A New One-Pot Way to Prepare Enzyme-Containing Coordination Polymers by Sonochemistry

2021 ◽  
Vol 21 (5) ◽  
pp. 2935-2938
Author(s):  
Alessandra Scano ◽  
Valentina Cabras ◽  
Guido Ennas
Keyword(s):  
Composite Material ◽  
Glucose Oxidase ◽  
Coordination Polymers ◽  
Thermal Characterization ◽  
Zinc Salt ◽  
Sonochemical Method ◽  
One Pot ◽  
Conventional Methods ◽  
Short Time

Enzyme-containing Coordination Polymers (CPs) were prepared by a one-pot sonochemical method, mixing Glucose Oxidase (GOx) enzyme, 4,4′-bipyridine as spacer ligand, and chloride zinc salt. The reaction took place in a very short time (a few minutes) with a minimum use of solvents compared to conventional methods. The obtained composite material, named GOx-[Zn(4,4′-bipy)Cl2]∞, resulted from embedding the GOx molecules into uniformly sized [Zn(4,4′-bipy)Cl2] nanocrystals. The structural and thermal characterization, confirmed that the adopted strategy allows the preparation of hybrid bio-nanomaterials in a very fast, facile and eco-friendly method, by simply synthesising the [Zn(4,4′-bipy)Cl2] nanocrystals in the presence of the enzyme.

scholarly journals One-Pot Three Component Synthesis of 2-(1H-Benzo[d]thiazole-2-yl)- N-Arylbenzamides in Glycerol Medium

2020 ◽  
Vol 32 (6) ◽  
pp. 1343-1351
Author(s):  
Swathi Thumula ◽  
Venkatesan Srinivasadesikan ◽  
Ravi K. Kottalanka ◽  
S. Rex Jeya Rajkumar ◽  
Balajee Ramchandran
Keyword(s):  
Docking Study ◽  
Molecular Docking Study ◽  
One Pot ◽  
Docking Result ◽  
Three Component Reaction ◽  
Antibacterial Target ◽  
Short Time ◽  
A549 Lung ◽  
Glycerol Medium ◽  
Mcf 7

In this work, a series of 2-(1H-benzo[d]thiazole-2-yl)-N-arylbenzamides is synthesized by using diethyl phthalate, anilines and 2-amino-benzenethiol by one-pot three component synthesis in glycerol medium. Phosphoric acid is used as an effective reagent for this one-pot three component reaction. This reaction got completed in a short time, easy workup and gave an excellent yield in glycerol medium. The N-arylbenzamides was found to have significant cytotoxic potentials against various cancer cells viz., A549 (lung cancer), HeLa (cervical cancer) and MCF-7 (breast cancer) using MTT assay. The molecular docking study is also employed to understand the binding mechanism of N-arylbenzamides against the antibacterial target. The docking result shows the binding energy of compound 4a is -8.6 kcal/mol. The binding affinity is a major concern and it shows that Asn and Thr residues have an interaction with compound 4a.

Structural, Textural and Thermal Characterization of Nano-Mg/Al Hydrotalcite before and after Cr (VI) Removal

2013 ◽  
Vol 755 ◽  
pp. 53-60
Author(s):  
Esthela Ramos Ramírez ◽  
Norma Leticia Gutiérrez Ortega ◽  
Cesar Augusto Contreras Soto ◽  
Gustavo Rangel Porras
Keyword(s):  
Crystalline Structure ◽  
Sol Gel ◽  
Textural Properties ◽  
Kinetic Studies ◽  
Thermal Characterization ◽  
Gel Method ◽  
Sol Gel Method ◽  
Before And After ◽  
Short Time

In this work there was studied the structural, textural and effect that has treat thermal on the removal of Cr (VI) of nanoMg/Al hydrotalcite (NHT) synthesized by the sol-gel method with a ratio of Mg/Al=3. These present the characterization of the nanoMg/Al hydrotalcite before and after Cr (VI) removal, as well as the kinetic studies and of balance. In agreement with the results, when the NHT are thermal treated to 350 °C the hydrotalcite crystalline structure remains but the textural properties are improved and structural. The NHT synthesized by the sol-gel method present a good capacity of removal with values of 91 mg of Cr (VI) removed / g of NHT. The above mentioned capacity of removal gets improved after thermal treating the material, reaching values of removal of 124 mg of Cr (VI) removed / g of NHT. The NHT with the Cr (VI) absorbed show decrease of the crystalline structure, as well as a saturation of the pores that annuls the porosity due to the fact that the Cr (VI) lodges both at the pores and at the intersheets. The time that him takes the HLM to remove the Cr (VI) of the watery solution is alone of 2 minutes, with which it is possible to conclude that the NHT have an excellent aptitude to remove Cr (VI) of watery solutions in an interval of very short time.

