Nigella Sativa: An immunity booster as pandemic treatment solution against SARS-CoV-2

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Afzal Hussain ◽  
Ashfaq Hussain ◽  
Chandan Kumar Verma
Keyword(s):  
Medicinal Plant ◽  
Therapeutic Efficacy ◽  
Nigella Sativa ◽  
Folk Medicine ◽  
The World ◽  
Immune Booster

: Nigella sativa (Family Ranunculaceae) is a common medicinal plant all across the world. It is quite popular in different traditional medicinal systems such as Unani, Ayurveda, Tibb, and Siddha. Oil and Seeds have a long tradition of folk medicine utilized in different medicinal systems and food. The seeds of N. Sativa have indeed been widely applied in the treatment of many diseases, ailments, and also the immune booster. Our goal primarily concentrated on the therapeutic efficacy of Nigella sativa in combating the COVID-19 pandemic.

scholarly journals MPDB 2.0: A Large Scale and Integrated Medicinal Plant Database of Bangladesh

2021 ◽  
Author(s):  
Nazmul Hussain ◽  
Rony Chando ◽  
Ruhshan Ahmed Abir ◽  
Mohsina Akter Mou ◽  
Md. Kamrul Hasan ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Medicinal Plant ◽  
Large Scale ◽  
East Asian ◽  
Folk Medicine ◽  
Human Diseases ◽  
Health Practitioners ◽  
The World ◽  
Medicine History ◽  
User Friendly

Medicinal plants are generally defined as rare herbals with potent medicinal activities that can be used as an alternative treatment for diseases. Recent studies exploring novel medicine developments, originating from folk-medicinal practices challenges this notion and suggests that both the circumference of the term medicinal plant and their potential application covers a substantially extensive verse than previously suggested. While medicinal plants are not limited to the borders of any country, Bangladesh and its south-east Asian neighbors do boast a huge collection of potent medicinal plants with considerable folk-medicine history compared to most other countries of the world. MPDB 2.0 is the continuation of MPDB 1.0, it serves as both a data repertoire for medicinal of Bangladesh and a user-friendly interface for researchers, health practitioners, drug developers, and students who wish to study the various medicinal & nutritive plants scattered around Bangladesh and the underlying phytochemicals contributing to their efficacy in folk medicine. While in developing MPDB 2.0 human diseases have been highly focused upon, the information in this database is not limited in its application for human diseases or diseases only, as many of the plants indexed here can serve in developing biofuel or bioremediation technologies or nutritive diets or cosmetics, etc. MPDB 2.0 comprises a collection of more than five hundred medicinal plants from Bangladesh along with a record of their corresponding scientific, family, and local names together with their utilized parts, information regarding ailments, active compounds, and PubMed ID of related publications.

Isolation and HPLC Determination of the Chemical Components of Gentianella acuta (Michx.) Hulten

2018 ◽  
Vol 15 (1) ◽  
pp. 21-33
Author(s):  
Ying Wei ◽  
Yongqiao Liu ◽  
Yifan Hele ◽  
Weiwei Sun ◽  
Yang Wang ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
High Speed ◽  
Chemical Constituents ◽  
Folk Medicine ◽  
Gradient Elution ◽  
Chemical Components ◽  
Isolation And Characterization ◽  
Major Chemical ◽  
Main Components ◽  
First Time

Background: Gentianella acuta (Michx.) Hulten is an important type of medicinal plant found in several Chinese provinces. It has been widely used in folk medicine to treat various illnesses. However, there is not enough detailed information about the chemical constituents of this plant or methods for their content determination. Objective: The focus of this work is the isolation and characterization of the major chemical constituents of Gentianella acuta, and developing an analytical method for their determination. Methods: The components of Gentianella acuta were isolated using (1) ethanol extraction and adsorption on macroporous resin. (2) and ethyl acetate extraction and high speed countercurrent chromatography. A HPLC-DAD method was developed using a C18 column and water-acetonitrile as the mobile phase. Based on compound polarities, both isocratic and gradient elution methods were developed. Results: A total of 29 compounds were isolated from this plant, of which 17 compounds were isolated from this genus for the first time. The main components in this plant were found to be xanthones. The HPLC-DAD method was developed and validated for their determination, and found to show good sensitivity and reliability. Conclusion: The results of this work add to the limited body of work available on this important medicinal plant. The findings will be useful for further investigation and development of Gentianella acuta for its valuable medicinal properties.

