Vitamin D Status in Egyptian Children With Allergic Rhinitis

Objective: This study aimed to assess the serum levels of vitamin D in an Egyptian cohort of children with allergic rhinitis (AR) and to evaluate any correlation of vitamin D status with the disease severity. Patient and methods: One hundred twenty children with AR and 100 healthy children were included in our study. We studied the serum levels of vitamin D 25(OH)D and 1,25(OH)2D in all participants. The associations between vitamin D levels and clinical characteristics of AR were examined. Results: In AR group, the serum levels of calcium, (25(OH)D and 1,25(OH)2D levels were significantly lower ( p < .0001, p < .001, and p < .0001, respectively) in AR children than in controls. Furthermore, the mean 25-OHD3 levels in patients with moderate/severe AR were significantly lower than those with mild AR ( p < .001). We found significant negative correlations between mean 25(OH)D levels and total nasal symptom score ( r = −.62, p = .002) and total immunoglobulin E levels ( r = −.27, p = .013) in AR group. Conclusions: Vitamin D deficiency is a frequent finding among Egyptian children with AR when compared to the healthy group. A significant inverse association was observed between vitamin D levels and AR disease severity.

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Adequate Vitamin D Intake but Low Serum Levels in Pediatric Asthma Patients: A Pilot Study, Alberta Children’s Hospital

Canadian Respiratory Journal ◽

10.1155/2016/6982010 ◽

2016 ◽

Vol 2016 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Sarah Howe McKenna ◽

Tanis R. Fenton ◽

Mary Noseworthy ◽

Mark Anselmo

Keyword(s):

Vitamin D ◽

Pediatric Asthma ◽

Serum Levels ◽

High Dose ◽

Healthy Children ◽

Vitamin D Status ◽

Vitamin D Intake ◽

Vitamin D Levels ◽

Asthma Patients ◽

25 Oh Vitamin D

Background. We assessed vitamin D intakes and serum 25(OH) vitamin D levels in pediatric asthma patients on moderate-to-high dose inhaled steroids and compared them to published findings of healthy children in our city.Methods. Parents and/or patients were interviewed to estimate the children’s vitamin D intakes from foods and supplements (using an adapted validated food frequency questionnaire) and asthma duration and management. Vitamin D status: serum 25-hyroxy vitamin D (25(OH)D) was obtained from the medical records.Results. Vitamin D intakes from food and supplements of the asthma patients (n=20, 742 ± 185 IU/day) were significantly higher compared to healthy Canadian children (n=1442, 229 ± 121 IU/day). Despite higher vitamin D intakes, the children had nonsignificantly lower serum 25(OH) vitamin D levels compared to the comparison group. Serum 25(OH)D levels increased by 3.6 nmol/L with each 100 IU of vitamin D intake (95% Confidence interval = 2.0–4.0,R2= 0.931, andp=0.001).Conclusion. Since adequate vitamin D status in asthma patients is necessary to support bone mineral accretion, it is important to achieve adequate vitamin D status by checking serum 25(OH)D status and supplement accordingly.

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Vitamin D status in asthmatic children and its correlation to asthma control

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20180547 ◽

2018 ◽

Vol 5 (2) ◽

pp. 520

Author(s):

Sandeep Karanam ◽

Soumya Reddy ◽

Ramesh H.

Keyword(s):

Vitamin D ◽

Asthma Control ◽

Serum Vitamin ◽

Serum Levels ◽

Inverse Association ◽

Vitamin D Status ◽

Asthmatic Children ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Children With Asthma

