scholarly journals U‐Shaped Association Between Serum Uric Acid Levels With Cardiovascular and All‐Cause Mortality in the Elderly: The Role of Malnourishment

2018 ◽  
Vol 7 (4) ◽  
Author(s):  
Wei‐Cheng Tseng ◽  
Yung‐Tai Chen ◽  
Shuo‐Ming Ou ◽  
Chia‐Jen Shih ◽  
Der‐Cherng Tarng ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
The Elderly ◽  
All Cause Mortality

scholarly journals Distinct Prognostic Role of Serum Uric Acid Levels for Predicting All-Cause Mortality Among Chinese Adults Aged 45~75 Years With and Without Diabetes

2021 ◽  
Vol 12 ◽  
Author(s):  
Bowen Zhu ◽  
Jian Zhang ◽  
Nana Song ◽  
Yiqin Shi ◽  
Yi Fang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Serum Uric Acid ◽  
Independent Risk Factor ◽  
Prognostic Role ◽  
Chinese Adults ◽  
Baseline Serum ◽  
All Cause Mortality

IntroductionThe current study sought to explore the effect of baseline serum uric acid (SUA) on the risk of all-cause mortality among Chinese adults aged 45~75 years and to determine its interaction relationship with diabetes.MethodsThe study was designed as a community-based cohort of 4467 adults aged between 45~75 years included in a 6-years follow-up period from 2009 to 2015 years by the China Health and Nutrition Survey (CHNS). Baseline SUA levels were grouped into quartiles and its association on all-cause mortality was explored using multivariate Cox proportional hazards models. Stratified analyses were performed to explore the associations of SUA quartiles with all-cause mortality among diabetic and non-diabetic individuals.ResultsA total of 141 deaths (5.3 per 1000 person-years) were recorded During a follow-up of 26431 person-years. Out of the 141 deaths, 28 deaths (10.1 per 1000 person-years) were reported in the diabetic groups and 113 deaths (4.8 per 1000 person-years) were recorded in the non-diabetic group. An increased risk of all-cause mortality was observed for participants in the first and fourth quartiles compared with the second SUA quartile, (Q1 SUA: aHR=2.1, 95% CI 1.1~4.1; Q4 SUA: aHR=2.1, 95% CI 1.1~4.0). Stratification of participants by diabetes status showed a U-shaped association for non-diabetic individuals. Whereas, declined eGFR, rather than SUA, was an independent risk factor for all-cause mortality in diabetic individuals (aHR=0.7, 95% CI 0.6~1.0).ConclusionOur study proved that the prognostic role of SUA for predicting all-cause death might be regulated by diabetes. Both low and high SUA levels were associated with increased mortality, supporting a U-shaped association only in non-diabetic individuals. Whereas, renal dysfunction rather than SUA was an independent risk factor for all-cause mortality. Further studies should be conducted to determine the SUA levels at which intervention should be conducted and explore target follow-up strategies to prevent progression leading to poor prognosis.

scholarly journals Dysfunctional ABCG2 gene polymorphisms are associated with serum uric acid levels and all-cause mortality in hemodialysis patients

Human Cell ◽  
2020 ◽  
Vol 33 (3) ◽  
pp. 559-568
Author(s):  
Akio Nakashima ◽  
Kimiyoshi Ichida ◽  
Ichiro Ohkido ◽  
Keitaro Yokoyama ◽  
Hirotaka Matsuo ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Gene Polymorphisms ◽  
Hemodialysis Patients ◽  
All Cause Mortality ◽  
Abcg2 Gene

scholarly journals Serum uric acid and disorders of glucose metabolism: the role of glycosuria

2014 ◽  
Vol 47 (10) ◽  
pp. 917-923 ◽  
Author(s):  
J.A.M. Andrade ◽  
H.C. Kang ◽  
S. Greffin ◽  
M.L. Garcia Rosa ◽  
J.R. Lugon
Keyword(s):  
Uric Acid ◽  
Glucose Metabolism ◽  
Serum Uric Acid

scholarly journals The controversial role of serum uric acid in essential hypertension: relationships with indices of target organ damage

