The T-Helper Cell Type 1 Immune Response to Gram-Negative Bacterial Infections Is Impaired in COPD

2011 ◽  
Vol 183 (2) ◽  
pp. 204-214 ◽  
Author(s):  
Jürgen Knobloch ◽  
Katharina Schild ◽  
David Jungck ◽  
Katja Urban ◽  
Katja Müller ◽  
...  
Keyword(s):  
Immune Response ◽  
Bacterial Infections ◽  
T Helper Cell ◽  
Helper Cell ◽  
Cell Type ◽  
T Helper ◽  
Gram Negative ◽  
Helper Cell Type

scholarly journals Immunomodulation of Helicobacter Infection

1999 ◽  
Vol 13 (3) ◽  
pp. 237-241 ◽  
Author(s):  
Ken Croitoru
Keyword(s):  
Immune Response ◽  
Bacterial Infections ◽  
T Cell Response ◽  
T Helper Cell ◽  
Helper Cell ◽  
General Tendency ◽  
Cell Type ◽  
T Helper ◽  
Helper Cell Type ◽  
H Pylori

Helicobacter pylorileads to a chronic infection in humans that is associated with gastric inflammation and a vigorous immune response. Despite the humoral and cellular responses that can be detected in both human and animal models of helicobacter infection, the immune response fails to eliminate the organism. Eradication failure may be due to the niche in whichH pyloriconfines itself, well away from direct contact with elements of the immune system. Alternatively, the general tendency of the intestinal immune response to down- regulate reactivity to noninvasive luminal bacteria also may contribute to the failure to eliminatehelicobacterinfection. Results of vaccine studies in mouse models indicate that modulating the helper T cell response from a T helper cell type 1 to a T helper cell type 2 response likely is required for the prevention and elimination of helicobacter infection. Understanding the mechanisms by which the immune response controls bacterial infections will allow for the design of novel strategies of immune modulation and the development of vaccines for both the treatment and prevention ofH pylori.

scholarly journals T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis

Immunology ◽  
2008 ◽  
Vol 125 (2) ◽  
pp. 161-169 ◽  
Author(s):  
Chris J. Hedegaard ◽  
Martin Krakauer ◽  
Klaus Bendtzen ◽  
Henrik Lund ◽  
Finn Sellebjerg ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Disease Activity ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
T Helper Cell ◽  
Helper Cell ◽  
Cell Type ◽  
T Helper ◽  
Helper Cell Type

scholarly journals Anti–Interleukin 10 Receptor Monoclonal Antibody Is an Adjuvant for T Helper Cell Type 1 Responses to Soluble Antigen Only in the Presence of Lipopolysaccharide

2000 ◽  
Vol 192 (10) ◽  
pp. 1529-1534 ◽  
Author(s):  
Antonio G. Castro ◽  
Margaret Neighbors ◽  
Stephen D. Hurst ◽  
Francesca Zonin ◽  
Regina A. Silva ◽  
...  
Keyword(s):  
T Cells ◽  
T Helper Cell ◽  
Helper Cell ◽  
Transfer Model ◽  
Soluble Antigen ◽  
Cell Type ◽  
T Helper ◽  
Peptide Antigen ◽  
Helper Cell Type

Soluble foreign antigen usually leads to a transient clonal expansion of antigen-specific T cells followed by the deletion and/or functional inactivation of the cells. As interleukin (IL)-10 is a key immunoregulatory cytokine, we questioned whether neutralization of IL-10 during priming with soluble antigen could prime for a subsequent T helper cell type 1 (Th1) effector recall response. By using an adoptive transfer model to track the fate of antigen-specific T cell receptor (TCR)-transgenic CD4+ T cells, we show that administration of soluble ovalbumin (OVA) protein, but not OVA323–339 peptide antigen, together with an anti–IL-10 receptor (R) mAb led to the enhancement of a Th1 response upon rechallenge. Lipopolysaccharide (LPS) present in the protein was necessary for priming for Th1 recall responses in the presence of anti–IL-10R mAb, as removal of LPS abrogated this effect. Moreover, addition of LPS to the peptide did not itself allow priming for recall Th1 effector responses unless endogenous levels of IL-10 were neutralized with an anti–IL-10R mAb. A significant increase in OVA-specific IgG1 and IgG2a isotypes was observed when the protein antigen was administered with anti–IL-10R mAb; however, this was not the case with peptide antigen administered together with anti–IL-10R and LPS. Our data, showing that LPS receptor signaling and neutralization of endogenous immunosuppressive cytokines is essential for Th1 priming, has important implications for the design of relevant vaccines for effective in vivo immunotherapy.

