Clinicopathologic Review of 31 Cases of Solid Pseudopapillary Pancreatic Tumors: Can We Use the Scoring System of Microscopic Features for Suggesting Clinically Malignant Potential?

2016 ◽  
Vol 82 (4) ◽  
pp. 308-313 ◽  
Author(s):  
Jang-hee Kim ◽  
Jae-myeong Lee
Keyword(s):  
Soft Tissue ◽  
Perineural Invasion ◽  
Pancreatic Neoplasm ◽  
Malignant Potential ◽  
Pancreatic Tumors ◽  
Solid Pseudopapillary Tumor ◽  
Nuclear Pleomorphism ◽  
Pathologic Features ◽  
Microscopic Features ◽  
Potentially Malignant

A solid pseudopapillary tumor (SPT) is a pancreatic neoplasm of low malignant potential. The potentially malignant pathologic features of SPTs were regarded as angioinvasion, perineural invasion, deep invasion of the surrounding acinar tissue, and nuclear pleomorphism. We retrospectively reviewed 31 cases of SPTs (25 female and 6 male patients, with an average age of 35 ± 14 years). The mean follow-up period was 132.0 ± 55.9 months. To evaluate the clinical impact of above pathological parameters, we analyzed their correlation with actually observed clinical malignancy. In three cases, the SPTs were clearly clinically malignant: one patient had recurrences three times, one showed lymph node metastases, and one deep soft tissue invasion around the gastroduodenal artery. Tumor infiltration to the peripancreatic soft tissue was observed in 17 cases (54.8%). The pathologic features considered suggestive of malignant potential were angioinvasion (25.8%), perineural invasion (6.5%), presence of mitosis in 10 high-power fields (16.1%), and moderate nuclear pleomorphism (19.4%). The presence of at least three of these features was not correlated with clinically confirmed malignant behavior ( P = 0.570). Microscopic pathologic features of SPTs cannot be reliably associated with aggressive clinical behavior. Moreover, the absence of these microscopic features cannot exclude clinical malignancy.

scholarly journals Solid Pseudopapillary Tumor of Pancreas: A Case Report

2013 ◽  
Vol 3 (1) ◽  
pp. 54-58
Author(s):  
Md. Mamunur Rashid ◽  
Hashim Rabbi ◽  
Azharul Islam ◽  
Muhd. Mustaque Hussain ◽  
Md. Mohsin Kabir ◽  
...  
Keyword(s):  
Frozen Section ◽  
Radical Resection ◽  
Young Female ◽  
Malignant Potential ◽  
Pancreatic Tumors ◽  
Solid Pseudopapillary Tumor ◽  
Term Survival ◽  
High Index Of Suspicion ◽  
Quality Imaging

Solid pseudopapillary tumor of pancreas is a rare tumor almost exclusively affecting the young female and accounts for <1% of all pancreatic tumors. Most hypothesis suggests that the tumor arises from embryonic pleuripotent stem cells. Although mostly benign in nature, the tumor may show malignant potentials and the patient may present with hepatic, omental or other meatstasis. High index of suspicion is the key for early dianosis. Good quality imaging (USG and CT scan) & FNAC are necessary for proper evaluation of the lesion. Peroperative frozen section biopsy may be necessary to ascertain its malignant potential. Radical resection is the best modality of treatment for achieving curative results and a better long-term survival. We are reporting our experience of treating a case of solid pseudopapillary tumor of pancreas in BIRDEM Hospital. Birdem Med J 2013; 3(1): 54-58 DOI: http://dx.doi.org/10.3329/birdem.v3i1.17129

scholarly journals Rare pancreatic neoplasm: MDCT and MRI features of a typical Solid Pseudopapillary Tumor

2012 ◽  
Vol 6 (1) ◽  
Author(s):  
Stefano Palmucci ◽  
Alessandra Uccello ◽  
Giorgia Leone ◽  
Giovanni Failla ◽  
Giovanni Carlo Ettorre
Keyword(s):  
Pancreatic Neoplasm ◽  
Solid Pseudopapillary Tumor ◽  
Mri Features

scholarly journals Adult Testicular Granulosa Cell Tumor: A Review of the Literature for Clinicopathologic Predictors of Malignancy

2011 ◽  
Vol 135 (1) ◽  
pp. 143-146 ◽  
Author(s):  
Joshua Anspach Hanson ◽  
Abiy B. Ambaye
Keyword(s):  
Granulosa Cell ◽  
Case Reports ◽  
Granulosa Cell Tumor ◽  
Malignant Potential ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Stromal Tumors ◽  
Granulosa Cell Tumors ◽  
Pathologic Features ◽  
Sex Cord Stromal Tumors

