Suppression of Human Lens Epithelial Cell Proliferation by Proteasome Inhibition, a Potential Defense against Posterior Capsular Opacification

2006 ◽  
Vol 47 (10) ◽  
pp. 4482 ◽  
Author(s):  
Niranjan Awasthi ◽  
B. J. Wagner
Keyword(s):  
Cell Proliferation ◽  
Epithelial Cell ◽  
Proteasome Inhibition ◽  
Lens Epithelial Cell ◽  
Human Lens ◽  
Posterior Capsular Opacification ◽  
Epithelial Cell Proliferation ◽  
Human Lens Epithelial Cell

Diclofenac sodium and cyclosporin A inhibit human lens epithelial cell proliferation in culture

1997 ◽  
Vol 235 (3) ◽  
pp. 180-185 ◽  
Author(s):  
Pedro Cortina ◽  
Maria Jos� G�mez-Lech�n ◽  
Amparo Navea ◽  
Jos� Luis Menezo ◽  
Maria Carmen Terencio ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Epithelial Cell ◽  
Cyclosporin A ◽  
Diclofenac Sodium ◽  
Lens Epithelial Cell ◽  
Human Lens ◽  
Epithelial Cell Proliferation ◽  
Human Lens Epithelial Cell

Characterization of Zinc Oxide Nanoparticles and their Inhibitory Effect on Human Lens Epithelial Cells under UVB Irradiation

2013 ◽  
Vol 788 ◽  
pp. 61-64
Author(s):  
Da Dong Guo ◽  
Hong Ying Tang ◽  
Hong Sheng Bi
Keyword(s):  
Epithelial Cells ◽  
Zno Nanoparticles ◽  
Lens Epithelial Cell ◽  
Human Lens ◽  
Posterior Capsular Opacification ◽  
Lens Epithelial Cells ◽  
Epithelial Cell Proliferation ◽  
Uvb Irradiation ◽  
Human Lens Epithelial Cell ◽  
Human Lens Epithelial Cells

Posterior capsular opacification is the most frequent complication after cataract surgery, which is induced by the proliferation, differentiation and migration of lens epithelial cells. Inhibiting the proliferation of human lens epithelial cells could reduce the occurrence of posterior capsular opacification. To explore the possible potential of ZnO nanoparticles in treating posterior capsular opacification, we investigated the effect of ZnO nanoparticles on the human lens epithelial cell proliferation in the presence and absence of ultraviolet B (UVB) irradiation via 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay. The results indicate that ZnO nanoparticles could apparently inhibit the proliferation of human lens epithelial cells in a dose-dependent manner, and UVB irradiation can further enhance this inhibitory role for the human lens epithelial cell proliferation, indicating the great potential of ZnO nanoparticles in treating posterior capsular opacification in clinical application.

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