Lung Ultrasound to Monitor Extremely Preterm Infants and Predict BPD: Multicenter Longitudinal Cohort Study

2020 ◽  
Author(s):  
Barbara Loi ◽  
Giulia Vigo ◽  
Eugenio Baraldi ◽  
Francesco Raimondi ◽  
Virgilio P Carnielli ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Infants ◽  
Lung Ultrasound ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

scholarly journals Patterns of reintubation in extremely preterm infants: a longitudinal cohort study

2018 ◽  
Vol 83 (5) ◽  
pp. 969-975 ◽  
Author(s):  
Wissam Shalish ◽  
Lara Kanbar ◽  
Martin Keszler ◽  
Sanjay Chawla ◽  
Lajos Kovacs ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Infants ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

Persistent pulmonary hypertension of the newborn in extremely preterm infants: a Japanese cohort study

2018 ◽  
Vol 103 (6) ◽  
pp. F554-F561 ◽  
Author(s):  
Hidehiko Nakanishi ◽  
Hideyo Suenaga ◽  
Atsushi Uchiyama ◽  
Satoshi Kusuda
Keyword(s):  
Pulmonary Hypertension ◽  
Cohort Study ◽  
Preterm Infants ◽  
Research Network ◽  
Persistent Pulmonary Hypertension ◽  
Neurodevelopmental Outcomes ◽  
Significant Independent Risk Factor ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
The Impact

ObjectiveTo investigate the characteristics of persistent pulmonary hypertension of the newborn (PPHN) in extremely preterm infants and its impact on neurodevelopmental outcomes at 3 years of age.DesignA retrospective multicentre cohort study.Settings202 tertiary perinatal centres registered in the Neonatal Research Network of Japan (NRNJ).PatientsInfants born at <28 weeks of gestational age (GA), between 2003 and 2012, were extracted from tertiary perinatal centres participating in NRNJ.Main outcome measuresDemographic characteristics, morbidity, interventions and mortality were compared for infants with and without PPHN. Multivariable logistic analysis was performed to evaluate the impact of PPHN on long-term neurodevelopmental outcomes (the prevalence rate of cerebral palsy, need for home oxygen therapy, and visual, hearing and cognitive impairment) at 3 years of age.ResultsThe prevalence of PPHN among the 12 954 extremely preterm infants enrolled was 8.1% (95% CI 7.7% to 8.6%), with the trend increasing annually, and a higher proportion as GA decreased: 18.5% (range, 15.2% to 22.4%) for infants born at 22 weeks compared with 4.4% (range, 3.8% to 5.2%) for those born at 27 weeks. Clinical chorioamnionitis and premature rupture of membranes were associated with PPHN. On multivariate analysis of the data from 5923 infants followed up for 3 years, PPHN was a significant independent risk factor for visual impairment (adjusted OR, 1.42, 95% CI 1.03 to 1.97).ConclusionsThe prevalence of PPHN in extremely preterm infants has been increasing over the past decade in Japan. Clinicians should be aware of visual impairments as a neurodevelopmental abnormality among infants with PPHN.

scholarly journals Extreme Prematurity and Pulmonary Outcomes Program in Saitama (EPOPS): A Study Protocol of a Prospective Multicenter Cohort Study of Extremely Preterm Infants in Japan (Preprint)

2020 ◽  
Author(s):  
Fumihiko Namba ◽  
Kosuke Tanaka ◽  
Sayu Omori ◽  
Kazushige Ikeda ◽  
Ken Kawabata ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Infants ◽  
Developed Countries ◽  
Respiratory Morbidity ◽  
Extreme Prematurity ◽  
Multicenter Cohort Study ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Definition Of

UNSTRUCTURED Introduction: Because of the improvements in survival rates for preterm infants, not only the rates of bronchopulmonary dysplasia (BPD) but also that of long-term respiratory complications of premature birth are increasing, which results in financial and health burdens in developed countries. Thus far, risk factors of respiratory morbidities of extremely preterm infants remain unknown. Furthermore, the definition, as well as the predictive ability, of BPD for long-term respiratory outcomes are yet to be determined. Therefore, Extreme Prematurity and Pulmonary Outcomes Program in Saitama (EPOPS) aims to develop the diagnostic criteria for BPD and to determine the prognostic factors contributing to the long-term pulmonary outcomes manifested in extremely preterm infants. Methods and analysis: The EPOPS is an observational prospective cohort study performed by a consortium of six neonatal intensive care units (NICUs) in Saitama, Japan. The subjects included in this study were infants (from each clinical center) with gestational ages 22 to 27 weeks, having an expected target of 400 subjects. This study aims to determine the definition of BPD and other perinatal factors which accurately predict the long-term pulmonary outcomes in survivors of extreme prematurity. Moreover, association between BPD and post-prematurity respiratory disease (PRD) will also be investigated using generalized linear models. Discussion: The EPOPS incorporates the aspects of neonatal care in secondary- and tertiary-level NICUs to develop the existing research studies on the definition of BPD, objective biomarkers, and outcome measures of respiratory morbidity in extremely preterm infants beyond the NICU hospitalization, thereby leading to a novel understanding of the nature and natural history of BPD and of potential mechanistic and therapeutic targets among at-risk subjects. Ethics and Dissemination: The protocol and consent forms were evaluated and approved by institutional review boards at each EPOPS center. Registration details: Not registered because of an observational study without any interventions.

scholarly journals Lung ultrasound during newborn resuscitation predicts the need for surfactant therapy in very- and extremely preterm infants

Resuscitation ◽  
2021 ◽  
Author(s):  
Shiraz Badurdeen ◽  
C. Omar F. Kamlin ◽  
Sheryle R. Rogerson ◽  
Stefan C. Kane ◽  
Graeme R. Polglase ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Lung Ultrasound ◽  
Surfactant Therapy ◽  
Newborn Resuscitation ◽  
Extremely Preterm ◽  
Extremely Preterm Infants
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