scholarly journals A Comprehensive Review of the Ethnotraditional Uses and Biological and Pharmacological Potential of the Genus Mimosa

2021 ◽  
Vol 22 (14) ◽  
pp. 7463
Author(s):  
Ismat Majeed ◽  
Komal Rizwan ◽  
Ambreen Ashar ◽  
Tahir Rasheed ◽  
Ryszard Amarowicz ◽  
...  
Keyword(s):  
Web Of Science ◽  
Scientific Literature ◽  
Therapeutic Potential ◽  
Current Knowledge ◽  
Folk Medicine ◽  
Nutritional Values ◽  
Biological Potential ◽  
The World ◽  
The Future ◽  
Pharmacological Potential

The Mimosa genus belongs to the Fabaceae family of legumes and consists of about 400 species distributed all over the world. The growth forms of plants belonging to the Mimosa genus range from herbs to trees. Several species of this genus play important roles in folk medicine. In this review, we aimed to present the current knowledge of the ethnogeographical distribution, ethnotraditional uses, nutritional values, pharmaceutical potential, and toxicity of the genus Mimosa to facilitate the exploitation of its therapeutic potential for the treatment of human ailments. The present paper consists of a systematic overview of the scientific literature relating to the genus Mimosa published between 1931 and 2020, which was achieved by consulting various databases (Science Direct, Francis and Taylor, Scopus, Google Scholar, PubMed, SciELO, Web of Science, SciFinder, Wiley, Springer, Google, The Plant Database). More than 160 research articles were included in this review regarding the Mimosa genus. Mimosa species are nutritionally very important and several species are used as feed for different varieties of chickens. Studies regarding their biological potential have shown that species of the Mimosa genus have promising pharmacological properties, including antimicrobial, antioxidant, anticancer, antidiabetic, wound-healing, hypolipidemic, anti-inflammatory, hepatoprotective, antinociceptive, antiepileptic, neuropharmacological, toxicological, antiallergic, antihyperurisemic, larvicidal, antiparasitic, molluscicidal, antimutagenic, genotoxic, teratogenic, antispasmolytic, antiviral, and antivenom activities. The findings regarding the genus Mimosa suggest that this genus could be the future of the medicinal industry for the treatment of various diseases, although in the future more research should be carried out to explore its ethnopharmacological, toxicological, and nutritional attributes.

Phenolic compounds from an Algerian medicinal plant (Pallenis spinosa): simulated gastrointestinal digestion, characterization, biological and enzymatic activities

2021 ◽  
Author(s):  
Hanane Amrani-Allalou ◽  
Lila Boulekbache ◽  
Luana Izzo ◽  
Lynda Arkoub-Djermoune ◽  
Mohamed Lamine Freidja ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Medicinal Plant ◽  
Folk Medicine ◽  
Enzymatic Activities ◽  
Gastrointestinal Digestion ◽  
Oral Infections ◽  
Simulated Gastrointestinal Digestion

Pallenis spinosa is a medicinal plant which is used in folk medicine as curative or preventive remedies for various diseases such diabetes, respiratory and oral infections. Individual phenolic compounds from...

Nigella Sativa, as Preventive Strategy in COVID-19

2021 ◽  
Vol 07 ◽  
Author(s):  
Vaishali Mathur ◽  
Mahak Sharma
Keyword(s):  
Immune System ◽  
Nigella Sativa ◽  
Preventive Strategy ◽  
Therapeutic Effects ◽  
Human Contact ◽  
The People ◽  
Home Based ◽  
Anti Oxidant ◽  
Immune Booster ◽  
Difficult Times

: During the recent difficult times when the whole world is fighting the pandemic named COVID-19, a herbal home based spice, which can help the people improve their immunity and fight against this infection. Nigella Sativa has been named as a prophetic Spice, as it has many therapeutic effects. It is found to control diabetes, reduce high cholesterol levels, and serve as an antioxidant, anti-cancer, anti – informatory and an immune booster. The compound Thymoquinone can be responsible for enhancing immune system as it acts as an anti-oxidant and has an anti-inflammatory property. As various research has showed that to protect from Coronavirus, it is important not only to avoid human contact, but also to strengthen the Immune system. This paper is a review of various studies which prove that Nigella Sativa, can be beneficial in enhancing the immune system and thus fight COVID – 19.

