scholarly journals Alveolar Soft-Part Sarcoma in Olfactory Cleft: A Case Report and Clinicopathological Review

2020 ◽  
pp. 014556132095513
Author(s):  
Saud Alromaih ◽  
Saleh Alqaryan ◽  
Saleh Alabood ◽  
Somaya Alabaishi ◽  
Abdulrazag Ajlan ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Malignant Disease ◽  
Clinical Presentation ◽  
Soft Part ◽  
Soft Tissue Sarcomas ◽  
Alveolar Soft Part Sarcoma ◽  
Olfactory Cleft

Sinonasal alveolar soft-part sarcoma (ASPS) is a rare malignant disease that comprises 0.4% to 1.2% of all soft-tissue sarcomas. Alveolar soft-part sarcoma is usually difficult to diagnose because it has many clinical and pathological mimickers. In this case study, ASPS occurred in the olfactory cleft, representing the second case in this location in the literature. This article presents the clinical presentation, radiologic, and histopathological case, and reviews the literature regarding the differentials.

Microsurgical Management of Early Onset Alveolar Soft Part Sarcoma of the Oral Tongue: Case Report and Review of the Literature

2021 ◽  
pp. 000348942110212
Author(s):  
Jacob C. Lucas ◽  
Omar A. Karadaghy ◽  
Brian Andrews ◽  
Elizabeth Friedman ◽  
Kiran Kakarala ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Soft Part ◽  
Soft Tissue Sarcomas ◽  
Alveolar Soft Part Sarcoma ◽  
Microvascular Reconstruction ◽  
Retrospective Case ◽  
Tissue Mass ◽  
Radial Forearm ◽  
Posterior Tongue

Objectives: Alveolar soft part sarcoma is a rare subset of soft tissue sarcomas, typically presenting in subjects 15 to 35 years of age. Usual presentation sites are the trunk, extremities, and the head and neck. Subjects younger than 5 years are rarely affected. Methods: In this retrospective case report, we present a 16-month old male with a rapidly growing soft tissue mass of the anterior and posterior tongue, found to be alveolar soft part sarcoma. Results: The subject was treated with primary surgical resection and the resulting defect was reconstructed with a radial forearm free flap. Conclusions: To our knowledge, this is the youngest subject to have been diagnosed with alveolar soft part sarcoma. Surgical extirpation and microvascular reconstruction were successful, and the patient remains disease free 4 years post-operatively.

A phase II trial of axitinib plus pembrolizumab for patients with advanced alveolar soft part sarcoma (ASPS) and other soft tissue sarcomas (STS).

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 11547-11547 ◽  
Author(s):  
Breelyn A. Wilky ◽  
Matteo Maria Trucco ◽  
Despina Kolonias ◽  
Eric Wieder ◽  
Ty Subhawong ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Soft Part ◽  
Soft Tissue Sarcomas ◽  
Alveolar Soft Part Sarcoma

Primary Alveolar Soft-Part Sarcoma of the Liver: Anomalous Presentation of a Rare Disease

2008 ◽  
Vol 74 (1) ◽  
pp. 43-46 ◽  
Author(s):  
Kyle K. Shaddix ◽  
G. Peter Fakhre ◽  
William W. Nields ◽  
Jeffery L. Steers ◽  
Winston R. Hewitt ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Soft Part ◽  
Case Reports ◽  
Pediatric Population ◽  
Female Genital Tract ◽  
Soft Tissue Sarcomas ◽  
Alveolar Soft Part Sarcoma ◽  
Anatomic Locations ◽  
Female Genital

Alveolar soft-part sarcoma is a highly vascular soft-tissue tumor that is uniformly malignant. It comprises less than 1 per cent of all soft-tissue sarcomas. Patients with alveolar soft-part sarcoma most frequently are aged 15 to 35 years, and the soft tissues of the lower extremities typically are affected. In the pediatric population, it most frequently occurs in the head and neck and particularly affects the tongue and orbit. Alveolar soft-part sarcoma has been described as a primary lesion in the trunk, upper extremities, and retroperitoneum; more novel locations include the mediastinum, female genital tract, stomach, bone, and larynx. Numerous case reports describe alveolar soft-part sarcoma in diverse anatomic locations, but this report is, to our knowledge, the first documentation of primary alveolar soft-part sarcoma of the liver. We describe a 47-year-old woman with such a manifestation. Despite surgical resection and numerous chemotherapeutic regimens, this patient had widespread metastasis and died approximately 2 years after the diagnosis was established.

scholarly journals Alveolar Soft Part Sarcoma with Unusual Cardiac Metastasis: A Case Report and Review of the Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Abhinav Tiwari ◽  
Bhavana Siddegowda Bangalore ◽  
Himani Sharma ◽  
Zaid Ammari ◽  
Mohammad S. Khan ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Soft Part ◽  
Vascular Tumor ◽  
Left Thigh ◽  
Alveolar Soft Part Sarcoma ◽  
Cardiac Metastasis ◽  
Review Of The Literature ◽  
History Of

