Differential Diagnosis of Sinonasal Lymphoma and Squamous Cell Carcinoma on CT, MRI, and PET/CT

2018 ◽  
Vol 159 (3) ◽  
pp. 494-500 ◽  
Author(s):  
Seok-Hyun Kim ◽  
Sue-Jean Mun ◽  
Hak-Jin Kim ◽  
Seon Lin Kim ◽  
Sung-Dong Kim ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Lymphoma ◽  
Bone Destruction ◽  
B Cell Lymphoma ◽  
Imaging Features ◽  
Mr Images ◽  
Pet Ct ◽  
Adc Values

Objective The purpose of this study was to analyze computed tomography (CT) and magnetic resonance (MR) images and to evaluate the maximum standardized uptake value (SUV max) of positron emission tomography (PET)/CT parameters between sinonasal non-Hodgkin’s lymphoma (NHL) and squamous cell carcinoma (SCC), knowing the imaging features that distinguish sinonasal NHL from SCC. Study Design Case series with chart review. Setting University tertiary care facility. Subjects and Methods We analyzed the features on CT, MR imaging, and PET/CT of 78 patients diagnosed with sinonasal NHL or SCC histopathologically. The CT (n = 34), MRI (n = 25), and PET/CT (n = 33) images of 39 patients with sinonasal NHL and the CT (n = 38), MR (n = 28), and PET/CT (n = 31) images of 39 patients with SCC were evaluated. The sinonasal NHL was diagnosed as natural killer/T-cell lymphoma (n = 28) and diffuse large B-cell lymphoma (n = 11). Results Patients with sinonasal NHL had a larger tumor volume and higher tumor homogeneity than patients with SCC on T2-weighted and postcontrast MR images. Most of the sinonasal NHL and SCC showed a high degree of enhancement. The apparent diffusion coefficient (ADC) values and adjacent bone destruction were significantly lower in sinonasal NHL than in SCC. However, cervical lymphadenopathy, Waldeyer’s ring involvement, and PET/CT SUV max showed no significant differences between sinonasal NHL and SCC. Conclusion CT and MR images of sinonasal masses showing a bulky lesion, marked homogeneity, and low ADC values without adjacent bone destruction are more suggestive of sinonasal NHL than SCC.

scholarly journals Differential Diagnosis of Sinonasal Extramedullary Plasmacytoma, Non-Hodgkin’s Lymphoma, and Squamous Cell Carcinoma Using CT Scan and MRI

2021 ◽  
Vol 18 (2) ◽  
Author(s):  
Dong-Joo Lee ◽  
Sang Duk Hong ◽  
Myeong Sang Yu ◽  
Sung Jae Heo ◽  
Joo-Yeon Kim ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Mr Imaging ◽  
Cell Carcinoma ◽  
Tumor Volume ◽  
Cell Lymphoma ◽  
Bone Destruction ◽  
Extramedullary Plasmacytoma ◽  
Imaging Features ◽  
Mr Images ◽  
Waldeyer’S Ring

Background: The imaging features of sinonasal extramedullary plasmacytoma (EMP) are non-specific and similar to those of other lesions, such as sinonasal non-Hodgkin’s lymphoma (NHL) and squamous cell carcinoma (SCC). Objectives: To analyze the computed tomography (CT) and magnetic resonance (MR) images of patients with EMP, NHL, and SCC to identify the radiological characteristics differentiating sinonasal EMP from NHL and SCC. Patients and Methods: In this cross-sectional study, the CT and MR imaging features of 37 patients with sinonasal EMP, 46 patients with NHL, and 44 patients with SCC were analyzed. Sinonasal NHL was categorized into two distinct types, namely, natural killer/T-cell lymphoma (n = 32) and diffuse large B-cell lymphoma (n = 14). The tumor volume was determined by measuring the region of interest (ROI) in the PACS program. Besides, homogeneity, apparent diffusion coefficient (ADC) in the ADC maps, degree of enhancement, adjacent bone destruction, and invasion to Waldeyer’s ring and cervical or retropharyngeal lymph nodes were evaluated. Results: Although the tumor volume was larger in the EMP group as compared to the NHL and SCC groups, the difference was not statistically significant. The NHL group showed the highest tumor homogeneity on both CT and MR images. EMP was more heterogenous than NHL, with moderate signal intensity on T1-weighted MR images. On the other hand, EMP and NHL showed significantly lower ADCs as compared to SCC. The majority of patients with sinonasal EMP, NHL, and SCC showed an avid enhancement. Also, destructive tumor growth involving the adjacent bone was more frequent in SCC than in EMP or NHL. However, there were no significant differences among sinonasal EMP, NHL, and SCC in terms of invasion to Waldeyer’s ring and cervical or retropharyngeal lymph node metastasis. Conclusion: Marked heterogeneity on T1-weighted images, low ADCs, and lack of adjacent bone destruction were the CT and MR imaging features that favored the diagnosis of EMP over NHL or SCC.