2005 ◽  
Vol 19 (3) ◽  
pp. 211-217 ◽  
Author(s):  
C Tsioufis ◽  
D Chatzis ◽  
E Vezali ◽  
K Dimitriadis ◽  
D Antoniadis ◽  
...  
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ

scholarly journals Upregulated Guanine Deaminase Is Involved in Hyperpigmentation of Seborrheic Keratosis via Uric Acid Release

2021 ◽  
Vol 22 (22) ◽  
pp. 12501
Author(s):  
Kyung Ah Cheong ◽  
In Sup Kil ◽  
Hyuk Wan Ko ◽  
Ai-Young Lee
Keyword(s):  
Uric Acid ◽  
The Elderly ◽  
Epidermal Keratinocytes ◽  
Seborrheic Keratosis ◽  
Human Epidermal Keratinocytes ◽  
Skin Hyperpigmentation ◽  
Guanine Deaminase ◽  
Acid Release ◽  
Skin Specimen

Seborrheic keratosis, which is a benign tumor composed of epidermal keratinocytes, develops common in the elderly. Uric acid generated by upregulated guanine deaminase (GDA) has been identified to cause UV-induced keratinocyte senescence in seborrheic keratosis. Seborrheic keratosis is also frequently pigmented. Growing evidences indicate that hyperuricemia is a risk factor of acanthosis nigricans, an acquired skin hyperpigmentation. The objective of this study was to investigate role of GDA and its metabolic end product, uric acid, in hyperpigmentation of patients with seborrheic keratosis using their lesional and non-lesional skin specimen sets and cultured primary human epidermal keratinocytes with or without GDA overexpression or uric acid treatment. GDA-overexpressing keratinocytes or their conditioned media containing uric acid increased expression levels of MITF and tyrosinase in melanocytes. Uric acid released from keratinocytes was facilitated by ABCG2 transporter with the help of PDZK1 interaction. Released uric acid was taken by URAT1 transporter in melanocytes, stimulating melanogenesis through p38 MAPK activation. Overall, GDA upregulation in seborrheic keratosis plays a role in melanogenesis via its metabolic end product uric acid, suggesting that seborrheic keratosis as an example of hyperpigmentation associated with photoaging.

scholarly journals Significant spike in excess mortality in England in winter 2014/15 – influenza the likely culprit

2018 ◽  
Vol 146 (9) ◽  
pp. 1106-1113 ◽  
Author(s):  
R. G. Pebody ◽  
H. K. Green ◽  
F. Warburton ◽  
M. Sinnathamby ◽  
J. Ellis ◽  
...  
Keyword(s):  
Poisson Regression ◽  
Influenza A ◽  
Excess Mortality ◽  
Extreme Temperature ◽  
The Elderly ◽  
Health Impact ◽  
Poisson Regression Model ◽  
Potential Health ◽  
All Cause Mortality

AbstractSignificant increases in excess all-cause mortality, particularly in the elderly, were observed during the winter of 2014/15 in England. With influenza A(H3N2) the dominant circulating influenza A subtype, this paper determines the contribution of influenza to this excess controlling for weather. A standardised multivariable Poisson regression model was employed with weekly all-cause deaths the dependent variable for the period 2008–2015. Adjusting for extreme temperature, a total of 26 542 (95% CI 25 301–27 804) deaths in 65+ and 1942 (95% CI 1834–2052) in 15–64-year-olds were associated with influenza from week 40, 2014 to week 20, 2015. This is compatible with the circulation of influenza A(H3N2). It is the largest estimated number of influenza-related deaths in England since prior to 2008/09. The findings highlight the potential health impact of influenza and the important role of the annual influenza vaccination programme that is required to protect the population including the elderly, who are vulnerable to a severe outcome.

Association Between the Serum Uric Acid Levels and Lacunar Infarcts in the Elderly

2018 ◽  
Vol 65 (3) ◽  
pp. 385-390 ◽  
Author(s):  
F. Crosta ◽  
U. Occhiuzzi ◽  
G. Passalacqua ◽  
E. Occhiuzzi ◽  
A. Cimini ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
The Elderly ◽  
Lacunar Infarcts
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