Background: Asthma is a common chronic inflammatory disease of the airways, affecting around 330 million individuals worldwide. Factors like genetic predisposition, early allergen exposure, diet and vitamin D status are all proposed to influence the development and severity of asthma. Epidemiologic data suggests that low serum vitamin D (<30 ng/mL) in children with asthma is associated with more symptoms and exacerbations. The objectives of this study were to determine serum levels of vitamin D in asthmatic children (6-15 years) and to establish a relation between serum vitamin D levels and asthma control.Methods: We conducted a cross sectional observational study. A total of 60 children with asthma were studied to know the relationship between serum vitamin D levels and asthma control, assessed according to Global Initiative for Asthma guidelines (GINA).Results: Only 33.33% of children had sufficient vitamin D levels. Mean±SD vitamin D level of study population was 23.38±8.75. 45% children had well controlled asthma, 28.3% were partly controlled and 26.7% were uncontrolled. Significant (p <0.001) inverse association was found between level of asthma control and vitamin D status. Significant positive correlation was found between percent predicted forced expiratory volume in 1 second and forced vital capacity (P <0.01). Subjects with well controlled asthma had higher serum levels of 25 (OH) D than children with partially controlled or uncontrolled asthma.Conclusions: Hypovitaminosis D is frequent in children with asthma and is associated with exacerbations, decreased lung functions and severe disease.

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Serum levels of 25(OH)D are not associated with venous thromboembolism in the elderly population

Thrombosis and Haemostasis ◽

10.1160/th15-02-0148 ◽

2016 ◽

Vol 115 (01) ◽

pp. 169-175 ◽

Cited By ~ 1

Author(s):

Aurélien Delluc ◽

Marie-Pierre Moineau ◽

Cécile Tromeur ◽

Maelenn Gouillou ◽

Karine Lacut ◽

...

Keyword(s):

Vitamin D ◽

Venous Thromboembolism ◽

Seasonal Variations ◽

Elderly Population ◽

Serum Levels ◽

The Elderly ◽

Vitamin D Status ◽

Increased Risk ◽

Vitamin D Levels ◽

Walking Capacity

SummaryThe prevalence of both vitamin D deficiency and venous thromboembolism (VTE) is important in the elderly. Previous studies have provided evidence for a possible association between vitamin D status and the risk of VTE. Thus, we aimed to investigate the association between vitamin D levels and VTE in the population aged 75 and over included in the EDITH case-control study. The association between vitamin D status and VTE was analysed. We also analysed the monthly and seasonal variations of VTE and vitamin D. Between May 2000 and December 2009, 340 elderly patients (mean age 81.5 years, 32 % men) with unprovoked VTE and their controls were included. The univariate and multivariate analysis found no significant association between serum levels of vitamin D and the risk of unprovoked VTE. In the unadjusted analysis, a higher BMI was statistically associated with an increased risk of VTE (OR 1.09; 95 % CI 1.05–1.13) whereas a better walking capacity and living at home were associated with a decreased rate of VTE: OR 0.57; 95 % CI 0.36–0.90 and 0.40; 95 % CI 0.25–0.66, respectively. Although not significant, more VTE events occurred during winter (p=0.09). No seasonal variations of vitamin D levels were found (p=0.11). In conclusion, in contrast with previous reports our findings suggest that vitamin D is not associated with VTE in the elderly population.

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Deficiency of Vitamin D in Allergic Rhinitis: A Possible Factor in Multifactorial Disease

Clinical Rhinology An International Journal ◽

10.5005/jp-journals-10013-1209 ◽

2014 ◽

Vol 7 (3) ◽

pp. 112-116

Author(s):

Anil Jain ◽

Pankaj Shah ◽

Datt Modh ◽

Bhaskar Thakkar ◽

Ashish Katarkar ◽

...

