INCREASED FIBRINOLYTIC ACTIVITY AND FIBRIN DEGRADATION PRODUCTS AFTER EXPERIMENTAL INTRACEREBRAL HAEMORRAGE

1972 ◽  
Vol 48 (4) ◽  
pp. 403-415 ◽  
Author(s):  
Davut Tovi ◽  
Inga Marie Nilsson
Keyword(s):  
Fibrinolytic Activity ◽  
Degradation Products ◽  
Fibrin Degradation Products

Effects of exercise and conditioning on clotting and fibrinolytic activity in men

1987 ◽  
Vol 62 (4) ◽  
pp. 1416-1421 ◽  
Author(s):  
E. W. Ferguson ◽  
L. L. Bernier ◽  
G. R. Banta ◽  
J. Yu-Yahiro ◽  
E. B. Schoomaker
Keyword(s):  
Fibrinolytic Activity ◽  
Blood Clotting ◽  
Degradation Products ◽  
Clot Lysis ◽  
Plasma Clot ◽  
Fitness Program ◽  
Fibrin Degradation Products ◽  
Before And After ◽  
Plasmin Inhibitor ◽  
Sedentary Subjects

Sixty healthy men in three physical fitness categories (sedentary, on no organized fitness program; joggers, running 5–15 miles/wk; and marathoners, running greater than 50 miles/wk) were evaluated for changes in blood clotting and fibrinolytic activity before and after maximum exercise on a treadmill according to the Bruce protocol. The rate of blood clotting, as measured by prothrombin times, partial thromboplastin times and thrombin times, was accelerated by exercise (all P less than 0.005). The ability of euglobulin clots and plasma clots to lyse incorporated 125I-fibrin, termed 125I-euglobulin clot lysis (IEL) and 125I-plasma clot lysis (IPCL), were used as indexes of fibrinolytic activity. Marathoners had greater increases in fibrinolytic activity with exercise (76% compared with 63% for joggers and 55% for sedentary subjects by IEL; 427% compared with 418% for joggers and 309% for sedentary subjects by IPCL; all P less than 0.05). Fibrin degradation products increased with exercise (P less than 0.005 for the total group of 60 subjects). The absolute concentrations of alpha 2-plasmin inhibitor, alpha 2-macroglobulin, and antithrombin III increased with exercise (all P less than 0.005), but when concentrations were corrected for acute shifts of plasma water during exercise, the quantity of these inhibitors actually decreased (all P less than 0.005). The changes in clotting assays with exercise were not significantly correlated with changes in whole blood lactate, blood pyruvate, or rectal temperatures. Fibrinolytic assays before and after exercise correlated poorly to moderately with blood lactates (IEL: r = 0.441 and r = 0.425, respectively; IPCL: r = 0.294 and r = 0.544, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Fibrinolytic Activity in Patients with Acute Tonsillitis

1979 ◽  
Vol 88 (3) ◽  
pp. 366-367 ◽  
Author(s):  
T. Kosugi ◽  
O. Matsuo ◽  
M. Hamaya ◽  
H. Mihara
Keyword(s):  
Fibrinolytic Activity ◽  
Degradation Products ◽  
Healthy Adults ◽  
Fibrinolytic System ◽  
Acute Tonsillitis ◽  
Fibrin Degradation Products ◽  
Fibrinogen Content

Three parameters in blood fibrinolysis, viz, the levels of fibrinogen, plasminogen, and fibrinogen and/or fibrin degradation products (FDP), were measured in patients with acute tonsillitis and the results were compared with those for healthy adults. The fibrinogen content in acute tonsillitis increased significantly ( P <.001), that of plasminogen decreased significantly ( P <.005), while FDP showed a higher value ( P <.01). The significance of the fibrinolytic system in acute tonsillitis is discussed.

