Abstract WP222: Comparison of Two Methods of External Prolonged Cardiac Monitoring for the Detection of Atrial Fibrillation: Cardiophone - satellite Real Time Device vs Sorin (Automated Software) for the Peaace Study

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Herbert Manosalva ◽  
Saad Hasan ◽  
Arif Pervez ◽  
Askar Mohammad ◽  
Dulara Hussain ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Real Time ◽  
Heart Rhythm ◽  
Cardiac Monitoring ◽  
Real Time Monitoring ◽  
Prolonged Monitoring ◽  
Stroke Type ◽  
Automated Software

Introduction: Recent evidence has shown that prolonged cardiac monitoring is superior to 24 hour Holter for detection of atrial fibrillation (AF). We compared two methods of prolonged monitoring in patients with acute ischemic stroke and TIAs. Objective: Comparison of the Cardiophone and Sorin monitor for detection of AF. Method: In the first part of the study (PEAACE I; 2011-2013), we used the spiderflash (Sorin, Italy) for up to 21 days of monitoring. In the second part (PEAACE II; 2013-2015), Cardiophone with real time monitoring of the heart rhythm for 14 days was used. Results: 102 patients in PEAACE I, (Mean age 72 +/-, 48.8% male) were compared to 120 patients in PEAACE II (Mean age 73 +/-, 70% male). Stroke type was “undetermined (cryptogenic) 92% and 91% in the two studies respectively. In PEAACE I, AF was detected in 43 out of 102 subjects (42%) (72% <30 seconds, 28% >30 seconds) with detection of 75% in the first week, 23% in the second, and 2% in the last week. In PEAACE II, 20 out of 120 subjects (17%) (70% <30 seconds, 30% >30 seconds) had AF, with 55% of detection in the first week, 45% in the second one (χ2 p=0.001). In PEAACE II, the results were available faster, within 2 days compared to 21 days in PEAACE I (χ2 p<0.0005). In PEAACE II, 90% of the patients received anticoagulation (93% of participants with A Fib <30 seconds, 83% with >30 seconds) compared to 77% in PEAACE I (68% with AF <30 seconds and 100% with AF >30 seconds) (χ2 p=0.021). Conclusion: There were significant differences noted in the rates of detection with the two techniques. Real-time monitoring resulted in recording of fewer events but lead to earlier initiation of treatment. All patients with >30 seconds of AF were anticoagulated whereas fewer patients with less than 30 seconds of AF were anticoagulated.

Abstract WP255: Can Normal Electrocardiogram Rule Out Newly Diagnosed Atrial Fibrillation in Ischemic Stroke Patients

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Joshua Santucci ◽  
Takashi Shimoyama ◽  
Ken Uchino
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Cryptogenic Stroke ◽  
Cardiac Monitoring ◽  
Large Artery ◽  
Newly Diagnosed ◽  
Stroke Patients ◽  
Stroke Subtype ◽  
History Of

Introduction: Electrocardiogram (ECG) findings of premature atrial contraction and prolonged PR interval are associated with risk of onset atrial fibrillation (AF) in cryptogenic stroke. We sought to see if normal ECG and AF incidence is incompletely understood. Methods: From a prospective single-hospital stroke registry from 2018, we identified ischemic stroke patients who had ECG done on admission for review. We excluded patients with AF on admission ECG, history of AF, and implanted device with cardiac monitoring capability. Normal ECG was interpreted based on the standardized reporting guidelines for ECG studies evaluating risk stratification of emergency department patients. Stroke subtype was diagnosed according to the TOAST classification: large artery atherosclerosis (LAA), small vessel occlusion (SVO), cardioembolism, others/undetermined and embolic stoke of undetermined source (ESUS) criteria. We compared the incidence of newly diagnosed AF during hospitalization and from outpatient cardiac event monitoring between normal and abnormal ECG. Results: Of the 558 consecutive acute ischemic stroke patients, we excluded 135 with AF on admission ECG or history of AF and 9 with implanted devices. Of the remaining 414 patients that were included in the study, ESUS (31.2%) was the most frequent stroke subtype, followed by LAA (30.0%), SVO (14.0%), others/undetermined (15.7%), and cardioembolism (9.2%). Normal ECG was observed in 125 patients (30.2%). Cardioembolic subtype was less frequent in the normal versus abnormal ECG group (1.6% vs. 12.5%, p<0.001). New AF was detected in 17/414 patients (4.1%) during hospitalization. Of these 17 patients, none had normal ECG (0/125) and all had abnormal ECG (17/289, 5.9%) (p=0.002). After discharge, of 111 patients undergoing 4-week outpatient cardiac monitoring, new AF was detected in 16 (14.4%). Of these 16 patients, only 1 had a normal ECG (1/35, 2.9%) while 15 had abnormal ECG (15/76, 19.7%) (p=0.02). Conclusions: Normal ECG at admission for acute ischemic stroke is associated with low likelihood of detection of new atrial fibrillation in either the inpatient or outpatient setting.