Keyword(s):

Vitamin D ◽

Allergic Rhinitis ◽

Normal Population ◽

Serum Vitamin ◽

Serum Levels ◽

Multifactorial Disease ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Immunological Effects ◽

K Deficiency

ABSTRACT Allergic rhinitis is a common condition affecting 5 to 40% of general population and its prevalence is increasing. It is a chronic condition characterized by inflammation of nasal mucosa. As per recent studies, there is an association between serum vitamin D levels and allergic rhinitis status. Vitamin D has major role in the regulation of calcium metabolism. In addition to this, it also has a number of immunological effects and takes part in immunomodulation, which can significantly affect the outcome of allergic responses like in allergic rhinitis. Aims and objectives To establish the correlation between vitamin D3 serum levels and allergic rhinitis. Materials and methods Vitamin D levels were assessed in 23 patients with allergic rhinitis diagnosed clinically by allergic rhinitis and its impact on asthma 2008 criteria and results were compared with vitamin D status in the normal population of same region. Results The levels of serum vitamin D levels were significantly low in the patients of allergic rhinitis. Conclusion Measuring of serum levels of vitamin D could be considered in the routine assessment of patients with allergic rhinitis. How to cite this article Thakkar B, Katarkar A, Modh D, Jain A, Shah P, Joshi K. Deficiency of Vitamin D in Allergic Rhinitis: A Possible Factor in Multifactorial Disease. Clin Rhinol An Int J 2014;7(3):112-116.

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Relation between serum levels of Vitamin D and Immunoglobulin E in Allergic Rhinitis in Upper Egypt

SVU-International Journal of Medical Sciences ◽

10.21608/svuijm.2020.45265.1014 ◽

2020 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

Aida A. Abdelmaksoud ◽

Shamardan ES Bazeed ◽

Mohamed F Alemam ◽

Zaky F Aref

Keyword(s):

Vitamin D ◽

Allergic Rhinitis ◽

Immunoglobulin E ◽

Serum Levels ◽

Upper Egypt

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Prevalence of vitamin D insufficiency in Qatar: a systematic review

Journal of Public Health Research ◽

10.4081/jphr.2012.e36 ◽

2012 ◽

Vol 1 (3) ◽

pp. 36 ◽

Cited By ~ 16

Author(s):

Alaa Badawi ◽

Paul Arora ◽

Eman Sadoun ◽

Al-Anoud Al-Thani ◽

Mohamed H. Al Thani

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Sample Size ◽

Serum Vitamin ◽

Weighted Average ◽

Serum Levels ◽

Vitamin D Insufficiency ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Vitamin D Levels

Qatar has a high burden of chronic diseases including obesity, cardiovascular disease and type 2 diabetes mellitus. Low serum vitamin D levels have been implicated in the development and progression of a range of these chronic conditions. The prevalence of vitamin D insufficiency or deficiency in the general population of Qatar has still not been investigated. The aim of this study was to carry out a systematic review of published studies documenting the prevalence of vitamin D insufficiency or deficiency in the Qatari population. A search strategy was developed for online databases (PubMed, Ovid MEDLINE, Embase and Embase Classic) between 1980 to the last week of August 2012, and bibliographies of the included studies were further searched for additional reports. Search terms used were QATAR and VITAMIN D. Studies reporting the serum levels of vitamin D in several Qatari sub-populations were identified. Weighted-average vitamin D serum levels and prevalence of low vitamin D status (<75 nmol/L) were calculated. Subgroup analysis was carried out by age. The quality of each study was evaluated according to four criteria: national representativeness, representation of males and females, the sample size, and the sampling protocol. A total of 16 relevant publications were identified, and 8 of these (reporting from 7 unique studies) met our inclusion and exclusion criteria with a total number of 1,699 Qatari subjects. The pooled sample size weighted-average vitamin D concentration (±SD) was 45.3±14.3 nmol/L (95% CI: 44.6-46.0; range 29.2-66.9 nmol/L). The weighted-average prevalence of low vitamin D status was 90.4% (95% CI: 90.1-91.0; range 83%-91%). Age was inversely correlated with vitamin D levels and directly with its insufficiency/deficiency prevalence. There have only been a few studies on the prevalence of low vitamin D in Qatar a very high prevalence of vitamin D insufficiency/deficiency in Qatar that increases with age has been suggested. The present report underlines the need to develop a nationally representative study to further evaluate vitamin D status in Qatar. Given the growing evidence of the role of vitamin D in chronic disease, this study could help develop public health strategies for disease prevention in Qatar.

