Mapping of Two Quantitative Trait Loci (QTL) for Blood Pressure (BP) on Rat Chromosome (CHR.) 2 Using Congenic Strains by Telemetry

Hypertension ◽  
2000 ◽  
Vol 36 (suppl_1) ◽  
pp. 718-719
Author(s):  
Alan Y Deng ◽  
Julie Dutil ◽  
Denis deBlois ◽  
Johanne Tremblay
Keyword(s):  
Blood Pressure ◽  
Quantitative Trait Loci ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Quantitative Trait ◽  
The Other ◽  
Angiotensin Receptor ◽  
Congenic Strains ◽  
The Mean ◽  
Chromosome Regions

P141 We previously mapped a BP QTL on rat Chr. 2 near the Na,K-ATPase ( Atp1a1) locus in two congenic strains. In the strain, S.MNS- Adh / D2Mit5, the Dahl salt sensitive (S) Chr. region, which was replaced by that of the Milan normotensive (MNS) strain, was quite large (roughly 80 cM). Now, we made 6 substrains from the original S.MNS- Adh / D2Mit5 strain, and then measured BP by telemetry for two (and will continue to measure for the rest) substrains. These two substrains do not contain overlapping chromosome regions. One, S.MNS-D2Mit6 / D2Rat166 (S.MNS1) , encompasses the angiotensin receptor AT1B ( Agtr1b ) and the other substrain, S.MNS-D2Mit9/ Camk2d (S.MNS2) includes Atp1a 1. Both substrains showed a significant (p<0.0001) effect in reducing the mean arterial pressure (MAP) in mmHg (see graph). This proves the presence of a QTL around Agtr1b. The BP effects of these QTL from the two separate substrains appeared to exceed those of the same number of QTL combined in one strain. This implies that these individual QTL on the same chromosome interact epistatically with one another.

scholarly journals The influence of increased atmospheric pressure on the circulation of the blood

1900 ◽  
Vol 66 (424-433) ◽  
pp. 478-479 ◽  
Keyword(s):  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Atmospheric Pressure ◽  
Pulse Frequency ◽  
The Other ◽  
The Mean ◽  
Circulation Of The Blood

Paul Bert recorded the arterial pressure in two dogs which he introduced, together with the kymograph, into a chamber, and submitted to a + pressure of 53 cm. Hg. The atmospheric pressure was raised to this height in the course of three-quarters of an hour. The mean arterial pressure rose in one dog 16 mm. Hg., in the other 46 mm. Hg.; the pulse frequency fell in the first from 216 to 200, and the respiration from 41 to 29 per minute.

scholarly journals Augmented mean arterial pressure supersedes STS-PROM risk score in predicting 1-year mortality in TAVR patients

2021 ◽  
Author(s):  
Chieh-Ju Chao ◽  
Timothy Barry ◽  
Anusha G Shanbhag ◽  
Pradyumma Agasthi ◽  
Amith Seri ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Mean Arterial Pressure ◽  
Aortic Valve ◽  
Arterial Pressure ◽  
Risk Score ◽  
Cox Regression ◽  
Cardiac Computed Tomography ◽  
Receiver Operating Curve ◽  
Mortality Data ◽  
The Mean

Abstract Background/Introduction In the era transcatheter aortic valve replacement (TAVR), predicting post-procedural outcome of patients is one of the most important goals in structural heart research. We proposed new parameters (augmented blood pressure) derived from blood pressure and aortic valve gradient measurements and hypothesized that they can predict post-TAVR 1-year mortality. Materials and Methods Patients in the Mayo Clinic National Cardiovascular Diseases Registry (NCDR)-TAVR database who underwent TAVR between January 1, 2014 and June 30, 2017 were identified to retrieve baseline demographics, STS risk score ECG, cardiac computed tomography, echocardiographic and mortality data. Augmented blood pressure parameters and valvulo-arterial impedance were evaluated by Cox regression. After logistic model generation, receiver operating curve analysis was used to assess the model performance against STS risk score. Results The final cohort contains 883 patients. The mean age is 81.3+/-8.5 years old, 58.2% are male. The mean STS risk score is 8.1+/-5.1. The median follow-up duration is 353 days and one-year all-cause mortality rates is 13.3%. Multivariate Cox regression showed that augmented SBP and augmented MAP parameters are independently predictors of 1-year mortality (all p<0.0001). A single-parameter model based on augmented MAP1 supersedes STS risk score in prediction mortality (AUC 0.697 vs. 0.591, p=0.0055). Conclusion Augmented mean arterial pressure provides a simple but effective approach for clinicians to quickly estimate the clinical outcome of TAVR patients and should be incorporated in the assessment of TAVR candidacy.

scholarly journals Mean Blood Pressure and Velocity for Calculation of Ventricular Systolic Work