Rare association of cystic squamous cell carcinoma and small lymphocytic B cell lymphoma: successful surgical approach

2016 ◽  
Vol 167 (5-6) ◽  
pp. 104-109
Author(s):  
Uwe Wollina ◽  
Jacqueline Schönlebe ◽  
Birgit Heinig ◽  
Andreas Nowak ◽  
Anastasiya Atanasova Chokoeva ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
B Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surgical Approach ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Rare Association

scholarly journals Case of a lung collision tumor consisting of squamous cell carcinoma of the lung and diffuse large B-cell lymphoma

2021 ◽  
Author(s):  
Masato SASAKI ◽  
Kayo SAKON ◽  
Kaede TANAKA ◽  
Tae MIZUNAGA ◽  
Keita YANO ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Malignant Lymphoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Collision Tumor ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Abstract Background The collision tumor consisted of two malignant tumors that independently developed and were contiguous or had invaded each other. Among the reports of malignant collision tumors, collision tumors consisting of lung cancer and malignant lymphoma are extremely rare. We report case of a lung collision tumor consisting of squamous cell carcinoma of the lung and diffuse large B-cell lymphoma.Case presentationA 74-year-old man was admitted to the hospital due to identification of an abnormal nodular shadow in the right upper lobe on chest computed tomography following a chest X-ray. At the time of admission, a swollen lymph node of 7 cm × 5 cm was palpated in the left neck, and serum examination showed an abnormally high level of soluble interleukin-2 receptor. Close examination led to a diagnosis of stage IA squamous cell carcinoma of the lung and stage IVA malignant lymphoma, and treatment for the malignant lymphoma was prioritized. However, due to progression of lung cancer, a right upper lobectomy with lymph node dissection was performed. Pathological findings showed that squamous cell carcinoma and malignant lymphoma were both present in the same lesion.ConclusionOnly two cases of collision tumors consisting of malignant lymphoma and primary lung cancer were reported [1] [2] and this case is considered to be the third rare case in the world. As the rate of complications with other malignancies in patients with diffuse large B-cell lymphoma is high, in the case of advanced stage malignant lymphoma, physicians must consider which treatment should be prioritized according to the degree of progression of coexisting solid tumors.

scholarly journals Potential Added Value of PET/CT Radiomics for Survival Prognostication beyond AJCC 8th Edition Staging in Oropharyngeal Squamous Cell Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1778
Author(s):  
Stefan P. Haider ◽  
Tal Zeevi ◽  
Philipp Baumeister ◽  
Christoph Reichel ◽  
Kariem Sharaf ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Risk Stratification ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Added Value ◽  
Imaging Features ◽  
Cervical Lymph Nodes ◽  
Pet Ct ◽  
8Th Edition

Accurate risk-stratification can facilitate precision therapy in oropharyngeal squamous cell carcinoma (OPSCC). We explored the potential added value of baseline positron emission tomography (PET)/computed tomography (CT) radiomic features for prognostication and risk stratification of OPSCC beyond the American Joint Committee on Cancer (AJCC) 8th edition staging scheme. Using institutional and publicly available datasets, we included OPSCC patients with known human papillomavirus (HPV) status, without baseline distant metastasis and treated with curative intent. We extracted 1037 PET and 1037 CT radiomic features quantifying lesion shape, imaging intensity, and texture patterns from primary tumors and metastatic cervical lymph nodes. Utilizing random forest algorithms, we devised novel machine-learning models for OPSCC progression-free survival (PFS) and overall survival (OS) using “radiomics” features, “AJCC” variables, and the “combined” set as input. We designed both single- (PET or CT) and combined-modality (PET/CT) models. Harrell’s C-index quantified survival model performance; risk stratification was evaluated in Kaplan–Meier analysis. A total of 311 patients were included. In HPV-associated OPSCC, the best “radiomics” model achieved an average C-index ± standard deviation of 0.62 ± 0.05 (p = 0.02) for PFS prediction, compared to 0.54 ± 0.06 (p = 0.32) utilizing “AJCC” variables. Radiomics-based risk-stratification of HPV-associated OPSCC was significant for PFS and OS. Similar trends were observed in HPV-negative OPSCC. In conclusion, radiomics imaging features extracted from pre-treatment PET/CT may provide complimentary information to the current AJCC staging scheme for survival prognostication and risk-stratification of HPV-associated OPSCC.