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Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese People

International Journal of Endocrinology ◽

10.1155/2018/1216370 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6

Author(s):

Bing Han ◽

Qin Li ◽

Ningjian Wang ◽

Yi Chen ◽

Chunfang Zhu ◽

...

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Serum Levels ◽

Vitamin D Supplementation ◽

Model Assessment ◽

Inverse Association ◽

Vitamin D Levels ◽

Males And Females

Background. The relationship between vitamin D and insulin resistance is still controversial. Many factors could influence this relationship. In addition, this relationship in different genders was still unclear. Methods. A total of 6597 subjects, including 2813 males and 3784 females, were analyzed. The serum levels of 25(OH)D, fasting blood glucose (FBG), fasting insulin, HbA1c, and other metabolic parameters were tested. The waist circumference (WC), weight, and height were also measured. Questionnaires regarding smoking and drinking were collected from these subjects. Results. Serum 25(OH)D was categorized into quartiles. Increasing 25(OH)D levels were associated with reduced trend of homeostasis model assessment of insulin resistance (HOMA-IR) in both males and females. Pearson’s correlation indicated 25(OH)D level was inversely associated with the HOMA-IR for male subjects (r=−0.055, P=0.028) but not for female subjects (r=−0.005, P=0.798). Age, triglyceride (TG), and low-density lipoprotein (LDL) were associated with the vitamin D levels in males and females. In regression analysis, serum 25(OH)D concentration was significantly associated with HOMA-IR only in overweight males. Conclusion. We found an inverse association between 25(OH)D and HOMA-IR in Chinese overweight males. Vitamin D supplementation might be beneficial in this population. However, further clinical trials are needed to confirm this association.

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Vitamin D Levels in Asymptomatic Children and Adolescents with Atopy during the COVID-19 Era

Journal of Personalized Medicine ◽

10.3390/jpm11080712 ◽

2021 ◽

Vol 11 (8) ◽

pp. 712

Author(s):

Gavriela Feketea ◽

Vasiliki Vlacha ◽

Georgios Tsiros ◽

Panagiota Voila ◽

Raluca Maria Pop ◽

...

Keyword(s):

Vitamin D ◽

Children And Adolescents ◽

Eosinophil Count ◽

Immunoglobulin E ◽

Serum Levels ◽

Asymptomatic Children ◽

Vitamin D Levels ◽

Median Level ◽

25 Hydroxy Vitamin D ◽

High Level

This study assessed vitamin D status in asymptomatic children and adolescents in Greece, with and without atopy, and possible changes during the coronavirus disease 2019 (COVID-19) pandemic. Serum levels of 25-hydroxy-vitamin D (25(OH)D) and total immunoglobulin E (IgE), and eosinophil count were measured in 340 asymptomatic children and adolescents (155 males, 185 females), mean age 8.6 ± 4.6 years, recruited over a period of 24 months (February 2019–January 2021). Atopy, defined by high level of IgE for age, was associated with vitamin D deficient status (p = 0.041). Subjects with and without atopy showed similar rates of insufficient and normal levels of 25(OH)D. The median level of 25(OH)D was significantly higher in subjects recruited during the pandemic, when home confinement rules were observed, than before the pandemic, and significantly more children had normal levels of 25(OH)D (p < 0.001), but no differences were noticed for IgE levels or eosinophil count. These results support a link between vitamin D and allergic and infectious inflammations, and specifically the association of vitamin D deficiency with asymptomatic atopy, defined as increased IgE level for age.

