Fabrication and characterization of nanostructured lipid carrier system for effective delivery of poorly water-soluble drug quetiapine fumarate

2021 ◽  
pp. 6235-6244
Author(s):  
Deepak Patil ◽  
Seema Pattewar ◽  
Sarvesh Palival ◽  
Gargi Patil ◽  
Swapnil Sharma
Keyword(s):  
Entrapment Efficiency ◽  
Water Soluble ◽  
Nanostructured Lipid Carrier ◽  
Quetiapine Fumarate ◽  
Water Soluble Drug ◽  
Effective Delivery ◽  
Capmul Mcm ◽  
Central Composite ◽  
Poorly Water Soluble Drug

The aim of present study is to investigate the potential of nanostructured lipid carriers (NLCs) in improving the oral bioavailability of quetiapine fumarate, a second-generation antipsychotic drug. Quetiapine Fumarate (QF) loaded NLC were prepared by hot homogenization followed by an ultrasonication method. Response surface methodology - central composite design (CCD) was used to systemically examine the influence of concentration of capmul MCM EP, concentration of poloxamer 188 and concentration of egg lecithin on particle size (PS) and % entrapment efficiency (% EE) and to optimize the NLC formulation. The CCD consists of three factored design with five levels, plus and minus alpha (axial points), plus and minus 1 (factorial points) and the centre point. A mathematical relationship between variables was created by using Design Expert software Version 12. The statistical evaluations revealed that three independent variables were the important factors that affected the PS and % EE of QF loaded NLC. The best fitted mathematical model was linear and quadratic for PS and % EE respectively. The optimized formulations found with 218.1±0.14nm of PS and 93±0.16% of % EE. Results illustrated the superiority of developed QF loaded NLC formulation as a stable drug delivery system, providing better bioavailability with the possibility of better treatment for psychological disorders.

Self-microemulsifying smaller molecular volume oil (Capmul MCM) using non-ionic surfactants: a delivery system for poorly water-soluble drug

2011 ◽  
Vol 38 (7) ◽  
pp. 883-892 ◽  
Author(s):  
Mithun Mohanraor Bandivadeka ◽  
Shyam Sundar Pancholi ◽  
Ruchika Kaul-Ghanekar ◽  
Amit Choudhari ◽  
Soumya Koppikar
Keyword(s):  
Delivery System ◽  
Water Soluble ◽  
Molecular Volume ◽  
Ionic Surfactants ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Capmul Mcm ◽  
Poorly Water Soluble Drug

Design, Optimization and Evaluation of Repaglinide Self-Nanoemulsifying Drug Delivery for Enhanced Solubility

2017 ◽  
Vol 10 (6) ◽  
pp. 3920-3928
Author(s):  
Mahalaxmi K ◽  
Sailu Ch
Keyword(s):  
Drug Delivery ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Antidiabetic Drug ◽  
Water Soluble Drug ◽  
Enhanced Solubility ◽  
Poorly Water Soluble ◽  
Capmul Mcm ◽  
Poorly Water Soluble Drug

The aim of study was to develop self-nanoemulsifying systems of poorly water-soluble drug repaglinide, which is an antidiabetic drug in the class of medications known as meglitinides. Solubility of repaglinide in oily phases and surfactants was determined to identify components of self-nanoemulsifying drug delivery system (SNEDDS). Surfactants and oil was selected based on solubility studies were further screened for their efficiency in formulation. Acrysol K 150, Kolliphor EL and Capmul MCM were selected as oil, surfactant and co-surfactant respectively. Formulation F8 was found to be optimized formulation on the basis of in vitro dissolution studies, particle size and zeta potential. The optimized formulation was then subjected to stability studies and was found to be stable after 6 months. Thus, SNEDDS were found to be influential in improving the release performance of repaglinide, indicating their potential to improve the solubility and oral bioavailability of repaglinide.  

scholarly journals Formulation and characterization of self emulsifing pellets of carvedilol

2015 ◽  
Vol 51 (3) ◽  
pp. 663-671 ◽  
Author(s):  
Vikas Bhandari ◽  
Amelia Avachat
Keyword(s):  
Ternary Phase Diagram ◽  
Xrd Analysis ◽  
Sem Analysis ◽  
Water Soluble ◽  
Tween 20 ◽  
Lipophilic Compounds ◽  
Water Soluble Drug ◽  
Pellet Form ◽  
Capmul Mcm

The purpose of present study was aimed at developing self emulsifying drug delivery system in liquid and then in pellet form that would result in improved solubility, dissolution and permeability of the poorly water soluble drug carvedilol. Pellets were prepared using extrusion-spheronization technique incorporating liquid SEDDS (carvedilol, capmul MCM EP, cremophore EL, tween 20, propylene glycol), adsorbents ( and crospovidone), microcrystalline cellulose and binder (povidone K-30). Ternary phase diagram was constructed to identify different oil-surfactant-cosurfactant mixtures according to the proportion of each point in it. The optimal CAR-SEDDS pellets showed a quicker redispersion with a droplet size of the reconstituted microemulsion being 160.47 nm, which was almost unchanged after solidification. SEM analysis confirmed good spherical appearance of solid pellets; DSC and XRD analysis confirmed that there was no crystalline carvedilol in the pellets. Pellets were then capable of transferring lipophilic compounds into the aqueous phase and significantly enhancing its release with respect to pure drug.

scholarly journals Review on Polymer Based Nanoparticles for Increase the Bioavalibilty of Poorly Water Soluble Drug

2021 ◽  
pp. 56-74
Author(s):  
Karishma Mahajan ◽  
Nishant Thakur ◽  
. Simran
Keyword(s):  
Polymeric Nanoparticles ◽  
Water Soluble ◽  
Water Soluble Drug ◽  
Number Of Factors ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Review Study ◽  
And Control ◽  
Poorly Water Soluble Drug

In this review study about the polymeric nanoparticles and how polymer based nanoparticles increase bioavailability of less water soluble drugs. Polymeric nanoparticles have a matrix of biodegradable and biocompatible polymers of synthetic and natural origin. Polymer based nanoparticles are very useful for increase the solubility of the poor water-soluble drugs by decrease the particles size. Polymeric nanoparticles are very useful for targeting the drug to the specific site. Polymeric nanoparticles are also used to maintain and control the release of the drug. In present review study on the type of polymer used for the preparation of the polymer based nanoparticles. The choice of method depends on a number of factors, such as, particles size, area of application and characterization of polymeric nanoparticles.

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