High Protein Intake Does Not Prevent Low Plasma Levels of Conditionally Essential Amino Acids in Very Preterm Infants Receiving Parenteral Nutrition

2016 ◽  
Vol 41 (3) ◽  
pp. 455-462 ◽  
Author(s):  
Colin Morgan ◽  
Laura Burgess
Keyword(s):  
Amino Acids ◽  
Parenteral Nutrition ◽  
Preterm Infants ◽  
Plasma Levels ◽  
Protein Intake ◽  
Essential Amino Acids ◽  
High Protein ◽  
Very Preterm Infants ◽  
High Protein Intake ◽  
Very Preterm

High Protein Intake during Continuous Hemodiafiltration: Impact on Amino Acids and Nitrogen Balance

2002 ◽  
Vol 25 (4) ◽  
pp. 261-268 ◽  
Author(s):  
R. Bellomo ◽  
H. K. Tan ◽  
S. Bhonagiri ◽  
I. Gopal ◽  
J. Seacombe ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Nitrogen Balance ◽  
Protein Intake ◽  
Protein Supplementation ◽  
High Protein ◽  
Total Serum ◽  
Amino Acid Supplementation ◽  
Continuous Hemodiafiltration ◽  
High Protein Intake

Aims To study the effect of combined continuous veno-venous hemodiafiltration (CVVHDF) and high (2.5 g/kg/day) parenteral amino acid supplementation on nitrogen balance, amino acid losses and azotemic control in a cohort of patients with severe acute renal failure (ARF). Methods We administered 2.5 grams/kg/day of amino acids intravenously to seven critically ill patients with ARF. We obtained paired blood and ultrafiltrate (UF) samples (n=20) and calculated amino acid clearances and losses, nitrogen balance, protein catabolic rate and total nitrogen losses. Results The median total serum amino acid concentration was high at 5.2 mmol/L with particularly high concentrations of ornithine, lysine, and phenylalanine, but a low level of histidine. The median overall amino acid clearance was 18.6 ml/min (range: 12 to 29 ml/min). UF losses as percentage of administered dose were high for tyrosine (53.6 %) but low for methionine (3.0 %) and arginine (2.3 %). A positive nitrogen balance was achieved in 7 (35%) of the 20 study days with an overall median nitrogen balance of -1.8 g/day. Urea levels were maintained at a median of 26.6 mmol/L. Conclusions High protein intake increases the serum concentrations of most amino acids. Such protein supplementation, when coupled with CVVHDF, achieves a slightly negative overall nitrogen balance in extremely catabolic patients while still allowing adequate azotemic control.

Bone metabolism in very preterm infants receiving total parenteral nutrition: do intravenous fat emulsions have an impact?

2015 ◽  
Vol 73 (12) ◽  
pp. 823-836 ◽  
Author(s):  
Kayla M. Bridges ◽  
Luis Pereira-da-Silva ◽  
Janet C. Tou ◽  
Jane Ziegler ◽  
Luigi Brunetti
Keyword(s):  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Bone Metabolism ◽  
Preterm Infants ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Fat Emulsions ◽  
Intravenous Fat Emulsions
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