Coincidental detection of T-cell rich B cell lymphoma in the para-aortic lymph nodes of a woman undergoing lymph node dissection for cervical cancer: A case report

2003 ◽  
Vol 13 (5) ◽  
pp. 687-689
Author(s):  
H. Abali ◽  
O. O. Eren ◽  
M. Erman ◽  
A. H. Uner ◽  
F. Kose ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
T Cell ◽  
Lymph Nodes ◽  
B Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Human Immuno Deficiency Virus

The diagnosis of cervical squamous cell carcinoma with concurrent T-cell rich B cell lymphoma in dissected lymph nodes has not been reported to our knowledge. In our case, the biopsy of an exophytic lesion at the uterine cervix showed squamous cell carcinoma in a 50-year-old woman presenting with postcoital bleeding. Type III hysterectomy, bilateral salpingo-oophorectemy, bilateral pelvic, para-aortic lymph node dissections were performed. Pathologic examination revealed a T-cell rich B cell lymphoma in some lymph nodes beside squamous cell carcinoma in several of others. ELISA for human immuno-deficiency virus (HIV) was negative. The cervical carcinoma was staged as FIGO clinical stage IB1 and the lymphoma as Ann Arbor IIA. Six cycles of CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolon) chemotherapy for the lymphoma and concomitant pelvic chemoradiotherapy with cisplatin for cervical cancer were given. In this rare coincidence, the best available therapy for each of the diseases should be considered individually. We also suggest that HIV screennig test be carried out, because both diseases may be related to human immuno-deficiency virus, although our patient is HIV-negative.

Coincidental detection of T-cell rich B-cell lymphoma in the paraaortic lymph nodes of a woman undergoing lymph node dissection for cervical cancer

2003 ◽  
Vol 13 (4) ◽  
pp. 548-550
Author(s):  
H. Abali ◽  
O. O. Eren ◽  
M. Erman ◽  
A. H. Uner ◽  
F. Kose ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
T Cell ◽  
Lymph Nodes ◽  
B Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Human Immuno Deficiency Virus

The diagnosis of cervical squamous cell carcinoma with concurrent T-cell rich B-cell lymphoma in dissected lymph nodes has not been reported to our knowledge. We report such a case. The biopsy of an exophytic lesion at the uterine cervix showed squamous cell carcinoma in a 50-year-old woman presenting with postcoital bleeding. Type III hysterectomy, bilateral salpingo-oophorectemy, bilateral pelvic, paraaortic lymph node dissections were performed. Pathologic examination revealed a T-cell rich B-cell lymphoma in some lymph nodes beside squamous cell carcinoma in several of others. ELISA for human immuno-deficiency virus (HIV) was negative. The cervical carcinoma was staged as FIGO clinical stage IB1 and the lymphoma as Ann Arbor IIA. Six cycles of CHOP (cyclophosphamide, adriamycin, vincristine, and prednisone) chemotherapy for the lymphoma and concomitant pelvic chemo-radiotherapy with cisplatin for cervical cancer were given. In this rare coincidence; the best available therapy for each of the diseases should be considered individually. We also suggest that HIV screening test be carried out, because both diseases may be related to human immuno-deficiency virus, although our patient was HIV-negative.

Immunotoxicologic effects of cyclosporine on tumor progression in models of squamous cell carcinoma and B-cell lymphoma in C3H mice

2012 ◽  
Vol 9 (1) ◽  
pp. 43-55 ◽  
Author(s):  
Patricia Rafferty ◽  
Devon Egenolf ◽  
Kerry Brosnan ◽  
Dorie Makropoulos ◽  
Jarrat Jordan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
B Cell ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
C3h Mice
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