Abstract TP509: Patterns of Injury in Children With Perinatal Arterial Ischemic Stroke and Infantile Spasms

Stroke ◽  
2019 ◽  
Vol 50 (Suppl_1) ◽  
Author(s):  
Ratika Srivastava ◽  
Oriana Shaw ◽  
Edward Armstrong ◽  
Francois-Dominique Morneau-Jacob ◽  
Jerome Y Yager
Keyword(s):  
Ischemic Stroke ◽  
Infantile Spasms ◽  
Arterial Ischemic Stroke ◽  
Patterns Of Injury ◽  
Perinatal Arterial Ischemic Stroke

Patterns of Brain Injury in Perinatal Arterial Ischemic Stroke and the Development of Infantile Spasms

2021 ◽  
pp. 088307382098605
Author(s):  
Ratika Srivastava ◽  
Oriana E. F. Shaw ◽  
Edward Armstrong ◽  
Francois-Dominique Morneau-Jacob ◽  
Jerome Y. Yager
Keyword(s):  
Ischemic Stroke ◽  
Brain Injury ◽  
Infantile Spasms ◽  
Control Group ◽  
Arterial Ischemic Stroke ◽  
Stroke Patients ◽  
Patients At Risk ◽  
Magnetic Resonance Imaging Mri ◽  
Perinatal Arterial Ischemic Stroke ◽  
Cerebral Structures

Introduction: Perinatal arterial ischemic stroke (PAIS) underlies approximately 10% of infantile spasms (IS). We aim to identify patterns of brain injury in ischemic stroke that may predispose infants to infantile spasms. Methods: Sixty-four perinatal arterial ischemic stroke patients were identified meeting the following inclusion criteria: term birth, magnetic resonance imaging (MRI) showing ischemic stroke or encephalomalacia in an arterial distribution, and follow-up records. Patients who developed infantile spasms (PAIS-IS) were analyzed descriptively for ischemic stroke injury patterns and were compared to a seizure-free control group (PAIS-only). Stroke injury was scored using the modified pediatric ASPECTS (modASPECTS). Results: The PAIS-IS (n = 9) group had significantly higher modASPECTS than the PAIS-only (n = 16) group ( P = .002, Mann-Whitney). A greater proportion of PAIS-IS patients had injury to deep cerebral structures (67%) than PAIS-only (25%). Conclusion: Infarct size was significantly associated with infantile spasms development. Results support theories implicating deep cerebral structures in infantile spasms pathogenesis. This may help identify perinatal arterial ischemic stroke patients at risk of infantile spasms, facilitating more timely diagnosis.

Neurocognitive outcome in a 6-year-old girl with a history of perinatal stroke

2011 ◽  
Vol 26 (S2) ◽  
pp. 1100-1100
Author(s):  
A. Matos-Pires ◽  
N. Cardoso-Pereira
Keyword(s):  
Working Memory ◽  
Ischemic Stroke ◽  
Verbal Learning ◽  
Arterial Ischemic Stroke ◽  
Intellectual Performance ◽  
Perinatal Stroke ◽  
Intellectual Outcome ◽  
History Of ◽  
Perinatal Arterial Ischemic Stroke

Perinatal Stroke involves an often poorly understood neurocognitive events affecting the fetus and the new born with a potential for serious intellectual outcome.Our aim is to present a case study on the issue of neurocognitive defects on domains such as intellectual performance, attention and vigilance, executive functioning, visual perception, speed of processing, verbal learning and memory, and working memory on a 6 year old girl with perinatal arterial ischemic stroke.

scholarly journals Risk of Later Seizure After Perinatal Arterial Ischemic Stroke: A Prospective Cohort Study

PEDIATRICS ◽  
2011 ◽  
Vol 127 (6) ◽  
pp. e1550-e1557 ◽  
Author(s):  
C. J. Wusthoff ◽  
S. K. Kessler ◽  
A. Vossough ◽  
R. Ichord ◽  
S. Zelonis ◽  
...  
Keyword(s):  
Cohort Study ◽  
Ischemic Stroke ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Arterial Ischemic Stroke ◽  
Perinatal Arterial Ischemic Stroke

scholarly journals Automatic Segmentation of Perinatal Arterial Ischemic Stroke Volume

2011 ◽  
Vol 70 ◽  
pp. 155-155
Author(s):  
N E van der Aa ◽  
I Isgum ◽  
F Groenendaal ◽  
M A Viergever ◽  
L S de Vries ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Stroke Volume ◽  
Automatic Segmentation ◽  
Arterial Ischemic Stroke ◽  
Perinatal Arterial Ischemic Stroke

New insights (and new interrogations) in perinatal arterial ischemic stroke

2011 ◽  
Vol 127 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Stéphane Chabrier ◽  
Béatrice Husson ◽  
Mickaël Dinomais ◽  
Pierre Landrieu ◽  
Sylvie Nguyen The Tich
Keyword(s):  
Ischemic Stroke ◽  
Arterial Ischemic Stroke ◽  
Perinatal Arterial Ischemic Stroke

Cerebral Palsy After Perinatal Arterial Ischemic Stroke

2008 ◽  
Vol 23 (3) ◽  
pp. 279-286 ◽  
Author(s):  
Meredith R. Golomb ◽  
Bhuwan P. Garg ◽  
Chandan Saha ◽  
Faouzi Azzouz ◽  
Linda S. Williams
Keyword(s):  
Cerebral Palsy ◽  
Ischemic Stroke ◽  
Arterial Ischemic Stroke ◽  
Perinatal Arterial Ischemic Stroke

scholarly journals Promoting neuroregeneration after perinatal arterial ischemic stroke: neurotrophic factors and mesenchymal stem cells

2017 ◽  
Vol 83 (1-2) ◽  
pp. 372-384 ◽  
Author(s):  
Nienke Wagenaar ◽  
Caroline G M de Theije ◽  
Linda S de Vries ◽  
Floris Groenendaal ◽  
Manon J N L Benders ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Ischemic Stroke ◽  
Neurotrophic Factors ◽  
Arterial Ischemic Stroke ◽  
Perinatal Arterial Ischemic Stroke

Two Children With Both Arm Ischemia and Arterial Ischemic Stroke During the Perinatal Period

2011 ◽  
Vol 26 (12) ◽  
pp. 1548-1554 ◽  
Author(s):  
Marilyn J. McKasson ◽  
Meredith R. Golomb
Keyword(s):  
Ischemic Stroke ◽  
Methylenetetrahydrofolate Reductase ◽  
Delayed Diagnosis ◽  
Limb Ischemia ◽  
Perinatal Period ◽  
Resonance Imaging ◽  
Arterial Ischemic Stroke ◽  
Cerebral Magnetic Resonance Imaging ◽  
Ischemic Limb ◽  
Perinatal Arterial Ischemic Stroke

It is rare for both limb ischemia and arterial ischemic stroke to occur in the same child during the perinatal period. Two children who appear to have had perinatal emboli to both an arm and a middle cerebral artery territory are presented here. One child required amputation of the ischemic limb below the shoulder, and the other required skin grafts to the distal ischemic fingers. Each of these children later received cerebral magnetic resonance imaging for evaluation of developmental delay and was found to have what appeared to be old perinatal arterial ischemic stroke. Both children were homozygous for the methylenetetrahydrofolate reductase C677T gene variant. Eight other children with perinatal limb ischemia and stroke were found on literature review; several also had delayed diagnosis of perinatal stroke. This report examines the approach to diagnosis and treatment in each of these and makes suggestions for the similar cases in the future.

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