Abstract Adult testicular granulosa cell tumors are rare sex cord–stromal tumors of which only 28 have been previously reported. As compared with their ovarian counterparts, these tumors may follow a more aggressive course because the proportion of malignant cases is higher. To date, there are no clinical or pathologic features that definitively predict malignancy. We reviewed all prior case reports for features that may predict their malignant potential. Tumor size greater than 5.0 cm is the only feature statistically associated with malignancy. Mitotic count, tumor necrosis, patient age, and the presence of gynecomastia do not, at present, predict benign versus malignant behavior.

scholarly journals Soft tissue giant cell tumor of low malignant potential of the neck: a case report and review of the literature

2014 ◽  
Vol 30 (1) ◽  
pp. 73 ◽  
Author(s):  
Aylin Orgen Calli ◽  
Mine Tunakan ◽  
Huseyin Katilmis ◽  
Sevil Kilciksiz ◽  
Sedat Ozturkcan
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Potential ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Low Malignant Potential

Malignant potential in pancreatic neoplasm; new insights provided by circulating miR-223 in plasma

2015 ◽  
Vol 15 (6) ◽  
pp. 773-785 ◽  
Author(s):  
Shuhei Komatsu ◽  
Daisuke Ichikawa ◽  
Mahito Miyamae ◽  
Tsutomu Kawaguchi ◽  
Ryo Morimura ◽  
...  
Keyword(s):  
Pancreatic Neoplasm ◽  
Malignant Potential

Retroperitoneal Mixed-Type Liposarcoma Showing Features of Four Different Subtypes

2008 ◽  
Vol 74 (12) ◽  
pp. 1202-1205 ◽  
Author(s):  
Akihiro Hosaka ◽  
Yukiyoshi Masaki ◽  
Kazuki Yamasaki ◽  
Fumio Aoki ◽  
Katsuyoshi Sugizaki ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Signal Intensity ◽  
Mixed Type ◽  
Soft Tissue Tumor ◽  
Retroperitoneal Mass ◽  
Pathologic Examination ◽  
Tissue Tumor ◽  
Pathologic Features ◽  
Preoperative Ct ◽  
Ct And Mri

Mixed-type liposarcoma is a rare soft tissue tumor. This report describes a 50-year-old man with retroperitoneal mixed-type liposarcoma that consisted of four pathologically different components. Preoperative CT and MRI showed a giant retroperitoneal mass composed of several nodules with various attenuation and signal intensity. At laparotomy, the tumor appeared to be composed of four components. Pathologic examination revealed that each component was of a histologically different subtype. Mixed-type liposarcoma containing four different subtypes is extremely rare. Its clinical and pathologic features are briefly reviewed.

scholarly journals The PTEN Tumor Suppressor Gene in Soft Tissue Sarcoma

Cancers ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1169 ◽  
Author(s):  
Sioletic Stefano ◽  
Scambia Giovanni
Keyword(s):  
Soft Tissue ◽  
Tumor Suppressor ◽  
Soft Tissue Sarcoma ◽  
Biological Significance ◽  
Treatment Strategies ◽  
Predictive Biomarkers ◽  
Suppressor Gene ◽  
Oncogenic Signaling ◽  
Tensin Homolog ◽  
Pathologic Features

Soft tissue sarcoma (STS) is a rare malignancy of mesenchymal origin classified into more than 50 different subtypes with distinct clinical and pathologic features. Despite the poor prognosis in the majority of patients, only modest improvements in treatment strategies have been achieved, largely due to the rarity and heterogeneity of these tumors. Therefore, the discovery of new prognostic and predictive biomarkers, together with new therapeutic targets, is of enormous interest. Phosphatase and tensin homolog (PTEN) is a well-known tumor suppressor that commonly loses its function via mutation, deletion, transcriptional silencing, or protein instability, and is frequently downregulated in distinct sarcoma subtypes. The loss of PTEN function has consequent alterations in important pathways implicated in cell proliferation, survival, migration, and genomic stability. PTEN can also interact with other tumor suppressors and oncogenic signaling pathways that have important implications for the pathogenesis in certain STSs. The aim of the present review is to summarize the biological significance of PTEN in STS and its potential role in the development of new therapeutic strategies.

Peripheral primitive neuroectodermal tumors in adults: documentation by molecular analysis.