Review on pharmacological and phytochemical prospects of traditional medicinal plant: Persicaria hydropiper (Smartweed)

2021 ◽  
Vol 21 ◽  
Author(s):  
Abdul Nasir ◽  
Atif Ali Khan Khalil ◽  
Muhammad Zeeshan Bhatti ◽  
Ashfaq Ur Rehman ◽  
Jiayi Li ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Traditional Medicine ◽  
Northern Hemisphere ◽  
Biological Activities ◽  
Folk Medicine ◽  
Present Review ◽  
Polygonum Hydropiper ◽  
Wide Range ◽  
Pharmacological Data ◽  
Different Parts

: Persicaria hydropiper (L.) Delarbre (family Polygonacea), commonly known as Polygonum hydropiper, is a popular medicinal plant used in traditional medicine. The plant is indigenous to the tropical northern hemisphere and temperate zone including China, Bangladesh, India, and Japan. The plant is used in folk medicine for numerous ailments such as hemorrhoids, antifertility, diarrhea, and dyspepsia. Its medicinal usage in Unani, Ayurveda, Siddha, and other traditional medicine is well-recognized. So far, a wide range of active phytochemicals of this plant has been identified, such as flavonoids, sulphated flavonoids, terpenoids, anthraquinones, steroids, coumarin, simple phenolics, and others. Pharmacological data reported in the literature suggest that various parts of P. hydropiper exhibit antimicrobial, antioxidant, hypoglycemic, antidepressant, cardioprotective, hepatoprotective, anticancer, and antifertility effects. The present review aim is to compile the coherently document research on the phytochemical, pharmacological, and biological activities of P. hydropiper from different parts of the globe.

Kolaviron, a Biflavonoid Compound: Pharmacological activity and Therapeutic Efficacy

2021 ◽  
Vol 18 ◽  
Author(s):  
Damilare Rotimi ◽  
Jennifer Chidubem Amanze ◽  
Adebola Busola Ojo ◽  
Matthew Iyobhebhe ◽  
Tobiloba Christiana Elebiyo ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Treatment Options ◽  
Herbal Remedies ◽  
Clinical Settings ◽  
Garcinia Kola ◽  
Anti Cancer ◽  
The World ◽  
Health Promoting ◽  
Grown Plant ◽  
Viable Treatment

Abstract: The use of herbal remedies for medicinal purposes is becoming more popular around the world. As a result, plants have become viable treatment options for a variety of diseases. Garcinia kola (bitter kola) is a perennially grown plant in the Guttiferae family that has been evaluated and reported to have numerous health-promoting properties. Kolaviron is a biflavanoid and major phytochemical found in Garcinia kola that includes Garcinia Biflavanoid-1 (GB-1), kolaflavanone, and Garcinia Biflavanoid-2 (GB-2). It is obtained as a fraction extracted from Garcinia kola. Kolaviron's pharmacological properties include anti-inflammatory, anti-spasmodic, ameliorative, anti-asthmatic, anti-cancer, anti-malarial, hepatoprotective, antioxidant, anti-atherogenic, neuroprotective, anti-diabetic, and anti-amnesic properties. Kolaviron is recommended for use in clinical settings because it has been shown to have a high therapeutic efficacy in clinical trials. The purpose of this review is to assess the therapeutic efficacy of kolaviron.

