scholarly journals The Induction of Pattern-Recognition Receptor Expression against Influenza A Virus through Duox2-Derived Reactive Oxygen Species in Nasal Mucosa

2015 ◽  
Vol 53 (4) ◽  
pp. 525-535 ◽  
Author(s):  
Hyun Jik Kim ◽  
Chang-Hoon Kim ◽  
Min-Ji Kim ◽  
Ji-Hwan Ryu ◽  
Sang Yeop Seong ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Pattern Recognition ◽  
Influenza A Virus ◽  
Nasal Mucosa ◽  
Influenza A ◽  
Reactive Oxygen ◽  
Pattern Recognition Receptor ◽  
Receptor Expression ◽  
Oxygen Species ◽  
Recognition Receptor

Mucosal Reactive Oxygen Species Are Required for Antiviral Response: Role of Duox in Influenza A Virus Infection

2014 ◽  
Vol 20 (17) ◽  
pp. 2695-2709 ◽  
Author(s):  
Monika Strengert ◽  
Richard Jennings ◽  
Suzel Davanture ◽  
Patti Hayes ◽  
Gülsah Gabriel ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Reactive Oxygen ◽  
Antiviral Response ◽  
Oxygen Species ◽  
Influenza A Virus Infection

scholarly journals Pattern recognition receptor mediated downregulation of microRNA-650 fine-tunes MxA expression in dendritic cells infected with influenza A virus

2015 ◽  
Vol 46 (1) ◽  
pp. 167-177 ◽  
Author(s):  
Tica Pichulik ◽  
Elham Khatamzas ◽  
Xiao Liu ◽  
Oliver Brain ◽  
Magno Delmiro Garcia ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Dendritic Cells ◽  
Influenza A Virus ◽  
Influenza A ◽  
Pattern Recognition Receptor ◽  
Recognition Receptor

scholarly journals Quinazolin-derived myeloperoxidase inhibitor suppresses influenza A virus-induced reactive oxygen species, pro-inflammatory mediators and improves cell survival

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0254632
Author(s):  
Juan A. De La Cruz ◽  
Thota Ganesh ◽  
Becky A. Diebold ◽  
Weiping Cao ◽  
Amelia Hofstetter ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Influenza A Virus ◽  
Inflammatory Mediators ◽  
Influenza A ◽  
Mononuclear Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Peripheral Blood Mononuclear ◽  
Tnf Α

Superoxide radicals and other reactive oxygen species (ROS) are implicated in influenza A virus-induced inflammation. In this in vitro study, we evaluated the effects of TG6-44, a novel quinazolin-derived myeloperoxidase-specific ROS inhibitor, on influenza A virus (A/X31) infection using THP-1 lung monocytic cells and freshly isolated peripheral blood mononuclear cells (PBMC). TG6-44 significantly decreased A/X31-induced ROS and virus-induced inflammatory mediators in THP-1 cells (IL-6, IFN-γ, MCP-1, TNF-α, MIP-1β) and in human PBMC (IL-6, IL-8, TNF-α, MCP-1). Interestingly, TG6-44-treated THP-1 cells showed a decrease in percent cells expressing viral nucleoprotein, as well as a delay in translocation of viral nucleoprotein into the nucleus. Furthermore, in influenza A virus-infected cells, TG6-44 treatment led to suppression of virus-induced cell death as evidenced by decreased caspase-3 activation, decreased proportion of Annexin V+PI+ cells, and increased Bcl-2 phosphorylation. Taken together, our results demonstrate the anti-inflammatory and anti-infective effects of TG6-44.

scholarly journals Differential Pattern Recognition Receptor Expression but Stereotyped Responsiveness in Rat Spleen Dendritic Cell Subsets

2006 ◽  
Vol 177 (2) ◽  
pp. 1007-1016 ◽  
Author(s):  
François-Xavier Hubert ◽  
Cécile Voisine ◽  
Cédric Louvet ◽  
Jean-Marie Heslan ◽  
Asmahan Ouabed ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Dendritic Cell ◽  
Pattern Recognition Receptor ◽  
Receptor Expression ◽  
Differential Pattern ◽  
Dendritic Cell Subsets ◽  
Recognition Receptor
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