A randomised controlled trial on roles of prostaglandin E1 nebulization among patients undergoing one lung ventilation

Abstract Background Prostaglandin E1 (PGE1) has been reported to maintain adequate oxygenation among patients under 60% FiO2 one-lung ventilation (OLV). This research aimed to explore whether PGE1 is safe in pulmonary shunt and oxygenation under 40% FiO2 OLV and provide a reference concentration of PGE1. Methods Totally 90 esophageal cancer patients treated with thoracotomy were enrolled in this study, randomly divided into three groups (n = 30/group): Group A (60% FiO2 and 0.1 µg/kg PGE1), Group B (40% FiO2 and 0.1 µg/kg PGE1), and Group C (40% FiO2, 0.2 µg/kg PGE1). Primary outcomes were oxygenation and pulmonary shunt during OLV. Secondary outcomes included oxidative stress after OLV. Results During OLV, patients in Group C and B had lower levels of PaO2, SaO2, SpO2, MAP, and Qs/Qt than those in Group A (P < 0.05). At T2 (OLV 10 min), patients in Group C and B exhibited a lower level of PaO2/FiO2 than those in Group A, without any statistical difference at other time points. The IL-6 levels of patients in different groups were different at T8 (F = 3.431, P = 0.038), with IL-6 in Group C being lower than that in Group B and A. MDA levels among the three groups differed at T5 (F = 4.692, P = 0.012) and T7 (F = 5.906, P = 0.004), with the MDA level of Group C being lower than that of Group B and A at T5, and the MDA level of Group C and B being lower than that of Group A at T7. In terms of TNF-α level, patients in Group C had a lower level than those in Group B and A at T8 (F = 3.598, P = 0.033). Compared with patients who did not use PGE1, patients in Group C had comparable complications and lung infection scores. Conclusion The concentration of FiO2 could be reduced from 60 to 40% to maintain oxygenation. 40% FiO2 + 0.2 µg/kg PGE1 is recommended as a better combination on account of its effects on the inflammatory factors. Trial registration: Chictr.org.cn identifier: ChiCTR1800018288, 09/09/2018.

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Effects of prostaglandin E1 nebulization of ventilated lung under 60%O2 one lung ventilation on patients’ oxygenation and oxidative stress: a randomised controlled trial

Respiratory Research ◽

10.1186/s12931-020-01380-6 ◽

2020 ◽

Vol 21 (1) ◽

Author(s):

Pengyi Li ◽

Lianbing Gu ◽

Qingming Bian ◽

Jing Tan ◽

Dian Jiao ◽

...

Keyword(s):

Oxidative Stress ◽

Randomised Controlled Trial ◽

Prostaglandin E1 ◽

Controlled Trial ◽

Lung Ventilation ◽

One Lung Ventilation ◽

Randomised Controlled ◽

And Oxidative Stress

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Gamification as an entrepreneur well-being intervention: A study protocol for a single-blinded randomised controlled trial

10.21203/rs.3.pex-1323/v1 ◽

2021 ◽

Author(s):

Waqar M. Naqvi

Keyword(s):

Controlled Trial ◽

Life Quality ◽

Well Being ◽

Likert Scale ◽

Control Group ◽

Group A ◽

Measuring Scale ◽

Group B ◽

Randomised Controlled

Abstract Entrepreneurs usually work for long hours resulting in exhaustion, stress, and burnout. The prevalent symptoms of burnout are reduced levels of physical and mental energy, reduced job efficiency and diminished productivity. Therefore, it is important to improve the health of entrepreneurs. Gamification has a positive relationship with improvements in health and well-being as it influences positive experiences and satisfaction. This trial aims to study how 30-minutes of virtual reality game use via Kinect Azure and Oculus platforms 3-times per week, for 4 weeks, relates to differences in entrepreneur stress, burnout, subjective life quality, and downstream firm performance. We will recruit entrepreneurs over the age of 18 for the gamification analysis. Analysis of previous power using G*Power will determine the sample size. We will divide the participants into 3 groups, wherein Group A will undergo gamification on the Kinect platform, Group B will undergo the Oculus Quest intervention, and Group C will be the control group. We will conduct the study at two sites, one at the HuMen research. The outcome measures include a five-point Likert scale for measuring entrepreneurial stress, burnout-measuring scale (BMS) for burnout, five-point Likert scale for performance and SF-12 for Quality of life. Since current strains pave ways to future accomplishment, entrepreneurs' eudemonic well-being might particularly relate to forward-looking challenge stressors and burnouts. The results will provide an insight into how gamification could help entrepreneurs to deal with work stress and maintain high well-being.