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Vitamin D Deficiency in Children and Adolescents: Role of Puberty and Obesity on Vitamin D Status

Nutrition and Metabolic Insights ◽

10.1177/11786388211018726 ◽

2021 ◽

Vol 14 ◽

pp. 117863882110187

Author(s):

Hedyeh Saneifard ◽

Marjan Shakiba ◽

Ali Sheikhy ◽

Leila Baniadam ◽

Fatemeh Abdollah Gorji ◽

...

Keyword(s):

Vitamin D ◽

Children And Adolescents ◽

Vitamin D Deficiency ◽

Tanner Stage ◽

Additional Risk Factor ◽

Healthy Children ◽

Vitamin D Status ◽

Obese Children ◽

Increased Risk ◽

Vitamin D Levels

Background: Vitamin D deficiency is common among children and adolescents and can be affected by several factors such as puberty and obesity. Objective: The aim of this study was to evaluate vitamin D status in children and adolescents and to analyse the influence of puberty and obesity on its level. Method: A cross-sectional study was carried-out, in which clinical and biochemical data were gathered from 384 healthy children and adolescents between May 2019 to May 2020. Results: 220 females and 164 males were enrolled (aged 7-16 years; mean ± SD: 11 ± 2.5). Vitamin D deficiency was found in 49% of the total cases and was significantly more prevalent in females than males (33.1% in female; 15.9% in male, P < .001). Mean vitamin D level was lower in obese children compared with non-obese ( P < .001). Non-obese group had significantly higher levels of vitamin D in Tanner stage IV of puberty than obese individuals (20.1 ± 17.0 vs 5.4 ± 2.0) ( P = .03). Vitamin D levels were significantly lower in females than males only in Tanner stage II (12.3 ± 9.0 vs 19.6 ± 16.6) ( P = .005). The lowest level of Vitamin D was in Tanner stage Ⅳ-Ⅴ in boys and in Tanner stage Ⅱ-Ⅲ in girls ( P < .001). Conclusion: Puberty is an additional risk factor for vitamin D deficiency especially in girls and obese children. This increased risk, together with the fact that most important time for building a proper skeleton is during childhood and adolescent, makes it essential to monitor vitamin D in these age groups.

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The availability of vitamin D in children of the first year of life with food allergies residing in conditions of military conflict in Donbass

Pediatrician (St Petersburg) ◽

10.17816/ped11251-56 ◽

2020 ◽

Vol 11 (2) ◽

pp. 51-56

Author(s):

Andrew V. Nalyotov ◽

Tatyana I. Shapchenko ◽

Natalia A. Svistunova ◽

Maxim V. Vakulenko

Keyword(s):

Vitamin D ◽

Food Allergy ◽

Clinical Symptoms ◽

Serum Levels ◽

Food Allergies ◽

Healthy Children ◽

Military Conflict ◽

Vitamin D Levels ◽

First Year Of Life

The problem of vitamin D deficiency is one of the most actual today. According to numerous clinical studies, its insufficiency of this micronutrient is registered in half of the worlds population. Aim of the study. To study the provision of vitamin D in infants, suffering from food allergy and living in the Donbass in a military conflict. Materials and methods. 105 infants living in the Donetsk Peoples Republic suffering from food allergy were examined. The level of vitamin D in serum in these patients was studied by determining serum levels of 25(OH)D. Results and discussion. Insufficient vitamin D levels were found in 57.1 4.8% infants with food allergy, which was significantly higher (р 0.05) compared to healthy children (12.5 5.2%). At the same time, children with food allergies, long-term living near the region of active hostilities, statistically significant (р 0.001) often had a reduced level of vitamin D. It was found that in the group of patients with low level of vitamin D polyvalent food allergy was determined statistically significantly more common compared to the group of patients with normal level of vitamin D. Conclusion. Infants, suffering from food allergy and living in the Donetsk Peoples Republic in a long-term military conflict are characterized by a decrease in vitamin D level, which may play a role in the formation of the immune response, the development of clinical symptoms of pathology and disrupt the development of tolerance to the food allergens.

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