scholarly journals Noninvasive Cardiac Monitoring for Detecting Paroxysmal Atrial Fibrillation or Flutter After Acute Ischemic Stroke

Stroke ◽  
2007 ◽  
Vol 38 (11) ◽  
pp. 2935-2940 ◽  
Author(s):  
Joy Liao ◽  
Zahira Khalid ◽  
Ciaran Scallan ◽  
Carlos Morillo ◽  
Martin O’Donnell
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Paroxysmal Atrial Fibrillation ◽  
Cardiac Monitoring ◽  
Noninvasive Cardiac Monitoring

Real-time monitoring of recanalization after intravenous thrombolysis for acute ischemic stroke

2006 ◽  
Vol 13 (4) ◽  
pp. 426-427 ◽  
Author(s):  
R. Delgado-Mederos ◽  
M. Ribo ◽  
J. Montaner ◽  
J. F. Arenillas ◽  
M. Rubiera ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Real Time ◽  
Intravenous Thrombolysis ◽  
Real Time Monitoring

Abstract 17804: Echocardiographic and Radiologic Predictors of Atrial Fibrillation in Acute Ischemic Stroke

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Shilpi Mittal ◽  
Janhavi Modak ◽  
Ilene Staff ◽  
Michael Phipps ◽  
Gilbert Fortunato ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Hemorrhagic Transformation ◽  
Left Ventricular ◽  
Cardiac Monitoring ◽  
Retrospective Case ◽  
Severe Aortic Regurgitation ◽  
Stroke Etiology ◽  
Radiologic Findings

Introduction: Atrial fibrillation (AF) is an important risk factor for stroke. Approximately 15-25% of cryptogenic ischemic strokes (CIS) are due to AF. Hypothesis: Patients with echocardiographic markers including left atrial dilatation (LAD) and valvular disease and/or radiologic findings including a hyper-dense vessel sign (HDV sign), prior cortical or cerebellar stroke, and hemorrhagic transformation (HT) are more likely to have stroke due to AF. Methods: This is a single center, retrospective case control study of patients admitted with acute ischemic stroke (AIS) from 2008-2013. Patients with a new diagnosis of stroke and a defined stroke etiology (large vessel, cardio-embolic, small vessel and other, TOAST classification) were included. CIS patients or those without imaging/echocardiographic studies were excluded. Images were reviewed for prior stroke, HT, a HDV sign and stroke location (left or right anterior, posterior, multifocal). Echocardiograms were reviewed for LAD, ejection fraction<35%, moderate-severe mitral regurgitation (MR), moderate-severe aortic regurgitation, mitral stenosis, aortic stenosis, left ventricular segmental akinesis, diastolic dysfunction, LVH and patent foramen ovale. Results: Charts of 600 patients were reviewed and 383 patients were included in the analysis. 185 patients had AF as the etiology of their stroke. The remainder had no known AF. Univariate and multivariate logistic regression was performed using SPSS. LAD, moderate to severe MR, HDV sign, and HT were found to accurately predict AF in patients with AIS. LAD had an OR of 6.9 (CI 4.4-10.8, p<.0001) and HDV predicted AF with an OR of 2.2 (CI 1.2-4.2, p<.016) even after controlling for LAD, MR, and HT. Conclusion: Echocardiographic and radiologic markers help predict AF as a stroke etiology in AIS patients. This is the first study, to the best of our knowledge, to show that HDV sign is a positive predictor of AF. Prospective studies with larger cohorts are needed to confirm these findings in CIS patients. These markers could be added to demographic information to enhance prediction of occult AF and the need for chronic cardiac monitoring.

Cardiac Monitoring in Stroke Units: Importance of Diagnosing Atrial Fibrillation in Acute Ischemic Stroke

2009 ◽  
Vol 62 (5) ◽  
pp. 564-567 ◽  
Author(s):  
Rosa María Vivanco Hidalgo ◽  
Ana Rodríguez Campello ◽  
Ángel Ois Santiago ◽  
Elisa Cuadrado Godia ◽  
Claustre Pont Sunyer ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Cardiac Monitoring ◽  
Stroke Units

Abstract WP229: Prolonged Monitoring of Cardiac Rhythm With Wireless Cardiophone for Real Time Detection of Atrial Fibrillation After a Cerebral Ischemic Event (PEAACE II Study) The Edmonton Alberta Experience

