Formulation and Characterization of Nanostructured Lipid Carrier of Ubiquinone (Coenzyme Q10)

Nitrofurantoin is effective against many urinary tract pathogens. It acts as bacteriostatic and/or bactericidal by inhibiting DNA-RNA protein& cell wall synthesis. Nanostructured Lipid Carriers (NLCs) of NFT was prepared by Hot Homogenization Process. Glyceryl Monostearate and Miglyol 812 were heated at 80ºC temperature on hot plate. In the melted lipid, drug was added with continuous stirring at high speed homogenization. Formulation NLC12B has % Entrapment efficiency 89.1 ± 0.5, PDI 0.11 ± 0.01 and mean particle size 237 ± 7nm represents narrow particle size distribution. Spherical feature of NLCs with better uniformity without aggregation of Nitrofurantoin loaded NLC was confirmed by TEM. Moreover, efficient miscibility of drug in lipids was confirmed by the absence of intense and characteristic peak of NFT in XRPD. After 6 month storage at 2-8°C there was no significant changes in the PDI as well as mean particle size.

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Quaternized Chitosan Modified Nanostructure Lipid Carriers for Topical Delivery of Coenzyme Q10

Nano LIFE ◽

10.1142/s1793984420400139 ◽

2020 ◽

Vol 10 (04) ◽

pp. 2040013 ◽

Cited By ~ 1

Author(s):

Rong Liang ◽

Yuxuan Wang ◽

Lina Wu ◽

Xinjiong Ni ◽

Cheng Yang

Keyword(s):

Delivery System ◽

Coenzyme Q10 ◽

Transdermal Delivery ◽

Laser Scanning ◽

Water Solubility ◽

Laser Scanning Microscopy ◽

Confocal Laser ◽

Nanostructured Lipid Carrier ◽

Quaternized Chitosan

Nanostructured lipid carrier (NLC) is a new colloidal delivery system which can effectively solve the problems of stability and transdermal delivery of active ingredients with poor water solubility and biocompatibility. Coenzyme Q10 (CoQ10), as a lipophilic antioxidant, has poor chemical stability due to unsaturated double bonds in its molecular structure, which limits its addition and application in cosmetics. In this study, CoQ10 NLC was prepared using the mixture of Caprylyl/Capryl Glycoside (APG) and quaternized chitosan (QCS). The particle size of the QCS–APG–NLC was around 250 nm. Compared to NLC stabilized by APG, QCS–APG–NLC has better storage stability under high temperature and light conditions. In vitro transdermal experiment analysis and confocal laser scanning microscopy (CLSM) observation found that QCS modification can effectively increase the penetration amount of CoQ10 in the skin. So, it is suggested that QCS modified APG–NLC can be used as an effective transdermal delivery system for lipophilic active components.

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Preparation and characterization of coenzyme Q10 loaded solid lipid-based formulations for enhancement of gastrointestinal solubilization

Journal of Dispersion Science and Technology ◽

10.1080/01932691.2018.1515023 ◽

2018 ◽

Vol 40 (10) ◽

pp. 1385-1395

Author(s):

Juan Huang ◽

Airui Qian ◽

Rui Sun ◽

Qiang Xia

Keyword(s):

Coenzyme Q10 ◽

Solid Lipid

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Physicochemical characterization of lycopene-loaded nanostructured lipid carrier formulations for topical administration

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2014.12.002 ◽

2015 ◽

Vol 478 (2) ◽

pp. 726-735 ◽

Cited By ~ 46

Author(s):

Siriporn Okonogi ◽

Pornthida Riangjanapatee

Keyword(s):

Physicochemical Characterization ◽

Topical Administration ◽

Nanostructured Lipid Carrier

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Fabrication and characterization of nanostructured lipid carrier system for effective delivery of poorly water-soluble drug quetiapine fumarate

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.01079 ◽

2021 ◽

pp. 6235-6244

Author(s):

Deepak Patil ◽

Seema Pattewar ◽

Sarvesh Palival ◽

Gargi Patil ◽

Swapnil Sharma

Keyword(s):

Entrapment Efficiency ◽

Water Soluble ◽

Nanostructured Lipid Carrier ◽

Quetiapine Fumarate ◽

Water Soluble Drug ◽

Effective Delivery ◽

Capmul Mcm ◽

Central Composite ◽

Poorly Water Soluble Drug

The aim of present study is to investigate the potential of nanostructured lipid carriers (NLCs) in improving the oral bioavailability of quetiapine fumarate, a second-generation antipsychotic drug. Quetiapine Fumarate (QF) loaded NLC were prepared by hot homogenization followed by an ultrasonication method. Response surface methodology - central composite design (CCD) was used to systemically examine the influence of concentration of capmul MCM EP, concentration of poloxamer 188 and concentration of egg lecithin on particle size (PS) and % entrapment efficiency (% EE) and to optimize the NLC formulation. The CCD consists of three factored design with five levels, plus and minus alpha (axial points), plus and minus 1 (factorial points) and the centre point. A mathematical relationship between variables was created by using Design Expert software Version 12. The statistical evaluations revealed that three independent variables were the important factors that affected the PS and % EE of QF loaded NLC. The best fitted mathematical model was linear and quadratic for PS and % EE respectively. The optimized formulations found with 218.1±0.14nm of PS and 93±0.16% of % EE. Results illustrated the superiority of developed QF loaded NLC formulation as a stable drug delivery system, providing better bioavailability with the possibility of better treatment for psychological disorders.

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