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Response to: ‘Postoperative pulmonary complications, pulmonary and systemic inflammatory responses after lung resection surgery with prolonged one-lung ventilation. Randomised controlled trial comparing intravenous and inhalational anaesthesia’

British Journal of Anaesthesia ◽

10.1016/j.bja.2017.12.016 ◽

2018 ◽

Vol 120 (2) ◽

pp. 411-412 ◽

Cited By ~ 1

Author(s):

E. Murphy ◽

B. Shelley

Keyword(s):

Randomised Controlled Trial ◽

Inflammatory Responses ◽

Controlled Trial ◽

Lung Resection ◽

Lung Ventilation ◽

Pulmonary Complications ◽

Postoperative Pulmonary Complications ◽

One Lung Ventilation ◽

Inhalational Anaesthesia ◽

Randomised Controlled

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Peer Review #2 of "Nebulized dexmedetomidine improves pulmonary shunt and lung mechanics during one-lung ventilation: a randomized clinical controlled trial (v0.1)"

10.7287/peerj.9247v0.1/reviews/2 ◽

2020 ◽

Author(s):

R Sampieri Cabrera

Keyword(s):

Peer Review ◽

Controlled Trial ◽

Lung Ventilation ◽

Lung Mechanics ◽

Pulmonary Shunt ◽

One Lung Ventilation

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Dexmedetomidine and Fentanyl for Postoperative Analgesia in Patients Undergoing Abdominal Surgery: Randomised Controlled Trial

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/48579.14973 ◽

2021 ◽

Author(s):

Prashant Sachan ◽

Prem Raj Singh ◽

Sateesh Verma ◽

Brij Bihari Kushwaha

Keyword(s):

Postoperative Pain ◽

Randomised Controlled Trial ◽

Abdominal Surgery ◽

Postoperative Analgesia ◽

Pain Control ◽

Controlled Trial ◽

Haemodynamic Stability ◽

Group A ◽

Group B ◽

Randomised Controlled

Introduction: Pain control is an important factor for postoperative recovery. Many drugs have been studied for effectiveness of postoperative analgesia. Fentanyl is a conventional drug and dexmedetomidine is one of the emerging drugs used for analgesia and postoperative pain control. Aim: To compare the effect of fentanyl and dexmedetomidine on pain control and haemodynamic stability. Materials and Methods: A randomised controlled trial was conducted on 60 patients (30 each group) undergoing for abdominal surgery, between January 2019 to January 2020. Group A received fentanyl loading dose 2 μg/kg I.V. followed by 0.5 μg/kg/hr infusion and group B received dexmedetomidine loading 1 μg/kg over 10 minutes followed by maintenance 0.5 μg/kg/hr infusion. Infusion was continued up to four hours during surgery and till eight hours of postoperative in both groups. Haemodynamic parameters {Heart Rate (HR), Mean Arterial Pressure (MAP)} were recorded after start of study drug infusion, after intubation, then every 15 minutes till 1 hour, then every 30 minutes till end of surgery and after extubation. In postoperative period, HR and MAP were recorded at interval of one hour till eight hours after extubation and postoperative analgesia was assessed by Visual Analogue Scale (VAS) at interval of one hour till eight hours. Present study used descriptive statistical analysis for data analysis. Analysis of variance (ANOVA) was used to compare data between two groups. Chi-square test was used to find the significance of difference on categorical scale between two groups. Results: This study showed that group-B had significantly less VAS score most of time in recovery period as compared to group-A (1.97±0.18 vs 2.10±0.31 at eight hours postoperative). HR, MAP was found significantly less all the time during surgery and most of the time postoperatively in group-B (p-value <0.05). Conclusion: Intravenous infusion of dexmedetomidine can be better for controlling postoperative pain and perioperative haemodynamic stability as compared to infusion of fentanyl in patients undergoing abdominal surgeries.