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Saad Hasan ◽  
Herbert Manosalva ◽  
Arif Pervez ◽  
Askar Mohammad ◽  
Dulara Hussain ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Medical Treatment ◽  
Real Time ◽  
Heart Rhythm ◽  
Primary Objective ◽  
Care Physician ◽  
Cardiac Monitoring ◽  
Chi Square ◽  
Hospital Patients ◽  
The Difference

Introduction: Atrial fibrillation (AF) is a leading cause of preventable stroke and can be prevented with anticoagulants. Prolonged cardiac monitoring can lead to better detection of AF. Real time cardiac monitoring may lead to earlier diagnosis and treatment. Objective: Primary objective is to detect AF using wireless cardiophone for 14 days in stroke patients. Secondary objective is to determine the reduction of time of AF diagnosis resulting in a prompt change in clinical management. Method: This was a Cohort/Prospective study at the Univesity of Alberta Hospital. Patients ≥40 years of age (without known AF on ECG/Holter) who had an ischemic stroke or TIA within ≤90 days were eligible. The signals from cardiophone were analyzed in real time at Canadian cardiac center in Windsor, Ontario. The incidence and time of onset of AF and change in medical treatment (anti-coagulation) was recorded. Results: Out of 120 patients, 118 completed monitoring for more than 48 hours. Twenty out of these 118 subjects (≈ 17 %) were shown positive for AF. When compared with the incidence of 5% reported in historical controls wearing 24 hour holter, the difference was significant (chi square p=0.004). Fourteen out of 20 AF subjects (70%)had AF duration of < 30 seconds, while 6/20 (30%) had a duration of >30 seconds. Mean time from onset of arrhythmia to report was ≈48 hours; shorter than the time for report with Holter (≈10 days in Alberta). Ninety percent of AF positive subjects were started on anti-coagulation therapies. Conclusion: Prolonged cardiac monitoring for 14 days increased the detection of AF approximately 3 fold as compared to 24 hour Holter. Cardiophone device allowed feasible real time monitoring of heart rhythm and faster reporting time (within 48 hours) that lead to prompt change in medical treatment by the health care physician.

Safety of early anticoagulation in patients treated with urgent reperfusion for acute ischemic stroke related to non-valvular atrial fibrillation

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Giustozzi
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Major Bleeding ◽  
Oral Anticoagulation ◽  
Primary Outcome ◽  
Oral Anticoagulants ◽  
Early Recurrence ◽  
Optimal Timing ◽  
Hemorrhagic Event

Abstract Background The optimal timing for starting anticoagulation after an acute ischemic stroke related to non-valvular atrial fibrillation (AF) remains a challenge, especially in patients treated with systemic thrombolysis or mechanical thrombectomy. Purpose We aimed to assess the rates of early recurrence and major bleeding in patients with acute ischemic stroke and AF treated with thrombolytic therapy and/or thrombectomy who received oral anticoagulants for secondary prevention. Methods We combined the dataset of the RAF and the RAF-NOACs studies, which were prospective observational studies carried out from January 2012 to March 2014 and April 2014 to June 2016, respectively. We included consecutive patients with acute ischemic stroke and AF treated with either vitamin K antagonists (VKAs) or new oral anticoagulants (NOACs). Primary outcome was the composite of stroke, transient ischemic attack, symptomatic systemic embolism, symptomatic cerebral bleeding, and major extracerebral bleeding within 90 days from the inclusion. Results A total of 2,159 patients were included in the RAF and RAF-NOACs trials, of which 564 patients (26%) were treated with urgent reperfusion therapy. After acute stroke, 505 (90%) patients treated with reperfusion and 1,287 out of the 1,595 (81%) patients not treated with reperfusion started oral anticoagulation. Timing of starting oral anticoagulation was similar in reperfusion-treated and untreated patients (13.5±23.3 vs 12.3±18.3 days, respectively, p=0.287). At 90 days, the composite rate of recurrence and major bleeding occurred in 37 (7%) of patients treated with reperfusion treatment and in 139 (9%) of untreated patients (p=0.127). Twenty-four (4%) reperfusion-treated patients and 82 (5%) untreated patients had early recurrence while major bleeding occurred in 13 (2%) treated and in 64 (4%) untreated patients, respectively. Seven patients in the untreated group experienced both an ischemic and hemorrhagic event. Figure 1 shows the risk of early recurrence and major bleeding over time in patients treated and not treated with reperfusion treatments. The use of NOACs was associated with a favorable rate of the primary outcome compared to VKAs (Odd ratio 0.4, 95% Confidence Interval 0.3–0.7). Conclusions Reperfusion treatment did not influence the risk of early recurrence and major bleeding in patients with AF-related acute ischemic stroke who started anticoagulant treatment. Figure 1 Funding Acknowledgement Type of funding source: None

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