A Randomized Controlled Pilot Trial of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children

2018 ◽  
Vol 43 (3) ◽  
pp. 330-360 ◽  
Author(s):  
Sarah M. Kennedy ◽  
Emily L. Bilek ◽  
Jill Ehrenreich-May
Keyword(s):  
Emotional Disorders ◽  
Emotional Reactivity ◽  
Negative Emotion ◽  
Pilot Trial ◽  
Specific Treatment ◽  
Control Treatment ◽  
Depression Symptoms ◽  
Transdiagnostic Treatment ◽  
Randomized Controlled ◽  
Unified Protocol

The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children (UP-C) is an intervention for children aged 7 to 13 targeting high negative emotion, emotional reactivity, and emotion regulation deficits common across emotional disorders. Our objective was to collect pilot randomized controlled trial (RCT) data on the efficacy of the UP-C, comparing UP-C with an active, anxiety-focused intervention. Participants were 47 children with at least one primary anxiety disorder; approximately one half had elevated depression symptoms. Participants received either UP-C or the anxiety-focused control treatment. No condition-related differences were found with respect to diagnostic remission and anxiety symptoms. However, differences in favor of UP-C were observed with respect to treatment response at follow-up, depression symptoms, sadness dysregulation, and cognitive reappraisal. Results provide preliminary evidence that the UP-C may be at least as efficacious in treating anxiety as well-supported anxiety-specific treatment protocols and may produce greater gains in certain emotion reactivity and regulation variables.

scholarly journals Transdiagnostic treatment of emotional disorders in people with multiple sclerosis: randomized controlled trial

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Nabi Nazari ◽  
Masood Sadeghi ◽  
Ezatolah Ghadampour ◽  
Davod Mirzaeefar
Keyword(s):  
Multiple Sclerosis ◽  
Emotional Disorders ◽  
Analysis Of Covariance ◽  
High Rate ◽  
Control Group ◽  
Depression Symptoms ◽  
Usual Condition ◽  
Transdiagnostic Treatment ◽  
Assessment Protocol ◽  
Unified Protocol

Abstract Background Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system. MS is significantly associated with a high rate of psychological, behavioral, and emotional consequences. Despite the frequent mental disorders, high rate of psychological comorbidities, and emotional problems in people with MS (PwMS), these conditions are often underdiagnosed and undertreated. This study aimed to examine the efficacy of a group format of the unified protocol for the transdiagnostic treatment of emotional disorders in adult PwMS associated with an emotional disorder. Methods Seventy adult PwMS were randomized using an internet-based computer system to either the unified protocol (n = 35) or treatment as usual condition. The assessment protocol included semi-structured clinical interviews and self-reports evaluating diagnostic criteria, depression, anxiety and worry symptoms, emotional dysregulation, and affectivity. Results The parametric test of analysis of covariance, followed the intent to treat analyses, revealed the unified protocol significantly changed depression symptoms (Cohen’s d = 1.9), anxiety symptoms (Cohen’s d = 2.16), worry symptoms (Cohen’s d = 1.27), emotion dysregulation (Cohen’s d = 0.44), positive affect (Cohen’s d = 1.51), and negative affect (Cohen’s d = 1.89) compared with the control group. The unified protocol also significantly improved outcome scores at the end of treatment relative to baseline (p < .001). Conclusion The findings support that the unified protocol could be an additional efficient psychological treatment for PwMS. Trial registration IRCT, number: IRCT20190711044173N1. Registered 31october 2019, https://en.irct.ir/user/trial/40779/view.

scholarly journals Clinical Utility of an Internet-Delivered Version of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents (iUP-A): A Pilot Open Trial

2020 ◽  
Vol 17 (22) ◽  
pp. 8306
Author(s):  
Bonifacio Sandín ◽  
Julia García-Escalera ◽  
Rosa M. Valiente ◽  
Victoria Espinosa ◽  
Paloma Chorot
Keyword(s):  
Depressive Symptoms ◽  
Panic Disorder ◽  
Emotional Disorders ◽  
Clinical Utility ◽  
Pilot Trial ◽  
Small Sample ◽  
Access To Treatment ◽  
Transdiagnostic Treatment ◽  
Unified Protocol ◽  
Improve Access