1998 ◽  
Vol 16 (3) ◽  
pp. 1150-1157 ◽  
Author(s):  
E R Lawlor ◽  
J A Mathers ◽  
T Bainbridge ◽  
D E Horsman ◽  
A Kawai ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Molecular Analysis ◽  
Fusion Gene ◽  
Molecular Diagnostic ◽  
Gene Fusions ◽  
Primitive Neuroectodermal Tumors ◽  
Pathologic Features ◽  
Neuroectodermal Tumors ◽  
Objective Evidence ◽  
Peripheral Primitive Neuroectodermal Tumors

PURPOSE The Ewing tumor (ET) family of peripheral primitive neuroectodermal tumors (pPNETs) are primitive small round-cell tumors (SRCTs) of the bone and soft tissue that occur predominantly in children and adolescents. However, pPNETs only rarely enter the differential diagnosis of bone and soft tissue SRCTs in adults. Recently, gene fusions between the EWS gene and different members of the ETS transcription factor family have been shown to occur in virtually all pPNETs and thus constitute a pathognomonic marker for this tumor subclass. The aim of the present study was to document EWS/ETS fusion gene expression in suspected pPNETs of adults as objective evidence for the existence of this tumor family in older patients. PATIENTS AND METHODS The three contributing molecular diagnostic laboratories retrospectively compiled a cohort of all SRCT cases in which EWS/ETS gene fusions had been shown by molecular analysis. This cohort was surveyed for cases that occurred in patients aged 40 years or older, which were then analyzed for their clinical and pathologic features. RESULTS Nine patients between 40 and 65 years of age were found to have tumors positive for EWS/ETS gene fusions. Standard histopathologic and clinical features of these cases, other than age, were similar to those of childhood pPNETs. Patients were initiated on appropriate therapy after molecular analysis confirmed the diagnosis of pPNET. CONCLUSION Identification of an EWS/ETS gene fusion is useful in providing objective evidence of the diagnosis of pPNET in patients over the age of 40 years. This diagnosis should be considered in adults who present with bone and soft tissue SRCTs and appropriate biopsy specimens should be collected for molecular analysis at the time of diagnosis.

scholarly journals Small Subcutaneous Soft Tissue Tumors (<5 cm) Can Be Sarcomas and Contrast-Enhanced Ultrasound (CEUS) Is Useful to Identify Potentially Malignant Masses

2020 ◽  
Vol 17 (23) ◽  
pp. 8868
Author(s):  
Armanda De Marchi ◽  
Simona Pozza ◽  
Lorena Charrier ◽  
Filadelfo Cannone ◽  
Franco Cavallo ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Malignant Tumors ◽  
Univariate Analysis ◽  
Soft Tissue Tumors ◽  
Deep Fascia ◽  
Contrast Enhanced Ultrasound ◽  
Predictive Values ◽  
Contrast Enhanced ◽  
Potentially Malignant ◽  
Sensitivity Specificity

Subcutaneous masses smaller than 5 cm can be malignant, in contrast with the international guidelines. Ultrasound (US) and magnetic resonance imaging (MRI) are useful to distinguish a potentially malignant mass from the numerous benign soft tissue (ST) lesions. Contrast-enhanced ultrasound (CEUS) was applied in ST tumors, without distinguishing the subcutaneous from the deep lesions. We evaluated CEUS and MRI accuracy in comparison to histology in differentiating malignant from nonmalignant superficial ST masses, 50% smaller than 5 cm. Sensitivity, specificity, and positive and negative predictive values (PPV, NPV) with their 95% confidence intervals (CI) were calculated. Of malignant cases, 44.4% measured ≤5 cm. At univariate analysis, no statistically significant differences emerged between benign and malignant tumors in relation with clinical characteristics, except for relationship with the deep fascia (p = 0.048). MRI accuracy: sensitivity 52.8% (CI 37.0, 68.0), specificity 74.1% (CI 55.3, 86.8), PPV 73.1% (CI 53.9, 86.3), and NPV 54.1% (CI 38.4, 69.0). CEUS accuracy: sensitivity 75% (CI 58.9, 86.3), specificity 37% (CI 21.5, 55.8), PPV 61.4% (CI 46.6, 74.3), and NPV 52.6% (CI 31.7, 72.7). CEUS showed a sensitivity higher than MRI, whereas PPV and NPV were comparable. Also, masses measuring less than 5 cm can be malignant and referral criteria for centralization could be revised.

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