Sudden Natural Death ‘At the Wheel’—Revisited

1987 ◽  
Vol 27 (2) ◽  
pp. 106-113 ◽  
Author(s):  
Arthur R. Copeland

A study of sudden natural death occurring in a motor vehicle was performed on the case files of the Office of the Medical Examiner of Metropolitan Dade County in Miami, Florida, during the years 1980–84. A total of 133 autopsied cases were collected and analysed as to the age, race, sex, cause of death, blood alcohol content, height, weight, heart weight, heart histology, severity of coronary artery disease, past medical history, medication, role of the occupant, time of occurrence, and scene circumstances. Essentially, the ‘natural death at the wheel’ of the 1980s involves an older (greater than age 55 years) white male who dies from atherosclerotic heart disease (occlusive coronary artery disease). He is most commonly sober at the time of the incident, which most frequently is the afternoon or evening. The deceased usually was the driver who either ‘veered off’ and crashed the vehicle into an object or was found ‘collapsed’ in the vehicle. ‘Veering off’ the road without a crash occurred less frequently. Most victims had a pre-existent medical condition but were without medication. At autopsy the heart weights (average 533.5 gm) were enlarged and severe coronary artery disease was present. A discussion ensues comparing these findings with other studies.

1987 ◽  
Vol 27 (4) ◽  
pp. 288-293 ◽  
Author(s):  
Arthur R. Copeland

A study of sudden natural death due to pulmonary thromboembolism was performed on the case files of the office of the Medical Examiner of Metropolitan Dade County in Miami, Florida; 150 cases which occurred during the five-year period 1982–6 were analysed. The average male victim was 63·4 years of age, 174·5 cm (68·7 in) in height, 78·0 kg (172 lb) in weight with a 475·5-gram (16·77 oz) heart, and with mild or moderate coronary artery disease. Racially, 42 per cent of the male victims were black and 58 per cent of them were white. The average female victim was 61·9 years of age, 162·3 cm (63·9 in) in height, 76·5 kg (168·7 lb) in weight with a 382·4-gram (13·49 oz) heart, and with mild or moderate coronary artery disease. Racially, the female group was approximately evenly divided between blaks and whites. In further analysis of the scene circumstances of the terminal event and the past medical history of the victim, approximately 21 per cent of the victims had had surgery or hospitalization within the 120 days preceeding demise. Only 4·7 per cent of the victims were taking anticoagulant medication at the time of their demise. A discussion ensues comparing these data to those from other studies and considering what role the forensic pathologist can have in future work on this phenomenon.


2011 ◽  
Vol 218 (1) ◽  
pp. 28-32 ◽  
Author(s):  
Antonio Oliva ◽  
Jose Flores ◽  
Sara Merigioli ◽  
Louis LeDuc ◽  
Begoña Benito ◽  
...  

Heart ◽  
2018 ◽  
Vol 105 (Suppl 1) ◽  
pp. s31-s37 ◽  
Author(s):  
Eddie D Davenport ◽  
Thomas Syburra ◽  
Gary Gray ◽  
Rienk Rienks ◽  
Dennis Bron ◽  
...  

This manuscript focuses on the broad aviation medicine considerations that are required to optimally manage aircrew with established coronary artery disease (CAD) without myocardial infarction (MI) or revascularisation (both pilots and non-pilot aviation professionals). It presents expert consensus opinion and associated recommendations and is part of a series of expert consensus documents covering all aspects of aviation cardiology.Aircrew may present with MI (both ST elevation MI (STEMI) and non-ST elevation MI (NSTEMI)) as the initial presenting symptom of obstructive CAD requiring revascularisation. Management of these individuals should be conducted according to published guidelines, ideally with consultation between the cardiologist, surgeon and aviation medical examiner. Return to restricted flight duties is possible in the majority of aircrew; however, they must have normal cardiac function, acceptable residual disease burden and no residual ischaemia. They must also be treated with aggressive cardiac risk factor modification. Aircrew should be restricted to dual pilot operations in non-high-performance aircraft, with return to flying no sooner than 6 months after the event. At minimum, annual follow-up with routine non-invasive cardiac evaluation is recommended.


2000 ◽  
Vol 139 (5) ◽  
pp. 0840-0847
Author(s):  
Ulrich R. Sigwart ◽  
Reginald L. Peniston ◽  
David Y. Lu ◽  
Vasilios Y. Papademetriou

2000 ◽  
Vol 139 (5) ◽  
pp. 840-847 ◽  
Author(s):  
Reginald L. Peniston ◽  
David Y. Lu ◽  
Vasilios Papademetriou ◽  
Ross D. Fletcher

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Fabio Tavora ◽  
Ling Li ◽  
Mary Ripple ◽  
David Fowler ◽  
Allen Burke

There are few pathologic descriptions of fatal coronary artery disease in the young. The morphologic characteristics of sudden coronary deaths in 47 hearts from patients younger than 40 years were studied. Numbers of plaques with necrotic cores were quantitated in each heart. Compared to 194 sudden coronary deaths >40 years, heart weight was lower, acute plaque erosions more frequent, and extent of disease less in the 40 years group. Plaque burden was less in hearts with erosions, and healed infarcts more common in hearts with stable plaque. The numbers of fibroatheromas increased with age until the 6th decade () as well as the proportion of total plaques that were atheromatous. Plaques in younger patients have fewer lipid-rich cores. Most thrombi show areas of organization, with layering frequent in erosions, suggesting a possible method of plaque enlargement in the absence of necrotic core formation.


2019 ◽  
Vol 133 (22) ◽  
pp. 2283-2299
Author(s):  
Apabrita Ayan Das ◽  
Devasmita Chakravarty ◽  
Debmalya Bhunia ◽  
Surajit Ghosh ◽  
Prakash C. Mandal ◽  
...  

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.


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