The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents (UP-A) has been shown to be effective for reducing symptoms of anxiety and depression in adolescents with emotional disorders. Internet-delivered psychological treatments have great potential to improve access to evidence-based psychological therapy since they are associated with reduced human and economic costs and less social stigma. Recently, our group developed an online version of the UP-A (the iUP-A) for the treatment of emotional disorders in adolescents. The aim of this pilot trial was to test the clinical utility of the iUP-A in a small sample (n = 12) of adolescents with elevated anxiety and/or depressive symptoms. Intention-to-treat and completer analyses revealed pre- to post-intervention self-reported decreases of anxiety and depressive symptoms, anxiety sensitivity, emotional avoidance, panic disorder symptoms, panic disorder severity, generalized anxiety disorder symptoms, pathological worry, and major depressive disorder symptoms. We found high feasibility and acceptability of the program with all participants and responsible parents reporting an improvement in the adolescents’ ability to cope with emotions. Results suggest that the iUP-A may provide a new approach to improve access to treatment for anxious and depressive adolescents in Spain; however, further research must be conducted before firm conclusions can be drawn.

A pilot trial of a transdiagnostic treatment for emotional disorders—a locally adapted variant of group Unified Protocol (UP) for Chinese adults

2020 ◽  
Author(s):  
Candice L Y M Powell ◽  
Todd J Farchione ◽  
David H Barlow ◽  
Patrick W L Leung
Keyword(s):  
Hong Kong ◽  
Mental Disorders ◽  
Positive Affect ◽  
Emotional Disorders ◽  
Common Mental Disorders ◽  
Pilot Trial ◽  
Effect Sizes ◽  
Chinese Adults ◽  
Transdiagnostic Treatment ◽  
Unified Protocol

Abstract There has been increasing interest in transdiagnostic cognitive-behavioral therapy (CBT), which is more cost efficient yet yields similar effect sizes when compared to disorder-specific CBT. The Unified Protocol (UP) for Transdiagnostic Treatment of Emotional Disorders was adapted for Hong Kong Chinese adults with common mental disorders, such as depression and anxiety. It was piloted in community settings and delivered in a group format. Thirty-one Chinese adults (female = 93.5%, mean age = 44 years) with heterogeneous anxiety and depressive disorders were recruited from a number of public-funded community mental health centers in Hong Kong to participate in a pilot trial of a locally adapted variant of UP. Treatment consisted of 14 group sessions plus one individual session. Each group included six to nine participants. The diagnostic and outcome measures included Anxiety Disorders Interview Schedule for DSM-IV, The Chinese versions of Beck Depression Inventory-Revised (C-BDI-II), Beck Anxiety Inventory (C-BAI), Positive Affect subscale of Positive and Negative Affect Scale, and Work and Social Adjustment Scale. Results indicate significant improvement across a number of outcome measures, with moderate-to-large effect sizes for measures of depression (d = 1.11), anxiety (d = 0.67), positive affect (d = 0.54), and work and social functioning (d = 0.49). Furthermore, 45.2% and 29.0% of the participants scored within the normal range of C-BDI-II and C-BAI at posttreatment, respectively, compared to 3.2% and 6.5% at pretreatment. This pilot, uncontrolled trial demonstrated potential effectiveness of a locally adapted variant of group UP for Chinese adults with common mental disorders. It achieved comparable effect sizes to those observed in western populations.

scholarly journals Unified Protocol for Transdiagnostic Treatment of Emotional Disorders: A Randomized Controlled Trial

2012 ◽  
Vol 43 (3) ◽  
pp. 666-678 ◽  
Author(s):  
Todd J. Farchione ◽  
Christopher P. Fairholme ◽  
Kristen K. Ellard ◽  
Christina L. Boisseau ◽  
Johanna Thompson-Hollands ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Emotional Disorders ◽  
Controlled Trial ◽  
Transdiagnostic Treatment ◽  
Randomized Controlled ◽  
Unified Protocol

scholarly journals Protocolo unificado para el tratamiento transdiagnóstico de los trastornos emocionales en adolescentes a través de internet (iUP-A): Aplicación web y protocolo de un ensayo controlado aleatorizado

2020 ◽  
Vol 24 (3) ◽  
pp. 197 ◽  
Author(s):  
Bonifacio Sandín ◽  
Rosa M. Valiente ◽  
Julia García-Escalera ◽  
David Pineda ◽  
Victoria Espinosa ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Emotional Disorders ◽  
Web Application ◽  
Behavioral Therapy ◽  
Controlled Trial ◽  
Transdiagnostic Treatment ◽  
Face To Face ◽  
Randomized Controlled ◽  
Unified Protocol ◽  
Empirically Supported