The Resistance of Soluble Derivatives of Fibrinogen and the Sensitivity of Its Insoluble Forms to Fibrinolytic Degradation in Blood

1974 ◽  
Vol 32 (02/03) ◽  
pp. 582-591 ◽  
Author(s):  
Victor Gurewich ◽  
Andrzej Nowak ◽  
Izabella Lipinska ◽  
Boguslaw Lipinski
Keyword(s):  
Fibrinolytic Activity ◽  
Degradation Products ◽  
Venous Occlusion ◽  
Protamine Sulfate ◽  
Electrophoretic Method ◽  
Soluble Fibrin ◽  
Fibrin Degradation Products ◽  
Fibrin Monomer ◽  
Derivatives Of

SummaryThe effect of naturally induced fibrinolytic activity on fibrinogen and certain soluble and insoluble derivatives was studied. Experiments were performed on blood removed after venous occlusion of the arm and immediately after death. A previously described electrophoretic method was used by which the heterogeneity of fibrinogen can be demonstrated directly in intact plasma. It was shown that fibrinogen, soluble fibrin monomer (FM) complexes and fibrin degradation products are resistant to degradation by naturally-induced fibrinolytic activity. By contrast, rapid lysis of fibrin, protamine sulfate (PS) precipitated fibrinogen, and PS and ethanol induced gels of FM occurred. The observations are believed relevant to our understanding of the pathway of fibrinogen and FM catabolism and the interpretation of the origin of serum FDP.

Sustained Fibrinolysis After Administration of t-PA Despite Its Short Half-Life in the Circulation

1987 ◽  
Vol 57 (01) ◽  
pp. 035-040 ◽  
Author(s):  
Paul R Eisenberg ◽  
Laurence A Sherman ◽  
Alan J Tiefenbrunn ◽  
Philip A Ludbrook ◽  
Burton E Sobel ◽  
...  
Keyword(s):  
Half Life ◽  
Fibrinolytic Activity ◽  
Degradation Products ◽  
Clinical Success ◽  
Tissue Type ◽  
Tissue Type Plasminogen Activator ◽  
Fibrin Degradation Products ◽  
Short Half Life ◽  
Type Plasminogen Activator ◽  
The Difference

SummaryTo characterize the duration of the fibrinolytic response to tissue-type plasminogen activator (t-PA) and streptokinase (SK) in patients with acute myocardial infarction we serially assayed crosslinked fibrin degradation products (XL-FDP) and Bβ15-42 fibrinopeptide. Use of specific monoclonal antibodies permitted quantification and differentiation of fibrin from fibrinogen degradation products. Marked elevations of XL-FDP occurred within 1 hour after administration of t-PA (n = 13) or SK (n = 35) to >1000 ng/ml in 79% of the patients. All patients given t-PA exhibited elevations of XL-FDP >1000 ng/ml, most exhibited values >5000 ng/ml (79% of patients). In contrast 6 of the patients given SK failed to exhibit XL-FDP >1000 ng/ml. XL-FDP >5000 ng/ml occurred in only 14%. The difference in the response to t-PA compared to SK was particularly striking 7 hours or more after administration of activator at which time XL-FDP were markedly elevated in patients given t-PA (5821 ± 1683 ng/ ml) compared with decreasing values in patients given SK (2924 ± 1186 ng/ml) (p <0.01). Levels of Bβ315-42 were significantly higher after t-PA compared with SK beginning 3 hours after treatment, consistent with a greater intensity of fibrinolytic response to t-PA. Marked elevations of this short lived degradation product of fibrin (t1/2 = 10-20 minutes) in the samples drawn late after administration of t-PA (44.3 ±12.8 nM) but not after SK (11.7 ± 4.5 nM) confirmed prolonged fibrinolytic activity of plasmin after t-PA. There was no discernible relationship between the extent of fibrinolysis as assessed by XL-FDP and Bβ 15-42 and the total dose of t-PA administered or the duration of the infusion. Elevations of XL-FDP invariably occurred after SK, and were not significantly different in patients with or without recanalization. Thus “clinical success” of coronary thrombolysis appears to depend on a favorable balance between thrombosis and fibrinolysis rather than the intensity of fibrinolysis alone. The prolonged fibrinolytic activity after t-PA appears to reflect the enhanced binding of this activator to fibrin and is likely to result in more sustained and hence more effective fibrinolysis with t-PA compared to SK despite the short half-life of t-PA (t1/2 = 6 minutes) in the circulation.

