Recent Sensing Technologies for First Line Anti-Tuberculosis Drugs in Pharmaceutical Dosages and Biological Fluids: A Review

Tuberculosis remains a global problem with a huge burden, estimated at 10.4 million new cases of infection in 2015. First line anti-tuberculosis drugs-based electrochemical sensors are being measured as an important development in the arenas of electroanalysis and are nowadays attracting the attention of several researchers. Transformation from classic electrochemical sensors which normally accept the complete value of the signal as the output, first line anti-tuberculosis drugs based electrochemical sensors retain dual electrochemical signals and the quantitative extent of target is based on the ratio of these two signals. Electrochemical methods have integral benefits over other well-established analytical procedures, this review pointing to offer an efficient summary of the newest developments in the voltammetric detection of anti-tuberculosis drugs. Moreover, the advantages and limits of these approaches are critically discussed and deliberated. The review exposes that in spite of exhausting a variation of chemically fabricated electrodes to isolate the first line anti-tuberculosis drugs, there is still a deficiency of applicability of the voltammetric techniques to measure these complexes in human body fluids, exclusively in blood plasma and pharmaceutical samples as well.