scholarly journals Shelf Cross-Shore Flows under Storm-Driven Conditions: Role of Stratification, Shoreline Orientation, and Bathymetry

2018 ◽  
Vol 48 (11) ◽  
pp. 2533-2553 ◽  
Author(s):  
Xiaodong Wu ◽  
George Voulgaris ◽  
Nirnimesh Kumar
Keyword(s):  
South Carolina ◽  
Initial Conditions ◽  
South Atlantic Bight ◽  
Wind Component ◽  
Shelf Circulation ◽  
Coastal Embayment ◽  
Long Bay ◽  
Bed Slope ◽  
Alongshore Wind

AbstractNumerical simulations are used to study the response of Long Bay, South Carolina, a typical coastal embayment with curved coastline located on the South Atlantic Bight, to realistic, climatologically defined, synoptic storm forcing. Synoptic storms, consisting of cold and warm fronts as well as tropical storms, are used as forcing under both mixed and stratified initial conditions. The analysis focuses on the development of cross-shore shelf circulation and the relative contributions of regionally defined cross-shore winds and alongshore bathymetric variation. The simulation results show that, under stratified conditions, the regionally defined offshore-directed wind component promotes upwelling during the developing stage of the cold front and enhances mixing during the decaying stage. No significant effect is found for warm front and tropical storm forcing conditions. Net cross-shore transports are induced at the southern and northern sides of the embayment that have opposing signs. Besides the surface and bottom Ekman transports, geostrophic transport due to alongshore shelf bed slope and horizontal advection are found to be important contributors to cross-shore flow development. Sea level variability along the curved coastline is driven by the regional alongshore wind, but a spatial variability is identified from the locally defined components of along- and cross-shore winds controlled by coastline orientation.

scholarly journals Storm-induced inner-continental shelf circulation and sediment transport: Long Bay, South Carolina

2012 ◽  
Vol 42 ◽  
pp. 51-63 ◽  
Author(s):  
John C. Warner ◽  
Brandy Armstrong ◽  
Charlene S. Sylvester ◽  
George Voulgaris ◽  
Tim Nelson ◽  
...  
Keyword(s):  
South Carolina ◽  
Sediment Transport ◽  
Continental Shelf ◽  
Shelf Circulation ◽  
Long Bay ◽  
Inner Continental Shelf

Reassessment of transient permeability measurement for tight rocks: The role of boundary and initial conditions

2021 ◽  
pp. 104173
Author(s):  
Yue Wang ◽  
Zhiguo Tian ◽  
Steffen Nolte ◽  
Alexandra Amann-Hildenbrand ◽  
Bernhard M. Krooss ◽  
...  
Keyword(s):  
Initial Conditions ◽  
Permeability Measurement ◽  
Tight Rocks

From Need to Policy: Community Supported Development and Implementation of the South Carolina Vulnerable Adult Guardian Ad Litem (SC VAGAL) Program

2020 ◽  
pp. 073346482097880
Author(s):  
M. Aaron Guest ◽  
Brenda Stalzer ◽  
Maria Patton
Keyword(s):  
South Carolina ◽  
Program Development ◽  
Public Service ◽  
Development Process ◽  
Vital Role ◽  
The South ◽  
Pilot Testing ◽  
Abuse And Neglect ◽  
Guardian Ad Litem

Adult guardian ad litem programs are a necessary public service to protect adults from abuse and neglect. This article describes the development and implementation of an adult guardian ad litem program. We discuss the program’s impetus, pilot testing, evaluation, and implementation of the program. Our experience highlights the vital role of diverse inter-sectoral stakeholders. Furthermore, the development process highlights the need for flexibility in program development, tension negotiation among stakeholders, and engagement of aging stakeholders in nontraditional arenas.

scholarly journals The role of masks in reducing the risk of new waves of COVID-19 in low transmission settings: a modeling study

2020 ◽  
Author(s):  
Robyn M Stuart ◽  
Romesh G Abeysuriya ◽  
Cliff C Kerr ◽  
Dina Mistry ◽  
Daniel J Klein ◽  
...  
Keyword(s):  
Initial Conditions ◽  
High Mobility ◽  
Baseline Scenario ◽  
New Wave ◽  
Policy Environment ◽  
Agent Based ◽  
Low Transmission ◽  
South Wales ◽  
Community Transmission

Objectives: To evaluate the risk of a new wave of coronavirus disease 2019 (COVID-19) in a setting with ongoing low transmission, high mobility, and an effective test-and-trace system, under different assumptions about mask uptake. Design: We used a stochastic agent-based microsimulation model to create multiple simulations of possible epidemic trajectories that could eventuate over a five-week period following prolonged low levels of community transmission. Setting: We calibrated the model to the epidemiological and policy environment in New South Wales, Australia, at the end of August 2020. Participants: None Intervention: From September 1, 2020, we ran the stochastic model with the same initial conditions (i.e., those prevailing at August 31, 2020), and analyzed the outputs of the model to determine the probability of exceeding a given number of new diagnoses and active cases within five weeks, under three assumptions about future mask usage: a baseline scenario of 30% uptake, a scenario assuming no mask usage, and a scenario assuming mandatory mask usage with near-universal uptake (95%). Main outcome measure: Probability of exceeding a given number of new diagnoses and active cases within five weeks. Results: The policy environment at the end of August is sufficient to slow the rate of epidemic growth, but may not stop the epidemic from growing: we estimate a 20% chance that NSW will be diagnosing at least 50 new cases per day within five weeks from the date of this analysis. Mandatory mask usage would reduce this to 6-9%. Conclusions: Mandating the use of masks in community settings would significantly reduce the risk of epidemic resurgence.