scholarly journals Fibrinogen, Fibrinogen Heterogeneity and Fibrinolytic Activity in Diabetes Mellitus

1977 ◽  
Author(s):  
Victor Gurewich ◽  
Izabella Lipinska ◽  
Maria Pulini ◽  
Edwin Gordon ◽  
Boguslaw Lipinski
Keyword(s):  
Diabetes Mellitus ◽  
Molecular Weight ◽  
Fibrinolytic Activity ◽  
Degradation Products ◽  
Microvascular Disease ◽  
Vascular Lesions ◽  
Mean Values ◽  
Fibrin Degradation Products ◽  
Degree Of Control ◽  
The Mean

Fibrinogen (F) concentration, fibrinogen heterogeneity on 3.5% Polyacrylamide gels, fibrinolytic activity (FA) measured by euglobulin fraction on fibrin plates and fibrin degradation products (FDP) were measured in 66 patients with well documented diabetes mellitus (DM) and in 50 healthy subjects of comparable age. A high molecular weight and 2 lower molecular weight (LMW and LMW1) fibrinogen fractions were identified. The mean values and statistical evaluation of their differences were as follows:The clinical duration of DM, degree of control or type of medication did not appear to influence these findings. However, within the patient group, those with clinical evidence of microvascular disease had significantly (p<0.02) higher LMW1 fibrinogen and lower FDP (p<0.01) than the remainder. These findings suggest that DM is associated with fibrin deposition, and accelerated F degradation to LMW and LMW1 fractions and that these processes may be associated with the development of vascular lesions.

scholarly journals Significance of Fibrinogen/Fibrin Degradation Products (FDP) after Cardiovascular Surgery

1977 ◽  
Author(s):  
R. Altman ◽  
A. Zielinsky ◽  
J. Rouvier ◽  
R.G. Favaloro
Keyword(s):  
Postoperative Period ◽  
Fibrinolytic Activity ◽  
Cardiovascular Surgery ◽  
Degradation Products ◽  
Diagnostic Value ◽  
Early Postoperative Period ◽  
High Concentration ◽  
Normal Value ◽  
Fibrin Degradation Products ◽  
Low Incidence

The frequent appearance of FDP during the postoperative of cardiovascular surgery using extracorporeal circulation, induced us to determine its diagnostic value. 17 patients were studied. Fibrinolytic activity was determinated using the staphylococcal clumping test (SCT) and the latex plasmmin-antiplasmin immunoassay (LPA). Normal value of LPA in plasma previously studied in 15 normal patients was negative to positive up to a dilution of 1/4. Normal value of SCT in our laboratory (in 200 normal patients studied) was less than lug/ml. All postoperative periods were normal and from 1 to 6 tests using both methods were performed. From 36 SCT readings, 27 were positive (in 13 patients) with a mean of 10.2ug/ml (range 1.2-96.8). Positive LPA was found in 5 readings in 4 patients. In only 2 cases the SCT detected high concentration of FDP together with strong positive LPA (dilutions 1/10 and 1/20). It is concluded that the frequent appearance of FDP during early postoperative period of cardiovascular surgery, because of the low incidence of positive LPA, does not necessarily indicate plasmatic fibrinolytic activity, as it is possible that this should appear as a result of absortion of extravascular resolution of fibrin related material.

