Abstract WP204: Low-grade Inflammation is Associated With Apathy Indirectly Through Deep White Matter Lesions in Community-dwelling Older Adults

Stroke ◽  
2019 ◽  
Vol 50 (Suppl_1) ◽  
Author(s):  
Hiroshi Yao ◽  
Yoshito Mizoguchi ◽  
Akira Monji ◽  
Yusuke Yakushiji ◽  
Yuki Takashima ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
White Matter Lesions ◽  
Community Dwelling ◽  
Low Grade ◽  
Deep White Matter ◽  
Low Grade Inflammation ◽  
Community Dwelling Older Adults

scholarly journals Low-Grade Inflammation Is Associated with Apathy Indirectly via Deep White Matter Lesions in Community-Dwelling Older Adults: The Sefuri Study

2019 ◽  
Vol 20 (8) ◽  
pp. 1905 ◽  
Author(s):  
Hiroshi Yao ◽  
Yoshito Mizoguchi ◽  
Akira Monji ◽  
Yusuke Yakushiji ◽  
Yuki Takashima ◽  
...  
Keyword(s):  
Older Adults ◽  
Metabolic Syndrome ◽  
White Matter ◽  
White Matter Lesions ◽  
Community Dwelling ◽  
Low Grade ◽  
Direct Path ◽  
Deep White Matter ◽  
Low Grade Inflammation ◽  
Community Dwelling Older Adults

Low-grade inflammation is implicated in the pathogenesis of atherosclerosis, metabolic syndrome, and apathy as a form of vascular depression. We analyzed the brain magnetic resonance imaging findings in 259 community-dwelling older adults (122 men and 137 women, with a mean age of 68.4 years). The serum concentrations of high-sensitivity C-reactive protein (hsCRP) were measured by a quantitative enzyme-linked immunosorbent assay. Logistic regression analysis revealed that the log10 hsCRP value and the presence of a metabolic syndrome were independently associated with confluent but not punctate deep white matter lesions (DWMLs). Path analysis based on structural equation modeling (SEM) indicated that the direct path from the log10 hsCRP to the DWMLs was significant (β = 0.119, p = 0.039). The direct paths from the metabolic syndrome to the log10 hsCRP and to the DWMLs were also significant. The direct path from the DWMLs to apathy (β = −0.165, p = 0.007) was significant, but the direct path from the log10 hsCRP to apathy was not significant. Inflammation (i.e., elevated serum hsCRP levels) was associated with DWMLs independent of common vascular risk factors, while DWMLs were associated with apathy. The present analysis with SEM revealed the more realistic scheme that low-grade inflammation was associated with apathy indirectly via DWMLs in community-dwelling older adults.

scholarly journals Associations Between Nutritional Deficits and Physical Performance in Community-Dwelling Older Adults

2021 ◽  
Vol 8 ◽  
Author(s):  
Wan-Hsuan Lu ◽  
Kelly Virecoulon Giudici ◽  
Yves Rolland ◽  
Sophie Guyonnet ◽  
Jean-François Mangin ◽  
...  
Keyword(s):  
Older Adults ◽  
Physical Performance ◽  
Rise Time ◽  
Community Dwelling ◽  
Low Grade ◽  
Omega 3 ◽  
Chair Rise ◽  
Nutritional Deficits ◽  
Low Grade Inflammation ◽  
Community Dwelling Older Adults

Background: Whether multiple nutritional deficiencies have a synergic effect on mobility loss remains unknown. This study aims to evaluate associations between multi-nutritional deficits and physical performance evolution among community-dwelling older adults.Methods: We included 386 participants from the Multidomain Alzheimer Preventive Trial (MAPT) (75.6 ± 4.5 years) not receiving omega-3 polyunsaturated fatty acid (PUFA) supplementation and who had available data on nutritional deficits. Baseline nutritional deficits were defined as plasma 25 hydroxyvitamin D <20 ng/ml, plasma homocysteine >14 μmol/L, or erythrocyte omega-3 PUFA index ≤ 4.87% (lower quartile). The Short Physical Performance Battery (SPPB), gait speed, and chair rise time were used to assess physical performance at baseline and after 6, 12, 24, 36, 48, and 60 months. We explored if nutrition-physical performance associations varied according to the presence of low-grade inflammation (LGI) and brain imaging indicators.Results: Within-group comparisons showed that physical function (decreased SPPB and gait speed, increased chair rise time) worsened over time, particularly in participants with ≥2 nutritional deficits; however, no between-group differences were observed when individuals without deficit and those with either 1 or ≥2 deficits were compared. Our exploratory analysis on nutritional deficit-LGI interactions showed that, among people with ≥2 deficits, chair rise time was increased over time in participants with LGI (adjusted mean difference: 3.47; 95% CI: 1.03, 5.91; p = 0.017), compared with individuals with no LGI.Conclusions: Accumulated deficits on vitamin D, homocysteine, and omega-3 PUFA were not associated with physical performance evolution in older adults, but they determined declined chair rise performance in subjects with low-grade inflammation.Clinical Trial Registration: [https://clinicaltrials.gov/ct2/show/NCT00672685], identifier [NCT00672685].

scholarly journals White matter correlates of scam susceptibility in community-dwelling older adults

