Selective Loading and Prolonged Release of 5-Fluorouracil in the Nanoconfined Interlayer Space of Montmorillonite

2021 ◽  
Vol 21 (1) ◽  
pp. 781-787
Author(s):  
Daoyong Tan ◽  
Yan Li ◽  
Zheng Zhang ◽  
Shiyong Sun ◽  
Hongjuan Sun ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Oral Administration ◽  
Anticancer Drug ◽  
Interlayer Space ◽  
External Surface ◽  
Amorphous State ◽  
High Thermal Stability ◽  
Prolonged Release ◽  
Outward Diffusion ◽  
Release Profiles

Montmorillonite was used as a carrier for the anticancer drug 5-fluorouracil (5FU). The selective loading of 5FU into the nanoconfined interlayer space of montmorillonite was achieved by rinsing off the weakly bonded 5FU from the external surface. The 5FU loading content in montmorillonite was 3.2 mass%. The intercalated 5FU was in an amorphous state and might be arranged as a roughly vertical monolayer in the interlayer space of montmorillonite. The intercalated 5FU showed a high thermal stability due to the protection of the montmorillonite layers. The release profiles of the intercalated 5FU were well fitted with the modified Korsmeyer-Peppas model. The montmorillonite exhibited a prolonged release of 5FU due to the restriction of the outward diffusion of intercalated 5FU. The 5FU/montmorillonite system has promising potential for oral administration for colonspecific delivery.

Wide-bandgap bipolar material with high thermal stability

2019 ◽  
pp. 903
Author(s):  
Sheng-Chieh Lin ◽  
Yu-Chieh Cheng ◽  
Man-Kit Leung ◽  
Jiun-Haw Lee ◽  
Tien-Lung Chiu
Keyword(s):  
Thermal Stability ◽  
Wide Bandgap ◽  
High Thermal Stability

New Deep Blue Emitting Materials Based on Indenopyrazine Core with High Thermal Stability

2011 ◽  
Vol 11 (5) ◽  
pp. 4639-4643 ◽  
Author(s):  
Chang-Hun Seok ◽  
Young-Il Park ◽  
Soo-Kang Kim ◽  
Ji-Hoon Lee ◽  
Jongwook Park
Keyword(s):  
Thermal Stability ◽  
High Thermal Stability ◽  
Deep Blue

scholarly journals Improved thermally stable oligoetherols from 6-aminouracil, ethylene carbonate and boric acid

2019 ◽  
Vol 17 (1) ◽  
pp. 1080-1086
Author(s):  
Elżbieta Chmiel-Szukiewicz
Keyword(s):  
Thermal Stability ◽  
Thermal Properties ◽  
Boric Acid ◽  
Ethylene Carbonate ◽  
Pyrimidine Ring ◽  
Polyurethane Foams ◽  
High Thermal Stability ◽  
H Nmr ◽  
Maldi Tof ◽  
Instrumental Methods

AbstractSyntheses of oligoetherols with a 1,3-pyrimidine ring and boron atoms using 6-aminouracil, ethylene carbonate and boric acid has been proposed. The structure of the obtained products were determined by instrumental methods (IR, 1H-NMR and MALDI-ToF spectra). The physicochemical and thermal properties of oligoetherols were examined. The products were characterized by high thermal stability. Based on the tests performed, it was found that oligoetherols obtained from 6-aminouracil, boric acid and ethylene carbonate are suitable for the manufacturing of polyurethane foams with improved thermal stability and reduced flammability.

Sr3LiTaO6:xMn4+ red-emitting phosphors for indoor plant growth lighting: High thermal stability and quantum efficiency

2021 ◽  
pp. 118234
Author(s):  
Yunlong Yang ◽  
Linyan Fu ◽  
Xuefei Ren ◽  
Yingjie Zhu ◽  
Jiajie Zhu ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Plant Growth ◽  
Quantum Efficiency ◽  
High Thermal Stability

scholarly journals Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double Drugs

Biomolecules ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 635
Author(s):  
Ding Li ◽  
Menglong Wang ◽  
Wen-Liang Song ◽  
Deng-Guang Yu ◽  
Sim Wan Annie Bligh
Keyword(s):  
Controlled Release ◽  
Combined Therapy ◽  
Diffusion Mechanism ◽  
Amorphous State ◽  
Electrospinning Process ◽  
Fickian Diffusion ◽  
In Vitro Dissolution ◽  
Sem Images ◽  
Release Profiles

A side-by-side electrospinning process characterized by a home-made eccentric spinneret was established to produce the Janus beads-on-a-string products. In this study, ketoprofen (KET) and methylene blue (MB) were used as model drugs, which loaded in Janus beads-on-a-string products, in which polyvinylpyrrolidone K90 (PVP K90) and ethyl cellulose (EC) were exploited as the polymer matrices. From SEM images, distinct nanofibers and microparticles in the Janus beads-on-a-string structures could be observed clearly. X-ray diffraction demonstrated that all crystalline drugs loaded in Janus beads-on-a-string products were transferred into the amorphous state. ATR-FTIR revealed that the components of prepared Janus nanostructures were compatibility. In vitro dissolution tests showed that Janus beads-on-a-string products could provide typical double drugs controlled-release profiles, which provided a faster immediate release of MB and a slower sustained release of KET than the electrospun Janus nanofibers. Drug releases from the Janus beads-on-a-string products were controlled through a combination of erosion mechanism (linear MB-PVP sides) and a typical Fickian diffusion mechanism (bead KET-EC sides). This work developed a brand-new approach for the preparation of the Janus beads-on-a-string nanostructures using side-by-side electrospinning, and also provided a fresh idea for double drugs controlled release and the potential combined therapy.

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