Validation of the 6-Month GRACE Score in Predicting 1-Year Mortality of Patients With Acute Coronary Syndrome Admitted to the Arabian Gulf Hospitals

Angiology ◽  
2016 ◽  
Vol 68 (3) ◽  
pp. 251-256 ◽  
Author(s):  
Lukman Thalib ◽  
Luis Furuya-Kanamori ◽  
Khalid F. AlHabib ◽  
Hussam F. Alfaleh ◽  
Mostafa Q. AlShamiri ◽  
...  
Keyword(s):  
United Arab Emirates ◽  
Risk Score ◽  
Goodness Of Fit ◽  
Arabian Gulf ◽  
Significant Risk ◽  
P Value ◽  
Coronary Syndrome ◽  
Grace Risk Score ◽  
Risk Of Mortality ◽  
Coronary Events

Acute coronary syndromes (ACS) are the most common cardiovascular diseases and are associated with a significant risk of mortality and morbidity. The Global Registry of Acute Coronary Events (GRACE) risk score postdischarge is a widely used ACS prediction model for risk of mortality (low, intermediate, and high); however, it has not yet been validated in patients from the Arabian Gulf. This prospective multicenter study (second Gulf Registry of Acute Coronary Events) provides detailed information of the GRACE risk score postdischarge in patients from the Arabian Gulf. Its prognostic utility was validated at 1-year follow-up in over 5000 patients with ACS from 65 hospitals in 6 Arabian Gulf countries (Bahrain, Saudi Arabia, Qatar, Oman, United Arab Emirates, and Yemen). Overall, the goodness of fit (Hosmer and Lemeshow statistic P value = .826), calibration, and discrimination (area under the receiver operating characteristic curve = 0.695; 95% confidence interval: 0.668-0.722) were good. The GRACE risk score postdischarge can be used to stratify 1 year mortality risk in the Arabian Gulf population; it does not require further calibration and has a good discriminatory ability.

scholarly journals Indications for an early invasive strategy in NSTE-ACS patients

2019 ◽  
Vol 28 (3) ◽  
pp. 131-135 ◽  
Author(s):  
B. Zwart ◽  
J. M. ten Berg ◽  
A. W. van ’t Hof ◽  
P. A. L. Tonino ◽  
Y. Appelman ◽  
...  
Keyword(s):  
High Risk ◽  
Coronary Angiography ◽  
Risk Score ◽  
Invasive Strategy ◽  
Coronary Syndrome ◽  
Grace Risk Score ◽  
Risk Patients ◽  
Coronary Events ◽  
Early Invasive Strategy ◽  
European Society Of Cardiology

Abstract An early invasive strategy in patients who have acute coronary syndrome without ST-elevation (NSTE-ACS) can improve clinical outcome in high-risk subgroups. According to the current guidelines of the European Society of Cardiology (ESC), the majority of NSTE-ACS patients are classified as “high-risk”. We propose to prioritise patients with a global registry of acute coronary events (GRACE) risk score >140 over patients with isolated troponin rise or electrocardiographic changes and a GRACE risk score <140. We also acknowledge that same-day transfer for all patients at a high risk is not necessary in the Netherlands since the majority of Dutch cardiology departments are equipped with a catheterisation laboratory where diagnostic coronary angiography is routinely performed in NSTE-ACS patients. Therefore, same-day transfer should be restricted to true high-risk patients (in addition to those NSTE-ACS patients with very high-risk (VHR) criteria) in centres without coronary angiography capabilities.

scholarly journals The value of the Global Registry of Acute Coronary Events and Gensini scores in predicting long-term outcomes in Vietnamese patients with non-ST-elevation acute coronary syndrome

2021 ◽  
Vol 8 (2) ◽  
pp. 4233-4240
Author(s):  
Sy Van Hoang ◽  
Kha Minh Nguyen ◽  
An Hoang Nguyen ◽  
Khoa Le Anh Huynh ◽  
Hai Phuong Nguyen Tran
Keyword(s):  
Risk Score ◽  
Gensini Score ◽  
Long Term Outcomes ◽  
Coronary Syndrome ◽  
Grace Risk Score ◽  
St Elevation ◽  
Coronary Events ◽  
Artery Disease ◽  
Grace Score

