The Effect of Magnetic Poly(lactic-co-glycolic acid) Microsphere-Gelatin Hydrogel on the Growth of Pre-Osteoblasts Under Static Magnetic Field

2020 ◽  
Vol 16 (11) ◽  
pp. 1658-1666
Author(s):  
Jingxi Wang ◽  
Ping Li ◽  
Kun Li ◽  
Junwei Xu ◽  
Meili Liu ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Static Magnetic Field ◽  
Bone Repair ◽  
Glycolic Acid ◽  
Magnetic Microspheres ◽  
Promoting Effect ◽  
Gelatin Hydrogel ◽  
Bone Injury ◽  
Repair Materials ◽  
Bone Repair Materials

A number of bone repair materials are demanded due to bone injury in clinical treatment. Magnetic hydrogels combined with the magnetic field have showed great promoting potential in the field of bone regeneration. Considering the superiority of magnetic microspheres in magnetic localization and drug release, magnetic poly(lactic-co-glycolic acid) microspheres, obtained by electrospraying, were combined with gelatin hydrogel to construct a magnetic poly(lactic-co-glycolic acid) microsphere-gelatin hydrogel for bone repair in our study. Particularly, we investigated the combined effect of 20 mT static magnetic field and magnetic poly(lactic-co-glycolic acid) microsphere-gelatin hydrogel on the proliferation of MC3T3-E1 pre-osteoblasts, indicating that it could significantly promote cell growth at a low concentration of Fe3 O4. Furthermore, the hydrogel containing 400 mg˙ L–1Fe3 O4 presented the highest growth-promoting effect under a 20 mT static magnetic field. Therefore, the magnetic poly(lactic-co-glycolic acid) microsphere-gelatin hydrogel possesses impressive application value in promoting osteogenesis and bone repair.

Peptide‐modified bone repair materials: Factors influencing osteogenic activity

2019 ◽  
Vol 107 (7) ◽  
pp. 1491-1512 ◽  
Author(s):  
Jie Liao ◽  
Shuai Wu ◽  
Kun Li ◽  
Yubo Fan ◽  
Nicholas Dunne ◽  
...  
Keyword(s):  
Bone Repair ◽  
Osteogenic Activity ◽  
Factors Influencing ◽  
Repair Materials ◽  
Bone Repair Materials

Self-assembly of pifithrin-α-loaded layered double hydroxide/chitosan nanohybrid composites as a drug delivery system for bone repair materials

2017 ◽  
Vol 5 (12) ◽  
pp. 2245-2253 ◽  
Author(s):  
Yi-Xuan Chen ◽  
Rong Zhu ◽  
Zheng-liang Xu ◽  
Qin-Fei Ke ◽  
Chang-Qing Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
Self Assembly ◽  
Bone Repair ◽  
Repair Materials ◽  
Double Hydroxide ◽  
First Time ◽  
Bone Repair Materials

The self-assembly of pifithrin-α-loaded layered double hydroxide/chitosan nanohybrid composites as a drug delivery system was demonstrated for the first time to improve the cytocompatibility and enhance the osteoinductivity for the treatment of bone defects.

Study on osteointegrative properties of a functional gradient tumor bone repair materials in ulna bone defect model of rabbits

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S432
Author(s):  
Shihui Chen ◽  
Tao Tang ◽  
Zhong Liu ◽  
Poying Lau ◽  
Xinhui Xie ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Repair ◽  
Defect Model ◽  
Functional Gradient ◽  
Repair Materials ◽  
Bone Repair Materials

Study on the Preparation of Strontium-Doped Hydroxyapatite Whisker

2013 ◽  
Vol 738 ◽  
pp. 26-29 ◽  
Author(s):  
Ting Ting Yan ◽  
Yong Shun Cui ◽  
Qing Hua Chen
Keyword(s):  
Mechanical Property ◽  
Bone Repair ◽  
Calcium Nitrate ◽  
Xrd Analysis ◽  
Strontium Nitrate ◽  
X Ray Diffraction ◽  
X Ray ◽  
Repair Materials ◽  
Bone Repair Materials ◽  
Scanning Electron

Hydroxyapatite is well used as bone repair materials, due to its properties that can be combined with strontium to improve mechanical property and degradation property. In this article, hydroxyapatite whiskers with different amount of doped strontium were prepared with diammonium phosphate, calcium nitrate and strontium nitrate at 94 °C. Fourier transform infrared spectroscopy (FTIR) was used to identify the functional groups. X-ray diffraction (XRD) analysis was carried out to study the phase composition and crystallinity of the whisker. The morphology of the whiskers was characterized by scanning electron microscope (SEM). It was indicated that strontium can be doped in hydroxyapatite with proper process and then the strontium-doped hydroxyapatite whiskers were produced successfully.

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