Effect of acupuncture anesthesia based on nanomaterial sensor on cognitive function after one-lung ventilation thoracotomy

2021 ◽  
Vol 11 (7) ◽  
pp. 1051-1056
Author(s):  
Maojun Li ◽  
Huawen Peng ◽  
Binxiu Wei ◽  
Qiuxia Deng ◽  
Fen Qian ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Treatment Effectiveness ◽  
Lung Ventilation ◽  
Casting Process ◽  
Patient Comfort ◽  
Inflammatory Factors ◽  
One Lung Ventilation ◽  
Acupuncture Needle ◽  
Anesthesia Group ◽  
Acupuncture Anesthesia

In this work, a new type of nanomaterial sensing acupuncture needle was developed to improve patient comfort and treatment effectiveness. Based on the convenient electrochemical casting process, multilayer nano-tapered holes were constructed on the needle surface to form a porous nano-sensing acupuncture needle (PNAN), which further increases the interface area of the acupuncture needle. To evaluate the effect of PNAN-induced anesthesia on cognitive function after one-lung ventilation and thoracotomy, 60 patients with esophageal cancer undergoing thoracotomy were randomly divided into an acupuncture-induced anesthesia (AIA) group and a conventional anesthesia (CA) group. The recovery time for cognitive function and the incidence of cognitive impairment in the PNAN-induced anesthesia group after one-lung ventilation and thoracotomy were significantly lower than those of the CA group (P < 0.05). The scores from the Mini Mental State Examination Scale (MMSE) and Self-Rating Anxiety Scale (SAS) for the AIA group were lower than the preoperative scores and were better than those for the CA group (P < 0.05). In addition, after one-lung ventilation and thoracotomy, the concentrations of cytokines and catecholamines (CAs) in both groups were lower than the preoperative values, and the levels of cytokines and CAs in the AIA group were significantly lower than those of the CA group. Therefore, acupuncture anesthesia based on a nanomaterial sensor can significantly improve the cognitive function of patients after one-lung ventilation and thoracotomy, inhibit inflammatory factors, and provide an optimal curative effect.

scholarly journals A randomised controlled trial on roles of prostaglandin E1 nebulization among patients undergoing one lung ventilation

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Pengyi Li ◽  
Lianbing Gu ◽  
Jing Tan ◽  
Zhenghuan Song ◽  
Qingming Bian ◽  
...  
Keyword(s):  
Prostaglandin E1 ◽  
Controlled Trial ◽  
Lung Ventilation ◽  
Inflammatory Factors ◽  
Pulmonary Shunt ◽  
One Lung Ventilation ◽  
Reference Concentration ◽  
Group A ◽  
Group B ◽  
Randomised Controlled

Abstract Background Prostaglandin E1 (PGE1) has been reported to maintain adequate oxygenation among patients under 60% FiO2 one-lung ventilation (OLV). This research aimed to explore whether PGE1 is safe in pulmonary shunt and oxygenation under 40% FiO2 OLV and provide a reference concentration of PGE1. Methods Totally 90 esophageal cancer patients treated with thoracotomy were enrolled in this study, randomly divided into three groups (n = 30/group): Group A (60% FiO2 and 0.1 µg/kg PGE1), Group B (40% FiO2 and 0.1 µg/kg PGE1), and Group C (40% FiO2, 0.2 µg/kg PGE1). Primary outcomes were oxygenation and pulmonary shunt during OLV. Secondary outcomes included oxidative stress after OLV. Results During OLV, patients in Group C and B had lower levels of PaO2, SaO2, SpO2, MAP, and Qs/Qt than those in Group A (P < 0.05). At T2 (OLV 10 min), patients in Group C and B exhibited a lower level of PaO2/FiO2 than those in Group A, without any statistical difference at other time points. The IL-6 levels of patients in different groups were different at T8 (F = 3.431, P = 0.038), with IL-6 in Group C being lower than that in Group B and A. MDA levels among the three groups differed at T5 (F = 4.692, P = 0.012) and T7 (F = 5.906, P = 0.004), with the MDA level of Group C being lower than that of Group B and A at T5, and the MDA level of Group C and B being lower than that of Group A at T7. In terms of TNF-α level, patients in Group C had a lower level than those in Group B and A at T8 (F = 3.598, P = 0.033). Compared with patients who did not use PGE1, patients in Group C had comparable complications and lung infection scores. Conclusion The concentration of FiO2 could be reduced from 60 to 40% to maintain oxygenation. 40% FiO2 + 0.2 µg/kg PGE1 is recommended as a better combination on account of its effects on the inflammatory factors. Trial registration: Chictr.org.cn identifier: ChiCTR1800018288, 09/09/2018.

scholarly journals Dexmedetomidine Improved One-lung Ventilation-induced Cognitive Dysfunction in Rats

2021 ◽  
Author(s):  
Mengyun LI ◽  
Zhe JIN ◽  
Jia ZHAN ◽  
Yanlin WANG ◽  
Kai CHEN
Keyword(s):  
Cognitive Function ◽  
Memory Function ◽  
Lung Ventilation ◽  
Sprague Dawley ◽  
One Lung Ventilation ◽  
Ca1 Region ◽  
Hippocampal Ca1 Region ◽  
Synaptic Structure ◽  
Transmission Electron ◽  
Hippocampal Ca1

Abstract Background: One-lung ventilation (OLV) is widely used in thoracic surgery. However, OLV may also increase CERO2 and aggravate delayed cognitive recovery. Here, we aimed to investigate the effect of dexmedetomidine (DEX) on cognitive function in rats undergoing OLV. Methods: Sprague-Dawley rats were randomly divided into two-lung ventilation (TLV) group, OLV group and OLV treated with DEX group. Group DEX received 25 μg/kg DEX i.p. 30 min before induction. After mechanical ventilation (MV), Morris water maze (MWM) test was carried out to examine spatial memory function. Western blotting was used to detect pERK1/2, pCREB, Bcl-2 and BAX in hippocampal tissues. Transmission electron microscopy (TEM) was used to observe the hippocampal CA1 region. Results: Post-MV, compared with group OLV, group DEX showed increases in percentage of target quadrant time (P<0.05), platform crossings (P<0.05), a reduction in CERO2 (P<0.05), and pERK1/2, pCREB, and Bcl-2 significantly increased (P<0.01 or P<0.05), while BAX significantly decreased (P<0.01), besides, a less damaged synaptic structure was observed in group DEX. Conclusions: DEX improved post-MV cognitive function in rats undergoing OLV, reduced cerebral oxygen consumption, protected synaptic structure and upregulated ERK1/2-CREB anti-apoptotic signaling pathway in hippocampal CA1 region.

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