Intra-Articular Injection of a Nanosuspension of Tetramethylpyrazine Dihydroxynaphthalenate for Stronger and Longer-Lasting Effects Against Osteoarthritis

2021 ◽  
Vol 17 (6) ◽  
pp. 1199-1207
Author(s):  
Hanmei Li ◽  
Hongyi Zhuo ◽  
Dan Yin ◽  
Wei Li ◽  
Yamei Zhang ◽  
...  
Keyword(s):  
Particle Size ◽  
Medicinal Plant ◽  
Treatment Effect ◽  
Retention Time ◽  
Therapeutic Efficacy ◽  
Ion Pairing ◽  
Systemic Toxicity ◽  
Joint Cavity ◽  
Hydrophobic Ion Pairing ◽  
Chinese Medicinal Plant

Tetramethylpyrazine (TMP), isolated from the rhizome of the traditional Chinese medicinal plant Chuanxiong (Ligusticum wallichii Franchat) shows therapeutic efficacy against osteoarthritis. After intra-articular injection, the retention time of TMP in the joint cavity is short, which limits its treatment effect. To avoid this problem, the present study explored the preparation of a TMP nanosuspension (TMP-NS) based on hydrophobic ion pairing. TMP-NS showed a particle size of approximately 588 nm and, after intra-articular injection in rats, it had longer retention in the articular cavity, higher TMP concentrations in joints, and greater anti-osteoarthritic efficacy than TMP solution. TMP-NS didn’t cause significant inflammation at the joint. These results suggest that TMP-NS may strengthen and prolong the therapeutic efficacy of TMP against osteoarthritis without systemic toxicity.

scholarly journals Seaweed as novel food for prevention and therapy for life style related disease

2021 ◽  
Vol 5 (1) ◽  
pp. 1
Author(s):  
Lindarsih Notowidjojo
Keyword(s):  
Cardiovascular Disease ◽  
Functional Food ◽  
Folk Medicine ◽  
Novel Food ◽  
Disease Epidemiology ◽  
Related Disease ◽  
The World ◽  
Alternative Sources ◽  
Epidemiology Studies ◽  
Prevention And Therapy

Seaweed has long been known and consumed as a functional food and folk medicine, especially in people who live in coastal areas. Research on seaweed has recently increased with the surge need for alternative sources of functional food to deal with health problems related to lifestyle, such as obesity, diabetes, hypertension and cardiovascular disease. Epidemiology studies have found that population consumed seaweed is on a regular basis have significantly less diet-related diseases.1,2 Even the largest population of old age is in Japan, which consumes the most seaweed in the world.1,3 In countries such as Japan, China, and Korea, approximately 66% of algae species have been used as a daily ingredient in their dishes for many years.

scholarly journals Investigation of the effects of six medicinal plants with antiviral effects against COVID-19

2021 ◽  
Author(s):  
Harun ALP ◽  
Hasan ASİL ◽  
Demet Duman
Keyword(s):  
Medicinal Plants ◽  
Nigella Sativa ◽  
Water Extract ◽  
Antiviral Effect ◽  
Vero Cells ◽  
Glycyrrhiza Glabra ◽  
Crocus Sativus ◽  
Medicinal And Aromatic Plants ◽  
The World

Abstract Today, the coronavirus epidemic, which caused the death of 79 million cases and 1743 thousand people in 218 countries around the world, continues to increase its impact all over the world. Researchers are still trying to develop an effective solution against covid-19, including vaccines and drugs. However, there are few studies that determine the effect of natural products obtained from plants on covid-19. Medicinal and aromatic plants have been used for therapeutic purposes since the existence of humanity. In this study, the effects of some important medicinal plants including Licorice (Glycyrrhiza glabra), Saffron (Crocus sativus L.), Nigella (Nigella sativa L.), Laurel (Lauris nobilis), Karabaş (Lavandula stoechas), and Zahter (Thymbra spicata L. var. Spicata) against Covid-19 were investigated in vitro conditions. The six plants were evaluated for cytotoxic effect on Vero cells and determining inhibition of viral replication in Vero-E6 cells at concentrations of broad-spectrum antiviral non-cytotoxic against Covid-19 in cell culture and an additional antiviral effect against Covid-19. According to the results, the five examined plants (Saffron, Nigella, Laurel, Karabaş, Zahter) were ineffective against Covid-19 in vitro conditions. Interisingly, the water extract obtained from the root of the licorice plant (Glycyrrhiza glabra) inhibited Covid-19 in vitro conditions in the 2nd dilution (1: 4) following the initial concentration in Vero-E6 cells.

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