Epileptogenic modulation index and synchronization in hypsarrhythmia of West syndrome secondary to perinatal arterial ischemic stroke

Perinatal Stroke involves an often poorly understood neurocognitive events affecting the fetus and the new born with a potential for serious intellectual outcome.Our aim is to present a case study on the issue of neurocognitive defects on domains such as intellectual performance, attention and vigilance, executive functioning, visual perception, speed of processing, verbal learning and memory, and working memory on a 6 year old girl with perinatal arterial ischemic stroke.

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Risk of Later Seizure After Perinatal Arterial Ischemic Stroke: A Prospective Cohort Study

PEDIATRICS ◽

10.1542/peds.2010-1577 ◽

2011 ◽

Vol 127 (6) ◽

pp. e1550-e1557 ◽

Cited By ~ 50

Author(s):

C. J. Wusthoff ◽

S. K. Kessler ◽

A. Vossough ◽

R. Ichord ◽

S. Zelonis ◽

...

Keyword(s):

Cohort Study ◽

Ischemic Stroke ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Arterial Ischemic Stroke ◽

Perinatal Arterial Ischemic Stroke

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Automatic Segmentation of Perinatal Arterial Ischemic Stroke Volume

Pediatric Research ◽

10.1038/pr.2011.380 ◽

2011 ◽

Vol 70 ◽

pp. 155-155

Author(s):

N E van der Aa ◽

I Isgum ◽

F Groenendaal ◽

M A Viergever ◽

L S de Vries ◽

...

Keyword(s):

Ischemic Stroke ◽

Stroke Volume ◽

Automatic Segmentation ◽

Arterial Ischemic Stroke ◽

Perinatal Arterial Ischemic Stroke

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New insights (and new interrogations) in perinatal arterial ischemic stroke

Thrombosis Research ◽

10.1016/j.thromres.2010.10.003 ◽

2011 ◽

Vol 127 (1) ◽

pp. 13-22 ◽

Cited By ~ 74

Author(s):

Stéphane Chabrier ◽

Béatrice Husson ◽

Mickaël Dinomais ◽

Pierre Landrieu ◽

Sylvie Nguyen The Tich

Keyword(s):

Ischemic Stroke ◽

Arterial Ischemic Stroke ◽

Perinatal Arterial Ischemic Stroke

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Cerebral Palsy After Perinatal Arterial Ischemic Stroke

Journal of Child Neurology ◽

10.1177/0883073807309246 ◽

2008 ◽

Vol 23 (3) ◽

pp. 279-286 ◽

Cited By ~ 63

Author(s):

Meredith R. Golomb ◽

Bhuwan P. Garg ◽

Chandan Saha ◽

Faouzi Azzouz ◽

Linda S. Williams

Keyword(s):

Cerebral Palsy ◽

Ischemic Stroke ◽

Arterial Ischemic Stroke ◽

Perinatal Arterial Ischemic Stroke

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Promoting neuroregeneration after perinatal arterial ischemic stroke: neurotrophic factors and mesenchymal stem cells

Pediatric Research ◽

10.1038/pr.2017.243 ◽

2017 ◽

Vol 83 (1-2) ◽

pp. 372-384 ◽

Cited By ~ 15

Author(s):

Nienke Wagenaar ◽

Caroline G M de Theije ◽

Linda S de Vries ◽

Floris Groenendaal ◽

Manon J N L Benders ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Ischemic Stroke ◽

Neurotrophic Factors ◽

Arterial Ischemic Stroke ◽

Perinatal Arterial Ischemic Stroke

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Two Children With Both Arm Ischemia and Arterial Ischemic Stroke During the Perinatal Period

Journal of Child Neurology ◽

10.1177/0883073811413277 ◽

2011 ◽

Vol 26 (12) ◽

pp. 1548-1554 ◽

Cited By ~ 2

Author(s):

Marilyn J. McKasson ◽

Meredith R. Golomb

Keyword(s):

Ischemic Stroke ◽

Methylenetetrahydrofolate Reductase ◽

Delayed Diagnosis ◽

Limb Ischemia ◽

Perinatal Period ◽

Resonance Imaging ◽

Arterial Ischemic Stroke ◽

Cerebral Magnetic Resonance Imaging ◽

Ischemic Limb ◽

Perinatal Arterial Ischemic Stroke

It is rare for both limb ischemia and arterial ischemic stroke to occur in the same child during the perinatal period. Two children who appear to have had perinatal emboli to both an arm and a middle cerebral artery territory are presented here. One child required amputation of the ischemic limb below the shoulder, and the other required skin grafts to the distal ischemic fingers. Each of these children later received cerebral magnetic resonance imaging for evaluation of developmental delay and was found to have what appeared to be old perinatal arterial ischemic stroke. Both children were homozygous for the methylenetetrahydrofolate reductase C677T gene variant. Eight other children with perinatal limb ischemia and stroke were found on literature review; several also had delayed diagnosis of perinatal stroke. This report examines the approach to diagnosis and treatment in each of these and makes suggestions for the similar cases in the future.

