scholarly journals Relation between serum levels of Vitamin D and Immunoglobulin E in Allergic Rhinitis in Upper Egypt

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Aida A. Abdelmaksoud ◽  
Shamardan ES Bazeed ◽  
Mohamed F Alemam ◽  
Zaky F Aref
Keyword(s):  
Vitamin D ◽  
Allergic Rhinitis ◽  
Immunoglobulin E ◽  
Serum Levels ◽  
Upper Egypt

scholarly journals Vitamin D Status in Egyptian Children With Allergic Rhinitis

2019 ◽  
Vol 99 (8) ◽  
pp. 508-512 ◽  
Author(s):  
Khaled Saad ◽  
Abobakr Abdelmoghny ◽  
Mohamed Diab Aboul-Khair ◽  
Yasser Farouk Abdel-Raheem ◽  
Eman Fathalla Gad ◽  
...  
Keyword(s):  
Vitamin D ◽  
Allergic Rhinitis ◽  
Disease Severity ◽  
Immunoglobulin E ◽  
Serum Levels ◽  
Healthy Children ◽  
Inverse Association ◽  
Vitamin D Status ◽  
Vitamin D Levels ◽  
Egyptian Children

Objective: This study aimed to assess the serum levels of vitamin D in an Egyptian cohort of children with allergic rhinitis (AR) and to evaluate any correlation of vitamin D status with the disease severity. Patient and methods: One hundred twenty children with AR and 100 healthy children were included in our study. We studied the serum levels of vitamin D 25(OH)D and 1,25(OH)2D in all participants. The associations between vitamin D levels and clinical characteristics of AR were examined. Results: In AR group, the serum levels of calcium, (25(OH)D and 1,25(OH)2D levels were significantly lower ( p < .0001, p < .001, and p < .0001, respectively) in AR children than in controls. Furthermore, the mean 25-OHD3 levels in patients with moderate/severe AR were significantly lower than those with mild AR ( p < .001). We found significant negative correlations between mean 25(OH)D levels and total nasal symptom score ( r = −.62, p = .002) and total immunoglobulin E levels ( r = −.27, p = .013) in AR group. Conclusions: Vitamin D deficiency is a frequent finding among Egyptian children with AR when compared to the healthy group. A significant inverse association was observed between vitamin D levels and AR disease severity.

scholarly journals The Study of a Possible Correlation between Serum Levels of Interleukin 17 and Clinical Severity in Patients with Allergic Rhinitis

2017 ◽  
Vol 8 (3) ◽  
pp. ar.2017.8.0207
Author(s):  
Mai Aly Gharib Aly ◽  
Mohamed Tawfik El Tabbakh ◽  
Waheed Fawzy Heissam ◽  
Said Hamed Abbadi
Keyword(s):  
Allergic Rhinitis ◽  
Immunoglobulin E ◽  
Skin Testing ◽  
Allergic Diseases ◽  
Serum Levels ◽  
Clinical Severity ◽  
Total Serum ◽  
Interleukin 17 ◽  
Serum Ige ◽  
Cluster Immunotherapy

Introduction Allergic rhinitis (AR) is one of the most common allergic diseases, which affects ~20% of the world's population. T-helper (Th) type 2 cells produce interleukin (IL) 4 and IL-13, and mediate allergic responses, and these cytokines have been extensively studied as key players in the atopic airway diseases. However, the involvement of Th17 cells and IL-17 in AR has not been clearly examined. Aim To reevaluate AR clinical severity with serum IL-17, whether IL-17 affects the disease alone or in contribution with the atopic predisposition. Patients and Methods During an 18-month period, 39 individuals were divided into three groups: A, (13 control), B (13 with mild-to-moderate AR), and C (13 with severe AR). Both group B and group C patients (26) were subjected to clinical examination and allergy skin testing, and to measurement of both total serum immunoglobulin E (IgE) and IL-17 levels. Eleven patients with AR then were exposed to 6 months of cluster immunotherapy, whereas the rest of the patients were not exposed. Results Revealed a significant elevation of serum IL-17 levels with an associated increase in serum IgE in the patients with AR compared with controls and revealed that the serum levels of both total serum IgE and IL-17 decreased significantly after cluster immunotherapy. Conclusion These preliminary results added new data about the use of injective immunotherapy as well as reported on the use of sublingual immunotherapy.

scholarly journals Vitamin D serum levels in allergic rhinitis: any difference from normal population?

