Conflict-Related Anterior Cingulate Functional Connectivity Is Associated With Past Suicidal Ideation and Behavior in Recent-Onset Psychotic Major Mood Disorders

Suicide is a leading cause of death among youth and is strongly associated with major depressive disorder (MDD). However, the neurobiological underpinnings of suicidal behaviour and the identification of risk for suicide in young depressed patients are not yet well-understood. In this study, we used a seed-based correlation analysis to investigate the differences in resting-state functional connectivity (RSFC) in depressed youth with or without a history of suicide attempts and healthy controls (HCs). Suicidal attempters (ATT group, n = 35), non-suicide attempters (NAT group, n = 18), and HCs exhibited significantly different RSFC patterns with the left superior prefrontal gyrus (L-SFG) and left middle prefrontal gyrus (L-MFG) serving as the regions of interest (ROIs). The ATT group showed decreased RSFC of the left middle frontal gyrus with the left superior parietal gyrus compared to the NAT and HC groups. Decreased RSFC between the left superior frontal gyrus and the right anterior cingulate cortex (rACC) was found in the ATT group compared to the NAT and HC groups. Furthermore, the left prefrontal-parietal connectivity was associated with suicidal ideation and levels of impulsivity, but RSFC of the left prefrontal cortex with the rACC was correlated exclusively with impulsivity levels and was not related to suicidal ideation in the ATT group. Our results demonstrated that altered RSFC of the prefrontal-parietal and prefrontal-rACC regions was associated with suicide attempts in depressed youth, and state-related deficits in their interconnectivity may contribute to traits, such as cognitive impairments and impulsivity to facilitate suicidal acts. Our findings suggest that the neural correlates of suicidal behaviours might be dissociable from those related to the severity of current suicidal ideation. Neural circuits underlying suicide attempts differ from those that underlie suicidal ideation.

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Suicidal ideation and behavior in recent-onset schizophrenia

Biological Psychiatry ◽

10.1016/0006-3223(96)84024-8 ◽

1996 ◽

Vol 39 (7) ◽

pp. 521

Author(s):

A.S. Young ◽

K.H. Nuechterlein ◽

J. Mintz ◽

J. Ventura ◽

M. Gitlin ◽

...

Keyword(s):

Suicidal Ideation ◽

Recent Onset ◽

And Behavior

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Trauma-Related Shame, Sexual Assault Severity, Thwarted Belongingness, and Perceived Burdensomeness Among Female Undergraduate Survivors of Sexual Assault

Crisis ◽

10.1027/0227-5910/a000549 ◽

2019 ◽

Vol 40 (2) ◽

pp. 134-140 ◽

Cited By ~ 2

Author(s):

Christopher R. DeCou ◽

Stephanie P. Kaplan ◽

Julie Spencer ◽

Shannon M. Lynch

Keyword(s):

Risk Factors ◽

Suicidal Ideation ◽

Sexual Assault ◽

Self Report ◽

Psychosocial Risk ◽

Thwarted Belongingness ◽

Female Undergraduate ◽

Perceived Burdensomeness ◽

Cross Sectional ◽

And Behavior

Abstract. Background and Aim: This study evaluated trauma-related shame as a mediator of the association between sexual assault severity and perceived burdensomeness and thwarted belongingness. Method: A total of 164 female undergraduates who reported attempted or completed sexual assault completed self-report measures of sexual assault, trauma-related shame, perceived burdensomeness, and thwarted belongingness. Results: Using path analysis, trauma-related shame mediated the association between sexual assault severity and perceived burdensomeness, and between sexual assault severity and thwarted belongingness. Limitations: The findings of this study are limited by the retrospective, self-report, and cross-sectional nature of these data, and do not allow for causal inference. Conclusion: Trauma-related shame warrants additional investigation as a mechanism that explains the association between sexual assault and psychosocial risk factors for suicidal ideation and behavior.

