scholarly journals Activation of T lymphocytes in dengue virus infections. High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon-gamma in sera of children with dengue.

1991 ◽  
Vol 88 (5) ◽  
pp. 1473-1480 ◽  
Author(s):  
I Kurane ◽  
B L Innis ◽  
S Nimmannitya ◽  
A Nisalak ◽  
A Meager ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Dengue Virus ◽  
Interferon Gamma ◽  
Interleukin 2 ◽  
Virus Infections ◽  
Interleukin 2 Receptor ◽  
Soluble Cd8 ◽  
Soluble Interleukin 2 Receptor ◽  
Soluble Cd4

Modification of Soluble Immunological Parameters during Treatment with Interleukin-2

1993 ◽  
Vol 8 (4) ◽  
pp. 227-232 ◽  
Author(s):  
I. Abbate ◽  
M. Correale ◽  
M.D. Musci ◽  
M. Guida ◽  
C.D. Dragone ◽  
...  
Keyword(s):  
Interleukin 2 ◽  
Advanced Cancer Patients ◽  
Immunological Parameters ◽  
Interleukin 2 Receptor ◽  
Soluble Cd8 ◽  
Recombinant Interleukin 2 ◽  
Clinical Responses ◽  
Soluble Interleukin 2 Receptor ◽  
Beta 2 Microglobulin ◽  
Cd8 Antigen

In the present study we tested numerous soluble immunological parameters (soluble Interleukin 2 receptor, Beta 2 microglobulin, Neopterin, soluble CD8 antigen, gamma Interferon and alpha Tumor Necrosis Factor) in sera obtained from 18 advanced cancer patients during subcutaneous treatment with recombinant Interleukin 2. The treatment cycles consisted of a dose of 9×106 IU/m2 twice daily for 2 days followed by 1.8×106 IU/m2 twice daily for 5 days/week during 6 weeks. Even before therapy, neoplastic patients had higher levels of soluble Interleukin 2 receptor than a group of healthy subjects. Moreover, basal soluble CD8 antigen levels showed significant differences (p<0.01) in patients with different clinical responses (responders and non-responders). During treatment we observed a fast increase (in the first or second week) of all parameters considered; soluble Interleukin 2 receptor and soluble CD8 antigen were the markers that were best related to the course of immunotherapy. In conclusion, monitoring recombinant Interleukin 2 immunotherapy with immunological parameters in serum seems to be of interest. However, more data are necessary to confirm the real value of the single markers.

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