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Risk Factors for Perinatal Arterial Ischemic Stroke

Cell Medicine ◽

10.1177/2155179018785341 ◽

2018 ◽

Vol 10 ◽

pp. 215517901878534 ◽

Cited By ~ 2

Author(s):

Daniela Munoz ◽

María José Hidalgo ◽

Fernanda Balut ◽

Mónica Troncoso ◽

Susana Lara ◽

...

Keyword(s):

Risk Factors ◽

Ischemic Stroke ◽

Cesarean Section ◽

Apgar Score ◽

Birth Asphyxia ◽

Arterial Ischemic Stroke ◽

Emergency Cesarean Section ◽

Emergency Cesarean ◽

Associated Risk Factors ◽

Perinatal Arterial Ischemic Stroke

Introduction: Arterial ischemic stroke in newborns is an important cause of neonatal morbidity and mortality. Its pathophysiology and associated risk factors are not yet clearly understood and defined. Objective: The aim of this retrospective study was to investigate possible risk factors in diagnosed cases of PAIS (perinatal arterial ischemic stroke). Materials and methods: Case–control study. Clinical data of patients with PAIS diagnosis were analyzed. Two healthy controls were selected for each PAIS case, matched for gestational age. Risk factors were explored using univariable and multivariable analysis. Outcome: 40 patients were included in the study, 24 males and 16 females; 52.5% of cases were diagnosed within the first month of birth, and 47.5% were retrospectively diagnosed. The results showed a male predominance (66.7%). The distribution of cerebral ischemic injury was predominantly medial cerebral artery (87.5%) and occurred more commonly in the left cerebral hemisphere (62.5%). Significant risk factors in the univariate analysis (P < 0.05) were primiparity, stillbirth, neonatal sepsis, asphyxia, twin pregnancy, placenta abruption, emergency cesarean section, Apgar score ≤7 after 5 min, breech presentation, and hyperbilirubinemia. In the multivariate analysis, primiparity (OR 11.74; CI 3.28–42.02), emergency cesarean section (OR 13.79; CI 3.51–54.13), birth asphyxia (OR 40.55; CI 3.08–532.94) and Apgar score ≤7 after 5 min (OR 13.75; CI 1.03–364.03) were significantly associated factors with PAIS. Only five (16.6%) patients had an abnormal thrombophilia study. Conclusion: Risk factors of primiparity, emergency cesarean section, birth asphyxia, and Apgar score ≤7 after 5 min were significantly associated with perinatal stroke. More studies with a larger number of patients and with prolonged follow up are required to establish more clearly the associated risk factors involved in this pathology.

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Does Diffusion Tensor Imaging-Based Tractography at 3 Months of Age Contribute to the Prediction of Motor Outcome After Perinatal Arterial Ischemic Stroke?

Stroke ◽

10.1161/strokeaha.111.624858 ◽

2011 ◽

Vol 42 (12) ◽

pp. 3410-3414 ◽

Cited By ~ 42

Author(s):

Niek E. van der Aa ◽

Alexander Leemans ◽

Frances J. Northington ◽

Henrica L. van Straaten ◽

Ingrid C. van Haastert ◽

...

Keyword(s):

Ischemic Stroke ◽

Diffusion Tensor Imaging ◽

Positive Predictive Value ◽

Predictive Value ◽

Neonatal Period ◽

Motor Behavior ◽

Diffusion Tensor ◽

Motor Deficits ◽

Arterial Ischemic Stroke ◽

Perinatal Arterial Ischemic Stroke

Background and Purpose— After perinatal arterial ischemic stroke, diffusion-weighted imaging (DWI) and early evaluation of spontaneous motor behavior can be used to predict the development of unilateral motor deficits. The aim of this study was to investigate whether diffusion tensor imaging-based tractography at 3 months of age contributes to this prediction. Methods— Twenty-two infants with unilateral perinatal arterial ischemic stroke were included and scanned during the neonatal period. DWI was used to assess restricted diffusion in the cerebral peduncle. At the age of 3 months, diffusion tensor imaging-based tractography of the corticospinal tracts was performed along with assessment of the movement repertoire. The role of DWI, diffusion tensor imaging, and motor assessment in predicting unilateral motor deficits were compared by calculating the positive and negative predictive values for each assessment. Results— Eleven infants (50%) showed abnormal motor behavior at 3 months with subsequent development of unilateral motor deficits in 8 as determined at follow-up (9–48 months, positive predictive value 73%). Diffusion tensor imaging-based tractography correctly predicted the development of unilateral motor deficits in all 8 infants (positive predictive value 100%). A diagnostic neonatal DWI was available in 20 of 22 (91%) infants. Seven infants showed an abnormal DWI, resulting in unilateral motor deficits in 6 infants (positive predictive value 86%). All assessments had a negative predictive value of 100%. Conclusions— Diffusion tensor imaging-based tractography at 3 months can be used to predict neurodevelopmental outcome after perinatal arterial ischemic stroke. It has a similar predictive value as DWI in the neonatal period and can especially be of additional value in case of an indecisive neonatal DWI or unexpected abnormal early motor development.

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