N-Methylated 1,8-Diaminonaphthalenes as Bifunctional Nucleo­philes in Reactions with α,ω-Dihalogenoalkanes: A Facile Route to Heterocyclic and Double Proton Sponges

Synthesis ◽  
2020 ◽  
Vol 52 (22) ◽  
pp. 3427-3438
Author(s):  
Valery A. Ozeryanskii ◽  
Ekaterina V. Kolupaeva ◽  
Alexander F. Pozharskii
Keyword(s):  
Nitrogen Atom ◽  
Starting Material ◽  
One Pot ◽  
Heterocyclization Reaction ◽  
New Type ◽  
Organic Receptor ◽  
Proton Sponges ◽  
Short Time ◽  
First Time ◽  
Facile Route

The reaction of 1-dimethylamino-8-(methylamino)naphthalene with 1,3-dibromopropane chemoselectively leads to the product of N,N′-heterocyclization, while in the case of 1,4-dibromobutane and 1,2-bis(bromomethyl)benzene the process results in heterocyclization onto the same nitrogen atom with the formation of previously unknown 1-dimethylamino-8-pyrrolidino- and 1-dimethylamino-8-isoindolino-naphthalenes. The same reactions conducted without adding any auxiliary base lead to the formation of N,N′-linked double proton sponges as a new type of polynitrogen organic receptor. Proceeding as a sequence of quaternization–demethylation–cyclization steps, this heterocyclization process can also be used to construct six-membered rings (piperidino, morpholino), albeit in lower yields. The ability of 1,2-dibromoethane to brominate N-alkylated 1,8-diaminonaphthalenes is also described. It is shown for the first time that a commercially available 1,8-bis(dimethylamino)naphthalene (DMAN) can be used as a starting material in a heterocyclization reaction, which via a one-pot approach and in a short time can be converted into 1,5-dimethylnaphtho[1,8-bc]-1,5-diazacyclooctane or 1-dimethylamino-8-(pyrrolidin-1-yl)naphthalene.

scholarly journals One-Pot Synthesis of 5-Hydroxymethylfurfural from Glucose by Brønsted Acid-Free Bifunctional Porous Coordination Polymers in Water

ACS Omega ◽  
2019 ◽  
Vol 4 (5) ◽  
pp. 9316-9323 ◽  
Author(s):  
Fengbing Liang ◽  
Dawei Chen ◽  
Huizhou Liu ◽  
Weimin Liu ◽  
Mo Xian ◽  
...  
Keyword(s):  
Coordination Polymers ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Porous Coordination Polymers ◽  
One Pot ◽  
One Pot Synthesis ◽  
Brönsted Acid

scholarly journals One-Pot, Water-Mediated, H2O2-HCl Catalyzed Synthesis of Benzazepines

2020 ◽  
Vol 32 (5) ◽  
pp. 1165-1168
Author(s):  
Nidhi Singh ◽  
Jaya Pandey
Keyword(s):  
Completion Time ◽  
Synthetic Route ◽  
One Pot ◽  
Conventional Methods ◽  
Time Required ◽  
Nitrogen Bonds

One-pot, multicomponent H2O2-HCl catalyzed system was employed for the synthesis of a series of benzazepine compounds. The implemented procedure oxidized the carbon-nitrogen bonds and produced benzazepines, while integrating diamines and substituted ketone. The advantage of the exercised synthetic route was that the reaction was water mediated and the completion time was quite reduced compared to the time required by conventional methods

Visible-Light-Induced Radical Polynitration of Arylboronic Acids: Synthesis of Polynitrophenols

Synthesis ◽  
2018 ◽  
Vol 50 (15) ◽  
pp. 2891-2896 ◽  
Author(s):  
Jinna Song ◽  
Xihe Bi ◽  
Qi Zhang ◽  
Kaki Raveendra Babu ◽  
Zhouliang Huang
Keyword(s):  
Visible Light ◽  
Aromatic Compounds ◽  
Functional Group ◽  
Simple Procedure ◽  
One Pot ◽  
Arylboronic Acids ◽  
Mild Conditions ◽  
Conventional Methods ◽  
Straightforward Approach

We report a visible light-assisted one-pot method for the synthesis of polynitrophenols through radical tandem hydroxylation and nitration of arylboronic acids by utilizing copper(II) nitrate tri­hydrate as the nitro source. This method features mild conditions, a simple procedure, and good functional group tolerance. Compared to conventional methods, this work provides a straightforward approach for the polynitration of aromatic compounds.

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