The effect of alpha-lipoic acid supplementation and electrical isotonic contraction on anthropometric parameters, body composition and angiogenesis factor, sirtunin-1 and peroxisome proliferator-activated receptor-γ coactivator-1α in obese people under a weight loss regime: A study protocol for a randomized controlled clinical trial

Background: Obesity is defined as a chronic disease, and is known as a public health problem in developed and developing countries. Several studies have shown the effects of anti-obesity of α-lactalbumin. Aim: This study was designed to investigate the effect of alpha-lipoic acid supplementation and electrical isotonic contraction on anthropometric parameters, body composition and angiogenesis factor, sirtunin-1 and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α) in obese people under a weight loss regime. Methods: Obese people who meet the inclusion criteria are included. Participants are randomly divided into four groups (alpha-lipoic (1200 mg) +weight loss regime group; Faradic (three 1 hour sessions) + weight loss regime group; alpha-lipoic (1200 mg) + Faradic (three 1 hour sessions) + weight loss regime group; control group (1200 mg placebo) for 2 months. At the beginning and the end of the study, demographic information, dietary intake, anthropometric parameters, body composition and serum levels of the angiogenesis factor (sirtunin-1, PGC1α and nitric oxide) are measured. Conclusion: Recent studies reported the anti-obesity effects of alpha-lipoic acid. This study is novel, since a similar study has not yet been carried out. This study evaluates the effect of 600 mg of alpha-lipoic acid supplementation or having three sessions of 1 hour per week electrical isotonic contraction induced by Faradic for 2 months alone or in combination in obese people that are undergoing a weight loss regime. Trial registration: Iran Clinical Trials Registry, ID: IRCT20131117015424N2. Registered 2018-04-02

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The effect of alpha-lipoic acid supplementation and Electrical isotonic contraction on anthropometric measurements, body composition, angiogenesis factors, sirtunin-1, and PGC1-α in obese people undergoing a weight loss diet

10.21203/rs.2.23152/v1 ◽

2020 ◽

Author(s):

Majid Mohammadshahi ◽

Elahe Zakizadeh ◽

Kambiz Ahmadi Angali ◽

Majid Ravanbakhsh ◽

Bijan Helli

Keyword(s):

Weight Loss ◽

Body Composition ◽

Lipoic Acid ◽

Anthropometric Measurements ◽

Fat Free Mass ◽

Control Group ◽

Alpha Lipoic Acid ◽

Anthropometric Parameters ◽

Obese People ◽

Isotonic Contraction

Abstract Background: The anti-obesity effects of Alpha-lipoic acid (α-LA) and isotonic contraction has been reported. However, the underlying mechanism is not fully understood. This study aimed to investigate the effect of α-LA supplementation and Faradic (an electrical stimulating system) on anthropometric parameters, body composition, VEGF, Sirtunin-1, nitric oxide (NO), and PGC1-α in obese people undergoing a weight loss regime.Methods: This randomized clinical trial was carried out on 100 obese adults. The subjects were randomly assigned to four groups of 25 subjects including Faradic, α-LA, -α-LA+Faradic, and control. A Bio Impedance Analyzer (BIA) was used to estimate anthropometric measurements including weight, body mass index (BMI), fat mass, and fat free mass. The serum levels of Sirtunin-1, PGC1-α, VEGF, and NO levels were measured. All measurements were done at baseline and after 8 weeks of intervention.Results: A significant weight reduction was observed in all four groups compared to baseline (p=<0.01). The placebo group had significantly higher weight, BMI, weight circumstance (WC), and body fat (BF) compared with the other groups. The α-LA+Faradic group had significantly lower weight, BMI, BF, WC than control, faradic, and α-LA groups and higher, Sitruin,, and PGC than the control group (all P <0.05).Conclusions: The findings indicated that the α-LA and Faradic interventions may have a synergistic effect on weight, BMI, BF, WC, and SLM, possibly through changes in serum level of VEGF, NO, and PGC. Further researches are warranted to clarify the mutual effects of –α-LA and Faradic on obesity and molecular biomarkers.Name of the registry: Iranian Registry of Clinical TrialsTrial registration number: IRCT20131117015424N2Date of registration: https://www.irct.ir/search/result?query=IRCT20131117015424N2URL of trial registry record: 04/04/2018

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The synergic effects of alpha-lipoic acid supplementation and electrical isotonic contraction on anthropometric measurements and the serum levels of VEGF, NO, sirtuin-1, and PGC1-α in obese people undergoing a weight loss diet

Archives of Physiology and Biochemistry ◽

10.1080/13813455.2020.1762660 ◽

2020 ◽

pp. 1-7

Author(s):

Majid Mohammadshahi ◽

Elahe Zakizadeh ◽

Kambiz Ahmadi-Angali ◽

Majid Ravanbakhsh ◽

Bijan Helli

Keyword(s):

Weight Loss ◽

Lipoic Acid ◽

Serum Levels ◽

Anthropometric Measurements ◽

Sirtuin 1 ◽

Alpha Lipoic Acid ◽

Obese People ◽

Isotonic Contraction ◽

Acid Supplementation ◽

Weight Loss Diet

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Nordic Walking Promoted Weight Loss in Overweight and Obese People: A Systematic Review for Future Exercise Prescription

Journal of Functional Morphology and Kinesiology ◽

10.3390/jfmk4020036 ◽

2019 ◽

Vol 4 (2) ◽

pp. 36 ◽

Cited By ~ 2

Author(s):

Stefano Gobbo ◽

Valentina Bullo ◽

Enrico Roma ◽

Federica Duregon ◽

Danilo Sales Bocalini ◽

...

Keyword(s):

Systematic Review ◽

Weight Loss ◽

Body Composition ◽

Glucose Tolerance ◽

Blood Sample ◽

Aerobic Capacity ◽

Nordic Walking ◽

Anthropometric Parameters ◽

Obese People ◽

Cardiovascular Parameters

The aim of this systematic review was to analyze the effect of Nordic Walking (NW) on anthropometric parameters, body composition, cardiovascular parameters, aerobic capacity, blood sample, and glucose tolerance in overweight and obese subjects. The main keywords “Nordic Walking” or “Pole Walking”, associated with either “obese”, “obesity”, “overweight”, or “weight loss” were used on the online database MEDLINE, PubMed, SPORTDiscus and Scopus. Additionally, references of the studies included were screened to identify eligible articles. Applying the inclusion and exclusion criteria, ten manuscripts were considered as eligible for this review. The results of the studies were categorized in several domains with regard to “anthropometric parameters and body composition”, “cardiovascular parameters and aerobic capacity”, and “blood sample and glucose tolerance”. The results showed positive effects on the anthropometric parameters, body composition, cardiovascular parameters, blood sample, and glucose tolerance. The greatest improvements were observed in supervised and high weekly frequency of NW interventions. NW could be considered as an effective modality through which to involve the obese in physical activity. For weight loss, NW should be prescribed 4–5 times per week, at least 60 min per session, preferably combined with diet control.

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