Introduction: Patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) should undergo risk stratification as soon as possible after their presentation. Early risk satisfaction provides good prognosis for patients as well as better decision for reperfusion therapy. The aim of this study is to find a correlation between the Global Registry of Acute Coronary Events (GRACE) risk score and severity of coronay artery disease assessed by Gensini score score and compare the value of GRACE and Gensini scores in predicting the long-term outcomes in patients with NSTE-ACS. Methods: A total of 220 patients with NSTE-ACS who underwent coronary angiography were enrolled in our study. The Gensini score was used to assess the severity of coronary artery disease. According to the GRACE score, the patients were grouped into low, intermediate and high groups. After 30 months of follow-up, 20 patients died. Results: The mean Gensini scores were 11.8 ± 11.5, 27.4 ± 30.9, and 42.9 ± 29.7 in the low, intermediate and high-risk groups, respectively. The GRACE scores and Gensini score had a moderate positive correlation (rho = 0.522, p < 0.001). The survival rates showed a less rapid deterioration from the low to high GRACE groups (P = 0.013) than when classified according to their Gensini tertiles (P = 0.02). Area under the ROC curve was statistically significant for both scores, but area of the GRACE risk score (0.71; 95% Cl = 0.60 - 0.82) was higher than that the Gensini risk score (0.66; 95% Cl = 0.53 – 0.80). Conclusion: Our study revealed that the Gensini score had a positive and significant relationship with the GRACE score in patients with NSTE-ACS. The GRACE score had a more value in predicting long-term outcomes in patients with NSTE-ACS.

scholarly journals Difference in the Mortality Between Weekend and Non-Weekend Coronary Artery Disease Admissions

2017 ◽  
Vol 02 (01) ◽  
pp. 036-041
Author(s):  
M. Sandeep ◽  
K. Satish
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Mortality Rate ◽  
Hospital Mortality ◽  
Risk Score ◽  
Wide Spectrum ◽  
P Value ◽  
Coronary Artery Diseases ◽  
Coronary Syndrome ◽  
Artery Disease

AbstractBackground: Acute coronary syndrome requires urgent diagnostic and therapeutic procedures, which may not be uniformly available throughout the week. So, we sought to examine the effects of admission on clinical outcomes in patients with wide spectrum coronary artery diseases.Methods: A retrospective analysis of ICCU Inpatient sample database of 17 months from 2015 to 2016 used to compare differences in in-hospital mortality between patients admitted on a non-weekday versus weekend for wide spectrum ACS which include STEMI, NSTEMI and unstable angina and patients with cardiogenic shock. Out of these 75% had higher TIMI risk score (5-7).Results: Total 2700 patients with ACS were included in the present study with wide spectrum coronary artery diseases. Out of that 20 % (n=541) were admitted in weekends and 79.9% (n=2159) were admitted in non-weekends. Total 804 females admitted on non-weekend had a mean age of 61.05±12 years and 162 females admitted on weekend had mean age 58.5±13.3 years (p value=0.025). Out of 2159 admitted on non-weekend, 1355 were males with mean age of 57.65±15.55 years and 379 were males admitted on weekend out of 541 patients with mean age of 56.85±13.1 years (p value =0.314). In-hospital mortality rate of these patients admitted on non-weekends was 9.4% (n=204) and those admitted on weekends was 5.9% (n=32) with statistically significant difference (95% CI; p= 0.003). The mortality rate of ACS without STEMI in non-weekend group was 8.6% (n=170) which was statistically significant (p = 0.006) with mortality of weekend group 5.3% (n=26).Conclusion: Our study shows that there is no added mortality in patients with coronary artery disease on weekend days compared with non-weekend days. As the patients admitted during non-weekend were elder and sicker than the weekend admissions (having the high risk score), the in-hospital mortality is higher on non-weekends. Efforts to improve health care system should ensure comparable outcomes for patients irrespective of time of hospital admission.

GRACE Risk Score Predicts Contrast-Induced Nephropathy in Patients With Acute Coronary Syndrome and Normal Renal Function

Angiology ◽  
2012 ◽  
Vol 64 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Sergio Raposeiras-Roubín ◽  
Pablo Aguiar-Souto ◽  
Cristina Barreiro-Pardal ◽  
Diego López Otero ◽  
Juliana Elices Teja ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Renal Function ◽  
Risk Score ◽  
Normal Renal Function ◽  
Contrast Induced Nephropathy ◽  
Coronary Syndrome ◽  
Grace Risk Score
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