2019 ◽  
Vol 14 (5) ◽  
pp. 1521-1530 ◽  
Author(s):  
Melissa Lamar ◽  
Konstantinos Arfanakis ◽  
Lei Yu ◽  
Shengwei Zhang ◽  
S. Duke Han ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
Community Dwelling ◽  
Community Dwelling Older Adults

scholarly journals Associations between self-reported sleep quality and white matter in community-dwelling older adults: A prospective cohort study

2017 ◽  
Vol 38 (11) ◽  
pp. 5465-5473 ◽  
Author(s):  
Claire E. Sexton ◽  
Enikő Zsoldos ◽  
Nicola Filippini ◽  
Ludovica Griffanti ◽  
Anderson Winkler ◽  
...  
Keyword(s):  
Older Adults ◽  
Cohort Study ◽  
White Matter ◽  
Sleep Quality ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Community Dwelling ◽  
Community Dwelling Older Adults

Abstract MP13: Evaluation Of The Effect Of Low Grade Inflammation And Hypertension On The Development Of White Matter Lesions

Hypertension ◽  
2021 ◽  
Vol 78 (Suppl_1) ◽  
Author(s):  
Chris Woldstad ◽  
Henry Rusinek ◽  
Elizabeth Sweeney ◽  
Tracy Butler ◽  
Yi Li ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesions ◽  
Low Grade ◽  
Entire Cohort ◽  
Flair Sequence ◽  
Inflammatory Score ◽  
The Central Nervous System ◽  
Fazekas Scale ◽  
Low Grade Inflammation ◽  
The Relationship

Introduction: The risk of degenerative disease development is closely linked to persistent and continuous systemic inflammation. Although relationships between chronic low-grade inflammation (LGI) measurements and the progression of cardiovascular diseases are becoming established, the burden of the cardio-pathology and LGI on the central nervous system has not been fully investigated. Specifically, there is limited data on how hypertension (HTN) and related LGI impact white matter lesion (WML) pathogenesis. Methods: We examined 448 subjects with a mean age of 69.3 ± 7.4 years, with 62% of the cohort being women (n=276), and 45% having hypertension (n=200). Components of the LGI score included white blood cell count, albumin levels, platelet counts, and granulocyte/lymphocyte ratio, modified after. Larger LGI scores represented an increase in measured LGI intensity at that time point. MR images were obtained on a 3T system using fluid attenuation inversion recovery (FLAIR) sequence. WML burden was ascertained using Fazekas scale, done separately for both deep WML and periventricular WML. Summated score of greater than or equal to 4 was considered high overall WML burden. Results: It was found that subjects with hypertension had significantly higher LGI score when compared to subjects without hypertension after accounting for sex and BMI (F=4.8, p=0.03). Using logistic regression. we found that LGI score was related to higher WML burden (p=0.047) within the entire cohort. However, further analyses have shown that this finding was driven by the normotensive group, in which the relationship between higher WML burden and respective LGI score was significant (p=0.007). This was not the case among hypertensive subjects. Conclusion: It is clear from the data presented that a relationship between LGI and hypertension exists, confirming that inflammation is an underlying process in cardiovascular pathogenesis. However, LGI scores were related to WML in only normotensive cohorts. We offer that the effects of chronic HTN (related to higher inflammatory score itself ) overshadow the effect of LGI among hypertensive subjects. It is worth emphasizing that even in subjects without HTN white matter damage is related to LGI

scholarly journals Localization of Brain White Matter Hyperintensities and Urinary Incontinence in Community-Dwelling Older Adults

2009 ◽  
Vol 64A (8) ◽  
pp. 902-909 ◽  
Author(s):  
G. A. Kuchel ◽  
N. Moscufo ◽  
C. R. Guttmann ◽  
N. Zeevi ◽  
D. Wakefield ◽  
...  
Keyword(s):  
Older Adults ◽  
Urinary Incontinence ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Community Dwelling ◽  
Brain White Matter ◽  
Community Dwelling Older Adults

scholarly journals Human anterolateral entorhinal cortex volumes are associated with preclinical cognitive decline

2016 ◽  
Author(s):  
RK Olsen ◽  
L-K Yeung ◽  
A Noly-Gandon ◽  
MC D’Angelo ◽  
A Kacollja ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
Cognitive Decline ◽  
Entorhinal Cortex ◽  
Medial Temporal Lobe ◽  
Cognitive Status ◽  
Community Dwelling ◽  
White Matter Hyperintensity ◽  
Whole Brain ◽  
Community Dwelling Older Adults

AbstractWe investigated whether older adults without subjective memory complaints, but who present with cognitive decline in the laboratory, demonstrate atrophy in medial temporal lobe (MTL) subregions associated with Alzheimer's disease. Forty community-dwelling older adults were categorized based on Montreal Cognitive Assessment (MoCA) performance. Total grey/white matter, cerebrospinal fluid, and white matter hyperintensity load were quantified from whole-brain T1-weighted and FLAIR magnetic resonance imaging scans, while hippocampal subfields and MTL cortical subregion volumes (CA1, dentate gyrus/CA2/3, subiculum, anterolateral and posteromedial entorhinal, perirhinal, and parahippocampal cortices) were quantified using high-resolution T2-weighted scans. Cognitive status was evaluated using standard neuropsychological assessments. No significant differences were found in the whole-brain measures. However, MTL volumetry revealed that anterolateral entorhinal cortex (alERC) volume -- the same region in which Alzheimer's pathology originates -- was strongly associated with MoCA performance. This is the first study to demonstrate that alERC volume is related to cognitive decline in preclinical, community-dwelling older adults.

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