2012 ◽  
Vol 2 (1) ◽  
pp. 45 ◽  
Author(s):  
Saba Arshi ◽  
Babak Ghalehbaghi ◽  
Seyyed-Kamran Kamrava ◽  
Mina Aminlou
Keyword(s):  
Vitamin D ◽  
Allergic Rhinitis ◽  
Normal Population ◽  
Serum Levels

scholarly journals Deficiency of Vitamin D in Allergic Rhinitis: A Possible Factor in Multifactorial Disease

2014 ◽  
Vol 7 (3) ◽  
pp. 112-116
Author(s):  
Anil Jain ◽  
Pankaj Shah ◽  
Datt Modh ◽  
Bhaskar Thakkar ◽  
Ashish Katarkar ◽  
...  
Keyword(s):  
Vitamin D ◽  
Allergic Rhinitis ◽  
Normal Population ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Multifactorial Disease ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Immunological Effects ◽  
K Deficiency

ABSTRACT Allergic rhinitis is a common condition affecting 5 to 40% of general population and its prevalence is increasing. It is a chronic condition characterized by inflammation of nasal mucosa. As per recent studies, there is an association between serum vitamin D levels and allergic rhinitis status. Vitamin D has major role in the regulation of calcium metabolism. In addition to this, it also has a number of immunological effects and takes part in immunomodulation, which can significantly affect the outcome of allergic responses like in allergic rhinitis. Aims and objectives To establish the correlation between vitamin D3 serum levels and allergic rhinitis. Materials and methods Vitamin D levels were assessed in 23 patients with allergic rhinitis diagnosed clinically by allergic rhinitis and its impact on asthma 2008 criteria and results were compared with vitamin D status in the normal population of same region. Results The levels of serum vitamin D levels were significantly low in the patients of allergic rhinitis. Conclusion Measuring of serum levels of vitamin D could be considered in the routine assessment of patients with allergic rhinitis. How to cite this article Thakkar B, Katarkar A, Modh D, Jain A, Shah P, Joshi K. Deficiency of Vitamin D in Allergic Rhinitis: A Possible Factor in Multifactorial Disease. Clin Rhinol An Int J 2014;7(3):112-116.

scholarly journals Mahuang Fuzi Xixin Decoction Attenuates Th1 and Th2 Responses in the Treatment of Ovalbumin-Induced Allergic Inflammation in a Rat Model of Allergic Rhinitis

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Mengyue Ren ◽  
Qingfa Tang ◽  
Feilong Chen ◽  
Xuefeng Xing ◽  
Yao Huang ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Rat Model ◽  
Immunoglobulin E ◽  
Allergic Inflammation ◽  
Wistar Rat ◽  
Serum Levels ◽  
Th2 Cells ◽  
Th2 Responses ◽  
Th1 And Th2 Responses ◽  
Th1 And Th2

Allergic rhinitis (AR) is one of the most common allergic diseases, which adversely affect patients’ quality of life. Mahuang Fuzi Xixin decoction (MFXD) has been widely used to treat AR in clinics in Asian countries. This study investigated the effect and possible therapeutic mechanisms of MFXD in the treatment of AR. A Wistar rat model of ovalbumin- (OVA-) induced AR was established and then treated with three doses of MFXD; AR symptoms, serum total immunoglobulin E, histamine, histopathological features, and release and expression of factors related to type 1 helper T (Th1) and type 2 helper T (Th2) responses were analyzed. Our study demonstrated that MFXD has a good therapeutic effect on OVA-induced allergic inflammation in an AR rat model as manifested in reduced frequencies of sneezing and nasal scratching and in reduced serum levels of total IgE and HIS. In addition, MFXD regulates imbalance in Th1/Th2 cells caused by AR by simultaneously attenuating Th1 and Th2 responses, such as by reducing the serum levels of IFN-γ and IL-4 and mRNA expression levels of IFN-γ, IL-4, GATA-3, and STAT-6. This study provided valuable information on the immunoregulatory effect of MFXD for the treatment of AR in future clinical studies.

scholarly journals Vitamin D Levels in Asymptomatic Children and Adolescents with Atopy during the COVID-19 Era

2021 ◽  
Vol 11 (8) ◽  
pp. 712
Author(s):  
Gavriela Feketea ◽  
Vasiliki Vlacha ◽  
Georgios Tsiros ◽  
Panagiota Voila ◽  
Raluca Maria Pop ◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Eosinophil Count ◽  
Immunoglobulin E ◽  
Serum Levels ◽  
Asymptomatic Children ◽  
Vitamin D Levels ◽  
Median Level ◽  
25 Hydroxy Vitamin D ◽  
High Level

This study assessed vitamin D status in asymptomatic children and adolescents in Greece, with and without atopy, and possible changes during the coronavirus disease 2019 (COVID-19) pandemic. Serum levels of 25-hydroxy-vitamin D (25(OH)D) and total immunoglobulin E (IgE), and eosinophil count were measured in 340 asymptomatic children and adolescents (155 males, 185 females), mean age 8.6 ± 4.6 years, recruited over a period of 24 months (February 2019–January 2021). Atopy, defined by high level of IgE for age, was associated with vitamin D deficient status (p = 0.041). Subjects with and without atopy showed similar rates of insufficient and normal levels of 25(OH)D. The median level of 25(OH)D was significantly higher in subjects recruited during the pandemic, when home confinement rules were observed, than before the pandemic, and significantly more children had normal levels of 25(OH)D (p < 0.001), but no differences were noticed for IgE levels or eosinophil count. These results support a link between vitamin D and allergic and infectious inflammations, and specifically the association of vitamin D deficiency with asymptomatic atopy, defined as increased IgE level for age.