The Role of Pierce Butler in the Constitutional Convention

1960 ◽  
Vol 22 (3) ◽  
pp. 361-374 ◽  
Author(s):  
S. Sidney Ulmer
Keyword(s):  
South Carolina ◽  
Constitutional Convention ◽  
Realistic Assessment ◽  
Biographical Sketches ◽  
The Subject ◽  
Fourth Member

It is quite well known that South Carolina sent four aristocrats to represent her in the 1787 Constitutional Convention. It is less well known that one of the four merited a listing in Burke's Peerage. In fact, while much has been written about Charles Pinckney, C. C. Pinckney, and John Rutledge, the fourth member of the delegation has been the subject of a few biographical sketches and virtually nothing more. And yet Pierce Butler was not an insignificant member of the delegation or of the Convention. Indeed, several positive claims to fame that can be established in his behalf suggest the need for a more realistic assessment of his role in the 1787 Convention. This paper is designed as a first step in that direction.

Nourish the soul or damage the body? Belief in the connection between Christian moral failure and diminished health

2018 ◽  
Vol 65 (2) ◽  
pp. 247-262
Author(s):  
Steven L Foy ◽  
Collin W Mueller
Keyword(s):  
South Carolina ◽  
Religious Involvement ◽  
The Body ◽  
Religion And Health ◽  
Telephone Interviews ◽  
Moral Failure ◽  
Physical Health Outcomes ◽  
Using Data ◽  
The Relationship

Scholars have increasingly noted mechanisms by which religion may be detrimental to one’s health, but few have explored how individuals understand linkages between religious involvement and adverse health. Using data gathered from telephone interviews with Protestants and Catholics in North Carolina and South Carolina, we explore how individuals understand the role of religious moral failure in shaping health consequences. When asked to discuss the relationship between religion and health, 23 respondents described experiences or beliefs regarding how failing to meet the expectations of their religion corresponded with a range of reduced mental and physical health outcomes. Findings underscore the need for additional research on the role of religious involvement and life course experiences in shaping expectations that health declines result from moral failure.

Abstract 2894: Essential Role of ERK 1/2 in Sildenafil-Induced Early and Delayed Cardioprotection in Mice

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Anindita das ◽  
Lei Xi ◽  
Fadi N Salloum ◽  
Yuan J Rao ◽  
Rakesh C Kukreja
Keyword(s):  
South Carolina ◽  
Infarct Size ◽  
Myocardial Infarct ◽  
Ischemia Reperfusion ◽  
Critical Role ◽  
Heart Association ◽  
Myocardial Infarct Size ◽  
Western Blots ◽  
Delayed Cardioprotection

Background: Sildenafil (SIL), a potent inhibitor of phosphodiesterase-5 induces powerful protection against myocardial ischemia-reperfusion (I-R) injury through activation of protein kinase G (PKG). However, the downstream targets of PKG in SIL-induced cardioprotection remain unclear. We hypothesized that PKG-dependent activation of survival kinase, ERK may play a critical role in SIL-induced cardioprotection in mice. Methods & Results: Ventricular myocytes were isolated from adult male ICR mice and exposed to 40 min of simulated ischemia (SI) with/without 1 hr pre-incubation of SIL (1 μM). Myocyte necrosis and apoptosis were determined after 1 hr or 18 hrs of reoxygenation (RO) using trypan blue or TUNEL assay, respectively. Pretreatment with SIL protected cardiomyocytes after SI-RO (necrosis 18.5±0.5% and apoptosis 6.6±0.7%; n=4, p<0.001) as compared with controls (necrosis 42.1±1.8% and apoptosis 23.3±0.9%). Co-incubation of PD98059 (20 μM), a selective ERK1/2 inhibitor blocked both anti-necrotic and anti-apoptotic protection in cardiomyocytes. Furthermore, intra-coronary infusion of SIL (1 μM) in Langendorff isolated mouse hearts 10 min prior to zero-flow global I (20 min) and R (30 min) significantly reduced myocardial infarct size (from 29.4±2.4% to 16.0±3.0%; p<0.05, n=6). Co-treatment of PD98059 abrogated SIL-induced protection (33.0±5.9; n=4). To evaluate the role of ERK1/2 in delayed cardioprotection, mice were treated with saline or SIL (0.7 mg/kg i.p.) 24 hours before global I-R in Langendorff mode. PD98059 (1 mg/kg) was administered (i.p.) 30 min before the treatment of SIL. Infarct size was reduced from 27.6±3.3% in saline-treated controls to 6.9±1.2% in SIL-treated mice (P<0.05, n=6). The delayed protective effect of SIL was also abolished by PD98059 (22.5±2.3%). Western Blots revealed that SIL significantly increased phosphorylation of ERK1/2 which was blocked by PKG inhibitor, KT5823 in the heart and adult myocytes. Selective knockdown of PKG in cardiomyocytes with short hairpin RNA of PKG also blocked the phosphorylation of ERK1/2. Conclusion: SIL-induced cardioprotection involves the activation and phosphorylation of ERK which appear to be intimately linked with a PKG-dependent survival pathway. This research has received full or partial funding support from the American Heart Association, AHA Mid-Atlantic Affiliate (Maryland, North Carolina, South Carolina, Virginia & Washington, DC).

Sign in / Sign up

Export Citation Format

Share Document