Alveolar soft part sarcoma is a very uncommon soft tissue malignancy which accounts for <1% of soft tissue sarcoma. It is a malignant and highly vascular tumor arising most commonly in the musculature of the lower extremities, with metastasis primarily to the lungs, bones, and brain. Cardiac metastasis is very rare and only 5 cases have been reported in the literature so far. We report a case of a young woman with a history of surgically resected alveolar soft part sarcoma of left thigh who presented with persistent dry cough and was found to have a cardiac mass, which on biopsy proved to be alveolar soft part sarcoma.

scholarly journals Male urethral sarcoma: a case report and literature review

2015 ◽  
Vol 14 (1) ◽  
pp. 64-66
Author(s):  
Magno Almeida Nogueira ◽  
Guilherme Campelo Lopes dos Santos ◽  
Roberto Iglesias Lopes ◽  
Octavio Henrique Arcos Campos ◽  
Marcos Francisco Dall'Oglio ◽  
...  
Keyword(s):  
Case Report ◽  
Urinary Tract ◽  
Soft Tissue ◽  
Literature Review ◽  
Soft Tissue Sarcomas ◽  
Heterogeneous Group ◽  
Men 2

Urethral tumors are rare and aggressive. They usually affect men (2:1) and occur more commonly in white (85% of cases). Soft tissue sarcomas are a heterogeneous group of tumors that arise from embryonic mesoderm. It represents 1% of all cases of urinary tract malignancies and rarely primary affect the ureter. We report a case of male urethral sarcoma. To date, only two similar cases have been published in literature.

scholarly journals Brain Metastasis of Alveolar Soft Part Sarcoma treated Successfully with Hypothermia: A Case Report

1997 ◽  
Vol 6 (6) ◽  
pp. 408-412
Author(s):  
Satoshi Sawauchi ◽  
Shigehiko Kabe ◽  
Kouichi Takahashi ◽  
Masahiko Akiyama ◽  
Ikuo Shukuya ◽  
...  
Keyword(s):  
Case Report ◽  
Brain Metastasis ◽  
Soft Part ◽  
Alveolar Soft Part Sarcoma

scholarly journals Monophasic Synovial Sarcoma of the Infratemporal Fossa—Case Report and Review of the Literature

2017 ◽  
Vol 13 (01) ◽  
pp. 01
Author(s):  
Ignacio Mendoza ◽  
Ilson Sepúlveda ◽  
Geraldine Ayres ◽  
◽  
◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
South America ◽  
Head And Neck ◽  
Synovial Sarcoma ◽  
Infratemporal Fossa ◽  
Soft Tissue Sarcomas ◽  
Complete Resection ◽  
Review Of The Literature ◽  
Histological Features

Synovial sarcoma (SS) represents about 10% of all soft tissue sarcomas. It is believed that its origin would be found in cells that are related neither to ultrastructural nor to histological features of the synovial tissue. Head and neck is very rarely affected, with the lower extremities being most frequent. Complete resection with or without radiotherapy and chemotherapy is currently considered the best available therapy. This time we present the case of a patient with SS located in the infratemporal fossa, its diagnosis, treatment and evolution. According to our knowledge it is the first reported case in South America.

scholarly journals A case of multiple synchronously diagnosed brain metastases from alveolar soft part sarcoma without concurrent lung involvement

2021 ◽  
Vol 12 ◽  
pp. 111
Author(s):  
Mark A. Damante ◽  
Kristin M. Huntoon ◽  
Joshua D. Palmer ◽  
David A. Liebner ◽  
James Bradley Elder
Keyword(s):  
Soft Tissue ◽  
Brain Metastasis ◽  
Lung Metastasis ◽  
Soft Tissue Mass ◽  
Soft Part ◽  
Primary Lesion ◽  
Alveolar Soft Part Sarcoma ◽  
Lung Involvement ◽  
Tissue Mass ◽  
Intracranial Involvement

Background: Alveolar soft part sarcoma (ASPS) is a rare soft-tissue sarcoma with a propensity for early hematogenous dissemination to the lungs and frequent brain metastasis. The development of lung metastasis almost invariably precedes intracranial involvement. There are no previously reported cases in which a patient was synchronously diagnosed with ASPS and multiple brain metastasis without lung involvement. Case Description: A 29-year-old gentleman was found to have three intracranial lesions following the onset of generalized seizures. Staging studies identified a soft-tissue mass in the left thigh and an adjacent femoral lesion. Biopsy of the soft-tissue mass was consistent with ASPS. The patient then underwent neoadjuvant stereotactic radiotherapy to all three brain lesions, followed by en bloc resection of the dominant lesion. The patient was then started on a programmed death-ligand 1 (PD-L1) inhibitor. Subsequent surgical resection of the primary lesion and femur metastasis demonstrates a histopathologic complete response of the bony metastasis and partial response of the primary lesion. At present, the patient has received 14 cycles of atezolizumab without recurrence of the primary or bony lesions and the irradiated intracranial disease has remained stable without recurrence of the resected dominant lesion. Conclusion: While intracranial involvement is relatively common in ASPS, a case with multiple, synchronously diagnosed brain metastasis without concurrent lung metastasis has not been described. The presented case discusses the safety and efficacy of aggressive management of intracranial disease in the setting of atezolizumab. Prospective evaluation of the efficacy of checkpoint inhibitors and the prognostic value of PD-L1 expression in ASPS with brain metastasis are necessary.

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