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Lipophilic Statin Use and Suicidal Ideation in a Sample of Adults With Mood Disorders

Crisis ◽

10.1027/0227-5910/a000260 ◽

2014 ◽

Vol 35 (4) ◽

pp. 278-282 ◽

Cited By ~ 14

Author(s):

Karen M. Davison ◽

Bonnie J. Kaplan

Keyword(s):

Suicidal Ideation ◽

Mood Disorders ◽

Prevalence Ratio ◽

Cross Sectional Study ◽

Community Based ◽

Cross Sectional ◽

Symptom Scores ◽

Unit Increase ◽

Predominantly Female ◽

Lipophilic Statin

Background: Mood disorders are associated with a high risk of suicide. Statin therapy has been implicated in this relationship. Aims: To further clarify reported associations between suicide and cholesterol in mental health conditions, we conducted an analysis of dietary, clinical, and suicidal ideation measures in community-living adults with mood disorders. Method: Data were used from a cross-sectional study of a randomly selected community-based sample (> 18 years; n = 97) with verified mood disorders. Dietary (e.g., fat, iron, vitamin intakes), clinical (e.g., current depression and mania symptoms, medications), and sociodemographic (age, sex, and income) measures were analyzed using bivariate statistics and Poisson regression with robust variance. Results: Participants were predominantly female (71.1%) with bipolar disorder (59.8%); almost one-third (28.9%) were taking lipophilic statins. The prevalence of suicidal ideation was more than 2.5 times in those taking statins, PR = 2.59, 95% CI 1.27–5.31, p < .05. The prevalence ratio for suicidal ideation was 1.10, 95% CI 1.06–1.15, p < .001, for each unit increase in mania symptom scores. No associations between suicidal ideation and dietary intake measures were identified. Conclusion: Individuals with mood disorders may be susceptible to neuropsychiatric effects of cholesterol-lowering drugs, which warrants further research.

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Age differences in ventromedial prefrontal cortex functional connectivity during socioemotional content processing

Social Behavior and Personality An International Journal ◽

10.2224/sbp.9380 ◽

2020 ◽

Vol 48 (7) ◽

pp. 1-19

Author(s):

Ryan T. Daley ◽

Holly J. Bowen ◽

Eric C. Fields ◽

Angela Gutchess ◽

Elizabeth A. Kensinger

Keyword(s):

Prefrontal Cortex ◽

Functional Connectivity ◽

Inferior Frontal Gyrus ◽

Age Groups ◽

Emotional Content ◽

Ventromedial Prefrontal Cortex ◽

Anterior Cingulate ◽

Supramarginal Gyrus ◽

Age Related ◽

Content Processing

Self-relevance effects are often confounded by the presence of emotional content, rendering it difficult to determine how brain networks functionally connected to the ventromedial prefrontal cortex (vmPFC) are affected by the independent contributions of self-relevance and emotion. This difficulty is complicated by age-related changes in functional connectivity between the vmPFC and other default mode network regions, and regions typically associated with externally oriented networks. We asked groups of younger and older adults to imagine placing emotional and neutral objects in their home or a stranger's home. An age-invariant vmPFC cluster showed increased activation for self-relevant and emotional content processing. Functional connectivity analyses revealed age × self-relevance interactions in vmPFC connectivity with the anterior cingulate cortex. There were also age × emotion interactions in vmPFC functional connectivity with the anterior insula, orbitofrontal gyrus, inferior frontal gyrus, and supramarginal gyrus. Interactions occurred in regions with the greatest differences between the age groups, as revealed by conjunction analyses. Implications of the findings are discussed.

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Understanding Emotions: Origins and Roles of the Amygdala

Biomolecules ◽

10.3390/biom11060823 ◽

2021 ◽

Vol 11 (6) ◽

pp. 823

Author(s):

Goran Šimić ◽

Mladenka Tkalčić ◽

Vana Vukić ◽

Damir Mulc ◽

Ena Španić ◽

...

