Lipoic Acid Supplementation Promotes Weight Loss and Improves Body Composition in Overweight or Obese Women: Results of a Randomized, Double-Blind, Placebo-Controlled Study

2014 ◽  
Vol 76 ◽  
pp. S57
Author(s):  
Weijian Zhang ◽  
Jonathan Purnell ◽  
Clive Woffendin ◽  
Cliff Pereira ◽  
Alexander J Michels ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Lipoic Acid ◽  
Controlled Study ◽  
Obese Women ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Acid Supplementation

The effect of alpha-lipoic acid supplementation and electrical isotonic contraction on anthropometric parameters, body composition and angiogenesis factor, sirtunin-1 and peroxisome proliferator-activated receptor-γ coactivator-1α in obese people under a weight loss regime: A study protocol for a randomized controlled clinical trial

2020 ◽  
pp. 026010602092683
Author(s):  
Majid Mohammadshahi ◽  
Elahe Zakizadeh ◽  
Kambiz Ahmadi-Angali ◽  
Majid Ravanbakhsh ◽  
Bijan Helli
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Lipoic Acid ◽  
Peroxisome Proliferator ◽  
Alpha Lipoic Acid ◽  
Anthropometric Parameters ◽  
Obese People ◽  
Isotonic Contraction ◽  
Angiogenesis Factor ◽  
Acid Supplementation

Background: Obesity is defined as a chronic disease, and is known as a public health problem in developed and developing countries. Several studies have shown the effects of anti-obesity of α-lactalbumin. Aim: This study was designed to investigate the effect of alpha-lipoic acid supplementation and electrical isotonic contraction on anthropometric parameters, body composition and angiogenesis factor, sirtunin-1 and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α) in obese people under a weight loss regime. Methods: Obese people who meet the inclusion criteria are included. Participants are randomly divided into four groups (alpha-lipoic (1200 mg) +weight loss regime group; Faradic (three 1 hour sessions) + weight loss regime group; alpha-lipoic (1200 mg) + Faradic (three 1 hour sessions) + weight loss regime group; control group (1200 mg placebo) for 2 months. At the beginning and the end of the study, demographic information, dietary intake, anthropometric parameters, body composition and serum levels of the angiogenesis factor (sirtunin-1, PGC1α and nitric oxide) are measured. Conclusion: Recent studies reported the anti-obesity effects of alpha-lipoic acid. This study is novel, since a similar study has not yet been carried out. This study evaluates the effect of 600 mg of alpha-lipoic acid supplementation or having three sessions of 1 hour per week electrical isotonic contraction induced by Faradic for 2 months alone or in combination in obese people that are undergoing a weight loss regime. Trial registration: Iran Clinical Trials Registry, ID: IRCT20131117015424N2. Registered 2018-04-02

scholarly journals Evaluation of the effect of oral taurine supplementation on levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in obese women on a weight-loss diet: a study protocol for a double-blind randomized controlled trial

2019 ◽  
Author(s):  
Fatemeh Haidari ◽  
Maryam Asadi ◽  
Javad Mohammadi-asl ◽  
Kambiz Ahmadi-angali
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Fibroblast Growth Factors ◽  
The Other ◽  
Fibroblast Growth ◽  
Obese Women ◽  
Double Blind ◽  
Randomized Controlled ◽  
Weight Loss Diet ◽  
Biochemical Indices

Abstract Background: according to studies, the function of FGFs are disturbed in obesity. So that, serum level of FGFs are correlated with insulin resistance and obesity. Besides the effects of eicosapentaenoic acid on serum FGF21 concentrations, the effect of other nutrients on FGFs is not clear. Since obesity as an important health problem is rising in the world and on the other side, taurine (Tau) biosynthesis is reduced by adipose tissue-derived factors in obesity, the effects of Tau and a weight loss diet on obesity need to be investigated further. Methods: We will conduct a 2 month’s double-blind, parallel-group, randomized controlled clinical trial to investigate the effect of Tau supplementation on serum levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in obese women on a weight-loss diet. Discussion: we will determine the other advantages of a weight loss diet on metabolic risk factors. Moreover, for the first time, the effects of a weight loss diet along with Tau supplementation on these variables will be assessed.

scholarly journals Effect of Citrulline and Leucine Intake with Exercises on Body Composition, Physical Activity, and Amino Acid Concentration in Older Women: A Randomized Double-Blind Placebo-Controlled Study

Foods ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3117
Author(s):  
Mijin Kim ◽  
Hiroko Isoda ◽  
Tomohiro Okura
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Body Weight ◽  
Amino Acid ◽  
Older Women ◽  
Body Mass ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Amino Acid Concentrations

The combined intake of citrulline (CIT) and leucine (LEU) can stimulate protein synthesis. Therefore, this study aimed to investigate the effect of combined intake of CIT and LEU accompanied by exercise for 20 weeks on body composition, physical activity (PA), and amino acid concentrations in older Japanese women with low body mass index (BMI) (16 to 21 kg/m2) using a randomized, double-blind, placebo-controlled design. The supplement was administered twice a day for 20 weeks (Ex (exercise) + CIT·LEU group, n = 10: mainly 0.8 g CIT and 1.6 g LEU; Ex + Placebo group, n = 13: mainly 3.5 g carbohydrate). Additionally, both groups exercised (weight-bearing exercise, square stepping exercise) once a week for 75 min. Body composition, PA, and amino acid concentrations in the plasma were measured. Body weight, BMI, body mass, household PA, total PA, and phenylalanine significantly increased in the Ex + CIT·LEU group (p < 0.05) post intervention. This study suggests that the combined intake of CIT and LEU accompanied by exercise can improve body weight, BMI, body mass, and PA in older women with low BMI, which may prevent sarcopenia and frailty.

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