1998 ◽  
Vol 41 (1) ◽  
pp. 27-28
Author(s):  
Milan Valach
Keyword(s):  
Blood Pressure ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Diastolic Pressure ◽  
Weighted Average ◽  
Average Pressure ◽  
Mean Pressure ◽  
The Mean ◽  
Definition Of ◽  
Ejection Phase

In physiology, the mean arterial pressure is defined as an average pressure during one or several cardiac cycles. When calculus is not used, the mean pressure is approximately calculated as the diastolic pressure plus one third of the pulse pressure. In this article it is demonstrated that, when ventricular systolic work is concerned, the above definition of mean pressure must be replaced by a weighted average during the ejection phase of the systole. This gives a formula, by which a much higher estimate of the mean pressure is obtained.

scholarly journals Refined mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models

2011 ◽  
Vol 34 (12) ◽  
pp. 1263-1270 ◽  
Author(s):  
Sivarajan Kumarasamy ◽  
Kathirvel Gopalakrishnan ◽  
Edward J Toland ◽  
Shane Yerga-Woolwine ◽  
Phyllis Farms ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Rat Models ◽  
Congenic Strains ◽  
Hypertensive Rat ◽  
Trait Loci ◽  
Genetically Hypertensive

Plasma Volume Decrease and Elevated Evans Blue Disappearance Rate in Essential Hypertension

1973 ◽  
Vol 45 (2) ◽  
pp. 173-181 ◽  
Author(s):  
Milos Ulrych
Keyword(s):  
Blood Pressure ◽  
Cardiac Output ◽  
Essential Hypertension ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Plasma Volume ◽  
Evans Blue ◽  
Disappearance Rate ◽  
The Mean ◽  
Volume Decrease

1. The disappearance rate of intravenously injected Evans Blue, plasma volume, cardiac output, and blood pressure were measured in seven normotensive and eighteen hypertensive subjects. 2. Plasma volume was found to be negatively correlated with the mean arterial pressure, Evans Blue disappearance rate and packed cell volume. 3. Faster disappearance rate of Evans Blue in hypertensive subjects may be due to an abnormality of mixing of the label or of the capillaries.

scholarly journals Two Linked Blood Pressure Quantitative Trait Loci on Chromosome 10 Defined by Dahl Rat Congenic Strains

Hypertension ◽  
2001 ◽  
Vol 38 (4) ◽  
pp. 779-785 ◽  
Author(s):  
Michael R. Garrett ◽  
Xiaotong Zhang ◽  
Oksana I. Dukhanina ◽  
Alan Y. Deng ◽  
John P. Rapp
Keyword(s):  
Blood Pressure ◽  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Chromosome 10 ◽  
Congenic Strains ◽  
Trait Loci

scholarly journals Comparison between esmolol and verapamil in attenuation of cardiovascular stress response to laryngoscopy and endotracheal intubation in elective surgery

2021 ◽  
Vol 12 (7) ◽  
pp. 64-68
Author(s):  
Nitisha Chakraborty ◽  
Sankar Roy ◽  
Debajyoti Sur ◽  
Arunava Biswas ◽  
Dipasri Bhattacharya ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Body Weight ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Diastolic Blood Pressure ◽  
Endotracheal Intubation ◽  
Efficacy And Safety ◽  
Cardiovascular Stress ◽  
The Mean

Background: Cardiovascular stress due to reflex sympathetic over activity is a great concern during laryngoscopy and endotracheal intubation. Aims and Objectives: To compare the efficacy and safety of esmolol and verapamil for attenuation of hemodynamic effects (heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure) due to laryngoscopy and endotracheal intubation in elective surgical cases. Materials and Methods: A prospective, randomized, double blinded, controlled study was conducted on 60 patients divided equally into 30 each receiving esmolol (2 mg/kg body weight) and verapamil (0.1 mg/kg body weight) respectively. Heart rate, systolic and diastolic blood pressure and mean arterial pressure were recordedat pre-operative stage, after administration of the study drugs, immediately after intubation and at 1 ,3 ,5 minutes after intubation. Data collected were statistically analyzed. Results: The mean systolic blood pressure was lower in the esmolol group at all times of estimation compared with the verapamil group and the difference was at the time of intubation (p value <0.001).The mean diastolic blood pressure was lower in the esmolol group at all times of estimation compared to the verapamil group which was not statistically significant at any time of estimation. The mean arterial pressure was significantly lower at the time of immediately after intubation (p<0.001) in esmolol as compared to verapamil group. Adverse effects in both the study groups were insignificant. Conclusion: Esmololand Verapamil can effectively attenuate the cardiovascular stress to laryngoscopy and endotracheal intubation with the former appears to be a better alternative from efficacy and safety perspectives.

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