Abstract: Internet-delivered unified protocol for transdiagnostic treatment of emotional disorders in adolescents (iUP-A): Web application and study protocol for a randomized controlled trial. A characteristic of transdiagnostic treatment is that it targets simultaneously the core symptoms and underlying vulnerabilities of several disorders. The UP-A is a new empirically supported cognitive-behavioral therapy (CBT) protocol developed by Ehrenreich-May’s group for the transdiagnostic treatment approach of emotional disorders (i.e., depression, anxiety and related disorders) in adolescents (Ehrenreich-May et al., 2018), to be applied in a face-to-face format. Internet-delivered psychological treatments represent an emerging model to improve access to evidence-based CBT. A first aim of this study is to describe the development of a web application named Aprende a Manejar Tus Emociones (AMTE; Learn to Manage Your Emotions), designed to implement the UP-A in order to be delivered via internet (iUP-A). A second objective is to test the efficacy of the iUP-A for the treatment of depression and anxiety disorders compared to waiting list, in a randomized controlled trial. We investigated changes in a broad range of primary, secondary and transdiagnostic outcome measures.Keywords: Transdiagnostic; UP-A; iUP-A; internet-delivered CBT; AMTE; anxiety; depression.Resumen: Una característica del tratamiento transdiagnóstico consiste en que aborda simultáneamente los síntomas principales y las vulnerabilidades que subyacen a varios trastornos. El UP-A es un nuevo protocolo de terapia cognitivo-conductual (TCC) basada en la evidencia desarrollado por el grupo de Ehrenreich-May para un tratamiento transdiagnóstico de los trastornos emocionales (i.e., depresión, ansiedad y trastornos relacionados) en adolescentes (Ehrenreich-May et al., 2018), para ser aplicado en un formato cara-a-cara. Los tratamientos psicológicos dispensados a través de internet representan un modelo emergente para mejorar el acceso a la TCC basada en la evidencia. Un primer objetivo del presente estudio consiste en describir el desarrollo de una aplicación web denominada Aprende a Manejar Tus Emociones (AMTE), diseñada para implementar el UP-A con objeto de ser dispensado a través de internet (iUP-A). Un segundo objetivo es probar la eficacia del iUP-A para el tratamiento de la depresión y los trastornos de ansiedad en comparación con una lista de espera, en un ensayo controlado aleatorizado. Se investigan los cambios en un amplio rango de medidas de resultado primarias, secundarias y transdiagnósticas.Palabras clave: Transdiagnóstico; UP-A; iUP-A; TCC por internet; AMTE; ansiedad; depresión. 

scholarly journals Initial Effectiveness Evaluation of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders for Homeless Women

2020 ◽  
pp. 014544552098256
Author(s):  
Sara Rodriguez-Moreno ◽  
Todd J. Farchione ◽  
Pablo Roca ◽  
Carolina Marín ◽  
Ana I. Guillén ◽  
...  
Keyword(s):  
Negative Affect ◽  
Emotional Disorders ◽  
Group Treatment ◽  
Linear Trend ◽  
Control Period ◽  
Well Being ◽  
Homeless Women ◽  
Depression And Anxiety ◽  
Transdiagnostic Treatment ◽  
Unified Protocol

The purpose of this study is to evaluate the effectiveness of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders adapted for homeless women (UPHW). Eighty-one homeless women participated in this single-blinded quasi-experimental clinical trial, involving up to 12 sessions of group treatment, and 3-and 6-month follow-ups. The participants received either immediate treatment with the UPHW ( n = 46) or delayed treatment, following a 12-week wait-list control period (WLC; n = 35). Primary outcomes included depression and anxiety. Secondary measures comprised positive and negative affect, psychological well-being, health perception, and social support. The UPHW resulted in significant improvement on measures of anxiety, depression and negative affect. Improvements in anxiety and depression were maintained over a 3-month follow-up period, but not at 6-month. The reliability of the clinical changes showed significant differences between UPHW and WLC for depression. Moreover, the inter-session assessment in the UPHW group showed a linear trend reduction for depression and anxiety scores along the 12 sessions. The clinical implications on the UPHW in social settings are also discussed.

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