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TP8.2.19 Virtual versus In-Person Education Research (VIPER) in Surgical Skills Teaching: A crossover randomised controlled trial

British Journal of Surgery ◽

10.1093/bjs/znab362.090 ◽

2021 ◽

Vol 108 (Supplement_7) ◽

Author(s):

Jih Dar Yau ◽

Radheswari Measuria ◽

Professor Mahmoud Loubani

Keyword(s):

Controlled Trial ◽

Training Needs ◽

Surgical Skills ◽

Student Feedback ◽

Written Feedback ◽

Initial Experience ◽

Knot Tying ◽

Group A ◽

Group B ◽

Randomised Controlled

Abstract Aims To compare effectiveness of virtual versus in-person teaching of one-handed reef knot to medical students. Methodology 20 students were randomised into 2 groups of 10, to learn to tie one-handed reef knot. Group A attended a 15-minute virtual session followed by a 15-minute in-person session; vice versa for Group B simultaneously. For the virtual session, trainer and students used online platform, Zoom, on an overhead webcam-laptop workstation in separate rooms. For the in-person session, trainer and students were in one room. Anonymous written feedback was collected from all students. Results 50% of the students had previous experience in knot-tying. On average, the instruction clarity and support received during the virtual session were reported to be less by Group A than Group B. 30% reported non-inferiority in the virtual method to in-person in fulfilling their training needs to learn this skill. 80% said they could have benefited from more time during the virtual session when compared to learning the same skill in-person. During the virtual sessions, 60% encountered technical difficulties relating to internet (20%), Zoom (25%), trainer availability (10%), and hardware (5%). 35% felt that a fully virtual session is suitable for learning one-handed reef knot. 30% stated they would attend a fully virtual basic surgical skills course whilst 40% would attend a partially virtual one. Conclusion Initial experience with virtual surgical skills teaching revealed promising potential based on student feedback. Further focused studies with targeted optimisation are warranted for it to be a viable alternative to traditional in-person teaching.

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A Pilot Study of Acupuncture for Tension Headache, Using a Novel Placebo

Acupuncture in Medicine ◽

10.1136/aim.14.1.11 ◽

1996 ◽

Vol 14 (1) ◽

pp. 11-15 ◽

Cited By ~ 48

Author(s):

AR White ◽

C Eddleston ◽

R Hardie ◽

KL Resch ◽

E Ernst

Keyword(s):

Controlled Trial ◽

Tension Headache ◽

Tension Type Headache ◽

Guide Tube ◽

Test Procedures ◽

Trial Duration ◽

Before And After ◽

Group A ◽

Group B ◽

Randomised Controlled

Tension headache is common, and treatment with acupuncture is frequently recommended, although the evidence of its effectiveness is contradictory. This small, randomised, controlled trial was designed as a pilot to test procedures in preparation for a multi-centre trial investigating the effect of acupuncture as a treatment for tension headache. Ten volunteers suffering from episodic, tension-type headache were recruited by local newspaper articles. Patients were randomised to receive either brief needling to tender areas or selected traditional points (Group A), or pressure from a cocktail stick supported within a guide tube to defined, non-tender and non-acupuncture areas (Group B). The patients’ view of the treatment sites was obstructed so that no indication could be gained as to which form of treatment was being given. Throughout the period of the trial, duration, frequency and intensity of headaches were recorded, from which the mean weekly headache index was calculated. There was no difference between the changes in weekly headache index in the two groups, comparing scores before and after treatment. However, Group A experienced a considerably higher number of headache-free weeks than Group B. The credibility of the two procedures was tested using a standard credibility questionnaire and a “final verdict”. One subject in Group B concluded that she had not received genuine acupuncture, but overall there was no statistical difference between the credibility of treatment in the two groups.

