Pulse Wave Velocity: Retrospective Analysis in a Balkan Normotensive and Hypertensive Population: A Study of 9923 Patients

Angiology ◽  
2017 ◽  
Vol 69 (1) ◽  
pp. 59-64
Author(s):  
Dragan Lovic ◽  
Manolis S. Kallistratos ◽  
Leonidas Poulimenos ◽  
Aggelos Skyrlas ◽  
V. Stojanov ◽  
...  

We compared pulse wave velocity (PWV) between hypertensive patients and control patients to identify demographics and patient characteristics related to PWV. We retrospectively analyzed 9923 participants (3105 controls and 6818 hypertensive patients) from 5 outpatient hypertensive clinics (in Serbia and Greece). Pulse wave velocity had different distribution between controls and hypertensive patients ( P < .001). The magnitude of PWV increase was related to blood pressure (BP) category (from optimal to stage III hypertension; P < .001). Even in hypertensive patients with systolic BP (SBP) <140 and/or diastolic BP (DBP) <90 mm Hg, PWV was greater than in control patients ( P < .001). Pulse wave velocity was associated with almost all baseline characteristics of hypertensive patients (body mass index [BMI], gender, age, SBP, DBP, smoking status, and heart rate; P < .001). This association remained after adjustment of PWV confounders. There were 2231 (32.7%) hypertensive patients who had reached SBP <140 mm Hg and DBP <90 mm Hg. Pulse wave velocity was increased in hypertensive patients, and the degree of PWV increase was associated with baseline BP as well as with anthropometric parameters (eg, BMI, gender, age, heart rate, and smoking status).

2020 ◽  
Vol 33 (12) ◽  
pp. 1146-1146
Author(s):  
Ling-yu Zhang ◽  
Li Luo ◽  
Yi-hua Shen ◽  
Guo-yan Xu ◽  
Liang-di Xie

Abstract Background To investigate the relationship between resting heart rate and carotid–femoral pulse wave velocity (cfPWV) in patients with prehypertension. Methods A total of 288 outpatients with prehypertension and 326 normotensive outpatients from the First Affiliated Hospital of Fujian Medical University were enrolled between March 2017 and March 2019. Body weight, resting heart rate, and blood pressure of all patients were recorded. Blood biochemical indexes and cfPWV were determined. Results Compared with the normotensive controls, cfPWV in the prehypertension group was significantly higher (P &lt; 0.01). There was an increase in cfPWV with advancing age in both prehypertension and control groups, and cfPWV in males was higher than females. In the prehypertension group, after stratified with age and gender, partial correlation analysis showed that resting heart rate was positively correlated with cfPWV (r = 0.230, P &lt; 0.01). After adjusted for other cardiovascular risk factors, multivariable stepwise regression analysis indicated that resting heart rate, age, and gender were independently associated with cfPWV in the prehypertension group (all P &lt; 0.01). Moreover, resting heart rate was independently associated with cfPWV in the patients with prehypertension aged ≥60 years in both males and females (all P &lt; 0.01). However, in patients with prehypertension aged &lt;60 years, no significant correlation was observed between resting heart rate and cfPWV. Conclusions In the elderly with prehypertension, resting heart rate is independently associated with cfPWV.


Author(s):  
Adriana Camargo Oliveira ◽  
Weimar Kunz Sebba Barroso ◽  
Priscila Valverde de Oliveira Vitorino ◽  
Ana Luiza Lima Sousa ◽  
Rayne Ramos Fagundes ◽  
...  

2007 ◽  
Vol 25 (6) ◽  
pp. 1279-1283 ◽  
Author(s):  
Sungha Park ◽  
Jin-Bae Kim ◽  
Chi Young Shim ◽  
Young-Guk Ko ◽  
Donghoon Choi ◽  
...  

2021 ◽  
Vol 39 (Supplement 1) ◽  
pp. e114-e115
Author(s):  
João Marcos De M Zanatta ◽  
Fábio Dos S Ricardi ◽  
Tatiana De A Rubio ◽  
Elizabeth E S Cestário ◽  
Luciana N Cosenso-Martin ◽  
...  

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Julia Wetzel ◽  
Nicolas Verheyen ◽  
Evgeny Belyavskiy ◽  
Albrecht Schmidt ◽  
Caterina Colantonio ◽  
...  

Introduction: Accumulating evidence indicated that high parathyroid hormone (PTH) is associated with increased cardiovascular risk. The impact of PTH on vascular structure and function is, however, still unclear. We evaluated the relationship between pulse wave velocity (PWV) as a novel index of arterial stiffness and circulating levels of PTH in patients with PTH-excess (primary hyperparathyroidism (pHPT)). Methods and Results: We analyzed baseline data of the ongoing randomized, double-blind, placebo-controlled “Effect of Eplerenone on Parathyroid Hormone Levels in Patients with Primary Hyperparathyroidism” (EPATH) study. Inclusion criteria were age of at least 18 years and a diagnosis of pHPT according to international guidelines. Standardized blood sampling was performed after an overnight fast and 24h PWV was measured by a validated non-invasive device for ambulatory hemodynamic monitoring (Mobil O Graph, I.E.M., Stolberg, Germany). Our analysis comprised 92 pHPT patients with a mean age of 68.5 +/- 9.7 years (71 % females) and a median PTH of 102 (IQR 81 - 132) pg/ml. Mean 24h PWV was 9.8 +/- 1.8 m/s, mean daytime and mean nighttime PWV were 10.0 +/- 1.7 m/s and 9.6 +/- 1.8 m/s, respectively. In multivariate linear regression analyses adjusted for age, sex, body mass index, smoking status, mean systolic and mean diastolic 24h blood pressure, antihypertensive medication, type 2 diabetes, 25-hydroxyvitamin D, serum calcium, intake of cinacalcet and fasting serum cholesterol PTH emerged as a strong predictor of mean 24h PWV (ß=0.30, p=0.012), daytime PWV and nighttime PWV (ß=0.30, p=0.011 and ß=0.30, p=0.019, respectively). Conclusion: In a selective cohort of patients with pHPT plasma PTH was strongly related to 24h PWV. These data strengthen the notion that PTH may impact on vascular function. Interventional and mechanistic trials are needed to evaluate modulatory effects on vasculature in patients with high PTH.


1975 ◽  
Vol 228 (1) ◽  
pp. 238-243 ◽  
Author(s):  
PG Katona ◽  
KS Tan

Changes in pulse-wave velocity were simulated by changing the relative timing between aortic and carotid sinus barorecptor activity in anesthetized rabbits and dogs. In the rabbit, electrical stimulation was used to vary the timing; in the dog, it was also varied by perfusing the carotid sinuses with externally generated pressure pulses that could be triggered in any portion of the cardiac cycle. Changing the relative delay between aortic and carotid sinsus nerve stimulation did not result in variations of blood pressure or heart rate in the rabbit. Varing the time of electrical stimulation of the carotid sinus nerve caused at most 5 mmHg change of blood pressure in the dog. Delay-related heart-rate changes could be usually observed only when the stimulus consisted of short, high-intensity bursts. When the carotid sinus was externally perfused with pulses of pressure, only one out of five dogs showed delay-related variations in blood pressure (3mmHg) and heart rate (6 beats/min). It is concluded that variations in pulse-wave velocity are unlikely to play a significant role in acute cardiovascular control.


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