scholarly journals Alterations in T-helper cell type 1 and blood cell parameters in malaria-infected patients

2017 ◽  
Vol 4 (3) ◽  
pp. 185-189 ◽  
Author(s):  
Olarewaju Abdulkareem Babamale ◽  
Adam Olaitan Abdulkareem ◽  
Olufunke A. Opeyemi ◽  
Uade Samuel Ugbomoiko
Keyword(s):  
Blood Cell ◽  
T Helper Cell ◽  
Helper Cell ◽  
Cell Type ◽  
T Helper ◽  
Cell Parameters ◽  
Helper Cell Type

scholarly journals 16α‐Bromoepiandrosterone Restores T Helper Cell Type 1 Activity and Accelerates Chemotherapy‐Induced Bacterial Clearance in a Model of Progressive Pulmonary Tuberculosis

2005 ◽  
Vol 191 (2) ◽  
pp. 299-306 ◽  
Author(s):  
Rogelio Hernández‐Pando ◽  
Diana Aguilar‐Leon ◽  
Hector Orozco ◽  
Alberto Serrano ◽  
Clarence Ahlem ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
T Helper Cell ◽  
Helper Cell ◽  
Bacterial Clearance ◽  
Cell Type ◽  
T Helper ◽  
Helper Cell Type

scholarly journals An Instructive Component in T Helper Cell Type 2 (Th2) Development Mediated by Gata-3

2001 ◽  
Vol 193 (5) ◽  
pp. 643-650 ◽  
Author(s):  
J. David Farrar ◽  
Wenjun Ouyang ◽  
Max Löhning ◽  
Mario Assenmacher ◽  
Andreas Radbruch ◽  
...  
Keyword(s):  
Cell Fate ◽  
T Helper Cell ◽  
Helper Cell ◽  
Cell Type ◽  
T Helper ◽  
Cell Fate Decisions ◽  
Helper Cell Type ◽  
Th2 Development

Although interleukin (IL)-12 and IL-4 polarize naive CD4+ T cells toward T helper cell type 1 (Th1) or Th2 phenotypes, it is not known whether cytokines instruct the developmental fate in uncommitted progenitors or select for outgrowth of cells that have stochastically committed to a particular fate. To distinguish these instructive and selective models, we used surface affinity matrix technology to isolate committed progenitors based on cytokine secretion phenotype and developed retroviral-based tagging approaches to directly monitor individual progenitor fate decisions at the clonal and population levels. We observe IL-4–dependent redirection of phenotype in cells that have already committed to a non–IL-4–producing fate, inconsistent with predictions of the selective model. Further, retroviral tagging of naive progenitors with the Th2-specific transcription factor GATA-3 provided direct evidence for instructive differentiation, and no evidence for the selective outgrowth of cells committed to either the Th1 or Th2 fate. These data would seem to exclude selection as an exclusive mechanism in Th1/Th2 differentiation, and support an instructive model of cytokine-driven transcriptional programming of cell fate decisions.

scholarly journals Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses

2016 ◽  
Vol 291 (45) ◽  
pp. 23672-23680 ◽  
Author(s):  
Nasrin Akhter ◽  
Yuji Takeda ◽  
Hidetoshi Nara ◽  
Akemi Araki ◽  
Naoto Ishii ◽  
...  
Keyword(s):  
T Helper Cell ◽  
Helper Cell ◽  
Cell Type ◽  
T Helper ◽  
Antigen Presenting Cell ◽  
Helper Cell Type ◽  
Antigen Presenting
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