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An intervention for improving the lifestyle habits of kindergarten children in Israel: a cluster-randomised controlled trial investigation

Public Health Nutrition ◽

10.1017/s136898001400024x ◽

2014 ◽

Vol 18 (9) ◽

pp. 1537-1544 ◽

Cited By ~ 9

Author(s):

Liat Lerner-Geva ◽

Elinor Bar-Zvi ◽

Gila Levitan ◽

Valentina Boyko ◽

Brian Reichman ◽

...

Keyword(s):

Controlled Trial ◽

Intervention Group ◽

Cluster Randomised Controlled Trial ◽

Nutritional Knowledge ◽

Intervention Programme ◽

Cluster Randomised ◽

Daily Energy ◽

Group A ◽

Group B ◽

Randomised Controlled

AbstractObjectiveTo assess the effectiveness of an intervention programme to improve kindergarten children's eating and leisure habits in Israel.DesignA cluster-randomised controlled trial.SettingSix full-day kindergartens in Israel were randomly divided into three groups. Group A received the full intervention programme, which included lessons on good eating habits and daily physical exercise. Group B received a partial intervention of lessons only. Group C, the reference group, did not receive any intervention.SubjectsChildren aged 4–6 years (n 204) were recruited for the study.MethodsObjective data for weight and height were collected to calculate BMI Z-scores. Activity, sedentary time, sleeping hours and daily energy intake were assessed via a parental questionnaire. Nutritional knowledge was assessed by a single dietitian using a questionnaire addressed to the children. Assessments were done at baseline and at the end of the intervention.ResultsAfter adjustment for baseline levels we observed a significant reduction in daily energy intake for the full intervention group A (P = 0·03). A positive intervention effect was demonstrated on nutritional knowledge in the partial intervention group B (P = 0·03), although no significant change was demonstrated for BMI Z-score.ConclusionsThe study supports the incorporation of education on healthy lifestyle habits and physical activity into the curricula of kindergartens.

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A Comparison of Acupuncture with Advice and Exercises on the Symptomatic Treatment of Osteoarthritis of the Hip – a Randomised Controlled Trial

Acupuncture in Medicine ◽

10.1136/aim.19.1.19 ◽

2001 ◽

Vol 19 (1) ◽

pp. 19-26 ◽

Cited By ~ 35

Author(s):

Roisin Haslam

Keyword(s):

Controlled Trial ◽

Randomised Trial ◽

Symptomatic Treatment ◽

Post Treatment ◽

Control Group ◽

Group A ◽

Pre Treatment ◽

Group B ◽

Randomised Controlled

Acupuncture is becoming a common technique within the physiotherapy profession as a treatment modality for pain relief; however, few randomised controlled trials have been undertaken to assess the effectiveness of acupuncture, particularly in the treatment of osteoarthritis (OA) of the hip. Therefore, a randomised trial to compare the effectiveness of acupuncture with advice and exercises on the symptomatic treatment of OA of the hip was carried out. Thirty-two patients awaiting a total hip arthroplasty were randomly allocated to either the experimental group, (A), to have six sessions of acupuncture each lasting up to 25 minutes, or the control group, (B), to be given advice and exercises for their hip over a six week period. Group A consisted of three men and 13 women, and group B consisted of four men and eight women. The average age in group A was 66 years and in group B it was 68 years. Patients were assessed for pain and functional ability, using a modified version of the WOMAC questionnaire, pre-treatment, immediately post-treatment and at eight weeks post-treatment. The pre-treatment WOMAC scores in the two groups were similar (p=0.85). There was a significant improvement in group A (decrease in WOMAC score) immediately post-treatment (p=0.002) and this was maintained at the eight-week follow-up (p=0.03). There were no significant changes in group B. When the changes in WOMAC scores were compared between groups, a significantly greater improvement was found between pre-treatment and immediately post-treatment in group A, compared with group B (p=0.02). The changes between pre-treatment and the eight-week follow-up also showed a significant improvement in group A compared with group B (p=0.03). In conclusion, this trial supports the hypothesis that acupuncture is more effective than advice and exercises in the symptomatic treatment of OA of the hip.

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