The Measurement of Fibrinolysis in the Rat

1971 ◽  
Vol 26 (02) ◽  
pp. 295-310 ◽  
Author(s):  
M. J Gallimore ◽  
H. M Tyler ◽  
J. T. B Shaw
Keyword(s):  
Whole Blood ◽  
Fibrinolytic Activity ◽  
Factor Xiii ◽  
Degradation Products ◽  
Blood Clot ◽  
Clot Lysis ◽  
Plate Assay ◽  
Fibrin Degradation Products ◽  
Fibrin Plate ◽  
Dilute Blood

SummaryMethods are described for measuring fibrinolytic activity in the rat. These include dilute blood clot lysis, euglobulin clot lysis, a fibrin plate assay with euglobulin solutions, and an accelerated whole blood clot lysis technique in which limited fibrinolysis is induced with urokinase. In addition, methods have been worked out for the estimation of four plasma components closely involved in fibrinolysis: fibrinogen, factor XIII, plasma inhibitors and fibrin degradation products. The sensitivity and validity of the assays were tested by studying their capacity to detect changes resulting from the administration of eledoisin, Neohydrin and turpentine.

Experimental Model of Pulmonary Thrombosis in Rat

1974 ◽  
Vol 31 (01) ◽  
pp. 086-102 ◽  
Author(s):  
Munehiro Tomikawa ◽  
Hidemasa Ogawa ◽  
Yasushi Abiko
Keyword(s):  
Lactic Acid ◽  
Fibrinolytic Activity ◽  
Degradation Products ◽  
Morphological Changes ◽  
Progressive Increase ◽  
Acid Infusion ◽  
Pulmonary Thrombosis ◽  
Fibrin Degradation Products ◽  
Lysis Time ◽  
Initial Stage

SummaryExperimental pulmonary thrombosis was induced in rats by intravenous infusion of 0.7 M lactic acid at a rate of 1.4 ml/100 g/hr for 2 hr. As acidosis progressed, a hyper-coagulable state developed and microthrombi were formed predominantly in the lung, but not conspicuously in other organs. Pulmonary thrombi thus formed were composed of aggregated platelets in the initial stage, and of fibrin in later stages. They progressively dissolved and had completely disappeared 12 hr after cessation of the lactic acid infusion.During the infusion of lactic acid, the following changes were observed: progressive decreases in platelet count, fibrinogen, antiplasmin activity and fibrinolytic activity, and progressive increase in platelet adhesiveness. Plasma clotting time decreased to its shortest interval after one hour of the lactic acid infusion and remained at that level during the rest of the infusion. No fibrin degradation products (FDP) were detected.After cessation of the lactic acid infusion, these parameters, except for fibrinolytic activity, tended to return to normal gradually while FDP increased markedly. Fibrinolytic activity measured by eugolobulin lysis time remained low, suggesting depletion of vascular activator. Plasminogen level began to fall gradually 6 hr after cessation of the lactic acid infusion.These dynamic coagulo-fibrinolytic changes are discussed in relation to the morphological changes of thrombi.

Haemostasis in Normal Pregnancy

1984 ◽  
Vol 52 (02) ◽  
pp. 176-182 ◽  
Author(s):  
Yvonne Stirling ◽  
Linda Woolf ◽  
W R S North ◽  
M J Seghatchian ◽  
T W Meade
Keyword(s):  
Fibrinolytic Activity ◽  
Antithrombin Iii ◽  
Marked Decrease ◽  
Degradation Products ◽  
Coagulation Factors ◽  
Normal Pregnancy ◽  
Mild Degree ◽  
Fibrin Degradation Products ◽  
Α2 Macroglobulin ◽  
Wide Range

SummaryA study has been undertaken in 72 women to provide systematic information on the changes that occur in a wide range of haemostatic variables during and after pregnancy. Factors VII, VIII :C, VIIIR:Ag, X, fibrinogen and α1 antitrypsin, rose markedly throughout pregnancy. Factors II and V and α2 macroglobulin all rose early on but then decreased steadily. Antithrombin III: C and Ag fell slightly. There was a marked decrease in fibrinolytic activity from 11-15 weeks onwards. Levels of fibrin degradation products rose from 21-25 weeks onwards. The rise in coagulation factors that occurs could be due to increased synthesis or increased activation by thrombin, or to both. The findings are consistent with a mild degree of local intravascular coagulation from early on in pregnancy in some women.

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