scholarly journals Association of Serum Vitamin D and Immunoglobulin E Levels With Severity of Allergic Rhinitis

Cureus ◽  
2021 ◽  
Author(s):  
Nukhbat U Awan ◽  
Shahzada K Sohail ◽  
FATIMA NAUMERI ◽  
Shahida Niazi ◽  
Khalid Cheema ◽  
...  
Keyword(s):  
Vitamin D ◽  
Allergic Rhinitis ◽  
Immunoglobulin E ◽  
Serum Vitamin ◽  
Serum Vitamin D

scholarly journals Comparison of 1α-25-dihydroxyvitamin D3 and IgE Levels between Allergic Rhinitis Patients and Healthy People

2018 ◽  
Vol 22 (04) ◽  
pp. 428-431
Author(s):  
Mehmet Demir
Keyword(s):  
Allergic Rhinitis ◽  
Immunoglobulin E ◽  
Allergic Diseases ◽  
Serum Levels ◽  
Mean Value ◽  
Lifestyle Changes ◽  
Healthy Population ◽  
Dihydroxyvitamin D3 ◽  
Control Subjects ◽  
Skin Prick Tests

Introduction Allergic rhinitis is one of the most common allergic diseases that cause a decrease in quality of life. Over the last decades, the increase in the number of cases is supposed to be a result of industrialization and lifestyle changes. Vitamin D, which is a steroid hormone, has a significant immunomodulatory and antioxidant role in the human body. Objective The objective of the present study is to investigate the role of 1α-25-dihydroxyvitamin D3 levels in allergic rhinitis patients and to compare them to the levels found in the healthy population. Methods A total of 256 participants were included in the present study. Allergic rhinitis is diagnosed with the help of the Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines confirmed through skin prick tests. Control subjects were selected among people without allergy history, which was also confirmed through skin prick tests. The levels of 1α-25-dihydroxyvitamin D3, immunoglobulin E (IgE), and eosinophil counts were measured in blood samples from both groups. Results The mean value of serum levels of 1α-25-hydroxyvitamin D3 was 25.5 ± 3.74 in the allergic rhinitis group, and 31.58 ± 3.85 in the control subjects. This difference reveals statistically-decreased levels in the allergic rhinitis group (p < 0.05). The total IgE levels are increased in the allergic rhinitis group (p < 0.05) and negatively correlated with the serum levels of 1α-25-hydroxyvitamin D3 (r = - 0.259, p < 0.05). Conclusion Lower serum levels of 1α-25-hydroxyvitamin D3 were detected in the allergic rhinitis population. This data is also correlated to the IgE response in the study group. A supplement of 1α-25-hydroxyvitamin D3 in deficient patients might be helpful to relieve symptoms and signs of allergic rhinitis, but further studies are needed.

scholarly journals Role of vitamin D supplementation in asthma and seasonal allergic rhinitis in eastern India

2017 ◽  
Vol 8 (3) ◽  
pp. 26-29 ◽  
Author(s):  
Manuprita Sharma ◽  
Anindita Banerjee ◽  
Vineet Kumar Khemka ◽  
Ravela Malathi ◽  
Sukanta Sen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Allergic Rhinitis ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Vitamin D Supplementation ◽  
Serum Samples ◽  
Major Health Problem ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Asthma Patients

Background: Allergic rhinitis (AR) known to be a common type of chronic rhinitis which affects 10-20% of the general population while asthma is another major health problem and leading cause of morbidity in the worldwide. Vitamin D, a steroid hormone known for its important role in immunological effects has a role in AR and asthma.Aims and Objectives: The aim of our study was to assess the serum vitamin D levels in patients with asthma and seasonal AR pre-treatment or post treatment with oral vitamin D supplementation (cholecalciferol – 1000 IU) and to study the pathogenesis of the disease.Materials and Methods: The study included 66 AR and asthma patients and 46 control subjects.Fasting serum samples of control and AR subjects were analyzed for routine biochemical parameters immediately after collection while aliquots of the samples were also stored at - 200 C for the assay of 25-hydroxyvitamin D by ELISA.Results: Serum vitamin D levels were found to be significantly lower in AR and asthma patients compared with controls (p < 0.0001). On receiving vitamin D supplementation (cholecalciferol – 1000 IU) we found an increase in vitamin D serum levels in AR and asthma patients as compared to controls (p < 0.0001).Conclusion: Supplementation of vitamin D may be beneficial in the prevention of the pathogenesis of AR and asthma.Asian Journal of Medical Sciences Vol.8(3) 2017 26-29

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