysis induces hemodynamic and pathological pulmonary hypertension: association with accelerated purine metabolism

2018 ◽  
Vol 8 (3) ◽  
pp. 204589401879155 ◽  
Author(s):  
Victor P. Bilan ◽  
Frank Schneider ◽  
Enrico M. Novelli ◽  
Eric E. Kelley ◽  
Sruti Shiva ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Rat Model ◽  
Vascular Remodeling ◽  
Purine Nucleoside Phosphorylase ◽  
Autologous Blood ◽  
Systolic Pressure ◽  
Per Se ◽  
Parenchymal Injury

Pulmonary hypertension (PH) is emerging as a serious complication associated with hemolytic disorders, and plexiform lesions (PXL) have been reported in patients with sickle cell disease (SCD). We hypothesized that repetitive hemolysis per se induces PH and angioproliferative vasculopathy and evaluated a new mechanism for hemolysis-associated PH (HA-PH) that involves the release of adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) from erythrocytes. In healthy rats, repetitive administration of hemolyzed autologous blood (HAB) for 10 days produced reversible pulmonary parenchymal injury and vascular remodeling and PH. Moreover, the combination of a single dose of Sugen-5416 (SU, 200 mg/kg) and 10-day HAB treatment resulted in severe and progressive obliterative PH and formation of PXL (Day 26, right ventricular peak systolic pressure (mmHg): 26.1 ± 1.1, 41.5 ± 0.5 and 85.1 ± 5.9 in untreated, HAB treated and SU+HAB treated rats, respectively). In rats, repetitive administration of HAB increased plasma ADA activity and reduced urinary adenosine levels. Similarly, SCD patients had higher plasma ADA and PNP activity and accelerated adenosine, inosine, and guanosine metabolism than healthy controls. Our study provides evidence that hemolysis per se leads to the development of angioproliferative PH. We also report the development of a rat model of HA-PH that closely mimics pulmonary vasculopathy seen in patients with HA-PH. Finally, this study suggests that in hemolytic diseases released ADA and PNP may increase the risk of PH, likely by abolishing the vasoprotective effects of adenosine, inosine and guanosine. Further characterization of this new rat model of hemolysis-induced angioproliferative PH and additional studies of the role of purines metabolism in HA-PH are warranted.

Sign in / Sign up

Export Citation Format

Share Document