scholarly journals Histone Deacetylase 1 Depletion Activates Human Cardiac Mesenchymal Stromal Cell Proangiogenic Paracrine Signaling Through a Mechanism Requiring Enhanced Basic Fibroblast Growth Factor Synthesis and Secretion

2017 ◽  
Vol 6 (7) ◽  
Author(s):  
Joseph B. Moore ◽  
John Zhao ◽  
Annalara G. Fischer ◽  
Matthew C.L. Keith ◽  
David Hagan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Histone Deacetylase ◽  
Basic Fibroblast Growth Factor ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Fibroblast Growth ◽  
Paracrine Signaling ◽  
Histone Deacetylase 1

Angiotensin II and Basic Fibroblast Growth Factor Induce Neonatal Bladder Stromal Cell Mitogenesis

1996 ◽  
pp. 593-597 ◽  
Author(s):  
Earl Y. Cheng ◽  
Tom Grammatopoulos ◽  
Chung Lee ◽  
Julia Sensibar ◽  
Robert Decker ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Stromal Cell ◽  
Fibroblast Growth

Heterogeneity of Capillary Endothelial Cells for Basic Fibroblast Growth Factor-Induced Paracrine Signaling

Endothelium ◽  
2006 ◽  
Vol 13 (3) ◽  
pp. 191-203 ◽  
Author(s):  
Tae-Hee Lee ◽  
Hyung-Chahn Lee ◽  
Young Sook Son ◽  
Mi-Ae Kang ◽  
Myung-Jin Park ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Paracrine Signaling ◽  
Capillary Endothelial Cells

scholarly journals Basic fibroblast growth factor expression in human bone marrow and peripheral blood cells

Blood ◽  
1993 ◽  
Vol 81 (3) ◽  
pp. 631-638 ◽  
Author(s):  
G Brunner ◽  
H Nguyen ◽  
J Gabrilove ◽  
DB Rifkin ◽  
EL Wilson
Keyword(s):  
Bone Marrow ◽  
Extracellular Matrix ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Cell Cultures ◽  
Stromal Cells ◽  
Peripheral Blood ◽  
Stromal Cell ◽  
Fibroblast Growth

We have shown previously that basic fibroblast growth factor (bFGF) is a mitogen for human bone marrow (BM) stromal cells and that bFGF stimulates myelopoiesis in primary BM cultures. In this article, we demonstrate the presence of bFGF in two cell lineages in human BM and peripheral blood as well as the deposition of bFGF into the extracellular matrix of BM stromal cell cultures. In immunofluorescence experiments on BM and peripheral blood smears, megakaryocytes and platelets stained strongly for bFGF, whereas weaker staining was observed in immature and mature cells of the granulocyte series. The presence of bFGF in platelets was confirmed by enzyme-linked immunosorbent assay as well as by immunoprecipitation followed by immunoblotting. bFGF was synthesized by BM stromal cell cultures and was found either cell associated or localized in the nucleus and the nucleoli, and its location was dependent on the fixation procedure used. Addition of exogenous bFGF to stromal cells showed the presence of extracellular binding molecules for this cytokine. bFGF could be released from these sites by soluble heparin or phosphatidylinositol- specific phospholipase C. This study supports the role of bFGF as a stromal cell mitogen and stimulator of myelopoiesis. The data indicate that the stromal cells produce bFGF and that their extracellular matrix can serve as a reservoir for this growth factor. In addition, the results suggest a possible involvement of bFGF in platelet function as well as in megakaryocytopoiesis.

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