Keyword(s):

Sensory Information ◽

Anterior Cingulate ◽

Central Nucleus ◽

Subcortical Structures ◽

Neuronal Populations ◽

Efferent Projections ◽

Short And Long Term ◽

Understanding Emotions ◽

Fight Or Flight Response ◽

And Behavior

Emotions arise from activations of specialized neuronal populations in several parts of the cerebral cortex, notably the anterior cingulate, insula, ventromedial prefrontal, and subcortical structures, such as the amygdala, ventral striatum, putamen, caudate nucleus, and ventral tegmental area. Feelings are conscious, emotional experiences of these activations that contribute to neuronal networks mediating thoughts, language, and behavior, thus enhancing the ability to predict, learn, and reappraise stimuli and situations in the environment based on previous experiences. Contemporary theories of emotion converge around the key role of the amygdala as the central subcortical emotional brain structure that constantly evaluates and integrates a variety of sensory information from the surroundings and assigns them appropriate values of emotional dimensions, such as valence, intensity, and approachability. The amygdala participates in the regulation of autonomic and endocrine functions, decision-making and adaptations of instinctive and motivational behaviors to changes in the environment through implicit associative learning, changes in short- and long-term synaptic plasticity, and activation of the fight-or-flight response via efferent projections from its central nucleus to cortical and subcortical structures.

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Altered Functional Connectivity between the Nucleus Basalis of Meynert and Anterior Cingulate Cortex is Associated with Declined Attentional Performance after Total Sleep Deprivation

Behavioural Brain Research ◽

10.1016/j.bbr.2021.113321 ◽

2021 ◽

pp. 113321

Author(s):

Jing Qi ◽

Bo-Zhi Li ◽

Ying Zhang ◽

Bei Pan ◽

Yu-Hong Gao ◽

...

Keyword(s):

Functional Connectivity ◽

Sleep Deprivation ◽

Anterior Cingulate Cortex ◽

Cingulate Cortex ◽

Anterior Cingulate ◽

Nucleus Basalis ◽

Nucleus Basalis Of Meynert ◽

Total Sleep Deprivation ◽

Attentional Performance

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Structural and functional brain-wide alterations in A350V Iqsec2 mutant mice displaying autistic-like behavior

Translational Psychiatry ◽

10.1038/s41398-021-01289-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Daniela Lichtman ◽

Eyal Bergmann ◽

Alexandra Kavushansky ◽

Nadav Cohen ◽

Nina S. Levy ◽

...

Keyword(s):

Social Behavior ◽

Functional Connectivity ◽

Mouse Model ◽

Ampa Receptor ◽

Social Preference ◽

Autism Spectrum ◽

Receptor Trafficking ◽

Anterior Cingulate ◽

The Impact ◽

Ampa Receptor Trafficking

AbstractIQSEC2 is an X-linked gene that is associated with autism spectrum disorder (ASD), intellectual disability, and epilepsy. IQSEC2 is a postsynaptic density protein, localized on excitatory synapses as part of the NMDA receptor complex and is suggested to play a role in AMPA receptor trafficking and mediation of long-term depression. Here, we present brain-wide structural volumetric and functional connectivity characterization in a novel mouse model with a missense mutation in the IQ domain of IQSEC2 (A350V). Using high-resolution structural and functional MRI, we show that animals with the A350V mutation display increased whole-brain volume which was further found to be specific to the cerebral cortex and hippocampus. Moreover, using a data-driven approach we identify putative alterations in structure–function relations of the frontal, auditory, and visual networks in A350V mice. Examination of these alterations revealed an increase in functional connectivity between the anterior cingulate cortex and the dorsomedial striatum. We also show that corticostriatal functional connectivity is correlated with individual variability in social behavior only in A350V mice, as assessed using the three-chamber social preference test. Our results at the systems-level bridge the impact of previously reported changes in AMPA receptor trafficking to network-level disruption and impaired social behavior. Further, the A350V mouse model recapitulates similarly reported brain-wide changes in other ASD mouse models, with substantially different cellular-level pathologies that nonetheless result in similar brain-wide alterations, suggesting that novel therapeutic approaches in ASD that result in systems-level rescue will be relevant to IQSEC2 mutations.

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